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Article ; Online: Expression of E-cadherin by CD8

Davies, Scott P / Ronca, Vincenzo / Wootton, Grace E / Krajewska, Natalia M / Bozward, Amber G / Fiancette, Rémi / Patten, Daniel A / Yankouskaya, Katharina / Reynolds, Gary M / Pat, Sofia / Osei-Bordom, Daniel C / Richardson, Naomi / Grover, Liam M / Weston, Christopher J / Oo, Ye H

Nature communications

2024 Volume 15, Issue 1, Page(s) 853

Abstract: The presence of ... ...

Abstract	The presence of CD8
MeSH term(s)	Humans ; Bile Ducts/metabolism ; Liver Cirrhosis, Biliary/pathology ; CD8-Positive T-Lymphocytes/metabolism ; Epithelial Cells/metabolism ; Cadherins/metabolism
Chemical Substances	Cadherins
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-44910-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Operationalizing COVID-19 testing: Who, what, when, where, why, and how.

Reddy, Anita J / Fraser, Thomas G / Grover, Purva / Weathers, Allison L / Cruise, Michael / Foxx, Meredith A / Babiuch, Christopher M / Henricks, Walter H / Meldon, Stephen W / Muenzenmeyer, Ashleigh / Pengel, Shannon L / Simon, James F / Procop, Gary W

Cleveland Clinic journal of medicine

2021

Abstract: The authors review the rationale behind and approaches to testing for COVID-19, the quality of currently available tests, the role of data analytics in strategizing testing, and using the electronic medical record and other programs designed to steward ... ...

Abstract	The authors review the rationale behind and approaches to testing for COVID-19, the quality of currently available tests, the role of data analytics in strategizing testing, and using the electronic medical record and other programs designed to steward COVID-19 testing and follow-up of patients.
Keywords	covid19
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	639116-3
ISSN	1939-2869 ; 0891-1150
ISSN (online)	1939-2869
ISSN	0891-1150
DOI	10.3949/ccjm.87a.ccc048
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Article ; Online: Intratumoral delivery of dendritic cells plus anti-HER2 therapy triggers both robust systemic antitumor immunity and complete regression in HER2 mammary carcinoma.

Ramamoorthi, Ganesan / Kodumudi, Krithika / Snyder, Colin / Grover, Payal / Zhang, Hongtao / Greene, Mark I / Basu, Amrita / Gallen, Corey / Wiener, Doris / Costa, Ricardo L B / Han, Hyo S / Koski, Gary / Czerniecki, Brian J

Journal for immunotherapy of cancer

2022 Volume 10, Issue 6

Abstract: Background: Human epidermal growth factor receptor 2 (HER2) targeted antibodies in combination with chemotherapy has improved outcomes of HER2 positive (pos) breast cancer (BC) but toxicity of therapy remains a problem. High levels of tumor-infiltrating ...

Abstract	Background: Human epidermal growth factor receptor 2 (HER2) targeted antibodies in combination with chemotherapy has improved outcomes of HER2 positive (pos) breast cancer (BC) but toxicity of therapy remains a problem. High levels of tumor-infiltrating lymphocytes are associated with increased pathologic complete responses for patients treated with neoadjuvant therapy. Here we sought to investigate whether delivery of intratumoral (i.t.) multiepitope major histocompatibility complex (MHC) class II HER2 peptides-pulsed type I polarized dendritic cells (HER2-DC1) in combination with anti-HER2 antibodies without chemotherapy could enhance tumor regression by increasing anti-HER2 lymphocyte infiltration into the tumor. Methods: BALB/c mice bearing orthotopic TUBO tumors, BALB/c mice bearing subcutaneous (s.c.) CT26 hHER2 tumors, or BALB-HER2/neu transgenic mice were all treated with i.t. or s.c. HER2-DC1, anti-HER2 antibodies, paclitaxel, T-DM1 or in combination. Immune response, host immune cells and effector function were analyzed using flow cytometry, interferon-γ ELISA and cytokine/chemokine arrays. The contributions of CD4 Results: HER2-DC1 combined with anti-HER2 antibodies delivered i.t. compared to s.c. induced complete tumor regression in 75-80% of treated mice, with increased tumor infiltrating CD4 Conclusions: HER2-DC1 i.t. with anti-HER2 antibodies mediates tumor regression through combined activation of T and B cell compartments and provides evidence that HER2-DC1 i.t. in combination with anti-HER2 antibodies can be tested as an effective alternative therapeutic strategy to current chemotherapy and anti-HER2 antibodies in HER2
MeSH term(s)	Animals ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; CD8-Positive T-Lymphocytes ; Carcinoma ; Dendritic Cells ; Female ; Humans ; Mice ; Receptor, ErbB-2
Chemical Substances	ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2022-03-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2022-004841
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Article: Mitochondrial ATP-sensitive potassium channels and mitochondrial protein kinase C: sometimes it's good to have a close neighbor.

