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Article ; Online: Effect of polyacid architecture and polycation molecular weight on lateral diffusion within multilayer films.

Brito, Jordan / Shah, Parin Purvin / Aliakseyeu, Aliaksei / Sukhishvili, Svetlana A

2024 Volume 160, Issue 12

Abstract: Despite the potential use of polyelectrolyte multilayers for biomedical, separation, and energy applications, their dynamic properties are not sufficiently understood. In this work, center-of-mass diffusion of a weak polyacid-poly(methacrylic acid) (PMAA) ...

Abstract	Despite the potential use of polyelectrolyte multilayers for biomedical, separation, and energy applications, their dynamic properties are not sufficiently understood. In this work, center-of-mass diffusion of a weak polyacid-poly(methacrylic acid) (PMAA) of linear and 8-arm architecture (L-PMAA and 8-PMAA, respectively) and matched molecular weight-was studied in layer-by-layer (LbL) assemblies with poly(diallyldimethylammonium) chloride (PDADMAC) of varied molecular weight. The film deposition at low-salt, acidic conditions when PMAA was only partially ionized yielded thicker, more diffused layers with shorter PDADMAC chains, and bilayer thickness decreased for multilayers constructed with longer PDADMAC. The molecular architecture of PMAA had a weak effect on film growth, with bilayer thickness being ∼20% larger for L-PMAA for the films constructed with the shortest PDADMAC (35 kDa) and identical film growth for L-PMAA and 8-PMAA with the longest PDADMAC (300 kDa). The exposure of the multilayer films to 0.2M NaCl triggered a reduction in PMAA ionization and significant lateral diffusivity of fluorescently labeled PMAA molecules (PMAA*), with diffusion coefficients D ranging from 10-13 to 10-12 cm2/s, as determined by the fluorescence recovery after photobleaching technique. For all the films, polymer mobility was higher for star polyacids as compared to their linear counterparts, and the dependence of PMAA diffusion coefficient D on PDADMAC molecular weight (D ∼ M-n) was relatively weak (n < 0.6). However, 8-PMAA demonstrated an approximately doubled power exponent compared to the L-PMAA chains, suggesting a stronger effect of the molecular connectivity of the partner polycation molecules on the diffusion of star polyelectrolytes.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0190377
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Article: Salt-Induced Diffusion of Star and Linear Polyelectrolytes within Multilayer Films.

Aliakseyeu, Aliaksei / Shah, Parin Purvin / Ankner, John F / Sukhishvili, Svetlana A

Macromolecules

2023 Volume 56, Issue 14, Page(s) 5434–5445

Abstract: This study explores the effect of salt on the diffusivity of polyelectrolytes of varied molecular architecture in layer-by-layer (LbL) films in directions parallel and perpendicular to the substrate using fluorescence recovery after photobleaching (FRAP) ...

Abstract	This study explores the effect of salt on the diffusivity of polyelectrolytes of varied molecular architecture in layer-by-layer (LbL) films in directions parallel and perpendicular to the substrate using fluorescence recovery after photobleaching (FRAP) and neutron reflectivity (NR) techniques, respectively. A family of linear, 4-arm, 6-arm, and 8-arm poly(methacrylic acids) (
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	3436-8
ISSN	0024-9297
ISSN	0024-9297
DOI	10.1021/acs.macromol.3c00777
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Article: Hypersensitivity Reactions to Components of Cardiac Implantable Electronic Devices and Their Treatment: A Systematic Review.

Kealaher, Emma / Shah, Parin / Dissanayake, Tharindra / Thomas, Dewi E / Barry, James / Margulescu, Andrei D

Arrhythmia & electrophysiology review

2023 Volume 12, Page(s) e08

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2813970-7
ISSN	2050-3377 ; 2050-3369
ISSN (online)	2050-3377
ISSN	2050-3369
DOI	10.15420/aer.2022.23
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Article ; Online: Prevalence and progression of LV dysfunction and dyssynchrony in patients with new-onset LBBB post TAVR.

