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Article ; Online: Research on single/cooperative emission reduction strategy under different power structures.

Ji, Jingna / Huang, Jiansheng

Environmental science and pollution research international

2022 Volume 29, Issue 36, Page(s) 55213–55234

Abstract: This paper develops low-carbon decisions in a two-echelon supply chain considering consumers' low-carbon preference and cap-and-trade (C&T) regulation. Two different power structures are considered, including manufacturer-dominated (MD) and retailer- ... ...

Abstract	This paper develops low-carbon decisions in a two-echelon supply chain considering consumers' low-carbon preference and cap-and-trade (C&T) regulation. Two different power structures are considered, including manufacturer-dominated (MD) and retailer-dominated (RD) cases. The single emission reduction (SER) mode where only the manufacturer invests in low-carbon technology and the cooperative emission reduction (CER) mode where the manufacturer invests in low-carbon technology and the retailer invest in low-carbon promotion are investigated respectively. It is found that a relatively loose C&T regulation helps to promote the cooperation of supply chain enterprises. Under both MD and RD cases, CER mode is always a rational choice for supply chain enterprises. Under SER mode, the manufacturer's profit will not always decrease when he loses the dominant position. However, the RD case is profitable for the retailer and the supply chain. Under CER mode, the dominant role is important for both the manufacturer and the retailer. However, the profit of the supply chain under RD case may be lower than that under MD case. Through numerical analysis, we found that the fluctuation of carbon price has a more significant impact on the manufacturer's emission reduction decision under CER mode than that under SER mode. In addition, with the increase of unit carbon price, the RD case performs better than the MD case in promoting supply chain's low-carbon level and profit.
MeSH term(s)	Carbon/analysis ; Commerce ; Consumer Behavior ; Costs and Cost Analysis ; Decision Making
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2022-03-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-19603-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Radiolabel Uncovers Nonintuitive Metabolites of BIIB104: Novel Release of [

Gu, Chungang / Huang, Jiansheng / Muste, Cathy / Zhong, Jeremy / Walker, Gregory S / Obach, R Scott / Shaffer, Christopher L

Drug metabolism and disposition: the biological fate of chemicals

2024 Volume 52, Issue 5, Page(s) 323–336

Abstract: BIIB104 (formerly PF-04958242), ...

Abstract	BIIB104 (formerly PF-04958242),
MeSH term(s)	Humans ; Rats ; Animals ; Dogs ; Cyanides/analysis ; Thiocyanates/analysis ; Biotransformation ; Feces/chemistry ; Nitriles ; Thiophenes/analysis ; Furans
Chemical Substances	Cyanides ; Thiocyanates ; Nitriles ; Thiophenes ; Furans
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	186795-7
ISSN	1521-009X ; 0090-9556
ISSN (online)	1521-009X
ISSN	0090-9556
DOI	10.1124/dmd.123.001462
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Article ; Online: Myclobutanil induces neurotoxicity by activating autophagy and apoptosis in zebrafish larvae (Danio rerio).

Zhu, Jiansheng / Huang, Mingtao / Jiang, Peiyun / Wang, Jingyu / Zhu, Renfei / Liu, Chunlan

Chemosphere

2024 Volume 357, Page(s) 142027

Abstract: Myclobutanil (MYC), a typical broad-spectrum triazole fungicide, is often detected in surface water. This study aimed to explore the neurotoxicity of MYC and the underlying mechanisms in zebrafish and in PC12 cells. In this study, zebrafish embryos were ... ...

Abstract	Myclobutanil (MYC), a typical broad-spectrum triazole fungicide, is often detected in surface water. This study aimed to explore the neurotoxicity of MYC and the underlying mechanisms in zebrafish and in PC12 cells. In this study, zebrafish embryos were exposed to 0, 0.5 and 1 mg/L of MYC from 4 to 96 h post fertilization (hpf) and neurobehavior was evaluated. Our data showed that MYC decreased the survival rate, hatching rate and heart rate, but increased the malformation rate and spontaneous movement. MYC caused abnormal neurobehaviors characterized by decreased swimming distance and movement time. MYC impaired cerebral histopathological morphology and inhibited neurogenesis in HuC:egfp transgenic zebrafish. MYC also reduced the activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and downregulated neurodevelopment related genes (gfap, syn2a, gap43 and mbp) in zebrafish and PC12 cells. Besides, MYC activated autophagy through enhanced expression of the LC3-II protein and suppressed expression of the p62 protein and autophagosome formation, subsequently triggering apoptosis by upregulating apoptotic genes (p53, bax, bcl-2 and caspase 3) and the cleaved caspase-3 protein in zebrafish and PC12 cells. These processes were restored by the autophagy inhibitor 3-methyladenine (3-MA) both in vivo and in vitro, indicating that MYC induces neurotoxicity by activating autophagy and apoptosis. Overall, this study revealed the potential autophagy and apoptosis mechanisms of MYC-induced neurotoxicity and provided novel strategies to counteract its toxicity.
Language	English
Publishing date	2024-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.142027
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Article: Research on single/cooperative emission reduction strategy under different power structures

Ji, Jingna / Huang, Jiansheng

Environmental science and pollution research. 2022 Aug., v. 29, no. 36

2022

Abstract: This paper develops low-carbon decisions in a two-echelon supply chain considering consumers’ low-carbon preference and cap-and-trade (C&T) regulation. Two different power structures are considered, including manufacturer-dominated (MD) and retailer- ... ...

