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Article ; Online: Accelerated point of muscle deoxygenation during the 20-m shuttle run test.

Kume, Daisuke / Iguchi, Akira / Endoh, Hiroshi

Clinical physiology and functional imaging

2017 Volume 38, Issue 3, Page(s) 390–395

Abstract: ... the 20-m shuttle run test (20mSRT) and, if so, whether it is associated with exercise performance ... Hb) and deoxyhaemoglobin (ΔDeoxy-Hb) in the m. vastus lateralis were measured using a portable ...

Abstract	This study examined whether the point of accelerated deoxygenation of active muscle occurs during the 20-m shuttle run test (20mSRT) and, if so, whether it is associated with exercise performance in the test. Twenty-nine male subjects performed the 20mSRT, and concentration changes in oxyhaemoglobin (ΔOxy-Hb) and deoxyhaemoglobin (ΔDeoxy-Hb) in the m. vastus lateralis were measured using a portable near-infrared spectroscopy device. The difference between the relative concentration changes in ΔOxy-Hb and ΔDeoxy-Hb (Δ[Oxy-Hb - Deoxy-Hb]) was regarded as the muscle oxygenation index. Group-averaged Δ[Oxy-Hb - Deoxy-Hb] showed progressive decrease during the test. However, among the individuals, we found an accelerated point of decrease in Δ[Oxy-Hb - Deoxy-Hb] in 20 subjects, which revealed that the laps at the accelerated point correlated with the total laps (r = 0·78). These results demonstrate that the accelerated deoxygenation of active muscle occurs during the 20mSRT, but not in all cases. Our findings also indicate that if the accelerated point of muscle deoxygenation occurs, the timing of its appearance is related to 20mSRT performance.
MeSH term(s)	Adolescent ; Equipment Design ; Exercise Test/instrumentation ; Hemoglobins/metabolism ; Humans ; Male ; Muscle Contraction ; Muscle Strength ; Oximetry/instrumentation ; Oxygen Consumption ; Oxyhemoglobins/metabolism ; Physical Endurance ; Predictive Value of Tests ; Quadriceps Muscle/metabolism ; Running ; Spectroscopy, Near-Infrared/instrumentation ; Time Factors ; Young Adult
Chemical Substances	Hemoglobins ; Oxyhemoglobins ; deoxyhemoglobin (9008-02-0)
Language	English
Publishing date	2017-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2071203-0
ISSN	1475-097X ; 1475-0961
ISSN (online)	1475-097X
ISSN	1475-0961
DOI	10.1111/cpf.12426
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Article ; Online: Onset of Accelerated Muscle Deoxygenation During the 20-m Shuttle Run Test in Boys.

Kume, Daisuke / Iguchi, Akira / Endoh, Hiroshi

Pediatric exercise science

2018 Volume 30, Issue 4, Page(s) 474–479

Abstract: ... of accelerated muscle deoxygenation occurs during the 20-m shuttle run test (20mSRT) between boys and men and ... in oxygenated and deoxygenated hemoglobin and myoglobin (ΔOxy-Hb and ΔDeoxy-Hb, respectively) in the m ...

Abstract	Purpose: This study aimed to compare the relative exercise intensity at which the onset of accelerated muscle deoxygenation occurs during the 20-m shuttle run test (20mSRT) between boys and men and to examine whether the timing of the onset of acceleration appearance is related to 20mSRT performance in boys. Methods: Twenty-four boys performed the 20mSRT, during which concentration changes in oxygenated and deoxygenated hemoglobin and myoglobin (ΔOxy-Hb and ΔDeoxy-Hb, respectively) in the m. vastus lateralis were monitored using a portable near-infrared spectroscopy device. The boys' data were compared with those of 29 men in a previous study. Results: An onset of accelerated decrease in Δ[Oxy-Hb - Deoxy-Hb] was found in 11 of the 24 boys (45.8%) and 20 of the 29 men (69.0%) and was found at a higher relative exercise intensity in the boys than in the men. The number of laps at which the onset of acceleration occurred correlated with total laps in the boys (r = .87). Conclusions: These findings demonstrate that the onset of accelerated muscle deoxygenation during the 20mSRT occurs at a higher relative exercise intensity in boys than in men. Our findings also show that the timing of the onset of acceleration appearance is associated with 20mSRT performance in boys.
MeSH term(s)	Child ; Exercise Test ; Hemoglobins/physiology ; Humans ; Male ; Myoglobin/physiology ; Oxygen/physiology ; Oxygen Consumption ; Quadriceps Muscle/physiology ; Running/physiology ; Spectroscopy, Near-Infrared ; Young Adult
Chemical Substances	Hemoglobins ; Myoglobin ; deoxyhemoglobin (9008-02-0) ; Oxygen (S88TT14065)
Language	English
Publishing date	2018-07-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1042382-5
ISSN	1543-2920 ; 0899-8493
ISSN (online)	1543-2920
ISSN	0899-8493
DOI	10.1123/pes.2017-0210
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Article ; Online: Epigenetic memory meets G2/M: to remember or to forget?

