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Book: Human Microanatomy

Stricker, Stephen A.

Cell Tissue and Organ Histology with Celebrity Medical Histories

2022

Abstract: Human Microanatomy is a comprehensive histology text that analyzes human structure and function from the subcellular to organ level of organization. In addition to emphasizing medically relevant information, each chapter considers developmental and ... ...

Author's details	Stephen A. Stricker is Professor Emeritus and former Director of the Electron Microscopy Facility in the Department of Biology at the University of New Mexico, Albuquerque, NM, USA. Dr. Stricker has published widely on microanatomy and has also designed and taught various courses in histology and microscopy techniques in the United States and other countries
Abstract	Human Microanatomy is a comprehensive histology text that analyzes human structure and function from the subcellular to organ level of organization. In addition to emphasizing medically relevant information, each chapter considers developmental and evolutionary aspects of microanatomy while also using celebrity medical histories to help provide real-world context for accompanying descriptions of normal histology. The book is richly illustrated with over 1400 full-color micrographs and drawing...
Keywords	histology ; human anatomy ; microscopic diagnosis ; medical histories ; Creative Commons License ; Spinal Cord ; Dynein Arms ; Beige Adipocytes ; Stratified Squamous Epithelium ; Primary Cilia ; Basilar Membrane ; Beige Fat ; Hair Cells ; Collecting Ducts ; Beige Cells ; Renal Corpuscle ; Seminiferous Epithelium ; Round Window ; Thin Filaments ; Tectorial Membrane ; SERCA Pump ; Semicircular Ducts ; Seminiferous Tubules ; Thick Filaments ; BLCs ; Scala Vestibuli ; Vas Deferens ; Parathyroid Glands ; White Adipocytes
Language	English
Size	538 p.
Edition	1
Publisher	Taylor & Francis Ltd
Document type	Book
Note	PDA Manuell_13
Format	210 x 280
ISBN	9780367364571 ; 0367364573
Database	PDA

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Book: Developmental biology of the sea urchin and other marine invertebrates

Carroll, David J. / Stricker, Stephen A.

methods and protocols

(Methods in molecular biology ; 2219 ; Springer protocols)

2021

Author's details	edited by David J. Carroll, Stephen A. Stricker
Series title	Methods in molecular biology ; 2219 Springer protocols
Collection
Keywords	Sea Urchins / growth & development ; Aquatic Organisms / growth & development ; Invertebrates / growth & development ; Seeigel ; Entwicklungsbiologie ; Meer ; Wirbellose
Subject	Evertebrata ; Invertebrata ; Niedere Tiere ; Invertebraten ; Ozean ; See ; Weltmeer ; Seegebiet ; Meere ; Ozeane ; Weltmeere ; Echinoidea
Language	English
Size	xiii, 309 Seiten, Illustrationen, Diagramme
Edition	Second edition, corrected publication
Publisher	Humana Press
Publishing place	New York, NY
Publishing country	United States
Document type	Book
HBZ-ID	HT020629199
ISBN	978-1-0716-0973-6 ; 9781071609743 ; 1-0716-0973-4 ; 1071609742
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: The Cytoskeleton and Nuclear Disassembly during Germinal Vesicle Breakdown in Starfish Oocytes: (1-methyladenine/cytochalasin B/microfilaments/microtubules/oocyte maturation).

Stricker, Stephen A / Schatten, Gerald

Development, growth & differentiation

2023 Volume 33, Issue 2, Page(s) 163–171

Abstract: In response to maturation-inducing hormone, prophase-arrested oocytes of the starfish Pisaster ochraceus resume meiosis and undergo nuclear disassembly during a process referred to as germinal vesicle breakdown (GVBD). Time-lapse video recordings of ... ...

Abstract	In response to maturation-inducing hormone, prophase-arrested oocytes of the starfish Pisaster ochraceus resume meiosis and undergo nuclear disassembly during a process referred to as germinal vesicle breakdown (GVBD). Time-lapse video recordings of maturing oocytes reveal that the nucleus lengthens along the animal-vegetal axis of the oocyte directly prior to GVBD. Neither taxol (10 μM) nor microtubule-depolymerizing agents [colcemid (50 μM), colchicine (250 μM), or nocodazole (1 μM)] prevent the pre-GVBD changes in nuclear shape from occurring, although correlative microscopical studies demonstrate that microtubules are nucleated (taxol) or depolymerized (colcemid, colchicine, nocodazole) at the concentrations listed above. The microtubule-altering drugs also do not affect the time at which GVBD begins or ends. A 10 μM solution of the microfilament-disrupting drug cytochalasin B (CB), on the other hand, essentially eliminates the pre-GVBD elongation of the nucleus. CB also slightly delays the onset of GVBD and significantly lengthens the time required to complete GVBD. Such studies suggest that: (i) drug-sensitive microtubules are not required for GVBD to proceed in a normal fasion; (ii) the pre-GVBD changes in nuclear shape involve microfilament-mediated events; and (iii) cytochalasin-induced depolymerization of microfilaments retards the normal timing of GVBD.
Language	English
Publishing date	2023-06-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	280433-5
ISSN	1440-169X ; 0012-1592
ISSN (online)	1440-169X
ISSN	0012-1592
DOI	10.1111/j.1440-169X.1991.00163.x
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Article ; Online: Marine Nemertean Worms for Immunoblotting Studies of Oocyte Aging.

