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  1. Article ; Online: Molecular aspects of asthma.

    Cazzola, Mario / Matera, Maria Gabriella

    Molecular aspects of medicine

    2022  Volume 85, Page(s) 101087

    MeSH term(s) Asthma/genetics ; Humans
    Language English
    Publishing date 2022-03-04
    Publishing country England
    Document type Editorial
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2022.101087
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    Zs.A 1189: Show issues Location:
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  2. Article ; Online: Dual Broncodilator and Triple Therapy in Bronchiectasis. Clinical Trials are Urgently Needed.

    Cazzola, Mario / Matera, Maria Gabriella / Martínez-García, Miguel Ángel

    Archivos de bronconeumologia

    2023  Volume 59, Issue 12, Page(s) 787–788

    MeSH term(s) Humans ; Bronchiectasis/drug therapy
    Language Spanish
    Publishing date 2023-07-22
    Publishing country Spain
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2023.07.013
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  3. Article ; Online: Clinically important deterioration: a composite tool for managing patients with COPD.

    Cazzola, Mario / Matera, Maria Gabriella

    Respiratory medicine

    2022  Volume 205, Page(s) 107054

    Abstract: Clinically important deterioration (CID) is a composite tool developed to measure COPD's progression. It is a promising concept that can improve treatment choices for COPD patients because it provides a more holistic assessment of their status in ... ...

    Abstract Clinically important deterioration (CID) is a composite tool developed to measure COPD's progression. It is a promising concept that can improve treatment choices for COPD patients because it provides a more holistic assessment of their status in everyday clinical practice. The post hoc analysis of several trials that were important for improving COPD treatment provides increasing evidence of the importance of assessing CID. These retrospective evaluations suggest that dual bronchodilation should be preferred over a single bronchodilator if treatment aims to reduce a possible clinical deterioration of COPD. Should dual bronchodilation prove ineffective, evidence shows that triple therapy, including an inhaled corticosteroid, is effective in preventing CID, especially in the presence of high blood eosinophil counts. CID initially included changes in FEV
    MeSH term(s) Humans ; Forced Expiratory Volume ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Retrospective Studies ; Prospective Studies ; Disease Progression ; Bronchodilator Agents ; Administration, Inhalation ; Treatment Outcome
    Chemical Substances Bronchodilator Agents
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2022.107054
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  4. Article ; Online: Might It Be Appropriate to Anticipate the Use of Long-Acting Muscarinic Antagonists in Asthma?

    Cazzola, Mario / Rogliani, Paola / Matera, Maria Gabriella

    Drugs

    2023  Volume 83, Issue 11, Page(s) 957–965

    Abstract: A growing number of clinical trials are documenting that adding a long-acting muscarinic antagonist (LAMA) to established asthma treatment with an inhaled corticosteroid (ICS) and a long-acting ... ...

    Abstract A growing number of clinical trials are documenting that adding a long-acting muscarinic antagonist (LAMA) to established asthma treatment with an inhaled corticosteroid (ICS) and a long-acting β
    MeSH term(s) Humans ; Muscarinic Antagonists/pharmacology ; Muscarinic Antagonists/therapeutic use ; Adrenergic beta-2 Receptor Agonists/pharmacology ; Adrenergic beta-2 Receptor Agonists/therapeutic use ; Administration, Inhalation ; Asthma/drug therapy ; Lung ; Drug Therapy, Combination ; Adrenal Cortex Hormones ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Bronchodilator Agents/therapeutic use
    Chemical Substances Muscarinic Antagonists ; Adrenergic beta-2 Receptor Agonists ; Adrenal Cortex Hormones ; Bronchodilator Agents
    Language English
    Publishing date 2023-06-12
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.1007/s40265-023-01897-2
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    Zs.A 762: Show issues Location:
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  5. Article ; Online: An Obvious Paradigm: Choosing Bronchodilators and Inhaled Corticosteroids for Their Pharmacologic Characteristics.