Abstract	This paper develops low-carbon decisions in a two-echelon supply chain considering consumers’ low-carbon preference and cap-and-trade (C&T) regulation. Two different power structures are considered, including manufacturer-dominated (MD) and retailer-dominated (RD) cases. The single emission reduction (SER) mode where only the manufacturer invests in low-carbon technology and the cooperative emission reduction (CER) mode where the manufacturer invests in low-carbon technology and the retailer invest in low-carbon promotion are investigated respectively. It is found that a relatively loose C&T regulation helps to promote the cooperation of supply chain enterprises. Under both MD and RD cases, CER mode is always a rational choice for supply chain enterprises. Under SER mode, the manufacturer’s profit will not always decrease when he loses the dominant position. However, the RD case is profitable for the retailer and the supply chain. Under CER mode, the dominant role is important for both the manufacturer and the retailer. However, the profit of the supply chain under RD case may be lower than that under MD case. Through numerical analysis, we found that the fluctuation of carbon price has a more significant impact on the manufacturer’s emission reduction decision under CER mode than that under SER mode. In addition, with the increase of unit carbon price, the RD case performs better than the MD case in promoting supply chain’s low-carbon level and profit.
Keywords	carbon markets ; pollution ; research ; supply chain
Language	English
Dates of publication	2022-08
Size	p. 55213-55234.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-19603-2
Database	NAL-Catalogue (AGRICOLA)

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Article: A study on the appropriate dose of rocuronium for intraoperative neuromonitoring in Da Vinci robot thyroid surgery: a randomized, double-blind, controlled trial.

Lan, Jianning / Huang, Qijian / Su, Jiansheng / Zhang, Xuru / Zhang, Liangcheng

Frontiers in endocrinology

2023 Volume 14, Page(s) 1216546

Abstract: Background: This study was to explore the effect of different doses of rocuronium bromide on neuromonitoring during Da Vinci robot thyroid surgery.: Methods: This was a prospective, randomized, double-blind, controlled trial that included 189 ... ...

Abstract	Background: This study was to explore the effect of different doses of rocuronium bromide on neuromonitoring during Da Vinci robot thyroid surgery. Methods: This was a prospective, randomized, double-blind, controlled trial that included 189 patients who underwent Da Vinci robot thyroidectomy with intraoperative neuromonitoring(IONM). Patients were randomly divided into three groups and given three different doses of rocuronium (0.3mg/kg, 0.6mg/kg, 0.9mg/kg). Outcome measurements included IONM evoked potential, postoperative Voice Handicap Index-30(VHI-30), intraoperative body movement incidence rate, Cooper score, and hemodynamic changes during anesthesia induction.Results: The difference in IONM evoked potentials at various time points between the three groups was not statistically significant (P>0.05). The difference in Cooper scores and intraoperative body movement incidence rate between 0.6 and 0.9mg/kg groups was statistically significant compared with the 0.3mg/kg group (both P<0.001). There was no statistically significant difference in VHI-30 score and hemodynamic changes during anesthesia induction among the three groups (both P>0.05). Conclusions: For patients undergoing Da Vinci robot thyroidectomy, a single dose of rocuronium at 0.6 and 0.9mg/kg during anesthesia induction can provide stable IONM evoked potential. Additionally, compared to 0.3 mg/kg, it can offer better tracheal intubation conditions and lower incidence of body movements during surgery. It is worth noting that the use of higher doses of rocuronium should be adjusted based on the duration of IONM and local practices.
MeSH term(s)	Humans ; Thyroid Gland/surgery ; Rocuronium ; Prospective Studies ; Robotics ; Robotic Surgical Procedures
Chemical Substances	Rocuronium (WRE554RFEZ)
Language	English
Publishing date	2023-09-07
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1216546
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Article ; Online: Green Credit Financing and Emission Reduction Decisions in a Retailer-Dominated Supply Chain with Capital Constraint

Jingna Ji / Dengli Tang / Jiansheng Huang

Sustainability, Vol 14, Iss 10553, p

2022 Volume 10553

Abstract: In the context of low-carbon transformation, many small and medium-sized suppliers face financial difficulties. How to encourage and motivate capital-constrained suppliers to implement low-carbon strategies has become an important problem. There is a ... ...