Stricker, Stephen A

Methods in molecular biology (Clifton, N.J.)

2020 Volume 2219, Page(s) 137–150

Abstract: Immunoblotting analyses employing phospho-specific antibodies can help elucidate potential roles played by protein kinases as oocytes age and lose their ability to undergo normal fertilization. This chapter updates a previously published protocol for ... ...

Abstract	Immunoblotting analyses employing phospho-specific antibodies can help elucidate potential roles played by protein kinases as oocytes age and lose their ability to undergo normal fertilization. This chapter updates a previously published protocol for conducting immunoblotting analyses of oocyte maturation in marine nemertean worms by adding general methods for obtaining adult worms and for handling their gametes in experiments assessing oocyte aging.
MeSH term(s)	Animals ; Cellular Senescence ; Electrophoresis/methods ; Female ; Immunoblotting/methods ; Invertebrates/cytology ; Invertebrates/embryology ; Oocytes/cytology ; Oogenesis
Language	English
Publishing date	2020-10-19
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-0974-3_8
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Article: Marine Nemertean Worms for Studies of Oocyte Maturation and Aging.

Stricker, Stephen A

Results and problems in cell differentiation

2018 Volume 65, Page(s) 3–14

Abstract: Many marine invertebrates are capable of providing an abundant supply of oocytes that are fertilized external to the female body, thereby making these specimens well suited for studies of development. Along with intensively analyzed model systems ... ...

Abstract	Many marine invertebrates are capable of providing an abundant supply of oocytes that are fertilized external to the female body, thereby making these specimens well suited for studies of development. Along with intensively analyzed model systems belonging to such groups as echinoderms, tunicates, mollusks, and annelids, various lesser-studied taxa can undergo an external mode of fertilization. For example, nemertean worms constitute a relatively small phylum of marine protostome worms whose optically clear oocytes are easily collected and fertilized in the laboratory. Thus, to help promote the use of nemertean oocytes as a potential model in embryological analyses, this chapter begins by describing general methods for obtaining adults and for handling their gametes. After presenting such protocols, this chapter concludes with some representative results obtained with these specimens by summarizing the roles played by adenosine monophosphate-activated kinase (AMPK) during oocyte maturation and by c-Jun N-terminal kinase (JNK) during oocyte aging and death.
MeSH term(s)	Animals ; Cellular Senescence ; Female ; Fertilization ; Invertebrates/cytology ; Oocytes/cytology ; Oogenesis ; Research
Language	English
Publishing date	2018-08-06
Publishing country	Germany
Document type	Journal Article
ISSN	0080-1844
ISSN	0080-1844
DOI	10.1007/978-3-319-92486-1_1
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Article ; Online: Calcium signaling and endoplasmic reticulum dynamics during fertilization in marine protostome worms belonging to the phylum Nemertea.

Stricker, Stephen A

Biochemical and biophysical research communications

2014 Volume 450, Issue 3, Page(s) 1182–1187

Abstract: Metaphase-I-arrested eggs of marine protostome worms in the phylum Nemertea generate a series of point-source calcium waves during fertilization. Such calcium oscillations depend on inositol-1,4,5-trisphosphate-mediated calcium release from endoplasmic ... ...

Abstract	Metaphase-I-arrested eggs of marine protostome worms in the phylum Nemertea generate a series of point-source calcium waves during fertilization. Such calcium oscillations depend on inositol-1,4,5-trisphosphate-mediated calcium release from endoplasmic reticulum (ER) stores that undergo structural reorganizations prior to and after fertilization. This article reviews fertilization-induced calcium transients and ER dynamics in nemertean eggs and compares these topics to what has been reported for other animals in order to identify unifying characteristics and distinguishing features of calcium responses during fertilization across the animal kingdom.
MeSH term(s)	Animals ; Aquatic Organisms/cytology ; Aquatic Organisms/physiology ; Calcium Signaling/physiology ; Endoplasmic Reticulum/physiology ; Female ; Fertilization/physiology ; Inositol Phosphates/metabolism ; Invertebrates/cytology ; Invertebrates/physiology ; Male ; Models, Biological ; Oocytes/cytology ; Oocytes/physiology ; Zygote/cytology ; Zygote/physiology
Chemical Substances	Inositol Phosphates
Language	English
Publishing date	2014-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2014.03.156
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Article ; Online: Larval morphology of the Nemertean Carcinonemertes epialti (Nemertea: Hoplonemertea).

