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Article ; Online: Bempedoic acid: Everything with a place and purpose.

Westerink, Jan

European journal of preventive cardiology

2021 Volume 28, Issue 8, Page(s) 823–824

MeSH term(s)	Dicarboxylic Acids ; Fatty Acids ; Humans
Chemical Substances	Dicarboxylic Acids ; Fatty Acids ; 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid (1EJ6Z6Q368)
Language	English
Publishing date	2021-02-18
Publishing country	England
Document type	Editorial
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1177/2047487320929779
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Article ; Online: Towards more biodiverse agricultural landscapes

Westerink, Judith / Hassink, Jan / Plomp, Marleen / van Os, Jaap

Journal of Rural Studies

How to make species-rich grassland a desirable and feasible option for dairy farmers

2024 Volume 105

Abstract: Species-rich grasslands are promoted by public and private actors for reasons of biodiversity, landscape amenity and animal health. There is little understanding of the considerations of farmers when they opt for or against species-rich grasslands. We ... ...

Abstract	Species-rich grasslands are promoted by public and private actors for reasons of biodiversity, landscape amenity and animal health. There is little understanding of the considerations of farmers when they opt for or against species-rich grasslands. We held a workshop with 20 farmers and conducted in-depth interviews with 15 livestock farmers in Alblasserwaard - Vijfheerenlanden, a peat meadow landscape in the West of the Netherlands. In these discussions we made an inventory of opportunities and barriers that the farmers experience in terms of willingness, ability and support from society. In our analysis we distinguished four farming styles accommodating species-rich grasslands, which differ in the way willingness, ability and support from society are experienced by the farmers. Based on these findings, we make generic and farming style-specific recommendations for public policy and parties in the supply chain for effectively promoting species-rich grasslands among livestock farmers. We propose that a diverse public-private policy mix is essential to reach as many farmers as possible, acknowledging their heterogeneity and addressing their multiple needs.
Keywords	Agri-environmental schemes ; Farmer behaviour ; Governance ; Herb-rich ; Multi-species ; Typology
Subject code	028
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	252458-2
ISSN	0743-0167
ISSN	0743-0167
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Generalisability of trials on antithrombotic treatment intensification in patients with cardiovascular disease.

Castelijns, Maria C / Hageman, Steven H J / Teraa, Martin / van der Meer, Manon G / Westerink, Jan / Ten Berg, Jurrien / Visseren, Frank L J

Heart (British Cardiac Society)

2024 Volume 110, Issue 7, Page(s) 482–490

Abstract: Objective: Assessment of generalisability of guideline-informing trials on antithrombotic treatment intensification to real-world patients with cardiovascular disease (CVD).: Methods: Inclusion and exclusion criteria of the Cardiovascular Outcomes ... ...

Abstract	Objective: Assessment of generalisability of guideline-informing trials on antithrombotic treatment intensification to real-world patients with cardiovascular disease (CVD). Methods: Inclusion and exclusion criteria of the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS), Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA), Prevention of Cardiovascular events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction (PEGASUS-TIMI) and Dual Antiplatelet Therapy (DAPT) study were applied to coronary artery disease (CAD) and/or peripheral artery disease (PAD) patients from Utrecht Cardiovascular Cohort-Second Manifestations of Arterial Disease (UCC-SMART) to determine real-world eligibility. Eligible and ineligible patients were compared on baseline characteristics, cardiovascular events, major bleeding and mortality. Results: Eligibility ranged from 11%-94% for CAD to 75%-90% for patients with PAD. Cardiovascular, bleeding and mortality risks were higher in COMPASS-eligible patients with CAD (rate ratios (RR) 1.98 (95% CI 1.74 to 2.26), 2.02 (95% CI 1.47 to 2.78) and 3.11 (95% CI 2.71 to 3.57), respectively) and CHARISMA-eligible patients (RR 1.51 (95% CI 1.12 to 2.06), 2.25 (95% CI 1.01 to 6.21) and 4.43 (95% CI 2.79 to 7.51), respectively), and lower in COMPASS-eligible patients with PAD (RR 0.45 (95% CI 0.36 to 0.56), 0.29 (95% CI 0.18 to 0.46) and 0.45 (95% CI 0.38 to 0.54), respectively) and DAPT-eligible patients with CAD (RR CVD 0.49 (95% CI 0.34 to 0.69) and mortality 0.67 (95% CI 0.48 to 0.94)) than ineligible patients. After adjustment for trial eligibility criteria, only higher cardiovascular and mortality risks in COMPASS-eligible patients with CAD and lower cardiovascular risks in CHARISMA-eligible and DAPT-eligible patients persisted with CAD. Conclusion: A large proportion of contemporary CVD patients would be eligible for intensified antithrombotic treatment trials, with mostly similar adjusted event risks to ineligible patients. Trial-based guideline recommendations are largely applicable to real-world patients.
MeSH term(s)	Humans ; Aspirin/therapeutic use ; Cardiovascular Diseases/drug therapy ; Coronary Artery Disease/therapy ; Fibrinolytic Agents/adverse effects ; Hemorrhage/chemically induced ; Myocardial Infarction ; Peripheral Arterial Disease/drug therapy ; Platelet Aggregation Inhibitors/therapeutic use ; Treatment Outcome ; Randomized Controlled Trials as Topic
Chemical Substances	Aspirin (R16CO5Y76E) ; Fibrinolytic Agents ; Platelet Aggregation Inhibitors
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2023-323519
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Article ; Online: When LDL Cholesterol Is Not LDL Cholesterol: LpX, A Clinical Lesson.

