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Article ; Online: Optimal Roux-en-Y reconstruction after distal gastrectomy for early gastric cancer as assessed using the newly developed PGSAS-45 scale.

Kawahira, Hiroshi / Kodera, Yasuhiro / Hiki, Naoki / Takahashi, Masazumi / Itoh, Seiji / Mitsumori, Norio / Kawashima, Yoshiyuki / Namikawa, Tsutomu / Inada, Takao / Nakada, Koji

Surgery today

2015 Volume 45, Issue 10, Page(s) 1307–1316

Abstract: Purpose: The optimal surgical procedure for distal gastrectomy with Roux-en-Y reconstruction (DGRY ...

Abstract	Purpose: The optimal surgical procedure for distal gastrectomy with Roux-en-Y reconstruction (DGRY) remains to be determined. Recently, a self-report assessment instrument, the Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45), was compiled to evaluate symptoms, the living status and the quality of life of patients who have undergone gastrectomy. We used this scale to evaluate procedures used for DGRY. Methods: The subjects included 475 patients who underwent DGRY for stage IA/IB gastric cancer. We evaluated whether the size of the remnant stomach, length of the Roux limb, reconstruction route and anastomotic procedure affected the patients' symptoms, living status and quality of life assessed using the PGSAS-45. Results: Patients with a residual stomach of more than half had significantly worse esophageal reflux scores than the patients with a smaller residual stomach (P = 0.0462); a residual stomach of one-third or one-fourth was favorable. A shorter length of the Roux limb was shown to be preferable to a longer Roux limb based on the results of the PGSAS-45. In addition, antecolic reconstruction and the anastomotic procedure using a linear stapler were found to be more favorable. Conclusions: The size of the remnant stomach and the length and route of the Roux limb significantly influence the patient-reported DGRY outcomes.
MeSH term(s)	Adult ; Aged ; Anastomosis, Roux-en-Y/methods ; Diagnostic Self Evaluation ; Female ; Gastrectomy/methods ; Humans ; Male ; Middle Aged ; Postgastrectomy Syndromes/diagnosis ; Quality of Life ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Surgical Staplers ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2015-10
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1115435-4
ISSN	1436-2813 ; 0941-1291
ISSN (online)	1436-2813
ISSN	0941-1291
DOI	10.1007/s00595-015-1111-9
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Article ; Online: Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence.

Okahisa, Yuko / Ujike, Hiroshi / Kotaka, Tatsuya / Morita, Yukitaka / Kodama, Masafumi / Inada, Toshiya / Yamada, Mitsuhiko / Iwata, Nakao / Iyo, Masaomi / Sora, Ichiro / Ozaki, Norio / Kuroda, Shigetoshi

Psychiatry and clinical neurosciences

2009 Volume 63, Issue 3, Page(s) 417–422

Abstract: Aims: Neuropeptide Y (NPY) is a 36-amino acid peptide that is widely distributed in the brain ...

Abstract	Aims: Neuropeptide Y (NPY) is a 36-amino acid peptide that is widely distributed in the brain, adrenal medulla, and sympathetic nervous system. Several lines of evidence suggest a possible involvement of the NPY system in the physiological effects of several classes of abused substances including alcohol, phencyclidine, cocaine, and marijuana and in endogenous psychosis. Accordingly, it was hypothesized that the NPY system may also be involved in methamphetamine dependence or psychosis. Methods: The single nucleotide polymorphisms rs16147 of the NPY gene (-485C>T) and rs7687423 of the NPY receptor Y1 (NPY1R) gene were analyzed in 222 patients with methamphetamine dependence and psychosis and 288 age- and gender-matched controls. Results: Genotypic distribution of the NPY1R gene showed a significant association with methamphetamine dependence and psychosis (P = 0.04), whereas the NPY gene had no significant association with them. Conclusion: It is possible that genetic variants of the NPY1R gene affect the NPY-NPY receptor type Y1 signaling system in the brain, which may result in susceptibility to methamphetamine dependence or the development of methamphetamine psychosis, but the present findings need to be confirmed on replication.
MeSH term(s)	Adult ; Amphetamine-Related Disorders/genetics ; Case-Control Studies ; Female ; Gene Frequency ; Genotype ; Humans ; Male ; Methamphetamine/adverse effects ; Neuropeptide Y/genetics ; Phenotype ; Polymorphism, Single Nucleotide ; Receptors, Neuropeptide Y/genetics
Chemical Substances	Neuropeptide Y ; Receptors, Neuropeptide Y ; neuropeptide Y-Y1 receptor ; Methamphetamine (44RAL3456C)
Language	English
Publishing date	2009-06
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1292906-2
ISSN	1440-1819 ; 1323-1316
ISSN (online)	1440-1819
ISSN	1323-1316
DOI	10.1111/j.1440-1819.2009.01961.x
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Article ; Online: Staple-Line Reinforcement of the Duodenal Stump With Intracorporeal Lembert's Sutures in Laparoscopic Distal Gastrectomy With Roux-en-Y Reconstruction for Gastric Cancer.