    Cazzola, Mario / Matera, Maria Gabriella

    Chest

    2021  Volume 160, Issue 4, Page(s) 1157–1159

    MeSH term(s) Administration, Inhalation ; Adrenal Cortex Hormones ; Bronchodilator Agents/therapeutic use ; Humans
    Chemical Substances Adrenal Cortex Hormones ; Bronchodilator Agents
    Language English
    Publishing date 2021-10-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.06.025
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  6. Article ; Online: Advances in adrenergic receptors for the treatment of chronic obstructive pulmonary disease: 2023 update.

    Matera, Maria Gabriella / Rinaldi, Barbara / Calzetta, Luigino / Rogliani, Paola / Cazzola, Mario

    Expert opinion on pharmacotherapy

    2024  Volume 24, Issue 18, Page(s) 2133–2142

    Abstract: Introduction: Strong scientific evidence and large experience support the use of β: Areas covered: Recent research on novel β: Expert opinion: Compounds that preferentially activate a ... ...

    Abstract Introduction: Strong scientific evidence and large experience support the use of β
    Areas covered: Recent research on novel β
    Expert opinion: Compounds that preferentially activate a G
    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Receptors, Adrenergic, beta-2/metabolism ; Receptors, Adrenergic, beta-2/therapeutic use ; Signal Transduction ; Adrenergic beta-2 Receptor Agonists/pharmacology ; Adrenergic beta-2 Receptor Agonists/therapeutic use
    Chemical Substances Receptors, Adrenergic, beta-2 ; Adrenergic beta-2 Receptor Agonists
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2023.2282673
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    Zs.A 5130: Show issues Location:
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  7. Article ; Online: The pharmacological management of asthma in adults: 2023 update.

    Matera, Maria Gabriella / Rinaldi, Barbara / Annibale, Rosa / De Novellis, Vito / Cazzola, Mario

    Expert opinion on pharmacotherapy

    2024  Volume 25, Issue 4, Page(s) 383–393

    Abstract: Introduction: The pharmacotherapy of asthma is a dynamic process that changes as our knowledge of the underlying pathophysiology and treatment of this disease continues to evolve. This implies the need for continuous revision of the recommendations of ... ...

    Abstract Introduction: The pharmacotherapy of asthma is a dynamic process that changes as our knowledge of the underlying pathophysiology and treatment of this disease continues to evolve. This implies the need for continuous revision of the recommendations of asthma guidelines and strategies.
    Areas covered: This review summarizes the latest key practical information on the pharmacological management of asthma in adults. We provide the background to the 2023 update of the GINA strategy report, focusing on changes and discussing areas of uncertainty. We review current and emerging pharmacotherapy for uncontrolled asthma, including synthetic agents and new biologics, and provide expert perspectives and opinions on the treatment of uncontrolled asthma.
    Expert opinion: The current pharmacological treatment of asthma, based on a step-by-step, control-based approach, with ICSs, LABAs and LAMAs being the mainstay generally provides good symptom control. Biologic therapies are often effective in treating T2
    MeSH term(s) Humans ; Asthma/drug therapy ; Asthma/physiopathology ; Anti-Asthmatic Agents/therapeutic use ; Adult ; Practice Guidelines as Topic ; Biological Products/therapeutic use ; Severity of Illness Index ; Administration, Inhalation
    Chemical Substances Anti-Asthmatic Agents ; Biological Products
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2024.2332627
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    Zs.A 5130: Show issues Location:
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  8. Article ; Online: Novel Anti-Inflammatory Approaches to COPD.

    Cazzola, Mario / Hanania, Nicola A / Page, Clive P / Matera, Maria Gabriella

    International journal of chronic obstructive pulmonary disease

    2023  Volume 18, Page(s) 1333–1352

    Abstract: Airway inflammation, driven by different types of inflammatory cells and mediators, plays a fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and ... ...

