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Article ; Online: Hot for Robots! Sexual Arousal Increases Willingness to Have Sex with Robots.

Dubé, S / Williams, M / Santaguida, M / Hu, R / Gadoury, T / Yim, B / Vachon, D / Johnson, A P

2022 Volume 61, Issue 4, Page(s) 638–648

Abstract: Robots designed to elicit sexual arousal are coming. Sexual arousal can increase our willingness to engage in risky or unconventional sexual behaviors. However, researchers have yet to examine whether this effect extends to robots. Hence, this study ... ...

Abstract	Robots designed to elicit sexual arousal are coming. Sexual arousal can increase our willingness to engage in risky or unconventional sexual behaviors. However, researchers have yet to examine whether this effect extends to robots. Hence, this study provides the first empirical evidence that state sexual arousal can increase our willingness to engage erotically with robots. Based on previous research, we hypothesized that levels of sexual arousal would positively predict willingness to engage erotically with robots (Hypothesis 1); and that men would be more willing to engage erotically with robots than women (Hypothesis 2). A convenience sample of 321 adults (≥18y) completed a two-part online survey measuring their willingness to have sex with, love, engage in an intimate relationship with, and be friends with a robot and a human before and after viewing a sexually explicit video. The results partly support Hypotheses 1-2. They show that state sexual arousal increases willingness to have sex with a robot, and that men are more willing to have sex and engage in an intimate relationship with a robot than women, pre- and post-manipulation. These findings are important given the rise of sex robots and their potential influence on our intimate decisions and behaviors.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Sexual Behavior/psychology ; Robotics ; Young Adult ; Sexual Arousal ; Middle Aged ; Adolescent ; Erotica/psychology ; Interpersonal Relations ; Sexual Partners/psychology
Language	English
Publishing date	2022-11-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	220889-1
ISSN	1559-8519 ; 0022-4499
ISSN (online)	1559-8519
ISSN	0022-4499
DOI	10.1080/00224499.2022.2142190
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Article ; Online: Postoperative C5 Palsy after Anterior or Posterior Decompression for Degenerative Cervical Myelopathy: A Subgroup Analysis of the Multicenter, Prospective, Randomized, Phase III, CSM-Protect Clinical Trial.

Bak, Alex B / Moghaddamjou, Ali / Alvi, Mohammed / Ahn, Henry / Farhadi, H Francis / Shaffrey, Christopher I / Nassr, Ahmad / Mummaneni, Praveen / Arnold, Paul M / Jacobs, W Bradley / Riew, K Daniel / Kelly, Michael / Brodke, Darrel S / Vaccaro, Alexander R / Hilibrand, Alan S / Wilson, Jason / Harrop, James S / Yoon, S Tim / Kim, Kee D /

Fourney, Daryl R / Santaguida, Carlo / Massicotte, Eric M / Kopjar, Branko / Fehlings, Michael

Spine

2024

Abstract: ... in patients that underwent posterior decompression compared to anterior decompression (11.26% vs. 3.03%, P=0 ... than four times the likelihood of postoperative C5 palsy (P=0.017). Rates of C5 palsy recovery were ...

Abstract	Study design: Retrospective cohort study of prospectively accrued data. Objective: To evaluate a large, prospective, multicentre dataset of surgically-treated DCM cases on the contemporary risk of C5 palsy with surgical approach. Summary of background data: The influence of surgical technique on postoperative C5 palsy after decompression for degenerative cervical myelopathy (DCM) is intensely debated. Comprehensive analyses are needed using contemporary data and accounting for covariates. Methods: Patients with moderate to severe DCM were prospectively enrolled in the multicenter, randomized CSM-Protect clinical trial and underwent either anterior or posterior decompression between Jan 31, 2012, to May 16, 2017. The primary outcome was the incidence of postoperative C5 palsy, defined as onset of muscle weakness by at least one grade in manual muscle test at the C5 myotome with slight or absent sensory disruption after cervical surgery. Two comparative cohorts were made based on anterior or posterior surgical approach. Multivariate hierarchical mixed-effects logistic regression was used to estimate odds ratios (OR) with 95% confidence intervals (CI) for C5 palsy. Results: A total of 283 patients were included, and 53.4% underwent posterior decompression. The total incidence of postoperative C5 palsy was 7.4% and was significantly higher in patients that underwent posterior decompression compared to anterior decompression (11.26% vs. 3.03%, P=0.008). After multivariable regression, posterior approach was independently associated with greater than four times the likelihood of postoperative C5 palsy (P=0.017). Rates of C5 palsy recovery were comparable between the two surgical approaches. Conclusion: The odds of postoperative C5 palsy are significantly higher after posterior decompression compared to anterior decompression for DCM. This may influence surgical decision-making when there is equipoise in deciding between anterior and posterior treatment options for DCM. Level of evidence: Therapeutic Level II.
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	752024-4
ISSN	1528-1159 ; 0362-2436
ISSN (online)	1528-1159
ISSN	0362-2436
DOI	10.1097/BRS.0000000000005007
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Article ; Online: Anxiety and Depression in Pediatric-Onset Traumatic Spinal Cord Injury: A Systematic Review.