Huygen, Lisa P M / Westerink, Jan / Mol, Gerben C / Bemelmans, Remy H H

JACC. Case reports

2022 Volume 4, Issue 11, Page(s) 690–693

Abstract: LpX is a lipoprotein formed in cholestatic conditions and often erroneously reported as LDL-C. A low ApoB level can support the diagnosis of LpX. Treatment should not automatically focus on lowering serum lipid levels, but primarily on resolving the ... ...

Abstract	LpX is a lipoprotein formed in cholestatic conditions and often erroneously reported as LDL-C. A low ApoB level can support the diagnosis of LpX. Treatment should not automatically focus on lowering serum lipid levels, but primarily on resolving the cause of cholestasis. (
Language	English
Publishing date	2022-06-01
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2022.03.009
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Article ; Online: Severe selection bias in deemed venous thoracic outlet syndrome-associated upper extremity deep venous thrombosis research.

Schropp, Ludo / Westerink, Jan / Nijkeuter, Mathilde / van Hattum, Eline S / Petri, Bart-Jeroen / de Borst, Gert J

Journal of vascular surgery

2023 Volume 78, Issue 3, Page(s) 841–842

MeSH term(s)	Humans ; Selection Bias ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/therapy
Language	English
Publishing date	2023-08-19
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2023.02.028
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Article ; Online: Outcomes of second opinions in general internal medicine.

Burger, Pascal M / Westerink, Jan / Vrijsen, Bram E L

PloS one

2020 Volume 15, Issue 7, Page(s) e0236048

Abstract: Background: To date, the outcomes of second opinions in internal medicine in terms of diagnostic yield and patient benefit have not been studied extensively. This retrospective study explores the outcomes of second opinions at a general internal ... ...

Abstract	Background: To date, the outcomes of second opinions in internal medicine in terms of diagnostic yield and patient benefit have not been studied extensively. This retrospective study explores the outcomes of second opinions at a general internal medicine outpatient clinic in an academic hospital. Methods: A register of all patients referred to the general internal medicine outpatient clinic of the University Medical Center in Utrecht for a second opinion, was kept. All 173 patients referred between June 2016 and August 2018 were selected. Case records were analyzed for patient characteristics, referring doctor, chief complaint, performed investigations, follow-up time and, established diagnosis, additional diagnoses, initiated treatment and reported benefit. Results: A new diagnosis was established in 13% of all patients. A new treatment was initiated in 56% of all patients: 91% and 51% of patients with and without a new diagnosis respectively (p < 0.001). Of all patients, 19% received an effective treatment (52% vs 14% of patients with vs without a new diagnosis, p < 0.001). Regardless of treatment, resolution or improvement of the chief complaint was achieved in 28% of all patients (52% vs 25% of patients with vs without a new diagnosis, p = 0.006). Regarding diagnostics, 23-33% of radiology, endoscopy and pathology tests performed during second opinion were a repetition of previously conducted investigations. Conventional blood tests were a repetition in 89% of cases. Median time to diagnosis was 64 days (IQR: 25-128 days) and median time to discharge was 75 days (IQR: 31-144 days). Conclusion: Second opinions in general internal medicine lead to the establishment of a new diagnosis in a small proportion of patients. However, the value of second opinions may not be limited to the establishment of diagnoses, as new treatments are often initiated and overall patients report improved symptomatology in 28% of cases.
MeSH term(s)	Adult ; Blood Chemical Analysis ; Female ; Follow-Up Studies ; General Practice/statistics & numerical data ; Humans ; Internal Medicine/statistics & numerical data ; Male ; Microbiology ; Referral and Consultation/statistics & numerical data ; Urinalysis
Language	English
Publishing date	2020-07-09
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0236048
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Article ; Online: Redundant laboratory testing on referral from general practice to the outpatient clinic: a post-hoc analysis.

Vrijsen, Bram El / Ten Berg, Maarten J / van Solinge, Wouter W / Westerink, Jan

BJGP open

2022 Volume 6, Issue 1

Abstract: Background: Inappropriately repeated laboratory testing is a commonly occurring problem. However, this has not been studied extensively in the outpatient clinic after referral by GPs.: Aim: The aim of this study was to investigate how often ... ...

