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  1. Book: Chen xian zhang, wang shou ren, li zhi

    Song, Zhiming / Wang, Xiyuan / Chen, Qinghui

    (Zhong guo li dai si xiang jia ; 13 ; 中國歷代思想家 ; 13)

    1999  

    Institution 中華文化復興運動總會
    Author's details Song zhi ming, wang xi yuan, chen qing hui zhu
    Series title Zhong guo li dai si xiang jia ; 13
    中國歷代思想家 ; 13
    Language Chinese
    Size 327 p, ill, 21 cm
    Edition Geng xin ban
    Publisher Tai wan shang wu yin shu guan
    Publishing place Tai bei
    Document type Book
    ISBN 9570515821 ; 9789570515824
    Database Former special subject collection: coastal and deep sea fishing

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  2. Article ; Online: Progress of engineered bacteria for tumour therapy.

    Xia, Xue / Zhang, Jing-Wen / Zhao, Bing / Zhang, Min / Chen, Zhang-Ren / Zhang, Bing-Feng / Ji, Yu-Long / Wang, Xia / Xiong, Wen-Min / Li, Jia-Wei / Lv, Qiao-Li

    International immunopharmacology

    2024  Volume 132, Page(s) 111935

    Abstract: Finding novel therapeutic modalities, improving drug delivery efficiency and targeting, and reducing the immune escape of tumor cells are currently hot topics in the field of tumor therapy. Bacterial therapeutics have proven highly effective in ... ...

    Abstract Finding novel therapeutic modalities, improving drug delivery efficiency and targeting, and reducing the immune escape of tumor cells are currently hot topics in the field of tumor therapy. Bacterial therapeutics have proven highly effective in preventing tumor spread and recurrence, used alone or in combination with traditional therapies. In recent years, a growing number of researchers have significantly improved the targeting and penetration of bacteria by using genetic engineering technology, which has received widespread attention in the field of tumor therapy. In this paper, we provide an overview and assessment of the advancements made in the field of tumor therapy using genetically engineered bacteria. We cover three major aspects: the development of engineered bacteria, their integration with other therapeutic techniques, and the current state of clinical trials. Lastly, we discuss the limitations and challenges that are currently being faced in the utilization of engineered bacteria for tumor therapy.
    MeSH term(s) Humans ; Neoplasms/therapy ; Neoplasms/immunology ; Animals ; Genetic Engineering ; Bacteria/genetics ; Immunotherapy/methods ; Drug Delivery Systems
    Language English
    Publishing date 2024-04-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2024.111935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: [Expressions of microRNAs in prostatic diseases: Advances in studies].

    Yan, Zhang-Ren / Chen, Qi / Wang, Wan-Chun

    Zhonghua nan ke xue = National journal of andrology

    2020  Volume 24, Issue 9, Page(s) 824–828

    Abstract: MicroRNAs (miRNAs) are a class of non-coding RNAs with about 22 nucleotides, which regulate a variety of biological processes, cells and gene expressions, playing significant roles in cells and disease progression. An insight into the relationship ... ...

    Abstract MicroRNAs (miRNAs) are a class of non-coding RNAs with about 22 nucleotides, which regulate a variety of biological processes, cells and gene expressions, playing significant roles in cells and disease progression. An insight into the relationship between the miRNA expressions and prostatic diseases may contribute to a better understanding of prostatic diseases from the perspective of molecular biology, explanation of their pathogenesis, and guidance for their clinical treatment and prognosis. At present, many studies are reported on prostate cancer-related miRNAs, involving the development, progression, pathogenesis, diagnosis, prognosis, and treatment of the disease. However, relatively fewer studies are seen on the miRNA expressions relating to prostatitis and BPH. This article briefly describes the origin and biological role of miRNAs and reviews the advances in the studies of the expressions of related miRNAs in prostatitis, BPH and prostate cancer, aiming for a deeper insight into the roles of miRNAs in prostatic diseases and some new ideas for their clinical diagnosis and treatment as well as for the future studies of miRNAs in prostatic diseases.
    Language Chinese
    Publishing date 2020-03-24
    Publishing country China
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6577: Show issues Location:
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  4. Article ; Online: Drug screening against F13 protein, the target of tecovirimat, as potential therapies for monkeypox virus.

