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  1. Article ; Online: Francesco Saverio Nitti dal lungo esilio al rientro in Italia

    Santi Fedele

    Humanities, Vol 1, Iss 1, Pp 1-

    2016  Volume 18

    Abstract: ...

    Abstract ***
    Keywords Anthropology ; GN1-890 ; History (General) ; D1-2009
    Language English
    Publishing date 2016-12-01T00:00:00Z
    Publisher University of Messina
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: Barāqish/Yathill (Yemen) 1986-2007 : Excavations of Temple B and related research and restoration

    Antonini, Sabina / Fedele, Francesco G.

    2021  

    Keywords Archaeology ; Social Science
    Size 1 Online-Ressource
    Publisher Archaeopress Publishing
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021232574
    ISBN 9781789694703 ; 1789694701
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: AI identifies potent inducers of breast cancer stem cell differentiation based on adversarial learning from gene expression data.

    Li, Zhongxiao / Napolitano, Antonella / Fedele, Monica / Gao, Xin / Napolitano, Francesco

    Briefings in bioinformatics

    2024  Volume 25, Issue 3

    Abstract: Cancer stem cells (CSCs) are a subpopulation of cancer cells within tumors that exhibit stem-like properties and represent a potentially effective therapeutic target toward long-term remission by means of differentiation induction. By leveraging an ... ...

    Abstract Cancer stem cells (CSCs) are a subpopulation of cancer cells within tumors that exhibit stem-like properties and represent a potentially effective therapeutic target toward long-term remission by means of differentiation induction. By leveraging an artificial intelligence approach solely based on transcriptomics data, this study scored a large library of small molecules based on their predicted ability to induce differentiation in stem-like cells. In particular, a deep neural network model was trained using publicly available single-cell RNA-Seq data obtained from untreated human-induced pluripotent stem cells at various differentiation stages and subsequently utilized to screen drug-induced gene expression profiles from the Library of Integrated Network-based Cellular Signatures (LINCS) database. The challenge of adapting such different data domains was tackled by devising an adversarial learning approach that was able to effectively identify and remove domain-specific bias during the training phase. Experimental validation in MDA-MB-231 and MCF7 cells demonstrated the efficacy of five out of six tested molecules among those scored highest by the model. In particular, the efficacy of triptolide, OTS-167, quinacrine, granisetron and A-443654 offer a potential avenue for targeted therapies against breast CSCs.
    MeSH term(s) Humans ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/pathology ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/drug therapy ; Cell Differentiation/drug effects ; Female ; Artificial Intelligence ; Gene Expression Regulation, Neoplastic/drug effects ; MCF-7 Cells ; Cell Line, Tumor ; Neural Networks, Computer ; Gene Expression Profiling
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2068142-2
    ISSN 1477-4054 ; 1467-5463
    ISSN (online) 1477-4054
    ISSN 1467-5463
    DOI 10.1093/bib/bbae207
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  4. Article: Ovarian Torsion in a Young Adolescent with Rokitansky Syndrome.

    Fedele, Francesco / Esposito, Giovanna / Busnelli, Andrea / Parazzini, Fabio

    Case reports in obstetrics and gynecology

    2024  Volume 2024, Page(s) 1305476

    Abstract: A case report of a premenarcheal patient with ovarian torsion and mullerian agenesis is presented. A 12-year-old prepubertal girl is presented with severe right lower quadrant abdominal pain and mild rebound. Laparoscopy showed mullerian agenesis and ... ...

    Abstract A case report of a premenarcheal patient with ovarian torsion and mullerian agenesis is presented. A 12-year-old prepubertal girl is presented with severe right lower quadrant abdominal pain and mild rebound. Laparoscopy showed mullerian agenesis and twisted right adnexa. Detorsion and cystectomy of the right ovary were done, and the ovary was fixed to the pelvic sidewall. The postoperative course was uneventful. An association between the lax attachment of the adnexa and torsion may be a contributing factor in this condition.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627654-9
    ISSN 2090-6692 ; 2090-6684
    ISSN (online) 2090-6692
    ISSN 2090-6684
    DOI 10.1155/2024/1305476
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  5. Article ; Online: Wave dispersion in moderate channel turbulence.

    Pilloton, Chiara / Lugni, Claudio / Graziani, Giorgio / Fedele, Francesco

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 6801

    Abstract: We study channel turbulence by interpreting its vorticity as a random sea of ocean wave packet analogues. In particular, we investigate the ocean-like properties of vortical packets applying stochastic methods developed for oceanic fields. Taylor's ... ...

    Abstract We study channel turbulence by interpreting its vorticity as a random sea of ocean wave packet analogues. In particular, we investigate the ocean-like properties of vortical packets applying stochastic methods developed for oceanic fields. Taylor's hypothesis of frozen eddies does not hold when turbulence is not weak, and vortical packets change shape as they are advected by the mean flow, altering their own speed. This is the physical manifestation of a hidden wave dispersion of turbulence. Our analysis at the bulk Reynolds number Re
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-32978-7
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  6. Article ; Online: Neovagina creation methods in Müllerian anomalies and risk of malignancy: insights from a systematic review.

