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Article ; Online: Rapid Reviews Methods Series: Involving patient and public partners, healthcare providers and policymakers as knowledge users.

Garritty, Chantelle / Tricco, Andrea C / Smith, Maureen / Pollock, Danielle / Kamel, Chris / King, Valerie J

BMJ evidence-based medicine

2024 Volume 29, Issue 1, Page(s) 55–61

Abstract: Rapid reviews (RRs) are a helpful evidence synthesis tool to support urgent and emergent decision-making in healthcare. RRs involve abbreviating systematic review methods and are conducted in a condensed timeline to meet the decision-making needs of ... ...

Abstract	Rapid reviews (RRs) are a helpful evidence synthesis tool to support urgent and emergent decision-making in healthcare. RRs involve abbreviating systematic review methods and are conducted in a condensed timeline to meet the decision-making needs of organisations or groups that commission them. Knowledge users (KUs) are those individuals, typically patient and public partners, healthcare providers, and policy-makers, who are likely to use evidence from research, including RRs, to make informed decisions about health policies, programmes or practices. However, research suggests that KU involvement in RRs is often limited or overlooked, and few RRs include patients as KUs. Existing RR methods guidance advocates involving KUs but lacks detailed steps on how and when to do so. This paper discusses the importance of involving KUs in RRs, including patient and public involvement to ensure RRs are fit for purpose and relevant for decision-making. Opportunities to involve KUs in planning, conduct and knowledge translation of RRs are outlined. Further, this paper describes various modes of engaging KUs during the review lifecycle; key considerations researchers should be mindful of when involving distinct KU groups; and an exemplar case study demonstrating substantive involvement of patient partners and the public in developing RRs. Although involving KUs requires time, resources and expertise, researchers should strive to balance 'rapid' with meaningful KU involvement in RRs. This paper is the first in a series led by the Cochrane Rapid Reviews Methods Group to further guide general RR methods.
MeSH term(s)	Humans ; Health Personnel ; Delivery of Health Care ; Health Policy
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ISSN	2515-4478
ISSN (online)	2515-4478
DOI	10.1136/bmjebm-2022-112070
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Updated recommendations for the Cochrane rapid review methods guidance for rapid reviews of effectiveness.

Garritty, Chantelle / Hamel, Candyce / Trivella, Marialena / Gartlehner, Gerald / Nussbaumer-Streit, Barbara / Devane, Declan / Kamel, Chris / Griebler, Ursula / King, Valerie J

BMJ (Clinical research ed.)

2024 Volume 384, Page(s) e076335

MeSH term(s)	Humans ; Evidence-Based Medicine ; Review Literature as Topic
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj-2023-076335
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rapid reviews methods series: Guidance on assessing the certainty of evidence.

Gartlehner, Gerald / Nussbaumer-Streit, Barbara / Devane, Declan / Kahwati, Leila / Viswanathan, Meera / King, Valerie J / Qaseem, Amir / Akl, Elie / Schuenemann, Holger J

BMJ evidence-based medicine

2024 Volume 29, Issue 1, Page(s) 50–54

Abstract: This paper is part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group. Rapid reviews (RRs) use modified systematic review methods to accelerate the review process while maintaining systematic, transparent and ... ...

Abstract	This paper is part of a series of methodological guidance from the Cochrane Rapid Reviews Methods Group. Rapid reviews (RRs) use modified systematic review methods to accelerate the review process while maintaining systematic, transparent and reproducible methods. This paper addresses considerations for rating the certainty of evidence (COE) in RRs. We recommend the full implementation of GRADE (Grading of Recommendations, Assessment, Development and Evaluation) for Cochrane RRs if time and resources allow.If time or other resources do not permit the full implementation of GRADE, the following recommendations can be considered: (1) limit rating COE to the main intervention and comparator and limit the number of outcomes to critical benefits and harms; (2) if a literature review or a Delphi approach to rate the importance of outcomes is not feasible, rely on informal judgements of knowledge users, topic experts or team members; (3) replace independent rating of the COE by two reviewers with single-reviewer rating and verification by a second reviewer and (4) if effect estimates of a well-conducted systematic review are incorporated into an RR, use existing COE grades from such a review. We advise against changing the definition of COE or the domains considered part of the GRADE approach for RRs.
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ISSN	2515-4478
ISSN (online)	2515-4478
DOI	10.1136/bmjebm-2022-112111
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Severe polycystic liver disease in a cat.

