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Article ; Online: Corrigendum to "Pharmacological prevention and treatment of opioid-induced constipation in cancer patients: A systematic review and meta-analysis" [Cancer Treat. Rev. 125 (2024) 102704].

Kistemaker, K R J / Sijani, F / Brinkman, D J / de Graeff, A / Burchell, G L / Steegers, M A H / van Zuylen, L

2024 Volume 127, Page(s) 102738

Language	English
Publishing date	2024-04-27
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	125102-8
ISSN	1532-1967 ; 0305-7372
ISSN (online)	1532-1967
ISSN	0305-7372
DOI	10.1016/j.ctrv.2024.102738
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Article ; Online: Pharmacological prevention and treatment of opioid-induced constipation in cancer patients: A systematic review and meta-analysis.

Kistemaker, K R J / Sijani, F / Brinkman, D J / de Graeff, A / Burchell, G L / Steegers, M A H / van Zuylen, L

Cancer treatment reviews

2024 Volume 125, Page(s) 102704

Abstract: ... osmotic (e.g. polyethylene glycol) and stimulant (e.g. bisacodyl) laxatives are widely used. Newer drugs ...

Abstract	Background: Cancer-related pain often requires opioid treatment with opioid-induced constipation (OIC) as its most frequent gastrointestinal side-effect. Both for prevention and treatment of OIC osmotic (e.g. polyethylene glycol) and stimulant (e.g. bisacodyl) laxatives are widely used. Newer drugs such as the peripherally acting µ-opioid receptor antagonists (PAMORAs) and naloxone in a fixed combination with oxycodone have become available for the management of OIC. This systematic review and meta-analysis aims to give an overview of the scientific evidence on pharmacological strategies for the prevention and treatment of OIC in cancer patients. Methods: A systematic search in PubMed, Embase, Web of Science and the Cochrane Library was completed from inception up to 22 October 2022. Randomized and non-randomized studies were systematically selected. Bowel function and adverse drug events were assessed. Results: Twenty trials (prevention: five RCTs and three cohort studies; treatment: ten RCTs and two comparative cohort studies) were included in the review. Regarding the prevention of OIC, three RCTs compared laxatives with other laxatives, finding no clear differences in effectivity of the laxatives used. One cohort study showed a significant benefit of magnesium oxide compared with no laxative. One RCT found a significant benefit for the PAMORA naldemedine compared with magnesium oxide. Preventive use of oxycodone/naloxone did not show a significant difference in two out of three other studies compared to oxycodone or fentanyl. A meta-analysis was not possible. Regarding the treatment of OIC, two RCTs compared laxatives, of which one RCT found that polyethylene glycol was significantly more effective than sennosides. Seven studies compared an opioid antagonist (naloxone, methylnaltrexone or naldemedine) with placebo and three studies compared different dosages of opioid antagonists. These studies with opioid antagonists were used for the meta-analysis. Oxycodone/naloxone showed a significant improvement in Bowel Function Index compared to oxycodone with laxatives (MD -13.68; 95 % CI -18.38 to -8.98; I Conclusions: Magnesium oxide and naldemedine are most likely effective for prevention of OIC in cancer patients. Naloxone in a fixed combination with oxycodone, naldemedine and methylnaltrexone effectively treat OIC in cancer patients with acceptable adverse events. However, their effect has not been compared to standard (osmotic and stimulant) laxatives. More studies comparing standard laxatives with each other and with opioid antagonists are necessary before recommendations for clinical practice can be made.
MeSH term(s)	Humans ; Laxatives/therapeutic use ; Analgesics, Opioid/adverse effects ; Narcotic Antagonists/therapeutic use ; Narcotic Antagonists/adverse effects ; Constipation/chemically induced ; Constipation/drug therapy ; Constipation/prevention & control ; Oxycodone/therapeutic use ; Oxycodone/adverse effects ; Opioid-Induced Constipation/drug therapy ; Opioid-Induced Constipation/etiology ; Magnesium Oxide/adverse effects ; Cohort Studies ; Naloxone/therapeutic use ; Naloxone/adverse effects ; Polyethylene Glycols/therapeutic use ; Neoplasms/drug therapy ; Drug-Related Side Effects and Adverse Reactions/drug therapy ; Quaternary Ammonium Compounds ; Naltrexone/analogs & derivatives
Chemical Substances	Laxatives ; Analgesics, Opioid ; Narcotic Antagonists ; methylnaltrexone (0RK7M7IABE) ; Oxycodone (CD35PMG570) ; Magnesium Oxide (3A3U0GI71G) ; Naloxone (36B82AMQ7N) ; Polyethylene Glycols (3WJQ0SDW1A) ; Quaternary Ammonium Compounds ; Naltrexone (5S6W795CQM)
Language	English
Publishing date	2024-03-01
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	125102-8
ISSN	1532-1967 ; 0305-7372
ISSN (online)	1532-1967
ISSN	0305-7372
DOI	10.1016/j.ctrv.2024.102704
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Article ; Online: New perspective on the pathophysiology of panic: merging serotonin and opioids in the periaqueductal gray.