Inoue, Kentaro / Michiura, Taku / Fukui, Junichi / Mukaide, Hiromi / Ozaki, Takashi / Miki, Hirokazu / Kobayashi, Toshinori / Oishi, Masaharu / Inada, Ryo / Matsumoto, Tomoko / Yamada, Masanori / Yanagimoto, Hiroaki / Kim, Songtae / Satoi, Sohei / Kaibori, Masaki / Kon, Masanori / Hamada, Madoka

Surgical laparoscopy, endoscopy & percutaneous techniques

2016 Volume 26, Issue 4, Page(s) 338–342

Abstract: ... with Roux-en-Y reconstruction.: Methods: We retrospectively reviewed the data of 223 patients ... who underwent laparoscopic distal gastrectomy with Roux-en-Y reconstruction for gastric cancer. We compared 2 ...

Abstract	Purpose: We report a duodenal stump reinforcement procedure in laparoscopic distal gastrectomy with Roux-en-Y reconstruction. Methods: We retrospectively reviewed the data of 223 patients who underwent laparoscopic distal gastrectomy with Roux-en-Y reconstruction for gastric cancer. We compared 2 groups: group NR (not reinforced, n=102, June 2009 to December 2011) when we did not perform reinforcement of the duodenal stump, and group R (reinforced, n=121, January 2012 to July 2014) when we did the reinforcement. The duodenum was divided with an endoscopic linear stapler. In group R, the duodenal staple line was reinforced by hand-sewn Lembert's sutures. Results: There were no significant differences between group NR and R in patients' characteristics. Duodenal stump leakage occurred in 2 patients in group NR (2.0%). By contrast, in R group, no patients had duodenal stump leakage or fistula. Conclusions: Duodenal stump leakage can be avoided by using reinforcement with Lembert's sutures.
MeSH term(s)	Anastomosis, Roux-en-Y/methods ; Female ; Gastrectomy/methods ; Gastroscopy/methods ; Humans ; Male ; Middle Aged ; Postoperative Hemorrhage/etiology ; Stomach Neoplasms/surgery ; Surgical Stapling/methods ; Suture Techniques
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	1475108-2
ISSN	1534-4908 ; 1530-4515 ; 1051-7200
ISSN (online)	1534-4908
ISSN	1530-4515 ; 1051-7200
DOI	10.1097/SLE.0000000000000291
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Article ; Online: Co-Translational Quality Control Induced by Translational Arrest.

Matsuo, Yoshitaka / Inada, Toshifumi

Biomolecules

2023 Volume 13, Issue 2

Abstract: Genetic mutations, mRNA processing errors, and lack of availability of charged tRNAs sometimes slow down or completely stall translating ribosomes. Since an incomplete nascent chain derived from stalled ribosomes may function anomalously, such as by ... ...

