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  1. Article ; Online: Extended-interval dosing of natalizumab in NOVA.

    Stüve, Olaf / Tugemann, Bastian

    The Lancet. Neurology

    2023  Volume 22, Issue 3, Page(s) 199–200

    MeSH term(s) Humans ; Natalizumab/therapeutic use ; Multiple Sclerosis/drug therapy ; Leukoencephalopathy, Progressive Multifocal ; Immunologic Factors/therapeutic use ; Multiple Sclerosis, Relapsing-Remitting
    Chemical Substances Natalizumab ; Immunologic Factors
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00032-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5955: Show issues Location:
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  2. Book ; Online: Geschlechterreflektierte Pädagogik gegen Rechts

    Stuve, Olaf / Hechler, Andreas

    2015  

    Abstract: Anyone who deals with neo-Nazi prevention must consider the category of gender, because gender is a core aspect of neo-Nazi ideology and life. The contributions examine this point of view as well as the pedagogical and theoretical practices of the triad ... ...

    Abstract Anyone who deals with neo-Nazi prevention must consider the category of gender, because gender is a core aspect of neo-Nazi ideology and life. The contributions examine this point of view as well as the pedagogical and theoretical practices of the triad gender - pedagogy - neo-Nazism. The authors make it clear that prevention of neo-Nazism must be streamed just as much as gender-reflected pedagogy
    Keywords Women. Feminism
    Size 1 electronic resource (390 p.)
    Publisher Verlag Barbara Budrich
    Document type Book ; Online
    Note German ; Open Access
    HBZ-ID HT020102487
    ISBN 9783847408413 ; 9783847406952 ; 3847408410 ; 3847406957
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Should ocrelizumab be used in non-active primary progressive multiple sclerosis? Time for a re-assessment.

    Manouchehri, Navid / Stüve, Olaf

    Therapeutic advances in neurological disorders

    2021  Volume 14, Page(s) 1756286421990500

    Language English
    Publishing date 2021-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442245-9
    ISSN 1756-2864 ; 1756-2856
    ISSN (online) 1756-2864
    ISSN 1756-2856
    DOI 10.1177/1756286421990500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Choroid plexus volumetrics and brain inflammation in multiple sclerosis.

    Manouchehri, Navid / Stüve, Olaf

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 40

    MeSH term(s) Brain ; Choroid Plexus ; Encephalitis ; Humans ; Multiple Sclerosis
    Language English
    Publishing date 2021-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2115221118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  5. Article: Exploring the association between weight loss-inducing medications and multiple sclerosis: insights from the FDA adverse event reporting system database.

    Shirani, Afsaneh / Cross, Anne H / Stuve, Olaf

    Therapeutic advances in neurological disorders

    2024  Volume 17, Page(s) 17562864241241383

    Abstract: Background: Several studies have demonstrated that early childhood and adolescent obesity are risk factors for multiple sclerosis (MS) susceptibility. Obesity is thought to share inflammatory components with MS through overproduction of pro-inflammatory ...

    Abstract Background: Several studies have demonstrated that early childhood and adolescent obesity are risk factors for multiple sclerosis (MS) susceptibility. Obesity is thought to share inflammatory components with MS through overproduction of pro-inflammatory adipokines (e.g., leptin) and reduction of anti-inflammatory adipokines (e.g, adiponectin). Recently, drug repurposing (i.e. identifying new indications for existing drugs) has garnered significant attention. The US Food and Drug Administration Adverse Event Reporting System (FAERS) database serves not only as a resource for mining adverse drug reactions and safety signals but also for identifying inverse associations and potential medication repurposing opportunities.
    Objective: We aimed to explore the association between weight-loss-inducing drugs and MS using real-world reports from the FAERS database.
    Design: Secondary analysis of existing data from the FAERS database.
    Methods: We conducted a disproportionality analysis using the FAERS database between the fourth quarter of 2003 and the second quarter of 2023 to explore associations between MS and weight loss-inducing drugs. Disproportionality was quantified using the reporting odds ratio (ROR). An inverse association was defined when the upper limit of the 95% confidence interval for ROR was <1.
    Results: We found an inverse association between MS and anti-diabetic weight loss-inducing drugs including semaglutide (ROR: 0.238; 95% CI: 0.132-0.429), dulaglutide (ROR: 0.165; 95% CI: 0.109-0.248), liraglutide (ROR: 0.161; 95% CI: 0.091-0.284), empagliflozin (ROR: 0.234; 95% CI: 0.146-0.377), and metformin (ROR: 0.387; 95% CI: 0.340-0.440). No inverse associations were found for other weight loss-inducing drugs such as phentermine, bupropion, topiramate, zonisamide, and amphetamine. An exception was naltrexone (ROR: 0.556; 95% CI: 0.384-0.806).
    Conclusion: Our findings suggest a potential consideration for repurposing anti-diabetic weight loss-inducing drugs including semaglutide, dulaglutide, and liraglutide (glucagon-like peptide-1 receptor agonists), empagliflozin (sodium-glucose cotransporter-2 inhibitor), and metformin (biguanide), for MS. This warrants validation through rigorous methodologies and prospective studies.
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442245-9
    ISSN 1756-2864 ; 1756-2856
    ISSN (online) 1756-2864
    ISSN 1756-2856
    DOI 10.1177/17562864241241383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Animal models of multiple sclerosis: can they advance future therapies?

