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  1. Book ; Online: IBD Management - Novel Targets and Therapeutic Perspectives

    Antonioli, Luca / Romano, Barbara / Blandizzi, Corrado / Fornai, Matteo

    2020  

    Keywords Science: general issues ; Pharmacology ; IBD ; immune cells ; novel therapeutic agents ; inflammatory resolution ; cytokines
    Size 1 electronic resource (140 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230172
    ISBN 9782889637713 ; 2889637719
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report.

    Tattersall, Luke / Adinolfi, Elena / Antonioli, Luca / Agrawal, Ankita

    Purinergic signalling

    2024  

    Abstract: PRESTO was established in 2022 and is a concerted effort by leading European experts in the field of P2XRs and extracellular ATP to promote and advance the transition to the clinic of P2XR-targeting therapies. Following the inaugural meeting in Ferrara ... ...

    Abstract PRESTO was established in 2022 and is a concerted effort by leading European experts in the field of P2XRs and extracellular ATP to promote and advance the transition to the clinic of P2XR-targeting therapies. Following the inaugural meeting in Ferrara which set the foundations of the action and generated interest from many groups and institutes, the second meeting covered the preclinical and clinical aspects of P2XRs as a common route in different diseases, recognising the multidisciplinary and collaborative approach required for a number of medical conditions.
    Language English
    Publishing date 2024-02-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-024-09994-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Editorial: Adenosine pathways in cancer immunity and immunotherapy.

    Fu, Junjiang / Antonioli, Luca / El-Far, Ali H

    Frontiers in immunology

    2023  Volume 14, Page(s) 1298487

    MeSH term(s) Humans ; Adenosine ; Immunotherapy ; Neoplasms
    Chemical Substances Adenosine (K72T3FS567)
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1298487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: May be adenosine an immuno-quorum-sensing signal?

    Antonioli, Luca / Haskó, György

    Purinergic signalling

    2022  Volume 18, Issue 2, Page(s) 205–209

    Abstract: Quorum sensing indicates a communication process between bacteria based on a coordinate variation in gene expression aimed at coordinating a collective comportment related to the bacterial population density. Increasing pieces of evidence pointed out ... ...

    Abstract Quorum sensing indicates a communication process between bacteria based on a coordinate variation in gene expression aimed at coordinating a collective comportment related to the bacterial population density. Increasing pieces of evidence pointed out that a quorum-sensing system can be a regulatory program also used in the immune field to organize the density of the various immune cell populations and to calibrate their responses. In particular, such equilibrium is achieved by the ability of immune cells to perceive the density of their own populations or those of other cells in their environment, through the release of several mediators able to finely shape the cell density via coordinated changes in gene expression and protein signaling. In this regard, adenosine displays the typical characteristics of a mediator involved in the regulation of quorum sensing, thus suggesting a putative role of this nucleoside in shaping the balance between diverse immune cell populations.
    MeSH term(s) Adenosine ; Quorum Sensing ; Signal Transduction
    Chemical Substances Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-04-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2172143-9
    ISSN 1573-9546 ; 1573-9538
    ISSN (online) 1573-9546
    ISSN 1573-9538
    DOI 10.1007/s11302-022-09866-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: When cointegration is interrupted: Price transmission analysis in the Italian dairy‐feed industry

    Cattivelli, Luca / Antonioli, Federico

    Agribusiness. 2023 July, v. 39, no. 3 p.744-761

    2023  

    Abstract: We analyze price transmission dynamics in the under‐investigated feed supply chain, applying a special case of the Threshold Vector Error Correction model where the cointegrating relationship is interrupted. Weekly Italian dairy feed and corn prices are ... ...

    Abstract We analyze price transmission dynamics in the under‐investigated feed supply chain, applying a special case of the Threshold Vector Error Correction model where the cointegrating relationship is interrupted. Weekly Italian dairy feed and corn prices are used, finding evidence of asymmetric price transmission when the feed industry's margins are squeezed and highly volatile. The proposed Interrupted Threshold Cointegration model represents a valid complement to existing threshold and regime‐switching techniques, allowing for the application of an agile nonstructural error correction model when standard cointegration tests fail to detect any long‐run relationship between price series. [EconLit Citations: Q11, Q13, C24].
    Keywords agribusiness ; complement ; corn ; feed industry ; models ; prices ; supply chain ; time series analysis
    Language English
    Dates of publication 2023-07
    Size p. 744-761.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 743656-7
    ISSN 0742-4477
    ISSN 0742-4477
    DOI 10.1002/agr.21797
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4188: Show issues

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  6. Article ; Online: Adenosine signaling as target in cardiovascular pharmacology.

    Antonioli, Luca / Fornai, Matteo / Pellegrini, Carolina / Pacher, Pál / Haskó, György

    Current opinion in pharmacology

    2023  Volume 71, Page(s) 102393

    Abstract: Increasing evidence demonstrated the relevance of adenosine system in the onset and development of cardiovascular diseases, such as hypertension, myocardial infarct, ischemia, hypertension, heart failure, and atherosclerosis. In this regard, intense ... ...