Graeff, F G

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

2012 Volume 45, Issue 4, Page(s) 366–375

Abstract: Panic disorder patients are vulnerable to recurrent panic attacks. Two neurochemical hypotheses have been proposed to explain this susceptibility. The first assumes that panic patients have deficient serotonergic inhibition of neurons localized in the ... ...

Abstract	Panic disorder patients are vulnerable to recurrent panic attacks. Two neurochemical hypotheses have been proposed to explain this susceptibility. The first assumes that panic patients have deficient serotonergic inhibition of neurons localized in the dorsal periaqueductal gray matter of the midbrain that organize defensive reactions to cope with proximal threats and of sympathomotor control areas of the rostral ventrolateral medulla that generate most of the neurovegetative symptoms of the panic attack. The second suggests that endogenous opioids buffer normal subjects from the behavioral and physiological manifestations of the panic attack, and their deficit brings about heightened suffocation sensitivity and separation anxiety in panic patients, making them more vulnerable to panic attacks. Experimental results obtained in rats performing one-way escape in the elevated T-maze, an animal model of panic, indicate that the inhibitory action of serotonin on defense is connected with activation of endogenous opioids in the periaqueductal gray. This allows reconciliation of the serotonergic and opioidergic hypotheses of panic pathophysiology, the periaqueductal gray being the fulcrum of serotonin-opioid interaction.
MeSH term(s)	Animals ; Humans ; Opioid Peptides/physiology ; Panic Disorder/physiopathology ; Periaqueductal Gray/metabolism ; Periaqueductal Gray/physiopathology ; Rats ; Serotonin/physiology
Chemical Substances	Opioid Peptides ; Serotonin (333DO1RDJY)
Language	English
Publishing date	2012-03-22
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	786234-9
ISSN	1414-431X ; 0100-879X
ISSN (online)	1414-431X
ISSN	0100-879X
DOI	10.1590/s0100-879x2012007500036
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Article ; Online: Reactivity of eumelanin building blocks: A DFT study of monomers and dimers.

Alves, Gabriel G B / Lavarda, Francisco C / Graeff, Carlos F O / Batagin-Neto, Augusto

Journal of molecular graphics & modelling

2020 Volume 98, Page(s) 107609

Abstract: Melanins are natural pigments with important biological properties and have been considered promising materials for several bio-electronic applications. In spite of it, until now there is no satisfactory understanding of the macromolecular structure of ... ...

Abstract	Melanins are natural pigments with important biological properties and have been considered promising materials for several bio-electronic applications. In spite of it, until now there is no satisfactory understanding of the macromolecular structure of these compounds. In this work, we have employed electronic structure calculations to evaluate the local reactivity on monomeric building blocks of eumelanin and on a varied combination of these units (dimers). The reactivity studies were accomplished by Condensed-to-Atoms Fukui Indexes in a DFT approach. The results have evidenced a dominance order in the reactivity of the building units that guides the polymerization process of melanin. In addition, from the differences of the local reactivities it was possible to better understand the reactions that can take place during eumelanin synthesis and estimate how they could be influenced by experimental conditions.
MeSH term(s)	Melanins ; Molecular Structure ; Polymers
Chemical Substances	Melanins ; Polymers ; eumelanin (12627-86-0)
Language	English
Publishing date	2020-04-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1396450-1
ISSN	1873-4243 ; 1093-3263
ISSN (online)	1873-4243
ISSN	1093-3263
DOI	10.1016/j.jmgm.2020.107609
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Article ; Online: New perspective on the pathophysiology of panic