Abstract	Genetic mutations, mRNA processing errors, and lack of availability of charged tRNAs sometimes slow down or completely stall translating ribosomes. Since an incomplete nascent chain derived from stalled ribosomes may function anomalously, such as by forming toxic aggregates, surveillance systems monitor every step of translation and dispose of such products to prevent their accumulation. Over the past decade, yeast models with powerful genetics and biochemical techniques have contributed to uncovering the mechanism of the co-translational quality control system, which eliminates the harmful products generated from aberrant translation. We here summarize the current knowledge of the molecular mechanism of the co-translational quality control systems in yeast, which eliminate the incomplete nascent chain, improper mRNAs, and faulty ribosomes to maintain cellular protein homeostasis.
MeSH term(s)	Protein Biosynthesis ; Saccharomyces cerevisiae/metabolism ; Ribosomes/metabolism ; RNA, Transfer/metabolism
Chemical Substances	RNA, Transfer (9014-25-9)
Language	English
Publishing date	2023-02-07
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13020317
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Article ; Online: Causal Relationships between Daily Physical Activity, Physical Function, and Cognitive Function Ultimately Leading to Happiness.

Inada, Yuna / Tohda, Chihiro

International journal of environmental research and public health

2023 Volume 20, Issue 4

Abstract: Frailty is a common age-related condition linked with mobility disorders, long-term care, and death. To prevent frailty, physical activities are considered effective. Several studies have indicated that physical activity can influence mental health as ... ...

Abstract	Frailty is a common age-related condition linked with mobility disorders, long-term care, and death. To prevent frailty, physical activities are considered effective. Several studies have indicated that physical activity can influence mental health as well as body function. Physical activity, cognitive function, and subjective mental health must relate to each other. However, most studies only focus on one-to-one interactions. This observational study aims to clarify the overall relationship and causality between subjective mental health, daily physical activity, and physical and cognitive functions. We recruited 45 people (24 males and 21 females) over 65 years old. Participants visited the university twice and were subjected to activity measurements at home. To examine the causal relationships and related structures between the indicators, structural equation modeling was performed. The results suggest that daily physical activity explains physical function, physical function explains cognitive function, and cognitive function explains subjective mental health, quality of life, and happiness. This study is the first to clarify interactive relationships as an axis that start from daily physical activity to happiness in older adults. Upregulating daily physical activity may improve physical and cognitive functions as well as mental health; this might protect and ameliorate physical, mental, and social frailties.
MeSH term(s)	Male ; Female ; Humans ; Aged ; Quality of Life ; Frailty/psychology ; Happiness ; Cognition/physiology ; Exercise/physiology
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20043016
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Article ; Online: NADPH oxidase-mediated sulfenylation of cysteine derivatives is key regulatory events for plant immune responses.

Hino, Yuta / Inada, Taichi / Yoshioka, Miki / Yoshioka, Hirofumi

Journal of experimental botany

2024

Abstract: Reactive oxygen species (ROS) are rapidly generated during plant immune responses by RBOH, which is a plasma membrane-localizing NADPH oxidase. Although regulatory mechanisms of RBOH activity have been well documented, the ROS-mediated downstream ... ...

Abstract	Reactive oxygen species (ROS) are rapidly generated during plant immune responses by RBOH, which is a plasma membrane-localizing NADPH oxidase. Although regulatory mechanisms of RBOH activity have been well documented, the ROS-mediated downstream signaling is unclear. We here demonstrated that ROS sensor proteins play a central role in the ROS signaling via oxidative post-translational modification of cysteine residues, sulfenylation. To detect protein sulfenylation, we used dimedone, which specifically and irreversibly binds to sulfenylated proteins. The sulfenylated proteins were labeled by dimedone in Nicotiana benthamiana leaves, and the conjugates were detected by immunoblot analyses. In addition, a reductant dissociated H2O2-induced conjugates, suggesting that cysteine persulfide and/or polysulfides are involved in sulfenylation. These sulfenylated proteins were continuously increased during both PTI and ETI in a RBOH-dependent manner. Pharmacological inhibition of ROS sensor proteins by dimedone perturbated cell death, ROS accumulation induced by INF1 and MEK2DD, and defense against fungal pathogens. On the other hand, Rpi-blb2-mediated ETI responses were rather enhanced by dimedone. These results suggest that the sulfenylation of cysteine and its derivatives in various ROS sensor proteins are important events in downstream of RBOH-dependent ROS burst to regulate plant immune responses.
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2976-2
ISSN	1460-2431 ; 0022-0957
ISSN (online)	1460-2431
ISSN	0022-0957
DOI	10.1093/jxb/erae111
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Article ; Online: Analysis of head motions during food intake in Japanese adults using a new motion capture system.