Stricker, Stephen A / Reed, Christopher G

Journal of morphology

2018 Volume 169, Issue 1, Page(s) 61–70

Abstract: The morphology of the newly hatched larva of Carcinonemertes epialti Coe has been examined by light and electron microscopy. The newly hatched larva is covered with cilia and measures about 110 μm in length. Four types of epidermal cells are recognizable: ...

Abstract	The morphology of the newly hatched larva of Carcinonemertes epialti Coe has been examined by light and electron microscopy. The newly hatched larva is covered with cilia and measures about 110 μm in length. Four types of epidermal cells are recognizable: (1) Multiciliated cells, (2) vacuolated cells, (3) mucous cells, and (4) "knob cells". The knob cells protrude from the posterior end of the larva and contain granules and bundles of microfilaments. The gut is incomplete and is located ventral to the bipartite proboscis. A bilobed brain and two subepidermal ocelli are found in the anterior end of the larva. The anterior and posterior cirri are composed of long, tightly appressed cilia that arise from an invagination of the epidermis at each end of the larva. The anterior cirrus is surrounded by two types of glandular cells. It is proposed that the knob cells have a role in larval attachment, combining the functions of the adhesive cells and anchor cells described in the duo-gland system of turbellarians. The cirri are believed to be larval sensory structures that function in substrate selection. Histological and ultrastructural observations suggest that the larvae of Carcinonemertes are relatively long lived and develop into juveniles without a drastic metamorphosis.
Language	English
Publishing date	2018-08-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	3084-3
ISSN	1097-4687 ; 0022-2887 ; 0362-2525
ISSN (online)	1097-4687
ISSN	0022-2887 ; 0362-2525
DOI	10.1002/jmor.1051690106
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Article ; Online: The potential roles of c-Jun N-terminal kinase (JNK) during the maturation and aging of oocytes produced by a marine protostome worm.

Stricker, Stephen A / Ravichandran, Niharika

Zygote (Cambridge, England)

2017 Volume 25, Issue 6, Page(s) 686–696

Abstract: Previous investigations have indicated that c-Jun N-terminal kinase (JNK) regulates the maturation and aging of oocytes produced by deuterostome animals. In order to assess the roles of this kinase in a protostome, oocytes of the marine nemertean worm ... ...

Abstract	Previous investigations have indicated that c-Jun N-terminal kinase (JNK) regulates the maturation and aging of oocytes produced by deuterostome animals. In order to assess the roles of this kinase in a protostome, oocytes of the marine nemertean worm Cerebratulus were stimulated to mature and subsequently aged before being probed with phospho-specific antibodies against active forms of JNK and maturation-promoting factor (MPF). Based on blots of maturing oocytes, a 40-kD putative JNK is normally activated during germinal vesicle breakdown (GVBD), which begins at 30 min post-stimulation with seawater, whereas treating immature oocytes with JNK inhibitors downregulates both the 40-kD JNK signal and GVBD, collectively suggesting a 40-kD JNK may facilitate oocyte maturation. Along with this JNK activity, mature oocytes also exhibit high levels of MPF at 2 h post-stimulation. However, by ~6-8 h post-GVBD, mature oocytes lose the 40-kD JNK signal, and at ~20-30 h of aging, an ~48-kD phospho-JNK band arises as oocytes deactivate MPF and begin to lyse during a necroptotic-like mode of death. Accordingly, JNK inhibitors reduce the aging-related 48-kD JNK phosphorylation while maintaining MPF activity and retarding oocyte degradation. Such findings suggest that a 48-kD JNK may help deactivate MPF and trigger death. Possible mechanisms by which JNK activation either together with, or independently of, protein neosynthesis might stimulate oocyte degradation are discussed.
MeSH term(s)	Animals ; Female ; Invertebrates/embryology ; Invertebrates/physiology ; JNK Mitogen-Activated Protein Kinases/metabolism ; Maturation-Promoting Factor/metabolism ; Oocytes/cytology ; Oocytes/physiology ; Oogenesis/physiology ; Phosphorylation ; Seawater ; Signal Transduction
Chemical Substances	Maturation-Promoting Factor (EC 2.7.11.22) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2017-10-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1166294-3
ISSN	1469-8730 ; 0967-1994
ISSN (online)	1469-8730
ISSN	0967-1994
DOI	10.1017/S0967199417000533
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Article ; Online: Inhibition of germinal vesicle breakdown by antioxidants and the roles of signaling pathways related to nitric oxide and cGMP during meiotic resumption in oocytes of a marine worm.