F.G. Graeff

Brazilian Journal of Medical and Biological Research, Vol 45, Iss 4, Pp 366-

merging serotonin and opioids in the periaqueductal gray

2012 Volume 375

Abstract	Panic disorder patients are vulnerable to recurrent panic attacks. Two neurochemical hypotheses have been proposed to explain this susceptibility. The first assumes that panic patients have deficient serotonergic inhibition of neurons localized in the dorsal periaqueductal gray matter of the midbrain that organize defensive reactions to cope with proximal threats and of sympathomotor control areas of the rostral ventrolateral medulla that generate most of the neurovegetative symptoms of the panic attack. The second suggests that endogenous opioids buffer normal subjects from the behavioral and physiological manifestations of the panic attack, and their deficit brings about heightened suffocation sensitivity and separation anxiety in panic patients, making them more vulnerable to panic attacks. Experimental results obtained in rats performing one-way escape in the elevated T-maze, an animal model of panic, indicate that the inhibitory action of serotonin on defense is connected with activation of endogenous opioids in the periaqueductal gray. This allows reconciliation of the serotonergic and opioidergic hypotheses of panic pathophysiology, the periaqueductal gray being the fulcrum of serotonin-opioid interaction.
Keywords	Panic ; Animal model ; Periaqueductal gray ; Serotonin ; Opioids ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	302
Language	English
Publishing date	2012-04-01T00:00:00Z
Publisher	Associação Brasileira de Divulgação Científica
Document type	Article ; Online
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Article ; Online: New perspective on the pathophysiology of panic

F.G. Graeff

Brazilian Journal of Medical and Biological Research, Vol 45, Iss 4, Pp 366-

merging serotonin and opioids in the periaqueductal gray

2012 Volume 375

Abstract	Panic disorder patients are vulnerable to recurrent panic attacks. Two neurochemical hypotheses have been proposed to explain this susceptibility. The first assumes that panic patients have deficient serotonergic inhibition of neurons localized in the dorsal periaqueductal gray matter of the midbrain that organize defensive reactions to cope with proximal threats and of sympathomotor control areas of the rostral ventrolateral medulla that generate most of the neurovegetative symptoms of the panic attack. The second suggests that endogenous opioids buffer normal subjects from the behavioral and physiological manifestations of the panic attack, and their deficit brings about heightened suffocation sensitivity and separation anxiety in panic patients, making them more vulnerable to panic attacks. Experimental results obtained in rats performing one-way escape in the elevated T-maze, an animal model of panic, indicate that the inhibitory action of serotonin on defense is connected with activation of endogenous opioids in the periaqueductal gray. This allows reconciliation of the serotonergic and opioidergic hypotheses of panic pathophysiology, the periaqueductal gray being the fulcrum of serotonin-opioid interaction.
Keywords	Panic ; Animal model ; Periaqueductal gray ; Serotonin ; Opioids ; Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	302
Language	English
Publishing date	2012-04-01T00:00:00Z
Publisher	Associação Brasileira de Divulgação Científica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Date fruit melanin is primarily based on (-)-epicatechin proanthocyanidin oligomers.

Alam, Muneeba Zubair / Okonkwo, Clinton Emeka / Cachaneski-Lopes, João P / Graeff, Carlos F O / Batagin-Neto, Augusto / Tariq, Saeed / Varghese, Sabu / O'Connor, Matthew J / Albadri, Abuzar E / Webber, J Beau W / Tarique, Mohammed / Ayyash, Mutamed / Kamal-Eldin, Afaf

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4863

Abstract: ... its importance in plant biology and medicinal applications, e.g. photoprotection, radical scavenging ... paramagnetic resonance (EPR) spectroscopy revealed a g-factor in the range 2.0034-2.005. Density functional ...

