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  1. Book ; Conference proceedings: Vasoactive peptides

    Santos, Robson A. S.

    4th International Symposium [on Vasoactive Peptides], Belo Horizonte, Minas Gerais, Brazil, October 19 - 21, 2001

    (Brazilian journal of medical and biological research ; 35,9)

    2002  

    Event/congress International Symposium on Vasoactive Peptides (4, 2001, BeloHorizonte)
    Author's details guest ed. board: Robson A. S. Santos
    Series title Brazilian journal of medical and biological research ; 35,9
    Collection
    Keywords Vasoactive Intestinal Peptide
    Language English
    Size S. 1001 - 1109 : Ill., graph. Darst.
    Publishing country Brazil
    Document type Book ; Conference proceedings
    HBZ-ID HT013585859
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs B 1359 -35- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Alternative Renin-Angiotensin System.

    Bader, Michael / Steckelings, U Muscha / Alenina, Natalia / Santos, Robson A S / Ferrario, Carlos M

    Hypertension (Dallas, Tex. : 1979)

    2024  Volume 81, Issue 5, Page(s) 964–976

    Abstract: The renin-angiotensin system is the most important peptide hormone system in the regulation of cardiovascular homeostasis. Its classical arm consists of the enzymes, renin, and angiotensin-converting enzyme, generating angiotensin II from angiotensinogen, ...

    Abstract The renin-angiotensin system is the most important peptide hormone system in the regulation of cardiovascular homeostasis. Its classical arm consists of the enzymes, renin, and angiotensin-converting enzyme, generating angiotensin II from angiotensinogen, which activates its AT
    MeSH term(s) Renin-Angiotensin System/physiology ; Angiotensin II ; Peptidyl-Dipeptidase A/metabolism ; Peptides ; Angiotensin I/metabolism ; Peptide Fragments/metabolism ; Renin ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Angiotensin II (11128-99-7) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Peptides ; Angiotensin I (9041-90-1) ; Peptide Fragments ; Renin (EC 3.4.23.15) ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.21364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Conference proceedings: Vasoactive peptides

    Santos, Robson A. S.

    III International Symposium [on Vasoactive Peptides], Belo Horizonte, MG, Brazil, October 8 - 10, 1999

    (Brazilian journal of medical and biological research ; 33,6)

    2000  

    Event/congress International Symposium on Vasoactive Peptides (3, 1999, BeloHorizonte)
    Author's details guest ed. board: Robson A. S. Santos
    Series title Brazilian journal of medical and biological research ; 33,6
    Collection
    Keywords Vasoactive Intestinal Peptide / congresses
    Language English
    Size S. 605 -721 : Ill., graph. Darst.
    Publishing country Brazil
    Document type Book ; Conference proceedings
    HBZ-ID HT012791244
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs B 1359 -33- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Improving the knowledge management of marine megafauna strandings.

    Oliveira, Bruno S S P / Santos, Robson G / Santos, Bráulio A

    Journal of environmental management

    2023  Volume 351, Page(s) 119815

    Abstract: Although the marine megafauna often strands on beaches around the world, such as sea turtles and whales, stranding data are poorly managed and incorporated into management and conservation strategies. Here we use a knowledge value chain framework to call ...

    Abstract Although the marine megafauna often strands on beaches around the world, such as sea turtles and whales, stranding data are poorly managed and incorporated into management and conservation strategies. Here we use a knowledge value chain framework to call attention for the urgent need to improve our data architecture and knowledge management on marine megafauna strandings. We use Brazil, a continental megadiverse federative republic, as study model. After describing the main components and identifying the strengths and weaknesses of the current Brazilian data architecture, we propose 10 practical measures for its improvement involving researchers, companies, non-governmental organizations, legislators, policy makers, public agents, citizen scientists, and local communities. Although Brazil has notable strengths such as comprehensive environmental legislation, hundreds of scientists and dozens of prestigious research institutions, stranding data is not translated into technical-scientific knowledge; technical-scientific knowledge is not transformed into effective public regulations; deficient regulations lead to bad decisions and limited actions, which in turn result in ineffective management and conservation strategies. In light of the UN Decade of Ocean Science for Sustainable Development (2021-2030), we propose (1) expanding standardized beach monitoring projects to the entire Brazilian coast; (2) creating a governmental database with FAIR principles; (3) encouraging the development of broad citizen science initiatives; (4) funding scientists and research institutions; (5) boosting outreach activities among researchers to popularize the scientific knowledge; (6) raising awareness among legislators and policy makers on the problem of strandings; (7) updating the existing legal provisions on the environmental licensing of activities developed at sea; (8) hiring new environmental analysts and inspectors and improving the infrastructure of executing environmental agencies; (9) strengthening existing conservation networks with multiple stakeholders; and (10) making the results of the management and conservation strategies broadly accessible to society. These recommendations may also apply to other coastal countries around the world.
    MeSH term(s) Knowledge Management ; Organizations ; Sustainable Development ; Brazil
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2023.119815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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  5. Book ; Conference proceedings: II International Symposium on Vasoactive Peptides

    Santos, Robson A. S.