Abstract	Background: Inappropriately repeated laboratory testing is a commonly occurring problem. However, this has not been studied extensively in the outpatient clinic after referral by GPs. Aim: The aim of this study was to investigate how often laboratory tests ordered by the GP were repeated on referral to the outpatient clinic, and how many of the normal test results remained normal on repetition. Design & setting: This is a post-hoc analysis of a study on laboratory testing strategies in patients newly referred to the outpatient clinic between April 2015 and April 2017. Method: All patients who had a referral letter including laboratory test results ordered by the GP were included. These results were compared with the laboratory test results ordered in the outpatient clinic. Results: Data were available for 295 patients, 191 of which had post-visit testing done. In this group, 56% of tests ordered by the GP were repeated. Tests with abnormal results were repeated more frequently than tests with normal results (65% versus 53%; Conclusion: Laboratory tests ordered by the GP are commonly repeated on referral to the outpatient clinic. The number of test results remaining normal on repetition suggests a high level of redundancy in laboratory test repetition.
Language	English
Publishing date	2022-03-22
Publishing country	England
Document type	Journal Article
ISSN	2398-3795
ISSN (online)	2398-3795
DOI	10.3399/BJGPO.2021.0134
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Article: Functional outcome of arterial thoracic outlet syndrome treatment.

de Kleijn, Robert J C M F / Schropp, Ludo / Westerink, Jan / van Hattum, Eline S / Petri, Bart-Jeroen / de Borst, Gert J

Frontiers in surgery

2023 Volume 9, Page(s) 1072536

Abstract: Introduction: The low prevalence of Arterial Thoracic Outlet Syndrome (ATOS) and diffuse symptomatology have resulted in limited data on optimal treatment strategies and long-term outcome. The aim of this study was to report and evaluate a single center ...

Abstract	Introduction: The low prevalence of Arterial Thoracic Outlet Syndrome (ATOS) and diffuse symptomatology have resulted in limited data on optimal treatment strategies and long-term outcome. The aim of this study was to report and evaluate a single center experience with the treatment of ATOS including midterm patient reported outcome. Methods: All patients treated for ATOS from 2004 to 2020 were retrospectively identified. Patients were divided into two groups based on presenting symptoms; ATOX group (Acute arterial occlusion with ischemia) and ATOS group (claudication symptoms). Baseline characteristics and treatment details were extracted from electronic patient files. A telephone survey was conducted to collect patients' follow-up data including a functional disability score using the Quick Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire. The primary endpoint of this study was symptom-free survival. Secondary endpoints were median QuickDASH scores during follow-up, postoperative complications and possible re-interventions. Results: A total of 20 patients (mean age 44.6 years, median follow-up 50.5 months) were included and divided into two groups (ATOX Conclusion: The mid-term self-reported symptom free survival in both the ATOX as well as ATOS group seems acceptable while median QuickDASH scores in both groups indicate a very good functional outcome. This however comes at the cost of treatment related bleeding complications in especially the ATOX group presumably due to thrombolysis, and re-interventions required in almost one out of three patients.
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.1072536
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Article ; Online: Letter by Westerink and Visseren Regarding Article, "Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial".

Westerink, Jan / Visseren, Frank

Arteriosclerosis, thrombosis, and vascular biology

2017 Volume 37, Issue 5, Page(s) e53

MeSH term(s)	Anticholesteremic Agents ; Cholesterol ; Coronary Vessels ; Ezetimibe ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
Chemical Substances	Anticholesteremic Agents ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Cholesterol (97C5T2UQ7J) ; Ezetimibe (EOR26LQQ24)
Language	English
Publishing date	2017-04-21
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.117.309295
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Article ; Online: HbA

Been, Riemer A / Noordstar, Ellen / Helmink, Marga A G / van Sloten, Thomas T / de Ranitz-Greven, Wendela L / van Beek, André P / Houweling, Sebastiaan T / van Dijk, Peter R / Westerink, Jan

Diagnosis (Berlin, Germany)

2024

Abstract: Objectives: Type 2 diabetes (T2DM) is associated with increased risk for cardiovascular disease (CVD). Whether screen-detected T2DM, based on fasting plasma glucose (FPG) or on HbA: Methods: 8,274 high-risk CVD participants were included from the UCC- ...

Abstract	Objectives: Type 2 diabetes (T2DM) is associated with increased risk for cardiovascular disease (CVD). Whether screen-detected T2DM, based on fasting plasma glucose (FPG) or on HbA Methods: 8,274 high-risk CVD participants were included from the UCC-SMART cohort. Participants were divided into groups based on prior T2DM diagnosis, and combinations of elevated/non-elevated FPG and HbA Results: During a median follow-up of 6.3 years (IQR 3.3-9.8), 712 cardiovascular events occurred. Compared to the reference (group 4), group 0 was at increased risk (HR 1.40; 95 % CI 1.16-1.68), but group 1 (HR 1.16; 95 % CI 0.62-2.18), 2 (HR 1.18; 95 % CI 0.84-1.67), 3 (HR 0.61; 95 % CI 0.15-2.44), 1 + 2 (HR 1.17; 95 % CI 0.86-1.59) and 1 + 3 (HR 1.01; 95 % CI 0.57-1.79) were not. However, spline interpolation showed a linearly increasing risk with increasing HbA Conclusions: Based on current cut-offs, FPG and HbA
Language	English
Publishing date	2024-02-29
Publishing country	Germany
Document type	Journal Article
ISSN	2194-802X
ISSN (online)	2194-802X
DOI	10.1515/dx-2024-0017
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