    Fedele, Francesco / Bulfoni, Alessandro / Parazzini, Fabio / Busnelli, Andrea

    Archives of gynecology and obstetrics

    2023  Volume 309, Issue 3, Page(s) 801–812

    Abstract: Purpose: This systematic review aims to provide a data synthesis about the risk of neovaginal cancer in women with Müllerian anomalies and to investigate the association between the adopted reconstructive technique and the cancer histotype.: Methods: ...

    Abstract Purpose: This systematic review aims to provide a data synthesis about the risk of neovaginal cancer in women with Müllerian anomalies and to investigate the association between the adopted reconstructive technique and the cancer histotype.
    Methods: PubMed, MEDLINE, Embase, Scopus, ClinicalTrials.gov and Web of Science databases were searched from inception to March 1st, 2023. Studies were included if: (1) only women affected by Müllerian malformations were included, (2) the congenital defect and the vaginoplasty technique were clearly reported, (3) the type of malignancy was specified.
    Results: Literature search yielded 18 cases of squamous cell carcinoma and two cases of vaginal intraepithelial neoplasia 3 (VAIN 3). Of these, 3 had been operated on according to the Wharton technique, 8 according to the McIndoe technique, 3 with a split-skin graft vaginoplasty, 2 according to the Davydov technique, 2 with a simple cleavage technique, 1 according to the Vecchietti technique and 1 with a bladder flap vaginoplasty. A total of 17 cases of adenocarcinoma and 1 case of high-grade polypoid dysplasia were also described. Of these, 15 had undergone intestinal vaginoplasty, 1 had been operated on according to the McIndoe technique and 1 had undergone non-surgical vaginoplasty. Finally, 1 case of verrucous carcinoma in a woman who had undergone a split-skin graft vaginoplasty, was reported.
    Conclusion: Although rare, neovaginal carcinoma is a definite risk after vaginal reconstruction, regardless of the adopted technique. Gynaecologic visits including the speculum examination, the HPV DNA and/or the Pap smear tests should be scheduled on an annual basis.
    MeSH term(s) Humans ; Female ; Vagina/pathology ; Plastic Surgery Procedures ; Vaginal Neoplasms/surgery ; Vaginal Neoplasms/pathology ; Carcinoma, Squamous Cell/pathology ; Adenocarcinoma/pathology ; Mullerian Ducts/surgery ; Mullerian Ducts/abnormalities ; 46, XX Disorders of Sex Development/surgery ; Congenital Abnormalities/surgery ; Congenital Abnormalities/pathology ; Gynecologic Surgical Procedures/methods ; Treatment Outcome
    Language English
    Publishing date 2023-07-19
    Publishing country Germany
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-023-07086-6
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  7. Article ; Online: Reconstructive surgery for congenital atresia of the uterine cervix: a systematic review.

    Fedele, Francesco / Parazzini, Fabio / Vercellini, Paolo / Bergamini, Valentino / Fedele, Luigi

    Archives of gynecology and obstetrics

    2022  Volume 308, Issue 3, Page(s) 685–700

    Abstract: The authors discuss the incidence, the embryological development, the classification, the presentation and the treatment options of this rare reproductive tract abnormality. In the past, the treatment proposed almost unanimously was hysterectomy and ... ...

    Abstract The authors discuss the incidence, the embryological development, the classification, the presentation and the treatment options of this rare reproductive tract abnormality. In the past, the treatment proposed almost unanimously was hysterectomy and subsequent construction, when necessary, of a neovagina. In recent decades, numerous experiences of conservative therapies have accumulated that allow the restoration of menstrual function and in some rare cases even the achievement of a pregnancy. However, complications associated with recanalization of the cervix frequently resulted in the need for repeated surgery, risk of serious and sometimes fatal ascending infection. This review aims to analyze the most recent and significant experiences of conservative surgery in this field to provide an accurate picture of the various techniques and their outcomes, especially from the point of view of fertility. Conservative surgery should now be considered as the first-line treatment option. On the other hand, it is not possible to draw conclusions on the superiority of one technique over another among the various conservative options. This would require large series with adequate follow-up, which unfortunately are not available.
    MeSH term(s) Pregnancy ; Female ; Humans ; Cervix Uteri/surgery ; Cervix Uteri/abnormalities ; Surgery, Plastic ; Uterine Cervical Neoplasms/surgery ; Plastic Surgery Procedures ; Hysterectomy ; Vagina/surgery ; Congenital Abnormalities/surgery
    Language English
    Publishing date 2022-10-28
    Publishing country Germany
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-022-06825-5
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  8. Article ; Online: Pian dei Cavalli, Borghetto, alta Val San Giacomo

    Fedele, Francesco G.