Grover, Gary J

American journal of physiology. Heart and circulatory physiology

2006 Volume 290, Issue 5, Page(s) H1752–3

MeSH term(s)	Adenosine Triphosphate/metabolism ; Animals ; Humans ; Ion Channel Gating ; Mitochondria, Heart/metabolism ; Mitochondrial Proteins/metabolism ; Myocardial Ischemia/metabolism ; Potassium Channels/metabolism ; Protein Kinase C/metabolism ; Signal Transduction ; Sodium Channels/metabolism
Chemical Substances	Mitochondrial Proteins ; Potassium Channels ; Sodium Channels ; Adenosine Triphosphate (8L70Q75FXE) ; Protein Kinase C (EC 2.7.11.13)
Language	English
Publishing date	2006-04-07
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00015.2006
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Article: Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia.

Grover, Gary J / Malm, Johan

Cardiovascular therapeutics

2008 Volume 26, Issue 4, Page(s) 287–296

Abstract: The mitochondrial F1F0 ATP synthase is responsible for the majority of ATP production in mammals and does this through a rotary catalytic mechanism. Studies show that the F1F0 ATP synthase can switch to an ATP hydrolase, and this occurs under conditions ... ...

Abstract	The mitochondrial F1F0 ATP synthase is responsible for the majority of ATP production in mammals and does this through a rotary catalytic mechanism. Studies show that the F1F0 ATP synthase can switch to an ATP hydrolase, and this occurs under conditions seen during myocardial ischemia. This ATP hydrolysis causes wasting of ATP that does not produce work. The degree of ATP inefficiently hydrolyzed during ischemia may be as high as 50-90% of the total. A naturally occurring, reversible inhibitor (IF-1) of the hydrolase activity is in the mitochondria, and it has a pH optimum of 6.8. Based on studies with the nonselective (inhibit both synthase and hydrolase activity) inhibitors aurovertin B and oligomycin B reduce the rate of ATP depletion during ischemia, showing that IF-1 does not completely block hydrolase activity. Oligomycin and aurovertin cannot be used for treating myocardial ischemia as they will reduce ATP production in healthy tissue. We generated a focused structure-activity relationship, and several compounds were identified that selectively inhibited the F1F0 ATP hydrolase activity while having no effect on synthase function. One compound, BMS-199264 had no effect on F1F0 ATP synthase function in submitochondrial particles while inhibiting hydrolase function, unlike oligomycin that inhibits both. BMS-199264 selectively inhibited ATP decline during ischemia while not affecting ATP production in normoxic and reperfused hearts. BMS-191264 also reduced cardiac necrosis and enhanced the recovery of contractile function following reperfusion. These data also suggest that the reversal of the synthase and hydrolase activities is not merely a chemical reaction run in reverse.
MeSH term(s)	Animals ; Aurovertins/pharmacology ; Enzyme Inhibitors/pharmacology ; Imidazoles/pharmacology ; Imidazoles/therapeutic use ; Mitochondria/drug effects ; Mitochondria/enzymology ; Mitochondria/metabolism ; Mitochondrial Proton-Translocating ATPases/antagonists & inhibitors ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/enzymology ; Oligomycins/pharmacology ; Prokaryotic Initiation Factor-1/physiology ; Proton-Translocating ATPases/antagonists & inhibitors ; Structure-Activity Relationship
Chemical Substances	Aurovertins ; BMS199264 ; Enzyme Inhibitors ; Imidazoles ; Oligomycins ; Prokaryotic Initiation Factor-1 ; oligomycin B (387OE420H7) ; aurovertin B (55350-03-3) ; Mitochondrial Proton-Translocating ATPases (EC 3.6.3.-) ; Proton-Translocating ATPases (EC 3.6.3.14)
Language	English
Publishing date	2008
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2428378-2
ISSN	1755-5922 ; 1755-5914
ISSN (online)	1755-5922
ISSN	1755-5914
DOI	10.1111/j.1755-5922.2008.00065.x
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Article: The isolated, perfused pseudo-working heart model.

Grover, Gary J / Singh, Rajni

Methods in molecular medicine

2008 Volume 139, Page(s) 145–150

Abstract: Increased interest in cardiac safety and renewed interest in drugs for treating myocardial ischemia and congestive heart failure have led to increased use of cardiovascular models. Unfortunately, many molecular or cell-based screens are not perfect ... ...