Abstract	Plant-based melanin seems to be abundant, but it did not receive scientific attention despite its importance in plant biology and medicinal applications, e.g. photoprotection, radical scavenging, antimicrobial properties, etc. Date fruit melanin (DM) has complex, graphene-like, polymeric structure that needs characterization to understand its molecular properties and potential applications. This study provides the first investigation of the possible molecular composition of DM. High performance size-exclusion chromatography (HPSEC) suggested that DM contains oligomeric structures (569-3236 Da) and transmission electron microscopy (TEM) showed agglomeration of these structures in granules of low total porosity (10-1000 Å). Nuclear magnetic resonance (NMR) spectroscopy provided evidence for the presence of oligomeric proanthocyanidins and electron paramagnetic resonance (EPR) spectroscopy revealed a g-factor in the range 2.0034-2.005. Density functional theory (DFT) calculations suggested that the EPR signals can be associated with oligomeric proanthocyanidin structures having 4 and above molecular units of (-)-epicatechin. The discovery of edible melanin in date fruits and its characterization are expected to open a new area of research on its significance to nutritional and sensory characteristics of plant-based foods.
MeSH term(s)	Proanthocyanidins/chemistry ; Catechin/analysis ; Phoeniceae ; Melanins/analysis ; Fruit/chemistry
Chemical Substances	proanthocyanidin (18206-61-6) ; Proanthocyanidins ; Catechin (8R1V1STN48) ; Melanins
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55467-x
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Article ; Online: Potential benefits of using radioactive ion beams for range margin reduction in carbon ion therapy.

Sokol, Olga / Cella, Laura / Boscolo, Daria / Horst, Felix / Oliviero, Caterina / Pacelli, Roberto / Palma, Giuseppe / De Simoni, Micol / Conson, Manuel / Caroprese, Mara / Weber, Ulrich / Graeff, Christian / Parodi, Katia / Durante, Marco

Scientific reports

2022 Volume 12, Issue 1, Page(s) 21792

Abstract: Sharp dose gradients and high biological effectiveness make ions such ... ...

Abstract	Sharp dose gradients and high biological effectiveness make ions such as
MeSH term(s)	Humans ; Tomography, X-Ray Computed ; Heavy Ion Radiotherapy/methods ; Positron-Emission Tomography/methods ; Ions ; Neoplasms/radiotherapy ; Carbon ; Radiotherapy Planning, Computer-Assisted/methods
Chemical Substances	Ions ; Carbon (7440-44-0)
Language	English
Publishing date	2022-12-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-26290-z
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Article ; Online: CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms.

Deshpande, Deepak A / Guedes, Alonso G P / Graeff, Richard / Dogan, Soner / Subramanian, Subbaya / Walseth, Timothy F / Kannan, Mathur S

Mediators of inflammation

2018 Volume 2018, Page(s) 8942042

Abstract: Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness. Inflammatory cytokines alter calcium ( ... ...

Abstract	Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness. Inflammatory cytokines alter calcium (Ca
MeSH term(s)	ADP-ribosyl Cyclase 1/metabolism ; Animals ; Calcium Signaling/physiology ; Cyclic ADP-Ribose/metabolism ; Humans ; Respiratory System/metabolism ; Signal Transduction/physiology
Chemical Substances	Cyclic ADP-Ribose (119340-53-3) ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6)
Language	English
Publishing date	2018-02-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2018/8942042
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Article ; Online: Eggs and Magnetism: New Approaches for Schistosomiasis Diagnosis.

Candido, Renata R F / St Pierre, Timothy G / Morassutti, Alessandra L / Graeff-Teixeira, Carlos / Jones, Malcolm K

Trends in parasitology

2018 Volume 34, Issue 4, Page(s) 267–271

Abstract: To date, reliable techniques that can provide accurate information on the local and global prevalence of schistosomiasis are still associated with high costs or labour-intensive processes. Here we discuss old and new concepts for diagnostic approaches, ... ...

Abstract	To date, reliable techniques that can provide accurate information on the local and global prevalence of schistosomiasis are still associated with high costs or labour-intensive processes. Here we discuss old and new concepts for diagnostic approaches, and we highlight structural properties of schistosome eggshells that result in their affinity for magnetic materials as a new diagnostic approach.
MeSH term(s)	Animals ; Diagnostic Techniques and Procedures/trends ; Humans ; Magnetics ; Ovum/chemistry ; Parasitology/methods ; Schistosoma/chemistry ; Schistosomiasis/diagnosis
Language	English
Publishing date	2018-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2036227-4
ISSN	1471-5007 ; 1471-4922
ISSN (online)	1471-5007
ISSN	1471-4922
DOI	10.1016/j.pt.2018.01.003
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