    Ouro Preto, MG, Brasil, october 6 - 8, 1997

    1998  

    Event/congress International Symposium on Vasoactive Peptides (2, 1997, OuroPrêto)
    Author's details guest eds.: Robson A. S. Santos
    Keywords Vasoactive Intestinal Peptide / congresses
    Language English
    Publishing country Brazil
    Document type Book ; Conference proceedings
    Note In: Brazilian journal of medical and biological research. - ISSN 0100-879X. - 31 (1998),9, S. [1170] - 1235
    HBZ-ID HT009236958
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs B 1359 -31- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Brown adipose tissue transcriptome unveils an important role of the Beta-alanine/alamandine receptor, MrgD, in metabolism.

    Cerri, Gabriela C / Santos, Sérgio H S / Bader, Michael / Santos, Robson A S

    The Journal of nutritional biochemistry

    2023  Volume 114, Page(s) 109268

    Abstract: Alamandine is a recently described heptapeptide component of the renin-angiotensin system (RAS), and its effects are mediated by the receptor Mas-related G protein-coupled receptor D (MrgD) RAS represents an important link between obesity and its ... ...

    Abstract Alamandine is a recently described heptapeptide component of the renin-angiotensin system (RAS), and its effects are mediated by the receptor Mas-related G protein-coupled receptor D (MrgD) RAS represents an important link between obesity and its consequences by directly modulating the thermogenesis and brown adipose tissue (BAT) function. The alamandine/MrgD metabolic effects and signaling remain unexplored. In this context, the main goal of the present study was to assess the metabolic consequences of MrgD genetic ablation in C57BL6/J mice by evaluating brown adipose tissue RNA sequencing. The main results showed that MrgD-KO mice have diminished brown adipose tissue and that a high-glucose diet (HG) decreased both circulating alamandine levels and MrgD expression in BAT from wild-type mice (WT). BAT transcriptome reveals that MrgD-KO HG mice regulated 45 genes, while WT HG mice regulated 1,148 genes. MrgD-KO mice fed a standard diet (ST) compared with WT ST mice regulated 476 genes, of which 445 genes were downregulated. BAT uses the MrgD receptor to display a normal pattern of gene expression and to respond, like WT mice, to an HG diet. In conclusion, the MrgD signaling is important for the metabolic regulation and manutention of BAT functionality.
    MeSH term(s) Animals ; Mice ; Adipose Tissue, Brown/metabolism ; beta-Alanine ; Mice, Inbred C57BL ; Oligopeptides/metabolism ; Thermogenesis ; Transcriptome ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances alamandine ; beta-Alanine (11P2JDE17B) ; Oligopeptides ; Mrgprd protein, mouse ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-01-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1014929-6
    ISSN 1873-4847 ; 0955-2863
    ISSN (online) 1873-4847
    ISSN 0955-2863
    DOI 10.1016/j.jnutbio.2023.109268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2838: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Angiotensin-(1-7) and Obesity: Role in Cardiorespiratory Fitness and COVID-19 Implications.

    Motta-Santos, Daisy / Santos, Robson A S / Santos, Sérgio Henrique Sousa

    Obesity (Silver Spring, Md.)

    2020  Volume 28, Issue 10, Page(s) 1786

    MeSH term(s) Angiotensin I ; Betacoronavirus ; COVID-19 ; Cardiorespiratory Fitness ; Coronavirus Infections ; Humans ; Infections ; Obesity ; Pandemics ; Peptide Fragments ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Peptide Fragments ; Angiotensin I (9041-90-1) ; angiotensin I (1-7) (IJ3FUK8MOF)
    Keywords covid19
    Language English
    Publishing date 2020-09-01
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.22949
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4061: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MG 87: Show issues

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  8. Article ; Online: Highly transparent sustainable biogel electrolyte based on cellulose acetate for application in electrochemical devices.