Margulescu, Andrei D / Thomas, Dewi E / Awadalla, Magid / Shah, Parin / Khurana, Ayush / Aldalati, Omar / Obaid, Daniel R / Chase, Alexander J / Smith, David

Cardiovascular revascularization medicine : including molecular interventions

2024

Abstract: Background: The impact of new-onset left bundle branch block (N-LBBB) developing after Transcatheter Aortic Valve Replacement (TAVR) on cardiac function and mechanical dyssynchrony is not well defined.: Methods: We retrospectively screened all ... ...

Abstract	Background: The impact of new-onset left bundle branch block (N-LBBB) developing after Transcatheter Aortic Valve Replacement (TAVR) on cardiac function and mechanical dyssynchrony is not well defined. Methods: We retrospectively screened all patients who underwent TAVR in our centre between Oct 2018 and Sept 2021 (n = 409). We identified 38 patients with N-LBBB post-operatively (of which 28 were persistent and 10 were transient), and 17 patients with chronic pre-existent LBBB (C-LBBB). We excluded patients requiring pacing post TAVR. For all groups, we retrospectively analysed stored echocardiograms at 3 time points: before TAVR (T0), early after TAVR (T1, 1.2 ± 1.1 days), and late follow-up (T2, 1.5 ± 0.8 years), comparing LV mass and volumes, indices of LV function (LV ejection fraction, LVEF; global longitudinal strain, GLS), and mechanical dyssynchrony indices (systolic stretch index, severity of septal flash). Results: At baseline (T0), C-LBBB had worse cardiac function, and larger LV volumes and LV mass, compared with patients with N-LBBB. At T1, N-LBBB resulted in mild dyssynchrony and decreased LVEF and GLS. Dyssynchrony progressed at T2 in persistent N-LBBB but not C-LBBB. In both groups however, LVEF remained stable at T2, although individual response was variable. Patients with better LVEF at baseline demonstrated a higher proportion of developing LBBB-induced LV dysfunction at T2. Lack of improvement of LVEF immediately after TAVR predicted deteriorating LVEF at T2. In transient LBBB, cardiac function and most dyssynchrony indices returned to baseline. Conclusions: N-LBBB after TAVR results in an immediate reduction of cardiac function, in spite of only mild dyssynchrony. When LBBB persists, patients with better cardiac function before TAVR are more likely to have LBBB-induced LV dysfunction after TAVR.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2212113-4
ISSN	1878-0938 ; 1553-8389
ISSN (online)	1878-0938
ISSN	1553-8389
DOI	10.1016/j.carrev.2024.04.011
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Article ; Online: Persistent 2-for-1 Atrioventricular Node Anterograde Conduction During a Supraventricular Tachycardia.

Shah, Ankur / Clark, Brad A / Gupta, Saarik / Gilge, Jasen L / Ahmed, Asim S / Patel, Parin J / Steinberg, Leonard A / Padanilam, Benzy J

JACC. Case reports

2022 Volume 4, Issue 10, Page(s) 621–625

Abstract: We present a case of persistent dual AV node conduction during AV node reentry tachycardia as a new clinical manifestation of 2-for-1 AV node conduction. The interpretation of the complex physiology ponders the possibility of an accessory pathway ... ...

Abstract	We present a case of persistent dual AV node conduction during AV node reentry tachycardia as a new clinical manifestation of 2-for-1 AV node conduction. The interpretation of the complex physiology ponders the possibility of an accessory pathway mediated atrioventricular reentry existing with more ventricular than atrial events.
Language	English
Publishing date	2022-05-18
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2022.03.003
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Article: Massively parallel base editing screens to map variant effects on anti-tumor hallmarks of primary human T cells.

Walsh, Zachary H / Shah, Parin / Kothapalli, Neeharika / Nikolenyi, Gergo / Shah, Shivem B / Leuzzi, Giuseppe / Mu, Michael / Ho, Patricia / Abuzaid, Sinan / Brodtman, Zack D / Vasan, Neil / AlQuraishi, Mohammed / Milner, Joshua D / Ciccia, Alberto / Melms, Johannes C / Izar, Benjamin

bioRxiv : the preprint server for biology

2023

Abstract: Base editing enables generation of single nucleotide variants, but large-scale screening in primary human T cells is limited due to low editing efficiency, among other ... ...

