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  1. Article ; Online: Occlusive Retinal Vasculitis After a Single Injection of Pegcetacoplan.

    Abi Karam, Mariana / Davis, Janet L / Schwartz, Stephen G

    Journal of vitreoretinal diseases

    2024  Volume 8, Issue 2, Page(s) 205–209

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Case Reports
    ISSN 2474-1272
    ISSN (online) 2474-1272
    DOI 10.1177/24741264241228648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online ; E-Book: Endophthalmitis in clinical practice

    Flynn Jr., Harry W. / Batra, Nidhi Relhan / Schwartz, Stephen G. / Grzybowski, Andrzej

    (In clinical practice)

    2018  

    Author's details Harry W. Flynn Jr., Nidhi Relhan Batra, Stephen G. Schwartz, Andrzej Grzybowski
    Series title In clinical practice
    Keywords Medicine ; Ophthalmology
    Subject code 617.7
    Language English
    Size 1 Online-Ressource (XVII, 211 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019582867
    ISBN 978-3-319-66351-7 ; 9783319663500 ; 3-319-66351-8 ; 331966350X
    DOI 10.1007/978-3-319-66351-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Genetics and Age-Related Macular Degeneration: A Practical Review for Clinicians.

    Nguyen, Julia / Brantley, Milam A / Schwartz, Stephen G

    Frontiers in bioscience (Scholar edition)

    2024  Volume 16, Issue 1, Page(s) 3

    Abstract: Age-related macular degeneration (AMD) is a multifactorial genetic disease, with at least 52 identifiable associated gene variants at 34 loci, including variants ... ...

    Abstract Age-related macular degeneration (AMD) is a multifactorial genetic disease, with at least 52 identifiable associated gene variants at 34 loci, including variants in
    MeSH term(s) Humans ; Proteins ; Macular Degeneration/drug therapy ; Macular Degeneration/genetics ; Dietary Supplements ; High-Temperature Requirement A Serine Peptidase 1/genetics ; Vascular Endothelial Growth Factors/genetics ; Vascular Endothelial Growth Factors/therapeutic use ; Polymorphism, Single Nucleotide ; Risk Factors
    Chemical Substances Proteins ; High-Temperature Requirement A Serine Peptidase 1 (EC 3.4.21.-) ; Vascular Endothelial Growth Factors
    Language English
    Publishing date 2024-03-27
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 2565100-6
    ISSN 1945-0524 ; 1945-0516
    ISSN (online) 1945-0524
    ISSN 1945-0516
    DOI 10.31083/j.fbs1601003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7071: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Infectious Endophthalmitis vs Noninfectious "Pseudohypopyon" After Intravitreal Triamcinolone Acetonide.

    Schwartz, Stephen G / Flynn, Harry W / Smiddy, William E

    Journal of vitreoretinal diseases

    2023  Volume 7, Issue 2, Page(s) 178–181

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Case Reports
    ISSN 2474-1272
    ISSN (online) 2474-1272
    DOI 10.1177/24741264231153027
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  5. Article ; Online: Jacques Daviel performed the first documented planned primary cataract extraction on Sep. 18, 1750.

    Leffler, Christopher T / Hogewind, B Frits / Schwartz, Stephen G / Grzybowski, Andrzej

    Eye (London, England)

    2023  

    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Letter
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-023-02874-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3010: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 603: Show issues

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  6. Article ; Online: Update on current pharmacologic therapies for diabetic retinopathy.

    Muns, Sofía M / Villegas, Victor M / Flynn, Harry W / Schwartz, Stephen G

    Expert opinion on pharmacotherapy

    2023  Volume 24, Issue 14, Page(s) 1577–1593

    Abstract: Introduction: Diabetic retinopathy is a major cause of visual loss worldwide. The most important clinical findings include diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR).: Areas covered: PubMed was used for our literature ... ...

    Abstract Introduction: Diabetic retinopathy is a major cause of visual loss worldwide. The most important clinical findings include diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR).
    Areas covered: PubMed was used for our literature review. Articles from 1995 to 2023 were included. Pharmacologic treatment of diabetic retinopathy generally involves the use of intravitreal anti-vascular endothelial growth factor (VEGF) therapy for DME and PDR. Corticosteroids remain important second-line therapies for patients with DME. Most emerging therapies focus on newly identified inflammatory mediators and biochemical signaling pathways involved in disease pathogenesis.
    Expert opinion: Emerging anti-VEGF modalities, integrin antagonists, and anti-inflammatory agents have the potential to improve outcomes with reduced treatment burdens.
    MeSH term(s) Humans ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/complications ; Angiogenesis Inhibitors ; Macular Edema/drug therapy ; Macular Edema/etiology ; Vascular Endothelial Growth Factor A ; Glucocorticoids/therapeutic use ; Intravitreal Injections ; Diabetes Mellitus/drug therapy
    Chemical Substances Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Glucocorticoids
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1080/14656566.2023.2230139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5130: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Clinical spectrum of blunted foveal contour.

    Muns, Sofía M / Villegas, Victor M / Schwartz, Stephen G

    Therapeutic advances in ophthalmology

    2022  Volume 14, Page(s) 25158414211070864

    Abstract: Foveal hypoplasia is the absence of a foveal depression and the presence of the ganglion cell layer in the foveola. A spectrum of clinical characteristics, including normal or variably decreased visual acuity, has been described in patients with blunted ... ...