    Chen, Zhang-Ren / Lv, Qiao-Li / Peng, Hong-Wei / Liu, Xiao-Yi / Hu, Wen-Lei / Hu, Jin-Fang

    The Journal of infection

    2022  Volume 86, Issue 2, Page(s) 154–225

    MeSH term(s) Humans ; Monkeypox virus ; Drug Evaluation, Preclinical ; Benzamides
    Chemical Substances Benzamides
    Language English
    Publishing date 2022-11-25
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.11.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 48: Show issues

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  5. Article ; Online: Acute cerebral infarction following type B aortic dissection: A case report.

    Zhang, Linming / Wei, Yangyan / Chen, Han / Ren, Haibo

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-03-27
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.03.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2831: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Online: Large Language Models are Zero Shot Hypothesis Proposers

    Qi, Biqing / Zhang, Kaiyan / Li, Haoxiang / Tian, Kai / Zeng, Sihang / Chen, Zhang-Ren / Zhou, Bowen

    2023  

    Abstract: Significant scientific discoveries have driven the progress of human civilisation. The explosion of scientific literature and data has created information barriers across disciplines that have slowed the pace of scientific discovery. Large Language ... ...

    Abstract Significant scientific discoveries have driven the progress of human civilisation. The explosion of scientific literature and data has created information barriers across disciplines that have slowed the pace of scientific discovery. Large Language Models (LLMs) hold a wealth of global and interdisciplinary knowledge that promises to break down these information barriers and foster a new wave of scientific discovery. However, the potential of LLMs for scientific discovery has not been formally explored. In this paper, we start from investigating whether LLMs can propose scientific hypotheses. To this end, we construct a dataset consist of background knowledge and hypothesis pairs from biomedical literature. The dataset is divided into training, seen, and unseen test sets based on the publication date to control visibility. We subsequently evaluate the hypothesis generation capabilities of various top-tier instructed models in zero-shot, few-shot, and fine-tuning settings, including both closed and open-source LLMs. Additionally, we introduce an LLM-based multi-agent cooperative framework with different role designs and external tools to enhance the capabilities related to generating hypotheses. We also design four metrics through a comprehensive review to evaluate the generated hypotheses for both ChatGPT-based and human evaluations. Through experiments and analyses, we arrive at the following findings: 1) LLMs surprisingly generate untrained yet validated hypotheses from testing literature. 2) Increasing uncertainty facilitates candidate generation, potentially enhancing zero-shot hypothesis generation capabilities. These findings strongly support the potential of LLMs as catalysts for new scientific discoveries and guide further exploration.

    Comment: Instruction Workshop @ NeurIPS 2023
    Keywords Computer Science - Computation and Language
    Subject code 160
    Publishing date 2023-11-10
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Molecular insights into sarcopenia: ferroptosis-related genes as diagnostic and therapeutic targets.

    Chen, Yanzhong / Zhang, Yaonan / Zhang, Sihan / Ren, Hong

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–19

    Abstract: Ferroptosis, characterized by iron accumulation and lipid peroxidation, leads to cell death. Growing evidence suggests the involvement of ferroptosis in sarcopenia. However, the fundamental ferroptosis-related genes (FRGs) for sarcopenia diagnosis, ... ...