King, Emily M / Pappano, Maria / Lorbach, Sarah K / Green, Eric M / Parker, Valerie J / Schreeg, Megan E

JFMS open reports

2023 Volume 9, Issue 2, Page(s) 20551169231216859

Abstract: Case summary: Ductal plate malformations (DPMs) are poorly documented in the veterinary literature, particularly those of the polycystic liver disease (PCLD) phenotype. A 13-year-old female spayed cat presented with progressive icterus, abdominal ... ...

Abstract	Case summary: Ductal plate malformations (DPMs) are poorly documented in the veterinary literature, particularly those of the polycystic liver disease (PCLD) phenotype. A 13-year-old female spayed cat presented with progressive icterus, abdominal distension, weight loss and elevated liver enzymes. Initial empirical treatment consisting of amoxicillin/clavulanate, ursodiol and later prednisolone was attempted; however, clinical signs progressed. On abdominal ultrasound, numerous large hepatic cystic masses were noted, characterized by an anechoic center with a heterogeneous, hyperechoic wall. A post-mortem examination confirmed numerous hepatic cysts, the larger of which resulted in hemorrhage and subsequent hemoabdomen. Histologically, these cysts were determined to be of biliary origin, and a diagnosis of PCLD was assigned. Relevance and novel information: Herein, we present a detailed report of clinical, gross and histologic findings in a cat clinically affected by PCLD. This case demonstrates that cysts present in this congenital disease can ultimately lead to hepatobiliary malfunction and clinical decline via marked expansion of cysts, compression of the liver and hemoabdomen from cyst rupture. DPMs, specifically PCLD, should be considered in cats presenting with multifocal large hepatic cysts.
Language	English
Publishing date	2023-12-24
Publishing country	England
Document type	Case Reports
ZDB-ID	2822177-1
ISSN	2055-1169 ; 2055-1169
ISSN (online)	2055-1169
ISSN	2055-1169
DOI	10.1177/20551169231216859
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Paper 2: Performing rapid reviews.

King, Valerie J / Stevens, Adrienne / Nussbaumer-Streit, Barbara / Kamel, Chris / Garritty, Chantelle

Systematic reviews

2022 Volume 11, Issue 1, Page(s) 151

Abstract: Background: Health policy-makers must often make decisions in compressed time frames and with limited resources. Hence, rapid reviews have become a pragmatic alternative to comprehensive systematic reviews. However, it is important that rapid review ... ...

Abstract	Background: Health policy-makers must often make decisions in compressed time frames and with limited resources. Hence, rapid reviews have become a pragmatic alternative to comprehensive systematic reviews. However, it is important that rapid review methods remain rigorous to support good policy development and decisions. There is currently little evidence about which streamlined steps in a rapid review are less likely to introduce unacceptable levels of uncertainty while still producing a product that remains useful to policy-makers. Methods: This paper summarizes current research describing commonly used methods and practices that are used to conduct rapid reviews and presents key considerations and options to guide methodological choices for a rapid review. Results: The most important step for a rapid review is for an experienced research team to have early and ongoing engagement with the people who have requested the review. A clear research protocol, derived from a needs assessment conducted with the requester, serves to focus the review, defines the scope of the rapid review, and guides all subsequent steps. Common recommendations for rapid review methods include tailoring the literature search in terms of databases, dates, and languages. Researchers can consider using a staged search to locate high-quality systematic reviews and then subsequently published primary studies. The approaches used for study screening and selection, data extraction, and risk-of-bias assessment should be tailored to the topic, researcher experience, and available resources. Many rapid reviews use a single reviewer for study selection, risk-of-bias assessment, or data abstraction, sometimes with partial or full verification by a second reviewer. Rapid reviews usually use a descriptive synthesis method rather than quantitative meta-analysis. Use of brief report templates and standardized production methods helps to speed final report publication. Conclusions: Researchers conducting rapid reviews need to make transparent methodological choices, informed by stakeholder input, to ensure that rapid reviews meet their intended purpose. Transparency is critical because it is unclear how or how much streamlined methods can bias the conclusions of reviews. There are not yet internationally accepted standards for conducting or reporting rapid reviews. Thus, this article proposes interim guidance for researchers who are increasingly employing these methods.
MeSH term(s)	Evidence-Based Medicine ; Health Policy ; Humans ; Research Design ; Research Report
Language	English
Publishing date	2022-07-30
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-022-02011-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genome Sequence of a Foot-and-Mouth Disease Virus Detected in Indonesia in 2022.