Mofatteh, Mohammad / Mashayekhi, Mohammad Sadegh / Arfaie, Saman / Chen, Yimin / Malhotra, Armaan K / Skandalakis, Georgios P / Alvi, Mohammed Ali / Afshari, Fardad T / Meshkat, Shakila / Lin, Famu / Abdulla, Ebtesam / Anand, Ayush / Liao, Xuxing / McIntyre, Roger S / Santaguida, Carlo / Weber, Michael H / Fehlings, Michael G

World neurosurgery

2023 Volume 184, Page(s) 267–282.e5

Abstract: Background: Traumatic spinal cord injury (TSCI) is a debilitating neurological condition with significant long-term consequences on the mental health and well-being of affected individuals. We aimed to investigate anxiety and depression in individuals ... ...

Abstract	Background: Traumatic spinal cord injury (TSCI) is a debilitating neurological condition with significant long-term consequences on the mental health and well-being of affected individuals. We aimed to investigate anxiety and depression in individuals with pediatric-onset TSCI. Methods: PubMed, Scopus, and Web of Science databases were searched from inception to December 20th, 2022 following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, and studies were included according to the eligibility criteria. Results: A total of 1013 articles were screened, and 18 studies with 4234 individuals were included in the final review. Of these, 1613 individuals (38.1%) had paraplegia, whereas 1658 (39.2%) had tetraplegia. A total of 1831 participants (43.2%) had complete TSCI, whereas 1024 (24.2%) had incomplete TSCI. The most common etiology of TSCI with 1545 people (36.5%) was motor vehicle accidents. The youngest mean age at the time of injury was 5.92 ± 4.92 years, whereas the oldest was 14.6 ± 2.8 years. Patient Health Questionnaire-9 was the most common psychological assessment used in 9 studies (50.0%). Various risk factors, including pain in 4 studies (22.2%), reduced sleep quality, reduced functional independence, illicit drug use, incomplete injury, hospitalization, reduced quality of life, and duration of injury in 2 (11.1%) studies, each, were associated with elevated anxiety and depression. Conclusions: Different biopsychosocial risk factors contribute to elevated rates of anxiety and depression among individuals with pediatric-onset TSCI. Individuals at risk of developing anxiety and depression should be identified, and targeted support should be provided. Future large-scale studies with long-term follow-up are required to validate and extend these findings.
MeSH term(s)	Child ; Humans ; Infant ; Child, Preschool ; Depression/epidemiology ; Depression/etiology ; Quality of Life ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/epidemiology ; Paraplegia/etiology ; Anxiety/epidemiology ; Anxiety/etiology
Language	English
Publishing date	2023-12-23
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.12.092
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Article: Learning From Strengths: Improving Care by Comparing Perinatal Approaches Between Japan and Canada and Identifying Future Research Priorities.

Yoneda, Noriko / Isayama, Tetsuya / Saito, Shigeru / Shah, Prakesh S / Santaguida, Pasqualina / Nakamura, Tomohiko / McDonald, Sarah D

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

2021 Volume 43, Issue 12, Page(s) 1388–1394.e1

Abstract: Objective: Preterm birth (PTB) is the leading cause of infant morbidity and mortality worldwide. Canada and Japan each have strengths that can inform clinical decision-making, research, and health care policy regarding the prevention of PTB and its ... ...

