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  1. Article: What Single Cell RNA Sequencing Has Taught Us about Chronic Obstructive Pulmonary Disease.

    Sin, Don D

    Tuberculosis and respiratory diseases

    2024  

    Abstract: Chronic obstructive pulmonary disease (COPD) affects close to 400 million people worldwide and is the 3rd leading cause of mortality. It is a heterogeneous disorder with multiple endo-phenotypes, each driven by specific molecular networks and processes. ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) affects close to 400 million people worldwide and is the 3rd leading cause of mortality. It is a heterogeneous disorder with multiple endo-phenotypes, each driven by specific molecular networks and processes. Therapeutic discovery in COPD has lagged behind other disease areas owing to a lack of understanding of its pathobiology and scarcity of biomarkers to guide therapies. Single cell RNA sequencing (scRNA-seq) is a powerful new tool to identify important cellular and molecular networks that play a crucial role in disease pathogenesis. This paper provides an overview of the scRNA-seq technology and its application in COPD and the lessons learned to date from scRNA-seq experiments in COPD.
    Language English
    Publishing date 2024-02-19
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2161256-0
    ISSN 1738-3536 ; 0378-0066
    ISSN 1738-3536 ; 0378-0066
    DOI 10.4046/trd.2024.0001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5937: Show issues Location:
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  2. Article ; Online: ERJ

    Sin, Don D / Chalmers, James D

    The European respiratory journal

    2024  Volume 63, Issue 1

    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02215-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is long COVID an autoimmune disease?

    Sin, Don D

    The European respiratory journal

    2023  Volume 61, Issue 1

    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; Autoantibodies ; COVID-19 ; Autoimmune Diseases/complications ; Autoimmune Diseases/epidemiology
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02272-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The Importance of Early Chronic Obstructive Pulmonary Disease: A Lecture from 2022 Asian Pacific Society of Respirology.

    Sin, Don D

    Tuberculosis and respiratory diseases

    2023  Volume 86, Issue 2, Page(s) 71–81

    Abstract: Chronic obstructive pulmonary disease (COPD) affects close to 400 million people worldwide. COPD is characterized by significant airflow limitation on spirometry. Most patients with COPD are diagnosed in their fifth or sixth decades of life. However, the ...

    Abstract Chronic obstructive pulmonary disease (COPD) affects close to 400 million people worldwide. COPD is characterized by significant airflow limitation on spirometry. Most patients with COPD are diagnosed in their fifth or sixth decades of life. However, the disease begins much earlier. By the time airflow limitation is detected on spirometry, patients with COPD have lost close to 50% of their small airways. Thus, identification of patients with early COPD, defined as persons with preserved spirometry, who demonstrate pathologic or functional hallmarks of COPD, is essential for disease modification and ultimately disease elimination. This paper provides an up-to-date overview of the current case definition of early COPD, its importance, the novel technologies required for its detection in young adults and future directions in therapeutics for treatment.
    Language English
    Publishing date 2023-03-28
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2161256-0
    ISSN 1738-3536 ; 0378-0066
    ISSN 1738-3536 ; 0378-0066
    DOI 10.4046/trd.2023.0005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Chronic Obstructive Pulmonary Disease and the Airway Microbiome: What Respirologists Need to Know.

    Sin, Don D

    Tuberculosis and respiratory diseases

    2023  Volume 86, Issue 3, Page(s) 166–175

    Abstract: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. The lower airways contain a rich and diverse microbiome, which may play a significant regulatory role in both health and disease. In COPD, the ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. The lower airways contain a rich and diverse microbiome, which may play a significant regulatory role in both health and disease. In COPD, the microbiome becomes perturbed, causing dysbiosis. Increased representation of members in the Proteobacteria phylum and certain members in the Firmicutes phylum has been associated with increased risk of exacerbations and mortality. Therapies such as inhaled corticosteroids and azithromycin may modulate the airway microbiome or its metabolites in patients with COPD. This paper provides an up-to-date overview of the airway microbiome and its importance in the pathophysiology of COPD and as potential therapeutic target in the future.
    Language English
    Publishing date 2023-04-11
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2161256-0
    ISSN 1738-3536 ; 0378-0066
    ISSN 1738-3536 ; 0378-0066
    DOI 10.4046/trd.2023.0015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Type 2 airway inflammation in chronic obstructive pulmonary disease.

    Polverino, Francesca / Sin, Don D

    The European respiratory journal

    2024  

    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00150-2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Granzyme B May Act as an Effector Molecule to Control the Inflammatory Process in COPD.

    Kim, Won-Dong / Sin, Don D

    COPD

    2024  Volume 21, Issue 1, Page(s) 1–11

    Abstract: Chronic obstructive pulmonary disease (COPD) is caused by smoking, but only a small proportion of smokers have disease severe enough to develop COPD. COPD is not always progressive. The question then arises as to what explains the different trajectories ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is caused by smoking, but only a small proportion of smokers have disease severe enough to develop COPD. COPD is not always progressive. The question then arises as to what explains the different trajectories of COPD. The role of autoimmunity and regulatory T (Treg) cells in the pathogenesis of COPD is increasingly being recognized. Nine published studies on Treg cells in the lung tissue or bronchoalveolar lavage fluid have shown that smokers with COPD have fewer Treg cells than smokers without COPD or nonsmokers. Three studies showed a positive correlation between Treg cell count and FEV
    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive ; Granzymes/metabolism ; Lung ; Pulmonary Emphysema/complications ; Smoking/adverse effects
    Chemical Substances Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2171107-0
    ISSN 1541-2563 ; 1541-2555
    ISSN (online) 1541-2563
    ISSN 1541-2555
    DOI 10.1080/15412555.2023.2299104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: RETHINCking COPD - Bronchodilators for Symptomatic Tobacco-Exposed Persons with Preserved Lung Function?

    Sin, Don D

    The New England journal of medicine

    2022  Volume 387, Issue 13, Page(s) 1230–1231

    MeSH term(s) Administration, Inhalation ; Bronchodilator Agents/therapeutic use ; Humans ; Lung/diagnostic imaging ; Lung/drug effects ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/etiology ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Nicotiana/adverse effects ; Tobacco Use/adverse effects
    Chemical Substances Bronchodilator Agents
    Language English
    Publishing date 2022-09-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2210347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Proposed Approach to Pulmonary Long COVID: A Viewpoint.

    Gerayeli, Firoozeh V / Eddy, Rachel / Sin, Don D

    The European respiratory journal

    2024  

    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02302-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Why Is BMI Related to COPD? Is It All in the Genes?

    Hernández Cordero, Ana I / Sin, Don D

    American journal of respiratory and critical care medicine

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202403-0601ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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