Zainuddin, Nuryani / Susila, Edy Budi / Wibawa, Hendra / Daulay, Rosmalina Sari Dewi / Wijayanti, Putriani Endah / Fitriani, Dini / Hidayati, Dewi Noor / Idris, Syafrison / Wadsworth, Jemma / Polo, Noemi / Hicks, Hayley M / Mioulet, Valerie / Knowles, Nick J / King, Donald P

Microbiology resource announcements

2023 Volume 12, Issue 2, Page(s) e0108122

Abstract: During 2022, outbreaks of foot-and-mouth disease (FMD) were reported across the islands of Indonesia, a country that had previously maintained an FMD-free (without vaccination) status since 1990. This report describes the near-complete genome sequence of ...

Abstract	During 2022, outbreaks of foot-and-mouth disease (FMD) were reported across the islands of Indonesia, a country that had previously maintained an FMD-free (without vaccination) status since 1990. This report describes the near-complete genome sequence of a representative FMD virus collected from these cases belonging to the O/ME-SA/Ind-2001e lineage.
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/mra.01081-22
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Article: Establishing a molecular toolbox of lineage-specific real-time RT-PCR assays for the characterization of foot-and-mouth disease viruses circulating in Asia.

Saduakassova, Meruyert A / Wood, Britta A / Henry, Elisabeth / Gray, Ashley R / Mioulet, Valérie / Sultanov, Akhmetzhan A / Wadsworth, Jemma / Knowles, Nick J / Di Nardo, Antonello / King, Donald P / Bachanek-Bankowska, Katarzyna

Frontiers in veterinary science

2023 Volume 10, Page(s) 1271690

Abstract: Foot-and-mouth disease (FMD) is endemic in many Asian countries, with outbreaks occurring regularly due to viruses from serotypes O, A, and Asia1 that co-circulate in the region. The ability to rapidly characterize new virus occurrences provides critical ...

Abstract	Foot-and-mouth disease (FMD) is endemic in many Asian countries, with outbreaks occurring regularly due to viruses from serotypes O, A, and Asia1 that co-circulate in the region. The ability to rapidly characterize new virus occurrences provides critical information to understand the epidemiology and risks associated with field outbreaks, and helps in the selection of appropriate vaccines to control the disease. FMD lineage-specific characterization is usually determined through sequencing; however, this capacity is not always readily available. In this study, we provide a panel of real-time RT-PCR (rRT-PCR) assays to allow differentiation of the FMD virus (FMDV) lineages known to have been co-circulating in Asia during 2020. This panel included five new rRT-PCR assays designed to detect lineages O/ME-SA/PanAsia-PanAsia-2, O/ME-SA/Ind-2001, O/SEA/Mya-98, O/CATHAY, and A/ASIA/Sea-97, along with three published rRT-PCR assays for A/ASIA/Iran-05, A/ASIA/G-VII, and Asia1 serotypes. Samples of known FMD lineage (
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1271690
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Paper 2

Valerie J. King / Adrienne Stevens / Barbara Nussbaumer-Streit / Chris Kamel / Chantelle Garritty

Systematic Reviews, Vol 11, Iss 1, Pp 1-

Performing rapid reviews

2022 Volume 10

Abstract: Abstract Background Health policy-makers must often make decisions in compressed time frames and with limited resources. Hence, rapid reviews have become a pragmatic alternative to comprehensive systematic reviews. However, it is important that rapid ... ...

Abstract	Abstract Background Health policy-makers must often make decisions in compressed time frames and with limited resources. Hence, rapid reviews have become a pragmatic alternative to comprehensive systematic reviews. However, it is important that rapid review methods remain rigorous to support good policy development and decisions. There is currently little evidence about which streamlined steps in a rapid review are less likely to introduce unacceptable levels of uncertainty while still producing a product that remains useful to policy-makers. Methods This paper summarizes current research describing commonly used methods and practices that are used to conduct rapid reviews and presents key considerations and options to guide methodological choices for a rapid review. Results The most important step for a rapid review is for an experienced research team to have early and ongoing engagement with the people who have requested the review. A clear research protocol, derived from a needs assessment conducted with the requester, serves to focus the review, defines the scope of the rapid review, and guides all subsequent steps. Common recommendations for rapid review methods include tailoring the literature search in terms of databases, dates, and languages. Researchers can consider using a staged search to locate high-quality systematic reviews and then subsequently published primary studies. The approaches used for study screening and selection, data extraction, and risk-of-bias assessment should be tailored to the topic, researcher experience, and available resources. Many rapid reviews use a single reviewer for study selection, risk-of-bias assessment, or data abstraction, sometimes with partial or full verification by a second reviewer. Rapid reviews usually use a descriptive synthesis method rather than quantitative meta-analysis. Use of brief report templates and standardized production methods helps to speed final report publication. Conclusions Researchers conducting rapid reviews need to make transparent ...
Keywords	Rapid review ; Systematic review ; Technology assessment ; Evidence-based medicine ; Medicine ; R
Subject code	306
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Molecular Epidemiology of Foot-and-Mouth Disease Viruses in the Emirate of Abu Dhabi, United Arab Emirates.