Abstract	Objective: Preterm birth (PTB) is the leading cause of infant morbidity and mortality worldwide. Canada and Japan each have strengths that can inform clinical decision-making, research, and health care policy regarding the prevention of PTB and its sequelae. Our objectives were to: 1) compare PTB rates, risk factors, management, and outcomes between Japan and Canada; 2) establish research priorities while fostering future collaborative opportunities; and 3) undertake knowledge translation of these findings. Methods: We conducted a literature review to identify publications that examined PTB rates, risk factors, prevention and management techniques, and outcomes in Japan and Canada. We conducted site visits at 4 Japanese tertiary centres and held a collaborative stakeholder meeting of parents, neonatologists, maternal-fetal medicine specialists, and researchers. Results: Japan reports lower rates of PTB, neonatal mortality, and several PTB risk factors than Canada. However, Canadian PTB data is population-based, whereas, in Japan, the rate of PTB is population-based, but outcomes are not. Rates of severe neurologic injury and necrotizing enterocolitis were lower in Japan, while Canada's rates of bronchopulmonary dysplasia and retinopathy of prematurity were lower. PTB prevention approaches differed, with less progesterone use in Japan and more long-term tocolysis. In Japan, there were lower rates of neonatal transfers and non-faculty overnight care, but also less use of antenatal corticosteroids and deferred cord clamping. Research priorities identified through the stakeholder meeting included early skin-to-skin contact, parental well-being after PTB, and transitions in care for the child. Conclusion: We identified key differences between Japan and Canada in the factors affecting PTB management and patient outcomes, which can inform future research efforts.
MeSH term(s)	Canada/epidemiology ; Child ; Female ; Humans ; Infant ; Infant, Newborn ; Japan/epidemiology ; Pregnancy ; Premature Birth/epidemiology ; Premature Birth/prevention & control ; Quality Improvement ; Research ; Translational Science, Biomedical
Language	English
Publishing date	2021-05-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2171082-X
ISSN	1701-2163
ISSN	1701-2163
DOI	10.1016/j.jogc.2021.04.018
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Article ; Online: CONSORT Harms 2022 statement, explanation, and elaboration: updated guideline for the reporting of harms in randomized trials.

Junqueira, Daniela R / Zorzela, Liliane / Golder, Susan / Loke, Yoon / Gagnier, Joel J / Julious, Steven A / Li, Tianjing / Mayo-Wilson, Evan / Pham, Ba / Phillips, Rachel / Santaguida, Pasqualina / Scherer, Roberta W / Gøtzsche, Peter C / Moher, David / Ioannidis, John P A / Vohra, Sunita

Journal of clinical epidemiology

2023 Volume 158, Page(s) 149–165

Abstract: Randomized controlled trials remain the reference standard for healthcare research on effects of interventions, and the need to report both benefits and harms is essential. The Consolidated Standards of Reporting Trials (the main CONSORT) statement ... ...

Abstract	Randomized controlled trials remain the reference standard for healthcare research on effects of interventions, and the need to report both benefits and harms is essential. The Consolidated Standards of Reporting Trials (the main CONSORT) statement includes one item on reporting harms (i.e., all important harms or unintended effects in each group). In 2004, the CONSORT group developed the CONSORT Harms extension; however, it has not been consistently applied and needs to be updated. Here, we describe CONSORT Harms 2022, which replaces the CONSORT Harms 2004 checklist, and shows how CONSORT Harms 2022 items could be incorporated into the main CONSORT checklist. Thirteen items from the main CONSORT were modified to improve harms reporting. Three new items were added. In this article, we describe CONSORT Harms 2022 and how it was integrated into the main CONSORT checklist and elaborate on each item relevant to complete reporting of harms in randomized controlled trials. Until future work from the CONSORT group produces an updated checklist, authors, journal reviewers, and editors of randomized controlled trials should use the integrated checklist presented in this paper.
MeSH term(s)	Humans ; Publishing ; Randomized Controlled Trials as Topic ; Reference Standards ; Checklist ; Research Report ; Research Design
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639306-8
ISSN	1878-5921 ; 0895-4356
ISSN (online)	1878-5921
ISSN	0895-4356
DOI	10.1016/j.jclinepi.2023.04.005
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Article ; Online: CONSORT Harms 2022 statement, explanation, and elaboration: updated guideline for the reporting of harms in randomised trials.

BMJ (Clinical research ed.)

2023 Volume 381, Page(s) e073725

MeSH term(s)	Humans ; Publishing ; Research Design ; Checklist ; Guideline Adherence
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj-2022-073725
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Article ; Online: Regulatory B Cells in Systemic Sclerosis Isolated or Concomitant With Hashimoto Thyroiditis.

Capriello, Silvia / Ferrari, Silvia Martina / Gatto, Ilenia / Santaguida, Maria Giulia / Fallahi, Poupak / Antonelli, Alessandro / Mangino, Giorgio / Romeo, Giovanna / Virili, Camilla / Centanni, Marco

Frontiers in immunology

2022 Volume 13, Page(s) 921260

Abstract: ... lymphocytes characterized HT patients as compared to both HD and the whole group of SSc patients (p = 0.0018 ... On the contrary, the percentage of unstimulated Breg cells in SSc patients was higher (p = 0.0260 ... increased in the whole sample of SSc patients (p < 0.001) as well as in isolated SSc and in SSc+HT ones ...