    Abstract Foveal hypoplasia is the absence of a foveal depression and the presence of the ganglion cell layer in the foveola. A spectrum of clinical characteristics, including normal or variably decreased visual acuity, has been described in patients with blunted foveal contours. Multiple systemic and ophthalmologic conditions including albinism, aniridia, nanophthalmos, prematurity, and fovea plana have been associated with this anomaly. This article illustrates select clinical conditions characterized by a blunted foveal contour. Given the heterogeneity of findings, a thorough medical history and detailed physical and ocular examinations are usually sufficient for the clinician to make the correct diagnosis.
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2515-8414
    ISSN (online) 2515-8414
    DOI 10.1177/25158414211070864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Extracapsular cataract extraction in Europe prior to Jacques Daviel.

    Grzybowski, Andrzej / Claoué, Charles / Schwartz, Stephen G

    Acta ophthalmologica

    2022  Volume 101, Issue 3, Page(s) 349–352

    Abstract: The first successful planned extracapsular cataract extraction was reported by Jacques Daviel in 1752. The history of European cataract surgery in the first half of the 18th century, immediately preceding Daviel's report, contains interesting information ...

    Abstract The first successful planned extracapsular cataract extraction was reported by Jacques Daviel in 1752. The history of European cataract surgery in the first half of the 18th century, immediately preceding Daviel's report, contains interesting information that explains the foundations of this accomplishment. Daviel himself credited the prior work of Francois Pourfour du Petit. Other important advances were reported by Michel Brisseau, Antoine Maitre-Jan, Jean Méry and others. A critical insight during this time period was the realization that the cataract was, in fact, the opacified crystalline lens, rather than a membrane or opacity located anterior to the lens.
    MeSH term(s) Humans ; Lens, Crystalline/surgery ; Cataract/epidemiology ; Europe/epidemiology ; Cataract Extraction ; Ophthalmology
    Language English
    Publishing date 2022-11-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.15282
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    Ul I Zs.90: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: AN 82-YEAR-OLD WOMAN WITH RETINAL VASCULAR SHEATHING AND VITREOUS HEMORRHAGE.

    Hudson, Julia L / Schwartz, Stephen G / Davis, Janet L

    Retinal cases & brief reports

    2022  Volume 17, Issue 4S, Page(s) S36–S40

    Abstract: Purpose: This report describes a case of hereditary transthyretin amyloidosis in an 82-year-old woman who presented with bilateral retinal arteriolar vascular sheathing and vitreous hemorrhage in one eye.: Methods: The patient underwent a full ... ...

    Abstract Purpose: This report describes a case of hereditary transthyretin amyloidosis in an 82-year-old woman who presented with bilateral retinal arteriolar vascular sheathing and vitreous hemorrhage in one eye.
    Methods: The patient underwent a full history, physical examination, genetic workup, and cardiac imaging to establish the diagnosis. Fundus photographs, optical coherence tomography, fluorescein angiography, and indocyanine green angiography were performed throughout the patient's treatment course.
    Results: Fundus examination demonstrated segmental sheathing of the retinal arterioles, telangiectasias, and intraretinal hemorrhages in both eyes without neovascularization. Fluorescein angiography revealed delayed filling of the nasal retinal arterioles in the right eye with severe temporal nonperfusion and areas hyperfluorescent segmental sheathing in both eyes. Ocular coherence tomography demonstrated retinal vessels with hyperreflective thickened walls. Cardiac amyloid nuclear scan was consistent with transthyretin-mediated amyloidosis amyloid heart disease, and genetic testing confirmed a heterozygous pathogenic transthyretin mutation: c.290 C>A (p.Ser97Tyr) also known as Ser77Tyr.
    Conclusion: Amyloidosis should be considered in the differential of vasculitis and vitreous hemorrhage with or without significant vitreous opacities. Ophthalmologists aware of this diagnosis should complete a full review of systems with specific focus on cardiac history and symptoms of peripheral neuropathy when amyloidosis is in the differential.
    MeSH term(s) Female ; Humans ; Aged, 80 and over ; Vitreous Hemorrhage ; Prealbumin/genetics ; Retinal Diseases/diagnosis ; Eye Diseases/diagnosis ; Amyloid Neuropathies, Familial ; Fluorescein Angiography ; Tomography, Optical Coherence
    Chemical Substances Prealbumin
    Language English
    Publishing date 2022-09-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: New Approaches to Overcoming Antimicrobial Resistance in Endophthalmitis.

    Garcia O'Farrill, Noraliz / Abi Karam, Mariana / Villegas, Victor M / Flynn, Harry W / Grzybowski, Andrzej / Schwartz, Stephen G

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 3

    Abstract: Endophthalmitis is a rare but vision-threatening infection characterized by marked inflammation of intraocular fluids and tissues, uncommonly seen following surgery and intravitreal injection. Antimicrobials are used worldwide in the prophylaxis and ... ...

    Abstract Endophthalmitis is a rare but vision-threatening infection characterized by marked inflammation of intraocular fluids and tissues, uncommonly seen following surgery and intravitreal injection. Antimicrobials are used worldwide in the prophylaxis and treatment of bacterial and fungal infections of the eye and are standard treatment in the preoperative and postoperative care of surgical patients. However, antimicrobials are reported to be overprescribed in many parts of the world, which contributes to antimicrobial resistance (AMR). AMR complicates the prophylaxis and treatment of endophthalmitis. This article examines the prevalence and mechanisms of AMR in ocular microorganisms, emphasizing the importance of understanding AMR patterns for tailored treatments. It also explores prophylaxis and management strategies for endophthalmitis, with a discussion on the use of intracameral antibiotic administration. The use of prophylactic intracameral antibiotics during cataract surgery is common in many parts of the world but is still controversial in some locations, especially in the US. Finally, it highlights the role of stewardship in ophthalmology and its benefits in the treatment of endophthalmitis.
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17030321
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