Eltahir, Yassir M / Ishag, Hassan Zackaria Ali / Wadsworth, Jemma / Hicks, Hayley M / Knowles, Nick J / Mioulet, Valérie / King, Donald P / Mohamed, Meera Saeed / Bensalah, Oum Keltoum / Yusof, Mohd Farouk / Gasim, Esmat Faisal Malik / Hammadi, Zulaikha Mohamed Al / Shah, Asma Abdi Mohamed / Abdelmagid, Yasir Ali / Gahlan, Moustafa Abdel Meguid El / Kassim, Mohanned Fawzi / Kayaf, Kaltham / Zahran, Ahmed / Nuaimat, Mervat Mari Al

Veterinary sciences

2024 Volume 11, Issue 1

Abstract: Foot-and-mouth disease (FMD) is an endemic disease in the United Arab Emirates (UAE) in both wild and domestic animals. Despite this, no systematic FMD outbreak investigation accompanied by molecular characterisation of FMD viruses (FMDVs) in small ... ...

Abstract	Foot-and-mouth disease (FMD) is an endemic disease in the United Arab Emirates (UAE) in both wild and domestic animals. Despite this, no systematic FMD outbreak investigation accompanied by molecular characterisation of FMD viruses (FMDVs) in small ruminants or cattle has been performed, and only a single report that describes sequences for FMDVs in wildlife from the Emirate has been published. In this study, FMD outbreaks that occurred in 2021 in five animal farms and one animal market in the Emirate of Abu Dhabi were investigated. Cases involved sheep, goats, and cattle, as well as
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci11010032
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Accelerated Approval of 17α-Hydroxyprogesterone Caproate: A Cautionary Tale.

Godlewski, Bethany J / Sobolik, Lily I / King, Valerie J / Harrod, Curtis S

Obstetrics and gynecology

2020 Volume 135, Issue 5, Page(s) 1207–1213

Abstract: Before 2011, 17α-hydroxyprogesterone caproate (17P) was used to prevent recurrent preterm birth in women with singleton pregnancies and was compounded at a low cost (∼$15 per injection). In 2011, the U.S. Food and Drug Administration (FDA) approved a ... ...

Abstract	Before 2011, 17α-hydroxyprogesterone caproate (17P) was used to prevent recurrent preterm birth in women with singleton pregnancies and was compounded at a low cost (∼$15 per injection). In 2011, the U.S. Food and Drug Administration (FDA) approved a commercial version of 17P (trade name "Makena") through their Accelerated Approval Program, and the price of 17P subsequently increased by nearly 100-fold. This approval was largely based on a methodologically limited, placebo-controlled trial, which found that although 17P significantly reduced preterm births, the placebo group had significantly more participants with a history of preterm birth, potentially confounding the results. The FDA required a confirmatory trial for continued approval that demonstrated clinical benefit. Eight years after accelerated approval, the confirmatory trial, PROLONG (Progestin's Role in Optimizing Neonatal Gestation), found no evidence of an effect of Makena for reducing recurrent preterm birth or perinatal mortality. Trial completion triggered an automatic review of Makena by an advisory committee, which voted 9-7 to recommend revoking approval of Makena for preterm birth. Although the FDA created the Accelerated Approval Program to introduce therapies for serious conditions that lacked treatment options, Makena is an example of the limitations of this program. We encourage the FDA to re-evaluate their program and consider improvements, such as shorter timeframes to complete confirmatory trials, potentially revoking approval if the studies are not completed within a predefined timeframe, and to hold manufacturers responsible, in part, for the costs of therapy if they cannot prove a clinical benefit.
MeSH term(s)	17 alpha-Hydroxyprogesterone Caproate/therapeutic use ; Clinical Trials as Topic/legislation & jurisprudence ; Clinical Trials as Topic/methods ; Drug Approval/methods ; Female ; Humans ; Infant, Newborn ; Perinatal Mortality ; Pregnancy ; Premature Birth/prevention & control ; Treatment Outcome ; United States ; United States Food and Drug Administration
Chemical Substances	17 alpha-Hydroxyprogesterone Caproate (276F2O42F5)
Language	English
Publishing date	2020-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0000000000003787
Database	MEDical Literature Analysis and Retrieval System OnLINE

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