Sharif, Jafar / Endoh, Mitsuhiro / Koseki, Haruhiko

Developmental cell

2011 Volume 20, Issue 1, Page(s) 5–6

Abstract: ... threonine residues by sensing developmental cues to mediate self-renewal or differentiation during G2/M ...

Abstract	The histone H3 lysine 27 (H3K27) methyltransferase EZH2 is essential for stem cell maintenance and proliferation. Recent insights suggest that the cyclin-dependent kinase CDK1 phosphorylates EZH2 at specific threonine residues by sensing developmental cues to mediate self-renewal or differentiation during G2/M phase.
MeSH term(s)	Animals ; Cell Differentiation ; Cell Proliferation ; Cyclin-Dependent Kinases/metabolism ; Epigenomics ; G2 Phase/genetics ; Histones/metabolism ; Humans ; Mitosis/genetics ; Models, Biological ; Phosphorylation ; Stem Cells/cytology ; Stem Cells/metabolism ; Transcription Factors/metabolism
Chemical Substances	Histones ; Transcription Factors ; Cyclin-Dependent Kinases (EC 2.7.11.22)
Language	English
Publishing date	2011-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2010.12.012
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Article: Epigenetic Memory Meets G2/M: To Remember or To Forget?

Sharif, Jafar / Endoh, Mitsuhiro / Koseki, Haruhiko

Developmental cell. 2011 Jan. 18, v. 20, no. 1

2011

Abstract: ... threonine residues by sensing developmental cues to mediate self-renewal or differentiation during G2/M ...

Abstract	The histone H3 lysine 27 (H3K27) methyltransferase EZH2 is essential for stem cell maintenance and proliferation. Recent insights suggest that the cyclin-dependent kinase CDK1 phosphorylates EZH2 at specific threonine residues by sensing developmental cues to mediate self-renewal or differentiation during G2/M phase.
Keywords	cyclin-dependent kinase ; epigenetics ; histones ; lysine ; stem cells ; threonine
Language	English
Dates of publication	2011-0118
Size	p. 5-6.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2010.12.012
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Article: Quantitative and qualitative comparison of virulence traits, including murine lethality, among different M types of group A streptococci.

Miyoshi-Akiyama, Tohru / Zhao, Jizi / Kikuchi, Ken / Kato, Hidehito / Suzuki, Rieko / Endoh, Miyoko / Uchiyama, Takehiko

The Journal of infectious diseases

2003 Volume 187, Issue 12, Page(s) 1876–1887

Abstract: ... a particular M serological type and pathologic conditions such as streptococcal toxic shock syndrome (STSS). M1 ... STSS cases more frequently. To investigate whether there is any difference contributing the M-type ... the presence of the speA and speC genes were closely associated with M type. These results indicate that M ...