Abstract	Systemic sclerosis (SSc) is a systemic autoimmune disease in which gastrointestinal disorders represent a complication in up to 90% of patients. SSc may associate with thyroid autoimmune disorders, with Hashimoto's thyroiditis (HT) being the more prevalent worldwide. Previous studies have examined the behavior of Th17 lymphocytes and Breg cells in patients with HT and concomitant autoimmune organ-specific disorders. These immune phenotypes seem to play a significant role in the pathogenesis of both these autoimmune processes, but their behavior when these two disorders coexist has not been described. We analyzed Th17 and Breg (CD24hiCD38hi) cell subsets in 50 subjects (45F/5M; median age = 49 years): 18 were healthy donors (HD), 20 had isolated HT, and 12 had SSc, seven of whom had both HT and SSc. Breg cells' function was also evaluated by measuring their IL-10 production when stimulated by specific activators. An increased percentage of Th17 lymphocytes characterized HT patients as compared to both HD and the whole group of SSc patients (p = 0.0018). On the contrary, the percentage of unstimulated Breg cells in SSc patients was higher (p = 0.0260), either associated or not with HT, as compared to both HT patients and HD, which, instead, showed a similar percentage of Breg cells. Following a specific stimulation with CpG, the percentages of Breg cells were increased in the whole sample of SSc patients (p < 0.001) as well as in isolated SSc and in SSc+HT ones as compared to isolated HT. However, qualitative analysis, obtained through the detection of the IL-10-producing phenotype, revealed that the percentage of CpG-stimulated CD24hiCD38hi-IL10+cells was significantly decreased in SSc patients (p < 0.0001) with no difference between isolated SSc and SSc+HT patients. The IL-10-producing phenotype was instead slightly increased in HT patients as compared to HD (4.1% vs. 2.8%). The presence of SSc seems to be characterized by an enrichment of total Breg cells but by a reduced Breg IL-10-producing phenotype, representing functional Bregs. This last finding was entirely due to the presence of SSc independently from the association with HT. This behavior is different from the ones described about the association of HT with organ-specific autoimmune disorders.
MeSH term(s)	Autoimmune Diseases/pathology ; B-Lymphocytes, Regulatory ; Hashimoto Disease ; Humans ; Interleukin-10 ; Scleroderma, Systemic
Chemical Substances	Interleukin-10 (130068-27-8)
Language	English
Publishing date	2022-07-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.921260
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Article ; Online: Active involvement of nursing staff in reporting and grading complication-intervention events-Protocol and results of the CAMUS Pilot Nurse Delphi Study.

Soliman, Christopher / Thomas, Benjamin C / Santaguida, Pasqualina / Lawrentschuk, Nathan / Mertens, Evie / Giannarini, Gianluca / Wuethrich, Patrick Y / Wu, Michael / Khan, Muhammad S / Nair, Rajesh / Thurairaja, Ramesh / Challacombe, Benjamin / Dasgupta, Prokar / Malde, Sachin / Corcoran, Niall M / Spiess, Philippe E / Dundee, Philip / Furrer, Marc A

BJUI compass

2022 Volume 3, Issue 6, Page(s) 466–483

Abstract: Objectives: The aim of this study is to gain experienced nursing perspective on current and future complication reporting and grading in Urology, establish the CAMUS CCI and quality control the use of the Clavien-Dindo Classification (CDC) in nursing ... ...

Abstract	Objectives: The aim of this study is to gain experienced nursing perspective on current and future complication reporting and grading in Urology, establish the CAMUS CCI and quality control the use of the Clavien-Dindo Classification (CDC) in nursing staff. Subjects and methods: The 12-part REDCap-based Delphi survey was developed in conjunction with expert nurse, urologist and methodologist input. Certified local and international inpatient and outpatient nurses specialised in urology, perioperative nurses and urology-specific advanced practice nurses/nurse practitioners will be included. A minimum sample size of 250 participants is targeted. The survey assesses participant demographics, nursing experience and opinion on complication reporting and the proposed CAMUS reporting recommendations; grading of intervention events using the existing CDC and the proposed CAMUS Classification; and rating various clinical scenarios. Consensus will be defined as ≥75% agreement. If consensus is not reached, subsequent Delphi rounds will be performed under Steering Committee guidance. Results: Twenty participants completed the pilot survey. Median survey completion time was 58 min (IQR 40-67). The survey revealed that 85% of nursing participants believe nurses should be involved in future complication reporting and grading but currently have poor confidence and inadequate relevant background education. Overall, 100% of participants recognise the universal demand for reporting consensus and 75% hold a preference towards the CAMUS System. Limitations include variability in nursing experience, complexity of supplemental grades and survey duration. Conclusion: The integration of experienced nursing opinion and participation in complication reporting and grading systems in a modern and evolving hospital infrastructure may facilitate the assimilation of otherwise overlooked safety data. Incorporation of focused teaching into routine nursing education will be essential to ensure quality control and stimulate awareness of complication-related burden. This, in turn, has the potential to improve patient counselling and quality of care.
Language	English
Publishing date	2022-06-15
Publishing country	United States
Document type	Journal Article
ISSN	2688-4526
ISSN (online)	2688-4526
DOI	10.1002/bco2.173
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Article ; Online: Effects of dance on cognitive function in older adults: a systematic review and meta-analysis.