Abstract	Base editing enables generation of single nucleotide variants, but large-scale screening in primary human T cells is limited due to low editing efficiency, among other challenges
Language	English
Publishing date	2023-12-14
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.12.13.571465
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Article: Upgrading to cardiac resynchronisation therapy: Concordance of real-world experience with clinical guidelines.

Tan, Laura / Ganesananthan, Sashiananthan / Huzaien, Hani / Elsayed, Hossam / Shah, Nisar / Shah, Parin / Yousef, Zaheer

International journal of cardiology. Heart & vasculature

2021 Volume 33, Page(s) 100746

Abstract: Objective: Revision to cardiac resynchronisation therapy (CRT) in patients with existing pacemakers with worsening heart failure (HF) can improve symptoms and cardiac function. We identify factors that predict improvement in left ventricular ejection ... ...

Abstract	Objective: Revision to cardiac resynchronisation therapy (CRT) in patients with existing pacemakers with worsening heart failure (HF) can improve symptoms and cardiac function. We identify factors that predict improvement in left ventricular ejection fraction (LVEF) within a year of CRT revision. Methods: We performed a retrospective study of 146 consecutive patients (16% female, mean age 73 ± 11 years, mean LVEF 27 ± 8%) undergoing revision to CRT (January 2012 to May 2018) in a single tertiary centre. LVEF was measured pre-revision and 3, 6 and 12 months post-upgrade. Results: At 6 months, 68% of patients demonstrated improvement in LVEF (mean ΔLVEF + 6.7% ± 9.6). Compared to patients in atrial fibrillation (AF), patients with sinus rhythm had a greater improvement in LVEF at 6 months (sinus 8.4 ± 10.3% vs. AF 4.2 ± 8.0%, p = 0.02). Compared to ischaemic cardiomyopathy (ICM), patients with non-ischaemic cardiomyopathy (NICM) had a greater improvement in LVEF at 6 months (NICM 8.4 ± 9.8% vs ICM 4.8 ± 9.2%, p = 0.05). Patients with RV pacing ≥40% at baseline had a greater improvement in LVEF at 6 months (≥40% RV pacing 9.3 ± 10.2 vs. < 40% RV pacing 4.0 ± 7.4%, p = 0.01). All improvements were sustained over 12 months post-revision. There was no significant difference between genders, years between initial implant and revision, or previous device type. Conclusions: Our real-world experience supports current guidelines on CRT revision. NICM, ≥40% RV pacing and sinus rhythm are the main predictors of improvement in LVEF in patients who underwent CRT revision.
Language	English
Publishing date	2021-03-11
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2021.100746
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Article ; Online: The indications and safety of prolonged temporary pacing using active-fixation leads and externalized pulse generator.

Shah, Nisar H / Shah, Parin / Elsayed, Hossam / O'Callaghan, Peter / Leong, Fong T / Yousef, Zaheer

Pacing and clinical electrophysiology : PACE

2021 Volume 44, Issue 3, Page(s) 506–512

Abstract: Background: Temporary cardiac pacing, conventionally achieved using a passive transvenous pacing wire, can be life-saving for unstable arrhythmias. However, they run the risk of complications, the longer they remain in-situ. Externalized prolonged ... ...