Abstract	Epidemiological studies have proposed an association between group A streptococci (GAS) bearing a particular M serological type and pathologic conditions such as streptococcal toxic shock syndrome (STSS). M1 and M3 GAS are isolated from STSS cases more frequently, whereas M4 and M12 GAS are isolated from non-STSS cases more frequently. To investigate whether there is any difference contributing the M-type association among GAS, we compared various virulence traits, including the murine lethality of M4, M12, M1, and M3 GAS clinical isolates, which are not clonally related to one another. Murine lethality, the activities of superantigens, streptolysin O, and nicotinamide adenine dinucleotide glycohydrolase, and the presence of the speA and speC genes were closely associated with M type. These results indicate that M types may serve, in part, as markers for strains/clones with particular profiles of virulence traits and mouse lethality.
MeSH term(s)	Animals ; Bacterial Capsules/metabolism ; Bacterial Proteins/metabolism ; Exotoxins ; Gene Expression Regulation, Bacterial ; Hemolysin Proteins/metabolism ; Humans ; Hyaluronic Acid/metabolism ; Japan ; Lethal Dose 50 ; Membrane Proteins/metabolism ; Mice ; NAD+ Nucleosidase/metabolism ; Risk Factors ; Serotyping ; Shock, Septic/microbiology ; Streptococcus pyogenes/classification ; Streptococcus pyogenes/genetics ; Streptococcus pyogenes/isolation & purification ; Streptococcus pyogenes/pathogenicity ; Streptolysins/metabolism ; Virulence
Chemical Substances	Bacterial Proteins ; Exotoxins ; Hemolysin Proteins ; Membrane Proteins ; SpeA protein, Streptococcus pyogenes ; Streptolysins ; Hyaluronic Acid (9004-61-9) ; NAD+ Nucleosidase (EC 3.2.2.5)
Language	English
Publishing date	2003-06-15
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1086/375348
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Zs.MO 445: Show issues

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Article ; Online: SERCA in heterogeneity of diastolic dysfunction in post-infarction heart failure with reduced ejection fraction.

Endoh, Masao

Cardiovascular research

2019 Volume 115, Issue 4, Page(s) 693–695

MeSH term(s)	Cardiomyopathies ; Heart Failure ; Humans ; Infarction ; Stroke Volume ; Ventricular Dysfunction, Left
Language	English
Publishing date	2019-02-04
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvz017
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Article ; Online: Stepwise pluripotency transitions in mouse stem cells.

Endoh, Mitsuhiro / Niwa, Hitoshi

EMBO reports

2022 Volume 23, Issue 9, Page(s) e55010

Abstract: Pluripotent cells in mouse embryos, which first emerge in the inner cell mass of the blastocyst, undergo gradual transition marked by changes in gene expression, developmental potential, polarity, and morphology as they develop from the pre-implantation ... ...

Abstract	Pluripotent cells in mouse embryos, which first emerge in the inner cell mass of the blastocyst, undergo gradual transition marked by changes in gene expression, developmental potential, polarity, and morphology as they develop from the pre-implantation until post-implantation gastrula stage. Recent studies of cultured mouse pluripotent stem cells (PSCs) have clarified the presence of intermediate pluripotent stages between the naïve pluripotent state represented by embryonic stem cells (ESCs-equivalent to the pre-implantation epiblast) and the primed pluripotent state represented by epiblast stem cells (EpiSCs-equivalent to the late post-implantation gastrula epiblast). In this review, we discuss these recent findings in light of our knowledge on peri-implantation mouse development and consider the implications of these new PSCs to understand their temporal sequence and the feasibility of using them as model system for pluripotency.
MeSH term(s)	Animals ; Blastocyst/metabolism ; Cell Differentiation ; Embryonic Stem Cells/metabolism ; Germ Layers/metabolism ; Mice ; Pluripotent Stem Cells
Language	English
Publishing date	2022-07-29
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.15252/embr.202255010
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Article ; Online: Cardiac α1-Adrenoceptors and Inotropy: Myofilament Ca2+ Sensitivity, Intracellular Ca2+ Mobilization, Signaling Pathway, and Pathophysiological Relevance.

Endoh, Masao

Circulation research

2016 Volume 119, Issue 5, Page(s) 587–590

MeSH term(s)	Adrenergic alpha-1 Receptor Agonists/pharmacology ; Animals ; Calcium Signaling/drug effects ; Calcium Signaling/physiology ; Heart/drug effects ; Heart/physiology ; Humans ; Intracellular Fluid/drug effects ; Intracellular Fluid/physiology ; Myocardial Contraction/drug effects ; Myocardial Contraction/physiology ; Myofibrils/drug effects ; Myofibrils/physiology ; Receptors, Adrenergic, alpha-1/physiology
Chemical Substances	Adrenergic alpha-1 Receptor Agonists ; Receptors, Adrenergic, alpha-1
Language	English
Publishing date	2016--19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.116.309502
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Article ; Online: [A case of crossed aphasia following infarction in the right anterior cerebral artery territory].