    DeSilva, Tara Maria / Stuve, Olaf

    Frontiers in molecular neuroscience

    2023  Volume 16, Page(s) 1229625

    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2023.1229625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Perspective: Industry-patient relationships for the promotion of pharmaceutical agents.

    Bryarly, Meredith A / Rubin, Michael A / Stuve, Olaf

    Therapeutic advances in neurological disorders

    2023  Volume 16, Page(s) 17562864231207560

    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442245-9
    ISSN 1756-2864 ; 1756-2856
    ISSN (online) 1756-2864
    ISSN 1756-2856
    DOI 10.1177/17562864231207560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Systems Approaches to Unravel T Cell Function and Therapeutic Potential in Autoimmune Disease.

    Salinas, Victor H / Stüve, Olaf

    Journal of immunology (Baltimore, Md. : 1950)

    2021  Volume 206, Issue 4, Page(s) 669–675

    Abstract: Producing Ag-specific immune responses constrained to target tissues or cells that can be engaged or disengaged at will is predicated on understanding the network of genes governing immune cell function, defining the rules underlying Ag specificity, and ... ...

    Abstract Producing Ag-specific immune responses constrained to target tissues or cells that can be engaged or disengaged at will is predicated on understanding the network of genes governing immune cell function, defining the rules underlying Ag specificity, and synthesizing the tools to engineer them. The successes and limitations of chimeric Ag receptor (CAR) T cells emphasize this goal, and advances in high-throughput sequencing, large-scale genomic screens, single-cell profiling, and genetic modification are providing the necessary data to bring it to fruition-including a broader application into the treatment of autoimmune diseases. In this review, we delve into the implementation of these developments, survey the relevant works, and propose a framework for generating the next generation of synthetic T cells informed by the principles learned from these systems approaches.
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Gene Editing ; Genetic Testing ; High-Throughput Nucleotide Sequencing ; Humans ; Immunotherapy, Adoptive/methods ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/metabolism ; Systems Biology/methods ; T-Lymphocytes/immunology
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2000954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
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    Zs.MG 28: Show issues

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  9. Article ; Online: Sodium Phenylbutyrate-Taurursodiol for ALS.

    Herz, Joachim / Stüve, Olaf

    The New England journal of medicine

    2020  Volume 383, Issue 23, Page(s) 2294

    MeSH term(s) Amyotrophic Lateral Sclerosis ; Humans ; Phenylbutyrates
    Chemical Substances Phenylbutyrates ; 4-phenylbutyric acid (7WY7YBI87E)
    Language English
    Publishing date 2020-11-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2030710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  10. Article ; Online: Distinctive transcriptomic and epigenomic signatures of bone marrow-derived myeloid cells and microglia in CNS autoimmunity.

    Manouchehri, Navid / Salinas, Victor H / Hussain, Rehana Z / Stüve, Olaf

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 6, Page(s) e2212696120

    Abstract: In the context of autoimmunity, myeloid cells of the central nervous system (CNS) constitute an ontogenically heterogeneous population that includes yolk sac-derived microglia and infiltrating bone marrow-derived cells (BMC). We previously identified a ... ...

    Abstract In the context of autoimmunity, myeloid cells of the central nervous system (CNS) constitute an ontogenically heterogeneous population that includes yolk sac-derived microglia and infiltrating bone marrow-derived cells (BMC). We previously identified a myeloid cell subset in the brain and spinal cord that expresses the surface markers CD88 and CD317 and is associated with the onset and persistence of clinical disease in the murine model of the human CNS autoimmune disorder, experimental autoimmune encephalomyelitis (EAE). We employed an experimental platform utilizing single-cell transcriptomic and epigenomic profiling of bone marrow-chimeric mice to categorically distinguish BMC from microglia during CNS autoimmunity. Analysis of gene expression and chromosomal accessibility identified CD88
    MeSH term(s) Mice ; Humans ; Animals ; Microglia/metabolism ; Bone Marrow/metabolism ; Autoimmunity/genetics ; Transcriptome ; Epigenomics ; Mice, Inbred C57BL ; Central Nervous System ; Encephalomyelitis, Autoimmune, Experimental ; Myeloid Cells/metabolism
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2212696120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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