Abstract	Increased interest in cardiac safety and renewed interest in drugs for treating myocardial ischemia and congestive heart failure have led to increased use of cardiovascular models. Unfortunately, many molecular or cell-based screens are not perfect predictors of activity in vivo. One rapid means to test "proof of principle" in hearts is the isolated or Langendorff perfused heart system. This allows direct measurement of cardiac contractile function and coronary flow without interference from changes in the systemic circulation. The setup basically is a heart whose coronary arteries are retrogradely perfused through the aortic root with heated and oxygenated buffer solutions. We will describe the constant pressure technique as this is the most commonly used and allows us to directly measure changes in coronary flow without changes in turgor noted with constant flow methods. Instead of a classical working heart preparation, we describe the use of a balloon properly fitted into the left ventricle to measure end diastolic and peak systolic pressure making this a much simpler and less expensive technique without loss of scientific quality. Such a setup can be used to measure effects of compounds or treatments on coronary flow, contractile function either in the normal or pathological states.
MeSH term(s)	Animals ; Heart/physiology ; Models, Cardiovascular ; Perfusion/instrumentation ; Perfusion/methods
Language	English
Publishing date	2008-01-31
Publishing country	United States
Document type	Journal Article
ISSN	1543-1894
ISSN	1543-1894
DOI	10.1007/978-1-59745-571-8_8
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Article ; Online: Establishment of Standards for the Referral of Large Non-Pedunculated Colorectal Polyps: An International Expert Consensus Using a Modified Delphi Process.

Khalaf, Kareem / Seleq, Samir / Bourke, Michael J / Alkandari, Asma / Bapaye, Amol / Bechara, Robert / Calo, Natalia C / Fedorov, Evgeniy D / Hassan, Cesare / Kalauz, Mirjana / Kandel, Gabor P / Matsuda, Takahisa / May, Gary R / Mönkemüller, Klaus / Mosko, Jeffrey D / Ohno, Akiko / Pavic, Tajana / Pellisé, Maria / Raos, Zoe /

Gastrointestinal endoscopy

2024

Abstract: Background and aims: Resection of colorectal polyps has been shown to decrease the incidence and mortality of colorectal cancer. Large non-pedunculated colorectal polyps are often referred to expert centres for endoscopic resection, which requires ... ...

Abstract	Background and aims: Resection of colorectal polyps has been shown to decrease the incidence and mortality of colorectal cancer. Large non-pedunculated colorectal polyps are often referred to expert centres for endoscopic resection, which requires relevant information to be conveyed to the therapeutic endoscopist to allow for triage and planning of resection technique. The primary objective of our study was to establish minimum expected standards for the referral of LNPCP for potential ER. Methods: A Delphi methodology was employed to establish consensus on minimum expected standards for the referral of large colorectal polyps among a panel of international endoscopy experts. The expert panel was recruited through purposive sampling, and three rounds of surveys were conducted to achieve consensus, with quantitative and qualitative data analysed for each round. Results: A total of 24 international experts from diverse continents participated in the Delphi study, resulting in consensus on 19 statements related to the referral of large colorectal polyps. The identified factors, including patient demographics, relevant medications, lesion factors, photodocumentation and the presence of a tattoo, were deemed important for conveying the necessary information to therapeutic endoscopists. The mean scores for the statements ranged from 7.04 to 9.29 out of 10, with high percentages of experts considering most statements as a very high priority. Subgroup analysis by continent revealed some variations in consensus rates among experts from different regions. Conclusion: The identified consensus statements can aid in improving the triage and planning of resection techniques for large colorectal polyps, ultimately contributing to the reduction of colorectal cancer incidence and mortality.
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2024.02.001
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Zs.B 283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 519: Show issues

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Article: Operationalizing COVID-19 testing: Who, what, when, where, why, and how

Clevel. clin. j. med

Abstract	The authors review the rationale behind and approaches to testing for COVID-19, the quality of currently available tests, the role of data analytics in strategizing testing, and using the electronic medical record and other programs designed to steward COVID-19 testing and follow-up of patients.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #592166
Database	COVID19

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Article ; Online: Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway.

Molecular therapy : the journal of the American Society of Gene Therapy

2021 Volume 29, Issue 4, Page(s) 1541–1556

Abstract: HER2 breast cancer (BC) remains a significant problem in patients with locally advanced or metastatic BC. We investigated the relationship between T helper 1 (Th1) immune response and the proteasomal degradation pathway (PDP), in HER2-sensitive and - ... ...