    Quaderni grigionitaliani ; 1168813-0 ; 1016-748X ; 89 ; 2020 ; 4 ; 67

    popolamento preistorico e storia ambientale

    2020  

    Publishing date 2020-12-01
    Publisher Pro Grigioni Italiano
    Publishing country ch
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Combined Topography-Guided Trans-Epithelial PRK and PTK for Recalcitrant Recurrent Corneal Erosions in Lattice Corneal Dystrophy.

    Pignatelli, Francesco / Passidomo, Fedele / Buonamassa, Rosa / Niro, Alfredo / Addabbo, Giuseppe

    International medical case reports journal

    2023  Volume 16, Page(s) 275–280

    Abstract: Purpose: To report morphologic and functional changes after topography-guided trans-epithelial photorefractive keratectomy (PRK) combined with phototherapeutic keratectomy (PTK) for recalcitrant recurrent corneal erosions in Lattice Corneal Dystrophy ( ... ...

    Abstract Purpose: To report morphologic and functional changes after topography-guided trans-epithelial photorefractive keratectomy (PRK) combined with phototherapeutic keratectomy (PTK) for recalcitrant recurrent corneal erosions in Lattice Corneal Dystrophy (LCD).
    Methods: One case report.
    Results: A 78-year-old man presented us with decreased visual acuity [20/100 in right eye (RE), and 20/400 in left eye (LE)], and redness with foreign body sensation in both eyes. Clinical examination revealed epithelial erosions, and linear stromal opacities involving the center of the cornea in both eyes, supporting the diagnosis of LCD. Several medical approaches including autologous serum, amniotic membrane extract, and nerve growth factor eye drops allowed a temporary improvement in symptoms. A single-step topography-guided trans-epithelial PRK combined with PTK (CIPTA
    Conclusion: Recalcitrant corneal erosions and stromal opacities in LCD may be successfully treated using combined topography-guided trans-epithelial PRK and PTK.
    Language English
    Publishing date 2023-05-10
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2495077-4
    ISSN 1179-142X
    ISSN 1179-142X
    DOI 10.2147/IMCRJ.S403451
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  10. Article ; Online: Histological Features of Neovaginal Epithelium after Vaginoplasty in Mayer-Rokitansky-Küster-Hauser Syndrome.

    Candiani, Massimo / Fedele, Francesco / Ruffolo, Alessandro Ferdinando / Di Fatta, Simona / Salvatore, Stefano / Parazzini, Fabio

    Journal of pediatric and adolescent gynecology

    2024  

    Abstract: Objective: To analyze the features of the epithelia coating neovaginas after vaginoplasty in women affected by Mayer-Rokitansky-Küster-Hauser syndrome STUDY DESIGN: We conducted a retrospective analysis of prospectively collected data. Women affected by ...

    Abstract Objective: To analyze the features of the epithelia coating neovaginas after vaginoplasty in women affected by Mayer-Rokitansky-Küster-Hauser syndrome STUDY DESIGN: We conducted a retrospective analysis of prospectively collected data. Women affected by Rokitansky syndrome who underwent neovaginal biopsy after vaginoplasty (McIndoe surgery, intestinal vaginoplasty, Vecchietti surgery, and Davydov surgery) were included. Macroscopic mucosal features were assessed through clinical examination and the Schilling test. Each biopsy specimen was prepared for examination by light microscopy and in some cases by scanning electron microscopy (SEM).
    Results: Thirty-six patients (4 McIndoe, 2 intestinal vaginoplasty, 14 Vecchietti, and 16 Davydov) were included. All biopsies were performed without complications. In McIndoe's neovaginas, the mucosal microscopic features were similar to normal skin, with large areas of preserved epithelium, heterogeneous presence of dermal papillae, and superficial keratinization. The characteristics of the intestinal neovagina's surface were similar to those of a sigmoid colon, with well-shaped glands, cylindrical cells, and a secreting mucosa. In Vecchietti neovaginas, the surface the epithelium was flat and multilayered, highly similar to that of a normal vagina, with the presence of glycogen and superficial desquamation. On medium SEM magnification evaluation, the epithelium presented flattened polygonal cells. Finally, in Davydov neovaginas, none of the specimens had persistent mesothelial elements. The squamous neo-epithelium had regular aspects of differentiation with the presence of glycogen. At greater SEM magnification, microridges were evident, with a regular distribution.
    Conclusion: Each different technique of vaginoplasty leads to unique histological and structural features of the neovagina's mucosa. Knowledge of these elements must be the basis for the choice of the most appropriate intervention.
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1325079-6
    ISSN 1873-4332 ; 1083-3188
    ISSN (online) 1873-4332
    ISSN 1083-3188
    DOI 10.1016/j.jpag.2024.01.002
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