Chinju, Kohei / Yamamoto, Yushi / Inada, Emi / Iwashita, Yoichiro / Sato, Hideo

Archives of oral biology

2024 Volume 160, Page(s) 105908

Abstract: Objective: A new motion capture system was developed to verify the hypothesis that "during food intake, head motion changes according to the properties of the food.": Design: Twenty healthy males and 20 healthy females with right-handed and normal ... ...

Abstract	Objective: A new motion capture system was developed to verify the hypothesis that "during food intake, head motion changes according to the properties of the food." Design: Twenty healthy males and 20 healthy females with right-handed and normal occlusion participated in this study. The motion capture system used consisted of a Microsoft Xbox One Kinect Sensor® and a newly-developed program. Meatballs (solid), yogurt (paste), and water (fluid) were used as food samples. Head motion distance, head turning angle, and head forward angle were measured during food intake. Unpaired t-tests were used to analyze each head motion and compare the sexes. A one-way repeated measures analysis of variance was used to analyze each head motion for different food samples. Results: Head motion distance was significantly smaller in females for the meatball and yogurt, but not for water. There were no significant differences between the sexes for head turning angle or head forward angle. Head motion distance and head forward angle were significantly larger for water than for meatballs and yogurt. The head turning angle was significantly smaller for the meatball than for yogurt and water. Conclusions: The results indicated that females tend to consume food without moving their heads when eating solid and paste foods. As the fluidity of the food increased, the head moved in a turning motion to avoid spilling the food, and the heads tilted forward. The motion capture system used in this study was also effective in analyzing head motion during eating.
MeSH term(s)	Male ; Female ; Humans ; Japan ; Motion Capture ; Food ; Eating ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2024-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	80227-x
ISSN	1879-1506 ; 0003-9969
ISSN (online)	1879-1506
ISSN	0003-9969
DOI	10.1016/j.archoralbio.2024.105908
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Article ; Online: Severity of Antipsychotic-Induced Cervical Dystonia Assessed by the Algorithm-Based Rating System.

Inada, Toshiya / Tanabe, Yuta / Fukaya, Yuji / Ogasawara, Kazuyoshi / Yamamoto, Nobutomo

The Journal of clinical psychiatry

2024 Volume 85, Issue 2

Abstract: Background:: Methods:: Results:: Conclusion: ...

Abstract	Background: Methods: Results: Conclusion:
MeSH term(s)	Humans ; Torticollis/chemically induced ; Torticollis/drug therapy ; Antipsychotic Agents/adverse effects ; Artificial Intelligence
Chemical Substances	Antipsychotic Agents
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	716287-x
ISSN	1555-2101 ; 0160-6689
ISSN (online)	1555-2101
ISSN	0160-6689
DOI	10.4088/JCP.23m14929
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Article ; Online: iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva.

Gao, Pan / Inada, Yoshiko / Hotta, Akitsu / Sakurai, Hidetoshi / Ikeya, Makoto

Stem cell research & therapy

2024 Volume 15, Issue 1, Page(s) 83

Abstract: Background: Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease caused by a gain-of-function mutation in ACVR1, which is a bone morphogenetic protein (BMP) type I receptor. Moreover, it causes progressive heterotopic ossification (HO) ... ...