    Abstract Increasing evidence demonstrated the relevance of adenosine system in the onset and development of cardiovascular diseases, such as hypertension, myocardial infarct, ischemia, hypertension, heart failure, and atherosclerosis. In this regard, intense research efforts are being focused on the characterization of the pathophysiological significance of adenosine, acting at its membrane receptors named A
    MeSH term(s) Humans ; Adenosine/pharmacology ; Cardiovascular Diseases/drug therapy ; Hypertension ; Receptor, Adenosine A2A ; Receptor, Adenosine A2B/metabolism
    Chemical Substances Adenosine (K72T3FS567) ; Receptor, Adenosine A2A ; Receptor, Adenosine A2B
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2023.102393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Caffeine and Bones: If Less Is Good, More May Not Be Better.

    Antonioli, Luca / Haskó, György

    Journal of caffeine and adenosine research

    2019  Volume 9, Issue 2, Page(s) 38–39

    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 2928613-X
    ISSN 2573-3400 ; 2573-3397
    ISSN (online) 2573-3400
    ISSN 2573-3397
    DOI 10.1089/caff.2019.29011.ah
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Adenosine and inflammation: it's time to (re)solve the problem.

    Antonioli, Luca / Pacher, Pál / Haskó, György

    Trends in pharmacological sciences

    2021  Volume 43, Issue 1, Page(s) 43–55

    Abstract: Resolution of inflammation requires proresolving molecular pathways triggered as part of the host response during the inflammatory phase. Adenosine and its receptors, which are collectively called the adenosine system, shape inflammatory cell activity ... ...

    Abstract Resolution of inflammation requires proresolving molecular pathways triggered as part of the host response during the inflammatory phase. Adenosine and its receptors, which are collectively called the adenosine system, shape inflammatory cell activity during the active phase of inflammation, leading these immune cells toward a functional repolarization, thus contributing to the onset of resolution. Strategies based on the resolution of inflammation have shaped a new area of pharmacology referred to as 'resolution pharmacology' and in this regard, the adenosine system represents an interesting target to design novel pharmacological tools to 'resolve' the inflammatory process. In this review, we outline the role of the adenosine system in driving the events required for an effective transition from the proinflammatory phase to the onset and establishment of resolution.
    MeSH term(s) Adenosine ; Humans ; Inflammation ; Inflammation Mediators/metabolism
    Chemical Substances Inflammation Mediators ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2021-11-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2021.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1513: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 6: Show issues

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  9. Article ; Online: Pharmacological modulation of P2X4 in inflammatory bowel diseases: the way towards novel therapeutics?

    D'Antongiovanni, Vanessa / Pellegrini, Carolina / Fornai, Matteo / Nemeth, Zoltan H / Haskó, György / Antonioli, Luca

    Journal of drug targeting

    2023  Volume 31, Issue 7, Page(s) 693–699

    Abstract: Inflammatory bowel diseases (IBDs) are a group of idiopathic, chronic, relapsing, inflammatory conditions, which include ulcerative colitis (UC) and Crohn's disease (CD). These disorders are characterised by intestinal symptoms associated with chronic ... ...

    Abstract Inflammatory bowel diseases (IBDs) are a group of idiopathic, chronic, relapsing, inflammatory conditions, which include ulcerative colitis (UC) and Crohn's disease (CD). These disorders are characterised by intestinal symptoms associated with chronic inflammation of the intestinal mucosa, such as gut dysmotility and visceral pain. Currently, the pharmacological management of IBD patients is far from satisfactory in terms of efficacy and safety, thus spurring the interest of the scientific community to identify novel molecular targets for the management of these disorders. According to recent research, it appears that P2 purinergic receptors, which can regulate the host's response to inflammation, have been identified as potential targets for the treatment of IBDs. In particular, among P2 receptors, the P2X4 receptor subtype has recently captured the attention of the research community owing to its role in shaping immune/inflammatory responses. Based on this evidence, the present review has been conceived to provide a critical appraisal of the available knowledge about the role of P2X4R subtype in the pathophysiological mechanisms underlying IBDs, pointing out its potential as therapeutic target to develop innovative therapeutic strategies aimed at counteracting the inflammatory process, gut dysmotility and visceral hypersensitivity associated with these disorders.
    MeSH term(s) Humans ; Inflammatory Bowel Diseases/drug therapy ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/therapy ; Crohn Disease/diagnosis ; Crohn Disease/therapy ; Intestines ; Inflammation
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2023.2235092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Editorial: Neurological, Metabolic and Inflammatory Disorders: A Common Root in Inflammasome.

    Pellegrini, Carolina / Antonioli, Luca / Lopez-Castejon, Gloria / Bertinaria, Massimo

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 808400

    Language English
    Publishing date 2021-12-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.808400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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