    Abstract Ferroptosis, characterized by iron accumulation and lipid peroxidation, leads to cell death. Growing evidence suggests the involvement of ferroptosis in sarcopenia. However, the fundamental ferroptosis-related genes (FRGs) for sarcopenia diagnosis, prognosis, and therapy remain elusive. This study aimed to identify molecular biomarkers of ferroptosis in sarcopenia patients. Gene expression profiles were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) between normal and sarcopenia samples were identified using the 'limma' package in R software. FRGs were extracted from GeneCards and FerrDB databases. Functional enrichment analysis determined the roles of DEGs using the 'clusterProfiler' package. A protein-protein network was constructed using Cytoscape software. Immune infiltration analysis and receiver operating characteristic (ROC) analysis were performed. mRNA-miRNA, mRNA-TF, and mRNA-drug interactions were predicted using ENCORI, hTFtarget, and CHIPBase databases. The network was visualized using Cytoscape. We identified 46 FRGs in sarcopenia. Functional enrichment analysis revealed their involvement in critical biological processes, including responses to steroid hormones and glucocorticoids. KEGG enrichment analysis implicated pathways such as carbon metabolism, ferroptosis, and glyoxylate in sarcopenia. Totally, 11 hub genes were identified, and ROC analysis demonstrated their potential as sensitive and specific markers for sarcopenia in both datasets. Additionally, differences in immune cell infiltration were observed between normal and sarcopenia samples. The hub genes identified in this study are closely associated with ferroptosis in sarcopenia and can effectively differentiate sarcopenia from controls. CDKN1A, CS, DLD, FOXO1, HSPB1, LDHA, MDH2, and YWHAZ show high sensitivity and specificity for sarcopenia diagnosis.Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2298390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: [Effect of Qianlie Jiedu Huoxue Decoction on cytokines in prostatic fluid of patients with type Ⅲ prostatitis].

    Wang, Wan-Chun / Chen, Jun / Chen, Qi / Yan, Zhang-Ren / Yi, Jun / Sun, Bo / Jiang, Xin

    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology

    2021  Volume 36, Issue 5, Page(s) 508–510

    MeSH term(s) Cytokines/metabolism ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Male ; Prostatitis/drug therapy ; Prostatitis/metabolism
    Chemical Substances Cytokines ; Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2021-03-08
    Publishing country China
    Document type Journal Article
    ISSN 1000-6834
    ISSN 1000-6834
    DOI 10.12047/j.cjap.6013.2020.108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Production of Aromatic Hydrocarbons from Co-Hydropyrolysis of Biomass Components and HDPE with Application of Modified HZSM-5 Catalyst.

    Ren, Long / Xu, Yupu / Chen, Wenjun / Zhang, Changsen

    Chemistry & biodiversity

    2024  , Page(s) e202400150

    Abstract: Experiments were conducted in this study on the co-hydropyrolysis of three components of biomass (cellulose, hemicellulose, and lignin) and HDPE by using SR-Pd/Trap-HZ-5 as catalyst. To control the variable, we use the same experiment conditions in co- ... ...

    Abstract Experiments were conducted in this study on the co-hydropyrolysis of three components of biomass (cellulose, hemicellulose, and lignin) and HDPE by using SR-Pd/Trap-HZ-5 as catalyst. To control the variable, we use the same experiment conditions in co-hydropyrolysis: Si/Al ratio of 50, Pd load 1 %, catalyst to reactant ratio of 1 : 10, 1 MPa, 400 °C, reaction time 1 h. Use XRD, TEM, BET, and NH
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202400150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: COVID-19 and gastroenteric manifestations.

    Chen, Zhang-Ren / Liu, Jing / Liao, Zhi-Guo / Zhou, Jian / Peng, Hong-Wei / Gong, Fei / Hu, Jin-Fang / Zhou, Ying

    World journal of clinical cases

    2021  Volume 9, Issue 19, Page(s) 4990–4997

    Abstract: Coronavirus disease 2019 (COVID-19), caused by the infection of a novel coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)], has become a pandemic. The infection has resulted in about one hundred million COVID-19 cases and millions ...

    Abstract Coronavirus disease 2019 (COVID-19), caused by the infection of a novel coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)], has become a pandemic. The infection has resulted in about one hundred million COVID-19 cases and millions of deaths. Although SARS-CoV-2 mainly spreads through the air and impairs the function of the respiratory system, it also attacks the gastrointestinal epithelial cells through the same receptor, angiotensin converting enzyme 2 receptor, which results in gastroenteric symptoms and potential fecal-oral transmission. Besides the infection of SARS-CoV-2, the treatments of COVID-19 also contribute to the gastroenteric manifestations due to the adverse drug reactions of anti-COVID-19 drugs. In this review, we update the clinical features, basic studies, and clinical practices of COVID-19-associated gastroenteric manifestations.
    Language English
    Publishing date 2021-07-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i19.4990
    Database MEDical Literature Analysis and Retrieval System OnLINE

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