Abstract	HER2 breast cancer (BC) remains a significant problem in patients with locally advanced or metastatic BC. We investigated the relationship between T helper 1 (Th1) immune response and the proteasomal degradation pathway (PDP), in HER2-sensitive and -resistant cells. HER2 overexpression is partially maintained because E3 ubiquitin ligase Cullin5 (CUL5), which degrades HER2, is frequently mutated or underexpressed, while the client-protective co-chaperones cell division cycle 37 (Cdc37) and heat shock protein 90 (Hsp90) are increased translating to diminished survival. The Th1 cytokine interferon (IFN)-γ caused increased CUL5 expression and marked dissociation of both Cdc37 and Hsp90 from HER2, causing significant surface loss of HER2, diminished growth, and induction of tumor senescence. In HER2-resistant mammary carcinoma, either IFN-γ or Th1-polarizing anti-HER2 vaccination, when administered with anti-HER2 antibodies, demonstrated increased intratumor CUL5 expression, decreased surface HER2, and tumor senescence with significant therapeutic activity. IFN-γ synergized with multiple HER2-targeted agents to decrease surface HER2 expression, resulting in decreased tumor growth. These data suggest a novel function of IFN-γ that regulates HER2 through the PDP pathway and provides an opportunity to impact HER2 responses through anti-tumor immunity.
MeSH term(s)	Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cellular Senescence/genetics ; Cellular Senescence/immunology ; Chaperonins/genetics ; Cullin Proteins/genetics ; Cullin Proteins/immunology ; Cytokines/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Proteolysis ; Receptor, ErbB-2/antagonists & inhibitors ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/immunology ; Th1 Cells/drug effects ; Th1 Cells/metabolism ; Vaccination
Chemical Substances	CDC37 protein, human ; CUL5 protein, human ; Cell Cycle Proteins ; Cullin Proteins ; Cytokines ; IFNG protein, human ; Interferon-gamma (82115-62-6) ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Chaperonins (EC 3.6.1.-)
Language	English
Publishing date	2021-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1016/j.ymthe.2020.12.037
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Zs.A 5640: Show issues

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Article ; Online: The Toronto Upper Gastrointestinal Cleaning Score: a prospective validation study.

Khan, Rishad / Gimpaya, Nikko / Vargas, Jose I / Ramkissoon, Anushka / Seleq, Samir / Gholami, Reza / Akhtar, Hisham J / Bansal, Rishi / Scaffidi, Michael A / Amin, Sunil / Bollipo, Steven / Kral, Jan / Lui, Rashid / Pawlak, Katarzyna M / Sandhu, Dalbir S / Bilal, Mohammad / de-Madaria, Enrique / Siau, Keith / Charabaty, Aline /

Hashim, Almoutaz / Sánchez-Luna, Sergio A / Teshima, Christopher W / May, Gary R / Mosko, Jeffrey D / Walsh, Catharine M / Grover, Samir C

Endoscopy

2022 Volume 55, Issue 2, Page(s) 121–128

Abstract: BACKGROUND : Assessment of mucosal visualization during esophagogastroduodenoscopy (EGD) can be improved with a standardized scoring system. To address this need, we created the Toronto Upper Gastrointestinal Cleaning Score (TUGCS). METHODS : We ... ...

Abstract	BACKGROUND : Assessment of mucosal visualization during esophagogastroduodenoscopy (EGD) can be improved with a standardized scoring system. To address this need, we created the Toronto Upper Gastrointestinal Cleaning Score (TUGCS). METHODS : We developed the TUGCS using Delphi methodology, whereby an international group of endoscopy experts iteratively rated their agreement with proposed TUGCS items and anchors on a 5-point Likert scale. After each Delphi round, we analyzed responses and refined the TUGCS using an 80 % agreement threshold for consensus. We used the intraclass correlation coefficient (ICC) to assess inter-rater and test-retest reliability. We assessed internal consistency with Cronbach's alpha and item-total and inter-item correlations with Pearson's correlation coefficient. We compared TUGCS ratings with an independent endoscopist's global rating of mucosal visualization using Spearman's ρ. RESULTS : We achieved consensus with 14 invited participants after three Delphi rounds. Inter-rater reliability was high at 0.79 (95 %CI 0.64-0.88). Test-retest reliability was excellent at 0.83 (95 %CI 0.77-0.87). Cronbach's α was 0.81, item-total correlation range was 0.52-0.70, and inter-item correlation range was 0.38-0.74. There was a positive correlation between TUGCS ratings and a global rating of visualization (r = 0.41,
MeSH term(s)	Humans ; Reproducibility of Results ; Endoscopy, Gastrointestinal ; Clinical Competence ; Prospective Studies ; Consensus
Language	English
Publishing date	2022-05-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/a-1865-4180
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Zs.MO 162: Show issues

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