Ishihara, Kenji / Kakurai, Misa / Endoh, Keiko / Kobayashi, Kazuhiko / Asahi, Toshiomi

Rinsho shinkeigaku = Clinical neurology

2023 Volume 63, Issue 7, Page(s) 450–455

Abstract: We report a patient presenting with crossed aphasia following infarction in the territory of the right anterior cerebral artery (ACA). A right-handed 68-year-old woman without a history of correction had acute disturbance of consciousness, left ... ...

Abstract	We report a patient presenting with crossed aphasia following infarction in the territory of the right anterior cerebral artery (ACA). A right-handed 68-year-old woman without a history of correction had acute disturbance of consciousness, left hemiparesis predominant in the lower extremity, speech disorder and left unilateral spatial neglect during the admission due to hypertensive emergency. No other family member was left-handed. MRI of the head revealed acute phase infarction in the territory of the right ACA: mesial frontal lobe including the supplementary motor area, anterior cingulate gyrus, and the corpus callosum. Language symptoms in the subacute phase included difficulty in initiation, slow speech rate, loss of intonation and phonetic paraphasia, and accompanying errors in comprehension, repetition, reading, and writing letters. These symptoms suggested "anomalous" type crossed aphasia. No limb apraxia, construction disorder or left unilateral spatial neglect was observed in this period. Only a few cases of crossed aphasia due to infarction in the territory of the ACA have been reported so far. However, language and concomitant symptoms differs, depending on each case, suggesting a difference in individual cerebral lateralization.
MeSH term(s)	Female ; Humans ; Aged ; Anterior Cerebral Artery/diagnostic imaging ; Aphasia/etiology ; Speech Disorders ; Infarction ; Frontal Lobe
Language	Japanese
Publishing date	2023-06-30
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001763
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Article ; Online: Impact of acute mental stress on ankle blood pressure in young healthy men: a pilot study.

Kume, Daisuke / Nishiwaki, Masato / Hotta, Norio / Endoh, Hiroshi

BMC research notes

2022 Volume 15, Issue 1, Page(s) 268

Abstract: Objective: Acute mental stress (MS) increases arm blood pressure (BP); however, it remains unclear whether a stress-induced pressor response is also observed in other vessels. This study aimed to examine the impact of acute MS on ankle BP. Fifty-six ... ...

Abstract	Objective: Acute mental stress (MS) increases arm blood pressure (BP); however, it remains unclear whether a stress-induced pressor response is also observed in other vessels. This study aimed to examine the impact of acute MS on ankle BP. Fifty-six young, healthy men aged 19-24 years were divided into the MS (n = 29) and control (CON) (n = 27) groups; each group performed 5-min MS (mental arithmetic) or CON tasks. Systolic and diastolic BPs (SBP and DBP, respectively) of both the brachial and posterior tibial arteries were simultaneously measured at the baseline and 5 and 30 min after the task. Results: In the MS group, brachial BP measures significantly increased (P < 0.05) until 30 min after the task; ankle BP measures were also significantly (P < 0.05) elevated during this time. In the CON group, no significant changes were found in brachial BP measures or ankle SBP, whereas a significant increase (P < 0.05) in ankle DBP was observed 30 min after the task. Our findings indicate that both brachial and ankle BP exhibit a sustained elevation after acute MS, suggesting a systemic pressor response by stress exposure. The measurement of ankle BP in addition to arm BP may be important to assess the stress response. Trial registration: UMIN Clinical Trials Registry UMIN000047796 Registered on: 20th May 2022.
MeSH term(s)	Ankle ; Blood Pressure/physiology ; Brachial Artery/physiology ; Humans ; Male ; Pilot Projects ; Stress, Psychological ; Systole ; Young Adult
Language	English
Publishing date	2022-07-30
Publishing country	England
Document type	Clinical Trial ; Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-022-06160-7
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