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  1. Article ; Online: Multi-target treatment of bone cancer pain using synergistic combinations of pharmacological compounds in experimental animals.

    Pertovaara, Antti

    Scandinavian journal of pain

    2016  Volume 14, Page(s) 69–70

    MeSH term(s) Analgesics ; Animals ; Cancer Pain ; Disease Models, Animal ; Mice ; Neprilysin ; Pain
    Chemical Substances Analgesics ; Neprilysin (EC 3.4.24.11)
    Language English
    Publishing date 2016-11-22
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 2515451-5
    ISSN 1877-8879 ; 1877-8860
    ISSN (online) 1877-8879
    ISSN 1877-8860
    DOI 10.1016/j.sjpain.2016.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sinomenine against neuropathic pain hypersensitivity.

    Pertovaara, Antti

    Scandinavian journal of pain

    2014  Volume 5, Issue 4, Page(s) 248

    Language English
    Publishing date 2014-10-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2515451-5
    ISSN 1877-8879 ; 1877-8860
    ISSN (online) 1877-8879
    ISSN 1877-8860
    DOI 10.1016/j.sjpain.2014.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Thalamus: The 'promoter' of endogenous modulation of pain and potential therapeutic target in pathological pain.

    You, Hao-Jun / Lei, Jing / Pertovaara, Antti

    Neuroscience and biobehavioral reviews

    2022  Volume 139, Page(s) 104745

    Abstract: More recently, the thalamic mediodorsal (MD) and ventromedial (VM) nuclei have been revealed to be functioned as 'nociceptive discriminator' in discriminating noxious and innocuous peripheral afferents, and exhibits distinct different descending controls ...

    Abstract More recently, the thalamic mediodorsal (MD) and ventromedial (VM) nuclei have been revealed to be functioned as 'nociceptive discriminator' in discriminating noxious and innocuous peripheral afferents, and exhibits distinct different descending controls of nociception. Of particularly importance, the function of thalamic nuclei in engaging descending modulation of nociception is 'silent' or inactive during the physiological state as well as in condition exposed to insufficient noxious stimulation. Once initiation by sufficient noxious or innocuous C-afferents associated with temporal and spatial summation, the thalamic MD and VM nuclei exhibit salient, different effects: facilitation and inhibition, on noxious mechanically and heat evoked nociception, respectively. Based on series of experimental evidence, we here summarize a novel hypothesis involving thalamic MD and VM nuclei functioned as 'promoter' in initiating descending facilitation and inhibition of pain with specific spatiotemporal characteristics. We further hypothesize that clinical remedy in targeting thalamic VM nucleus by enhancing its activities in recruiting inhibition alone or decreasing thalamic MD nucleus induced facilitation may provide promising way in effectively control of pathological pain.
    MeSH term(s) Animals ; Humans ; Nociception/physiology ; Pain ; Rats ; Rats, Sprague-Dawley ; Thalamic Nuclei ; Thalamus
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2022.104745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Mechanisms of cognitive impairment in chronic pain patients can now be studied preclinically by inducing cognitive deficits with an experimental animal model of chronic neuropathic pain.

    Pertovaara, Antti

    Scandinavian journal of pain

    2015  Volume 10, Page(s) 106–107

    MeSH term(s) Animals ; Chronic Pain ; Cognition ; Cognitive Dysfunction ; Disease Models, Animal ; Humans ; Models, Animal ; Neuralgia ; Pain Threshold ; Rats, Sprague-Dawley
    Language English
    Publishing date 2015-12-01
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 2515451-5
    ISSN 1877-8879 ; 1877-8860
    ISSN (online) 1877-8879
    ISSN 1877-8860
    DOI 10.1016/j.sjpain.2015.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: It's not cool to reduce the skin temperature and activate the TRPM8 ion channel after spinal injury.

    Pertovaara, Antti

    Scandinavian journal of pain

    2013  Volume 4, Issue 1, Page(s) 31–32

    Language English
    Publishing date 2013-01-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2515451-5
    ISSN 1877-8879 ; 1877-8860
    ISSN (online) 1877-8879
    ISSN 1877-8860
    DOI 10.1016/j.sjpain.2012.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Sex-related correspondence between mechanical hypersensitivity and the discharge of medullary pain control neurons in neuropathic rats.