Abstract	In the context of low-carbon transformation, many small and medium-sized suppliers face financial difficulties. How to encourage and motivate capital-constrained suppliers to implement low-carbon strategies has become an important problem. There is a lack of quantitative research on green financing problems in the supply chain, especially considering the bank’s green credit financing (GCF) with discounted interest rates related to a low-carbon level. This paper formulates a Stackelberg game model to analyze the green financing and emission reduction decisions of a retailer-dominated supply chain consisting of one capital-constrained supplier and one capital-sufficient retailer. The retailer’s environmental purchasing requirement is considered. The result shows that the retailer’s procurement requirement cannot always motivate the capital-constrained supplier to improve their emission reduction rate. The mixed credit mode, which includes the bank’s GCF and the retailer’s partial prepayment, can help relieve the financing pressure of the capital-constrained supplier. It is found that the GCF at a discounted interest rate can effectively improve the supplier’s emission reduction enthusiasm. This paper tries to provide some meaningful insights for the government and supply chain members when making sustainable strategies.
Keywords	green credit financing ; prepayment ; capital-constrained supplier ; emission reduction ; retailer-dominated ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	338
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of Dietary Alpha-Lipoic Acid on Growth Performance, Serum Biochemical Indexes, Liver Antioxidant Capacity and Transcriptome of Juvenile Hybrid Grouper (

Ou, Guanghai / Xie, Ruitao / Huang, Jiansheng / Huang, Jianpeng / Wen, Zhenwei / Li, Yu / Jiang, Xintao / Ma, Qian / Chen, Gang

Animals : an open access journal from MDPI

2023 Volume 13, Issue 5

Abstract: We aimed to investigate the effects of dietary alpha-lipoic acid (α-LA) on the growth performance, serum biochemical indexes, liver morphology, antioxidant capacity, and transcriptome of juvenile hybrid groupers ( ...

Abstract	We aimed to investigate the effects of dietary alpha-lipoic acid (α-LA) on the growth performance, serum biochemical indexes, liver morphology, antioxidant capacity, and transcriptome of juvenile hybrid groupers (
Language	English
Publishing date	2023-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13050887
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Article: Combining bulk RNA-sequencing and single-cell RNA-sequencing data to reveal the immune microenvironment and metabolic pattern of osteosarcoma.

Huang, Ruichao / Wang, Xiaohu / Yin, Xiangyun / Zhou, Yaqi / Sun, Jiansheng / Yin, Zhongxiu / Zhu, Zhi

Frontiers in genetics

2022 Volume 13, Page(s) 976990

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-10-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.976990
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Article ; Online: Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes.

Johnson, Joshua L / Huang, Jiansheng / Rooney, Michael / Gu, Chungang

Xenobiotica; the fate of foreign compounds in biological systems

2022 Volume 52, Issue 2, Page(s) 105–112

Abstract: Vixotrigine is a voltage- and use-dependent sodium channel blocker under investigation for the potential treatment of neuropathic pain. One of the ... ...

Abstract	Vixotrigine is a voltage- and use-dependent sodium channel blocker under investigation for the potential treatment of neuropathic pain. One of the major
MeSH term(s)	Carboxylesterase/metabolism ; Carboxylic Ester Hydrolases/metabolism ; Humans ; Hydrogen-Ion Concentration ; Hydrolysis ; Liver/metabolism ; Microsomes, Liver/metabolism ; Phenyl Ethers ; Proline/analogs & derivatives
Chemical Substances	Phenyl Ethers ; Proline (9DLQ4CIU6V) ; Carboxylic Ester Hydrolases (EC 3.1.1.-) ; Carboxylesterase (EC 3.1.1.1) ; vixotrigine (QQS4J85K6Y)
Language	English
Publishing date	2022-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	120287-x
ISSN	1366-5928 ; 0049-8254
ISSN (online)	1366-5928
ISSN	0049-8254
DOI	10.1080/00498254.2021.2018629
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Article: Magnetic nanoparticles enhance the cellular immune response of dendritic cell tumor vaccines by realizing the cytoplasmic delivery of tumor antigens.

Huang, Linghong / Liu, Zonghua / Wu, Chongjie / Lin, Jiansheng / Liu, Ning

Bioengineering & translational medicine

2022 Volume 8, Issue 2, Page(s) e10400

Abstract: Dendritic cells (DCs)-based tumor vaccines have the advantages of high safety and rapid activation of T cells, and have been approved for clinical tumor treatment. However, the conventional DC vaccines have some severe problems, such as poor activation ... ...

Abstract	Dendritic cells (DCs)-based tumor vaccines have the advantages of high safety and rapid activation of T cells, and have been approved for clinical tumor treatment. However, the conventional DC vaccines have some severe problems, such as poor activation of DCs in vitro, low level of antigen presentation, reduced cell viability, and difficulty in targeting lymph nodes in vivo, resulting in poor clinical therapeutic effects. In this research, magnetic nanoparticles Fe
Language	English
Publishing date	2022-09-09
Publishing country	United States
Document type	Journal Article
ISSN	2380-6761
ISSN	2380-6761
DOI	10.1002/btm2.10400
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