    Balboni, Raphael D C / Cholant, Camila M / Lemos, Rafaela M J / Rodrigues, Lucas S / Carreno, Neftali L V / Santos, Marcos J L / Avellaneda, Cesar A O / Andreazza, Robson

    International journal of biological macromolecules

    2024  Volume 265, Issue Pt 1, Page(s) 130757

    Abstract: In this study, an easy and low-cost production method for a cellulose acetate-based gel polymer containing lithium perchlorate and propylene carbonate is described, as well as the investigation of its properties for potential use as an electrolyte in ... ...

    Abstract In this study, an easy and low-cost production method for a cellulose acetate-based gel polymer containing lithium perchlorate and propylene carbonate is described, as well as the investigation of its properties for potential use as an electrolyte in electrochemical devices. Cellulose acetate, a biopolymer derived from natural matrix, is colourless and transparent, as confirmed by the UV-Vis spectroscopy, with 85 % transparency in visible spectrum. The gels were prepared and tested at different concentrations and proportions to optimise their properties. Thermogravimetry, XRD, and FTIR analyses revealed crucial characteristics, including a substantial 90 % mass loss between 150 and 250 °C, a semi-crystalline nature with complete salt dissociation within the polymer matrix, and a decrease in intensity at 1780 cm
    MeSH term(s) Electrolytes ; Cellulose/analogs & derivatives ; Polymers ; Electric Conductivity
    Chemical Substances acetylcellulose (3J2P07GVB6) ; Electrolytes ; Cellulose (9004-34-6) ; Polymers
    Language English
    Publishing date 2024-03-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.130757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2374: Show issues Location:
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  9. Article ; Online: The Mas agonist CGEN-856S prevents Ang II induced cardiomyocyte hypertrophy via nitric oxide production.

    Nocchi, Eduardo / Scalzo, Sérgio / Rocha-Resende, Cibele / Almeida, Pedro / Parreira, Amanda / Miranda, Kiany / Moura, Victor / Dos Santos, Robson A S / Guatimosim, Silvia

    Peptides

    2024  Volume 175, Page(s) 171182

    Abstract: With the previous knowledge of the cardioprotective effects of the Angiotensin-(1-7) axis, a agonist of Mas receptor has been described, the CGEN-856S. This peptide is more stable than Ang-(1-7), and has a low binding affinity to Angiotensin II receptors. ...

    Abstract With the previous knowledge of the cardioprotective effects of the Angiotensin-(1-7) axis, a agonist of Mas receptor has been described, the CGEN-856S. This peptide is more stable than Ang-(1-7), and has a low binding affinity to Angiotensin II receptors. Although the cardioprotective effects of CGEN-856S were previously shown in vivo, the mechanisms behind its effects are still unknown. Here, we employed a combination of molecular biology, confocal microscopy, and genetically modified mouse with Mas deletion to investigate the CGEN-856S protective signaling in cardiomyocytes. In isolated adult ventricular myocytes, CGEN-856S induced an increase in nitric oxide (NO) production which was absent in cells from Mas knockout mice. Using western blot, we observed a significant increase in phosphorylation of AKT after treatment with CGEN-856S. In addition, CGEN-856S prevented the Ang II induced hypertrophy and the nuclear translocation of GRK5 in a culture model of rat neonatal cardiomyocytes. Blockage of Mas receptor and inhibition of the NO synthase abolished the effects of CGEN-856S on Ang II treated cardiomyocytes. In conclusion, we show that CGEN-856S acting via receptor Mas induces NO raise to block Ang II induced cardiomyocyte hypertrophy. These results indicate that CGEN-856S acts very similarly to Ang-(1-7) in cardiac myocytes, highlighting its therapeutic potential for treating cardiovascular diseases.
    MeSH term(s) Rats ; Mice ; Animals ; Myocytes, Cardiac/metabolism ; Nitric Oxide/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Mas ; Receptors, G-Protein-Coupled/metabolism ; Hypertrophy/metabolism ; Angiotensin II/metabolism
    Chemical Substances Nitric Oxide (31C4KY9ESH) ; Proto-Oncogene Proteins ; Proto-Oncogene Mas ; Receptors, G-Protein-Coupled ; Angiotensin II (11128-99-7)
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2024.171182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1649: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: Angiotensin-(1-7) and Obesity: Role in Cardiorespiratory Fitness and COVID-19 Implications

    Motta-Santos, Daisy / Santos, Robson A S / Santos, Sérgio Henrique Sousa

    Obesity (Silver Spring)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #629183
    Database COVID19

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