    Wei, Hong / Chen, Zuyue / Lei, Jing / You, Hao-Jun / Pertovaara, Antti

    Neuroscience letters

    2023  Volume 813, Page(s) 137415

    Abstract: Here we studied whether the sex-related difference in mechanical hypersensitivity induced by neuropathy is associated with the discharge rate of medullary pain control neurons. We performed experiments in male and female rats with spared nerve injury ( ... ...

    Abstract Here we studied whether the sex-related difference in mechanical hypersensitivity induced by neuropathy is associated with the discharge rate of medullary pain control neurons. We performed experiments in male and female rats with spared nerve injury (SNI) model of peripheral neuropathy. Mechanical hypersensitivity was assessed behaviorally by monofilaments. Discharge rates of pain-control neurons were determined using in vivo single unit recordings under light anesthesia. Recording targets were two medullary nuclei involved in descending pain control: the rostral ventromedial medulla (RVM) and the medullary dorsal reticular nucleus (DRt). Based on the response to peripheral noxious stimulus, neurons were classified as pronociceptive RVM ON-like or DRt neurons, or antinociceptive RVM OFF-like neurons. Behavioral results indicated that the mechanical hypersensitivity induced by SNI was significantly stronger in females than males. The ongoing discharge rates of pronociceptive RVM ON-like neurons were higher and those of antinociceptive RVM OFF-like neurons lower in SNI females than SNI males. Ongoing discharge rates of pronociceptive DRt neurons were not significantly different between SNI females and males. The results suggest that a sex difference in the discharge rate of pain control neurons in the RVM but not DRt may contribute to the maintenance of stronger neuropathic hypersensitivity in females.
    MeSH term(s) Female ; Rats ; Male ; Animals ; Humans ; Patient Discharge ; Hyperalgesia ; Peripheral Nervous System Diseases ; Pain ; Neurons/physiology ; Medulla Oblongata ; Analgesics
    Chemical Substances Analgesics
    Language English
    Publishing date 2023-08-06
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2023.137415
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Effective treatment of osteoarthritic pain, tackling the challenge with pets.

    Pertovaara, Antti

    Scandinavian journal of pain

    2012  Volume 3, Issue 2, Page(s) 82–83

    Language English
    Publishing date 2012-04-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2515451-5
    ISSN 1877-8879 ; 1877-8860
    ISSN (online) 1877-8879
    ISSN 1877-8860
    DOI 10.1016/j.sjpain.2012.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Spinal TRPA1 Contributes to the Mechanical Hypersensitivity Effect Induced by Netrin-1.

    Wei, Hong / Ailanen, Liisa / Morales, Miguel / Koivisto, Ari / Pertovaara, Antti

    International journal of molecular sciences

    2022  Volume 23, Issue 12

    Abstract: Netrin-1, a chemoattractant expressed by floor plate cells, and one of its receptors (deleted in colorectal cancer) has been associated with pronociceptive actions in a number of pain conditions. Here, we addressed the question of whether spinal TRPC4/C5 ...

    Abstract Netrin-1, a chemoattractant expressed by floor plate cells, and one of its receptors (deleted in colorectal cancer) has been associated with pronociceptive actions in a number of pain conditions. Here, we addressed the question of whether spinal TRPC4/C5 or TRPA1 are among the downstream receptors contributing to pronociceptive actions induced by netrin-1. The experiments were performed on rats using a chronic intrathecal catheter for administration of netrin-1 and antagonists of TRPC4/C5 or TRPA1. Pain sensitivity was assessed behaviorally by using mechanical and heat stimuli. Effect on the discharge rate of rostral ventromedial medullary (RVM) pain control neurons was studied in lightly anesthetized animals. Netrin-1, in a dose-related fashion, induced mechanical hypersensitivity that lasted up to three weeks. Netrin-1 had no effect on heat nociception. Mechanical hypersensitivity induced by netrin-1 was attenuated by TRPA1 antagonist Chembridge-5861528 and by the control analgesic compound pregabalin both during the early (first two days) and late (third week) phase of hypersensitivity. TRPC4/C5 antagonist ML-204 had a weak antihypersensitivity effect that was only in the early phase, whereas TRPC4/C5 antagonist HC-070 had no effect on hypersensitivity induced by netrin-1. The discharge rate in pronociceptive ON-like RVM neurons was increased by netrin-1 during the late but not acute phase, whereas netrin-1 had no effect on the discharge rate of antinociceptive RVM OFF-like neurons. The results suggest that spinal TRPA1 receptors and pronociceptive RVM ON-like neurons are involved in the maintenance of submodality-selective pronociceptive actions induced by netrin-1 in the spinal cord.
    MeSH term(s) Animals ; Hyperalgesia/chemically induced ; Netrin-1/pharmacology ; Pain ; Pain Threshold ; Rats ; Rats, Wistar ; TRPA1 Cation Channel
    Chemical Substances TRPA1 Cation Channel ; Trpa1 protein, rat ; Netrin-1 (158651-98-0)
    Language English
    Publishing date 2022-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23126629
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  9. Article ; Online: Is finding the common biological link(s) between pain and affect an infinity quest?