Abstract	Background: Temporary cardiac pacing, conventionally achieved using a passive transvenous pacing wire, can be life-saving for unstable arrhythmias. However, they run the risk of complications, the longer they remain in-situ. Externalized prolonged temporary pacing (EPTP), using active-fixation lead and an externalized pulse generator; may be an alternative for transient pacing indications, concurrent illness or sepsis that precludes permanent pacing. Methods: Sixty-seven patients (mean age 69 ± 14 years; 82% male) underwent EPTP between November 2011 and April 2019. EPTP was performed in a sterile facility, under fluoroscopy, using active-fixation leads anchored to the right ventricle septum. Externalized lead was connected to a re-sterilized pulse generator and secured to anterior chest wall with transparent dressings. EPTP indications and patient outcomes were evaluated. Results: Pacing indications were high-grade atrio-ventricular (AV) block (73.2%), sinus arrest (14.9%), overdrive suppression of VT (5.9%) and pause-dependent VT (4.5%). Reasons for ETPT rather than permanent pacing included: sepsis (38.8%), CIED-related infection (8.9%), transient pacing indication (25%), to allow further investigations prior to decision on CIED type (22%), and over-drive arrhythmia suppression (6%). Sixty three percent patients were severely ill in an ICU. Mean duration of pacing was 16 ± 12 days. Sixty seven percent patients subsequently received a CIED and had no evidence of device-related infection at 1-year post-implant. There were three non-fatal complications during EPTP while no deaths were attributed to EPTP. Conclusion: EPTP is a safe and useful method of prolonged temporary pacing for patients who require chronotropic support, but in whom immediate permanent pacemaker implantation is contraindicated.
MeSH term(s)	Aged ; Cardiac Pacing, Artificial/methods ; Electric Power Supplies ; Electrodes, Implanted ; Female ; Heart Block/therapy ; Humans ; Male ; Risk Factors ; Time Factors
Language	English
Publishing date	2021-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14187
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Article: Use of diaphragmatic compound motor action potential monitoring to prevent right phrenic nerve palsy during atrial tachycardia ablation.

Gilge, Jasen L / Prystowsky, Eric N / Padanilam, Benzy J / Clark, Bradley A / Shah, Ankur / Steinberg, Leonard A / Nair, Girish V / Patel, Parin J

HeartRhythm case reports

2021 Volume 7, Issue 11, Page(s) 739–742

Language	English
Publishing date	2021-08-12
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834871-0
ISSN	2214-0271
ISSN	2214-0271
DOI	10.1016/j.hrcr.2021.08.001
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Article ; Online: The effect of digoxin on renal function in patients with heart failure.

Shah, Parin / Pellicori, Pierpaolo / Hanning, Ian / Zhang, Jufen / Clark, Andrew L / Bhandari, Sunil

BMC nephrology

2021 Volume 22, Issue 1, Page(s) 349

Abstract: Introduction: Digoxin is used in patients with chronic heart failure (CHF) who remain symptomatic despite optimal medical treatment. Impaired renal function is commonly associated with CHF. We investigated the relation between digoxin use and change in ... ...

Abstract	Introduction: Digoxin is used in patients with chronic heart failure (CHF) who remain symptomatic despite optimal medical treatment. Impaired renal function is commonly associated with CHF. We investigated the relation between digoxin use and change in renal function over time in patients with CHF. Methods: One thousand two hundred forty-one patients with symptoms and signs of CHF (average age 72 years (64% male), and median NTproBNP 1426 ng/l (interquartile range 632-2897) were divided into four groups: never on digoxin (N = 394); digoxin throughout (N = 449); started digoxin at some point after baseline (N = 367); and stopped digoxin at some point after baseline (N = 31). The rate of change of estimated glomerular filtration rate (eGFR) was calculated using linear regression. Results: Patients on digoxin throughout had a significantly greater rate of decline in eGFR per year than patients not on digoxin throughout (mean (± standard deviation); - 5 (14) ml/min/1.73m Conclusion: The rate of decline in renal function is greater in patients with CHF who are taking digoxin.
MeSH term(s)	Aged ; Aged, 80 and over ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/therapeutic use ; Digoxin/pharmacology ; Digoxin/therapeutic use ; Female ; Glomerular Filtration Rate/drug effects ; Heart Failure/drug therapy ; Humans ; Kidney/drug effects ; Kidney/physiopathology ; Male ; Middle Aged ; Retrospective Studies ; Time Factors
Chemical Substances	Cardiotonic Agents ; Digoxin (73K4184T59)
Language	English
Publishing date	2021-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-021-02562-0
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