Hewston, Patricia / Kennedy, Courtney Clare / Borhan, Sayem / Merom, Dafna / Santaguida, Pasqualina / Ioannidis, George / Marr, Sharon / Santesso, Nancy / Thabane, Lehana / Bray, Steven / Papaioannou, Alexandra

Age and ageing

2020 Volume 50, Issue 4, Page(s) 1084–1092

Abstract: Background: dance is a mind-body activity that stimulates neuroplasticity. We explored the effect of dance on cognitive function in older adults.: Methods: we searched MEDLINE, EMBASE, CENTRAL and PsycInfo databases from inception to August 2020 ( ... ...

Abstract	Background: dance is a mind-body activity that stimulates neuroplasticity. We explored the effect of dance on cognitive function in older adults. Methods: we searched MEDLINE, EMBASE, CENTRAL and PsycInfo databases from inception to August 2020 (PROSPERO:CRD42017057138). Inclusion criteria were (i) randomised controlled trials (ii) older adults (aged ≥ 55 years), (iii) intervention-dance and (iv) outcome-cognitive function. Cognitive domains were classified with the Diagnostic and Statistical Manual of Mental Disorders-5 Neurocognitive Framework. Meta-analyses were performed in RevMan5.3 and certainty of evidence with GradePro. Results: we reviewed 3,997 records and included 11 studies (N = 1,412 participants). Seven studies included only healthy older adults and four included those with mild cognitive impairment (MCI). Dance interventions varied in frequency (1-3×/week), time (35-60 minutes), duration (3-12 months) and type. We found a mean difference (MD) = 1.58 (95% confidence interval [CI) = 0.21-2.95) on the Mini Mental State Examination for global cognitive function (moderate-certainty evidence), and the Wechsler Memory Test for learning and memory had an MD = 3.02 (95% CI = 1.38-4.65; low-certainty evidence). On the Trail Making Test-A for complex attention, MD = 3.07 (95% CI = -0.81 to 6.95; high-certainty evidence) and on the Trail Making Test-B for executive function, MD = -4.12 (95% CI = -21.28 to 13.03; moderate-certainty evidence). Subgroup analyses did not suggest consistently greater effects in older adults with MCI. Evidence is uncertain for language, and no studies evaluated social cognition or perceptual-motor function. Conclusions: dance probably improves global cognitive function and executive function. However, there is little difference in complex attention, and evidence also suggests little effect on learning and memory. Future research is needed to determine the optimal dose and if dance results in greater cognitive benefits than other types of physical activity and exercise.
MeSH term(s)	Aged ; Cognition ; Cognitive Dysfunction ; Executive Function ; Humans
Language	English
Publishing date	2020-12-21
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	186788-x
ISSN	1468-2834 ; 0002-0729
ISSN (online)	1468-2834
ISSN	0002-0729
DOI	10.1093/ageing/afaa270
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Zs.A 877: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Recurrent Pregnancy Loss in Women with Hashimoto's Thyroiditis with Concurrent Non-Endocrine Autoimmune Disorders.

Cellini, Miriam / Santaguida, Maria Giulia / Stramazzo, Ilaria / Capriello, Silvia / Brusca, Nunzia / Antonelli, Alessandro / Fallahi, Poupak / Gargano, Lucilla / Centanni, Marco / Virili, Camilla

Thyroid : official journal of the American Thyroid Association

2020 Volume 30, Issue 3, Page(s) 457–462

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Abortion, Habitual/immunology ; Adult ; Autoimmune Diseases/complications ; Autoimmunity/physiology ; Female ; Hashimoto Disease/complications ; Humans ; Pregnancy ; Retrospective Studies
Language	English
Publishing date	2020-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1086044-7
ISSN	1557-9077 ; 1050-7256
ISSN (online)	1557-9077
ISSN	1050-7256
DOI	10.1089/thy.2019.0456
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