    Bourbia, Nora / Pertovaara, Antti

    Scandinavian journal of pain

    2018  Volume 2, Issue 3, Page(s) 137–138

    Language English
    Publishing date 2018-07-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2515451-5
    ISSN 1877-8879 ; 1877-8860
    ISSN (online) 1877-8879
    ISSN 1877-8860
    DOI 10.1016/j.sjpain.2011.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Spinal mechanisms contributing to the development of pain hypersensitivity induced by sphingolipids in the rat.

    Wei, Hong / Chen, Zuyue / Koivisto, Ari / Pertovaara, Antti

    Pharmacological reports : PR

    2021  Volume 73, Issue 2, Page(s) 672–679

    Abstract: Background: Earlier studies show that endogenous sphingolipids can induce pain hypersensitivity, activation of spinal astrocytes, release of proinflammatory cytokines and activation of TRPM3 channel. Here we studied whether the development of pain ... ...

    Abstract Background: Earlier studies show that endogenous sphingolipids can induce pain hypersensitivity, activation of spinal astrocytes, release of proinflammatory cytokines and activation of TRPM3 channel. Here we studied whether the development of pain hypersensitivity induced by sphingolipids in the spinal cord can be prevented by pharmacological inhibition of potential downstream mechanisms that we hypothesized to include TRPM3, σ
    Methods: Experiments were performed in adult male rats with a chronic intrathecal catheter for spinal drug administrations. Mechanical nociception was assessed with monofilaments and heat nociception with radiant heat. N,N-dimethylsphingosine (DMS) was administered to induce pain hypersensitivity. Ononetin, isosakuranetin, naringenin (TRPM3 antagonists), BD-1047 (σ
    Results: DMS alone produced within 15 min a dose-related mechanical hypersensitivity that lasted at least 24 h, without effect on heat nociception. Preemptive treatments with ononetin, isosakuranetin, naringenin, BD-1047, carbenoxolone, MK-801 or AS-057278 attenuated the development of the DMS-induced hypersensitivity, but had no effects when administered alone. Pregnenolone sulphate (TRPM3 agonist) alone induced a dose-related mechanical hypersensitivity that was prevented by ononetin, isosakuranetin and naringenin.
    Conclusions: Among spinal pronociceptive mechanisms activated by DMS are TRPM3, gap junction coupling, the σ
    MeSH term(s) Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Flavanones/pharmacology ; Flavonoids/pharmacology ; Glucosides/pharmacology ; Hyperalgesia/physiopathology ; Hyperalgesia/prevention & control ; Isoflavones/pharmacology ; Male ; Rats ; Rats, Wistar ; Sphingolipids/metabolism ; Sphingosine/analogs & derivatives ; Sphingosine/toxicity ; Spinal Cord/metabolism
    Chemical Substances Flavanones ; Flavonoids ; Glucosides ; Isoflavones ; Sphingolipids ; calycosin-7-O-beta-D-glucoside ; naringenin (HN5425SBF2) ; N,N-dimethylsphingosine (L9QRA71834) ; Sphingosine (NGZ37HRE42) ; isosakuranetin (U02X7TF8UA)
    Language English
    Publishing date 2021-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2186248-5
    ISSN 1734-1140
    ISSN 1734-1140
    DOI 10.1007/s43440-020-00207-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 861: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)

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