Abstract	Background: Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease caused by a gain-of-function mutation in ACVR1, which is a bone morphogenetic protein (BMP) type I receptor. Moreover, it causes progressive heterotopic ossification (HO) in connective tissues. Using FOP patient-derived induced pluripotent stem cells (FOP-iPSCs) and mouse models, we elucidated the underlying mechanisms of FOP pathogenesis and identified a candidate drug for FOP. Methods: In the current study, healthy mesenchymal stem/stromal cells derived from iPSCs (iMSCs) expressing ACVR2B-Fc (iMSC Results: We found that secreted ACVR2B-Fc attenuated BMP signaling initiated by Activin-A and BMP-9 in both iMSCs and FOP-iMSCs in vitro. Transplantation of ACVR2B-Fc-expressing iMSCs reduced primary HO in a transgenic mouse model of FOP. Notably, a local injection of ACVR2B-Fc-expressing iMSCs and not an intraperitoneal injection improved the treadmill performance, suggesting compound effects of ACVR2B-Fc and iMSCs. Conclusions: These results offer a new perspective for treating FOP through stem cell therapy.
MeSH term(s)	Female ; Humans ; Mice ; Animals ; Myositis Ossificans/genetics ; Myositis Ossificans/therapy ; Ossification, Heterotopic/therapy ; Ossification, Heterotopic/genetics ; Bone Morphogenetic Proteins/genetics ; Bone Morphogenetic Proteins/metabolism ; Bone Morphogenetic Proteins/pharmacology ; Signal Transduction ; Mice, Transgenic ; Mutation ; Activin Receptors, Type II/genetics ; Activin Receptors, Type II/metabolism ; Activin Receptors, Type II/pharmacology
Chemical Substances	Bone Morphogenetic Proteins ; ACVR2B protein, human (EC 2.7.11.30) ; Activin Receptors, Type II (EC 2.7.11.30)
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-024-03691-7
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Article ; Online: Greb1 Transiently Accelerates Pancreatic β-Cell Proliferation in Diabetic Mice Exposed to Estradiol.

Inada, Akari / Yasunami, Yohichi / Yoshiki, Atsushi / Nabeshima, Yo-Ichi / Inada, Oogi

The American journal of pathology

2023 Volume 193, Issue 8, Page(s) 1081–1100

Abstract: Decrease of pancreatic β cells leads to diabetes. In an inducible cAMP early suppressor (ICER-Iγ) transgenic mouse model of severe type 2 diabetes with reduced insulin production and depleted β cells, supplementation with high concentrations of 17β- ... ...

Abstract	Decrease of pancreatic β cells leads to diabetes. In an inducible cAMP early suppressor (ICER-Iγ) transgenic mouse model of severe type 2 diabetes with reduced insulin production and depleted β cells, supplementation with high concentrations of 17β-estradiol (E2) markedly enhances β-cell proliferation and normalizes glucose levels. The current study explored the underlying mechanisms leading to a dynamic increase of β cells and pathologic changes in diabetic mice exposed to E2. Gene expression profiling of pancreatic islets of 6-month-old ICER-transgenic mice recovering from diabetes due to elevated E2 levels identified growth regulation by estrogen in breast cancer 1 (Greb1) as a gene significantly up-regulated during the recovery phase. To substantiate this, β-cell-specific Greb1-deficient mice were generated, and Greb1 was shown to be essential for recovery of depleted β cells in diabetic mice. Graft growth and glucose lowering were observed in 50 islets with increased Greb1 expression transplanted adjacent to E2 pellets beneath the kidney capsule of streptozotocin-induced diabetic mice. Greb1 expression due to a drastic increase in exogenous or endogenous E2 was transient and closely correlated with changes in E2-related and some cell cycle-related genes. These findings provide new insights into in vivo proliferation of deficient β cells and suggest the possibility of new therapeutic approaches targeting pancreatic β cells that could revolutionize the concept of diabetes treatment, which has been considered difficult to cure completely.
MeSH term(s)	Mice ; Animals ; Estradiol/pharmacology ; Diabetes Mellitus, Experimental ; Diabetes Mellitus, Type 2 ; Cell Proliferation ; Mice, Transgenic ; Glucose
Chemical Substances	Estradiol (4TI98Z838E) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-04-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2943-9
ISSN	1525-2191 ; 0002-9440
ISSN (online)	1525-2191
ISSN	0002-9440
DOI	10.1016/j.ajpath.2023.04.012
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