    Abstract Airway inflammation, driven by different types of inflammatory cells and mediators, plays a fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and CD4
    MeSH term(s) Animals ; Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Lung ; Eosinophils ; Neutrophils ; Inflammation/drug therapy ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2023-06-29
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2212419-6
    ISSN 1178-2005 ; 1176-9106
    ISSN (online) 1178-2005
    ISSN 1176-9106
    DOI 10.2147/COPD.S419056
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  9. Article ; Online: Biologics for asthma and risk of pneumonia.

    Matera, Maria Gabriella / Ora, Josuel / Calzetta, Luigino / Rogliani, Paola / Cazzola, Mario

    The Journal of asthma : official journal of the Association for the Care of Asthma

    2024  , Page(s) 1–7

    Abstract: Objective: Modification of the immune system with biologics raises theoretical concerns about the risk of infections but it is still unclear whether currently routinely used biologics in severe asthma may facilitate the development of pneumonia. ... ...

    Abstract Objective: Modification of the immune system with biologics raises theoretical concerns about the risk of infections but it is still unclear whether currently routinely used biologics in severe asthma may facilitate the development of pneumonia. Therefore, we aimed to determine whether omalizumab, mepolizumab, benralizumab, and dupilumab are associated with pneumonia in a real-world setting.
    Methods: A retrospective disproportionality analysis was performed using adverse event (AE) reports submitted to FAERS from January 2020 to September 30, 2023. MedDRA was used to identify infections and infestations and then pneumonia cases. ROR and PRR were used to measure disproportionality.
    Results: The percentage of reported cases of pneumonia compared to infections and infestations was highest for mepolizumab (36.8%), followed by omalizumab (32.6%), benralizumab (19.2%) and dupilumab (5.7%). We found a moderate or strong signal for increased risk of pneumonia with mepolizumab (ROR = 3.74, 95%CI 3.50-4.00), omalizumab (ROR = 3.26, 95%CI 3.06-3.49) and benralizumab (ROR = 2.65, 95%CI 2.49-2.83).
    Conclusions: Mepolizumab, omalizumab and benralizumab, but not dupilumab, were associated with high odds of reporting pneumonia. Our results represent only potential associations between these biologics and pneumonia but not causality. The nature of the FAERS database is such that the cause of the reported events is uncertain. Therefore, we can only roughly estimate the incidence of AEs by the signal strength (ROR value). Nevertheless, although causality could not be assessed, the signal from our study is interesting. We believe it deserves to be further substantiated by real-world studies with robust designs.
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 603816-5
    ISSN 1532-4303 ; 0277-0903
    ISSN (online) 1532-4303
    ISSN 0277-0903
    DOI 10.1080/02770903.2024.2311236
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  10. Article ; Online: The impact of genomic variants on patient response to inhaled bronchodilators: a comprehensive update.

    Matera, Maria Gabriella / Rogliani, Paola / Novelli, Giuseppe / Cazzola, Mario

    Expert opinion on drug metabolism & toxicology

    2023  Volume 19, Issue 5, Page(s) 285–295

    Abstract: Introduction: The bronchodilator response (BDR) depends on many factors, including genetic ones. Numerous single nucleotide polymorphisms (SNPs) influencing BDR have been identified. However, despite several studies in this field, genetic variations are ...

    Abstract Introduction: The bronchodilator response (BDR) depends on many factors, including genetic ones. Numerous single nucleotide polymorphisms (SNPs) influencing BDR have been identified. However, despite several studies in this field, genetic variations are not currently being utilized to support the use of bronchodilators.
    Areas covered: In this narrative review, the possible impact of genetic variants on BDR is discussed.
    Expert opinion: Pharmacogenetic studies of β
    MeSH term(s) Humans ; Bronchodilator Agents/pharmacology ; Albuterol ; Polymorphism, Single Nucleotide ; Pharmacogenetics ; Receptors, Adrenergic, beta-2/genetics ; Genomics
    Chemical Substances Bronchodilator Agents ; Albuterol (QF8SVZ843E) ; Receptors, Adrenergic, beta-2
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2214462-6
    ISSN 1744-7607 ; 1742-5255
    ISSN (online) 1744-7607
    ISSN 1742-5255
    DOI 10.1080/17425255.2023.2221848
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