Stricker, Stephen A

Reproduction (Cambridge, England)

2012 Volume 143, Issue 3, Page(s) 261–270

Abstract: In mammalian oocytes, cAMP elevations prevent the resumption of meiotic maturation and thereby block nuclear disassembly (germinal vesicle breakdown (GVBD)), whereas nitric oxide (NO) and its downstream mediator cGMP can either inhibit or induce GVBD. ... ...

Abstract	In mammalian oocytes, cAMP elevations prevent the resumption of meiotic maturation and thereby block nuclear disassembly (germinal vesicle breakdown (GVBD)), whereas nitric oxide (NO) and its downstream mediator cGMP can either inhibit or induce GVBD. Alternatively, some invertebrate oocytes use cAMP to stimulate, rather than inhibit, GVBD, and in such cases, the effects of NO/cGMP signaling on GVBD remain unknown. Moreover, potential interactions between NO/cGMP and AMP-activated kinase (AMPK) have not been assessed during GVBD. Thus, this study analyzed intraoocytic signaling pathways related to NO/cGMP in a marine nemertean worm that uses cAMP to induce GVBD. For such tests, follicle-free nemertean oocytes were stimulated to mature by seawater (SW) and cAMP elevators. Based on immunoblots and NO assays of maturing oocytes, SW triggered AMPK deactivation, NO synthase (NOS) phosphorylation, and an NO elevation. Accordingly, SW-induced GVBD was blocked by treatments involving the AMPK agonist AICAR, antioxidants, the NO scavenger carboxy-PTIO, NOS inhibitors, and cGMP antagonists that target the NO-stimulated enzyme, soluble guanylate cyclase (sGC). Conversely, SW solutions combining NO/cGMP antagonists with a cAMP elevator restored GVBD. Similarly, AICAR plus a cAMP-elevating drug reestablished GVBD while deactivating AMPK and phosphorylating NOS. Furthermore, sGC stimulators and 8-Br-cGMP triggered GVBD. Such novel results indicate that NO/cGMP signaling can upregulate SW-induced GVBD and that cAMP-elevating drugs restore GVBD by overriding the inhibition of various NO/cGMP downregulators, including AMPK. Moreover, considering the opposite effects of intraoocytic cAMP in nemerteans vs mammals, these data coincide with previous reports that NO/cGMP signaling blocks GVBD in rats.
MeSH term(s)	Animals ; Annelida/drug effects ; Annelida/metabolism ; Annelida/physiology ; Antioxidants/pharmacology ; Aquatic Organisms/drug effects ; Aquatic Organisms/metabolism ; Aquatic Organisms/physiology ; Blastodisc/drug effects ; Blastodisc/metabolism ; Cyclic GMP/metabolism ; Cyclic GMP/pharmacology ; Down-Regulation/drug effects ; Female ; Meiosis/drug effects ; Meiosis/physiology ; Nitric Oxide/metabolism ; Nitric Oxide/pharmacology ; Oocytes/drug effects ; Oocytes/metabolism ; Oocytes/physiology ; Oogenesis/drug effects ; Rats ; Seawater ; Signal Transduction/drug effects ; Signal Transduction/physiology
Chemical Substances	Antioxidants ; Nitric Oxide (31C4KY9ESH) ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2012-03
Publishing country	England
Document type	Evaluation Studies ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2034501-X
ISSN	1741-7899 ; 1470-1626 ; 1476-3990
ISSN (online)	1741-7899
ISSN	1470-1626 ; 1476-3990
DOI	10.1530/REP-11-0358
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Article: Small Molecule Regulators of microRNAs Identified by High-Throughput Screen Coupled with High-Throughput Sequencing.

Krichevsky, Anna / Nguyen, Lien / Wei, Zhiyun / Silva, M / Barberán-Soler, Sergio / Rabinovsky, Rosalia / Muratore, Christina / Stricker, Jonathan / Hortman, Colin / Young-Pearse, Tracy / Haggarty, Stephen

Research square

2023

Abstract: MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be harnessed as potential therapeutics. However, existing strategies for miRNA ... ...

Abstract	MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be harnessed as potential therapeutics. However, existing strategies for miRNA modulation using oligonucleotides and gene therapies are challenging, especially for neurological diseases, and none have yet gained clinical approval. We explore a different approach by screening a biodiverse library of small molecule compounds for their ability to modulate hundreds of miRNAs in human induced pluripotent stem cell-derived neurons. We demonstrate the utility of the screen by identifying cardiac glycosides as potent inducers of miR-132, a key miRNA downregulated in Alzheimer's disease and other tauopathies. Coordinately, cardiac glycosides downregulate known miR-132 targets, including Tau, and protect rodent and human neurons against various toxic insults. More generally, our dataset of 1370 drug-like compounds and their effects on the miRNome provide a valuable resource for further miRNA-based drug discovery.
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-2617979/v1
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