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  1. Article ; Online: COVID-19

    Amariles, Pedro

    Agenda Cultural Alma Máter; Núm.; 0124-0854

    enfermedad que nos demanda acciones para engrandecer a la Nación

    2020  Volume 275, Issue : Pandemia: COVID-19

    Keywords covid19
    Language Spanish
    Publishing date 2020-07-16
    Publisher Universidad de Antioquia
    Publishing country co
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Clinical Relevance of Drug Interactions in People Living with Human Immunodeficiency Virus on Antiretroviral Therapy-Update 2022: Systematic Review.

    Amariles, Pedro / Rivera-Cadavid, Mónica / Ceballos, Mauricio

    Pharmaceutics

    2023  Volume 15, Issue 10

    Abstract: Background: The clinical outcomes of antiretroviral drugs may be modified through drug interactions; thus, it is important to update the drug interactions in people living with HIV (PLHIV).: Aim: To update clinically relevant drug interactions in ... ...

    Abstract Background: The clinical outcomes of antiretroviral drugs may be modified through drug interactions; thus, it is important to update the drug interactions in people living with HIV (PLHIV).
    Aim: To update clinically relevant drug interactions in PLHIV on antiretroviral therapy with novel drug interactions published from 2017 to 2022.
    Methods: A systematic review in Medline/PubMed database from July 2017 to December 2022 using the Mesh terms antiretroviral agents and drug interactions or herb-drug interactions or food-drug interactions. Publications with drug interactions in humans, in English or Spanish, and with full-text access were retrieved. The clinical relevance of drug interactions was grouped into five levels according to the gravity and probability of occurrence.
    Results: A total of 366 articles were identified, with 219 (including 87 citation lists) were included, which allowed for the identification of 471 drug interaction pairs; among them, 291 were systematically reported for the first time. In total 42 (14.4%) and 137 (47.1%) were level one and two, respectively, and 233 (80.1%) pairs were explained with the pharmacokinetic mechanism. Among these 291 pairs, protease inhibitors (PIs) and ritonavir/cobicistat-boosted PIs, as well as integrase strand transfer inhibitors (InSTIs), with 70 (24.1%) and 65 (22.3%) drug interaction pairs of levels one and two, respectively, were more frequent.
    Conclusions: In PLHIV on antiretroviral therapy, we identify 291 drug interaction pairs systematically reported for the first time, with 179 (61.5%) being assessed as clinically relevant (levels one and two). The pharmacokinetic mechanism was the most frequently identified. PIs, ritonavir/cobicistat-boosted PIs, and InSTIs were the antiretroviral groups with the highest number of clinically relevant drug interaction pairs (levels one and two).
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15102488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Drugs as Possible Triggers of Takotsubo Cardiomyopathy- Update 2022: Systematic Review.

    Lopera, Valentina / Pereañez, Jaime Andrés / Amariles, Pedro Jose

    Current vascular pharmacology

    2023  Volume 21, Issue 5, Page(s) 304–315

    Abstract: Background: A list of drugs that can induce takotsubo cardiomyopathy (TCM) was published in 2011 and 2016. The aim of the present review was to update this list.: Methods: Similar to the 2011 and 2016 reviews, from April 2015 to May 2022 case reports ...

    Abstract Background: A list of drugs that can induce takotsubo cardiomyopathy (TCM) was published in 2011 and 2016. The aim of the present review was to update this list.
    Methods: Similar to the 2011 and 2016 reviews, from April 2015 to May 2022 case reports of druginduced TCM were identified by a comprehensive search in Medline/PubMed database. The search terms were: takotsubo cardiomyopathy, tako-tsubo cardiomyopathy, stress cardiomyopathy, transientleft- ventricular ballooning syndrome, apical ballooning syndrome, ampulla cardiomyopathy OR broken heart syndrome; together with "iatrogenic", "induced by" OR "drug-induced". Registers published in English or Spanish, in humans, and with full texts were retrieved. Articles that recognized any drug associated with the development of TCM were selected.
    Results: Overall, 184 manuscripts were identified by the search. A total of 39 articles were included after an exhaustive revision. Eighteen drugs as possible triggers of TCM were identified in the current update. Of them, 3 (16.7%) have been previously identified, and 15 (83.3%) are different from the previous reports. Thus, the list of drugs as possible triggers of TCM updated in 2022 includes 72 drugs.
    Conclusion: There are new case reports that link drugs with the development of TCM. The current list is principally made up of drugs that generate sympathetic overstimulation. However, some of the listed drugs do not have a clear link with sympathetic activation.
    MeSH term(s) Humans ; Takotsubo Cardiomyopathy/chemically induced ; Takotsubo Cardiomyopathy/diagnosis ; Takotsubo Cardiomyopathy/complications ; Heart Ventricles
    Language English
    Publishing date 2023-11-24
    Publishing country United Arab Emirates
    Document type Systematic Review ; Journal Article
    ZDB-ID 2192362-0
    ISSN 1875-6212 ; 1570-1611
    ISSN (online) 1875-6212
    ISSN 1570-1611
    DOI 10.2174/1570161121666230517121037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ethical, Economic, Societal, Clinical, and Pharmacology Uncertainties Associated With Milasen and Other Personalized Drugs.

    Amariles, Pedro / Madrigal-Cadavid, Juliana

    The Annals of pharmacotherapy

    2020  Volume 54, Issue 9, Page(s) 937–938

    Language English
    Publishing date 2020-03-04
    Publishing country United States
    Document type Letter
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/1060028020909118
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  5. Article: Clinical Relevance of Drug Interactions with Cannabis: A Systematic Review.

    Lopera, Valentina / Rodríguez, Adriana / Amariles, Pedro

    Journal of clinical medicine

    2022  Volume 11, Issue 5

    Abstract: Concomitant use of cannabis with other drugs may lead to cannabis-drug interactions, mainly due to the pharmacokinetic mechanism involving the family of CYP450 isoenzymes. This narrative systematic review aimed to systematize the available information ... ...

    Abstract Concomitant use of cannabis with other drugs may lead to cannabis-drug interactions, mainly due to the pharmacokinetic mechanism involving the family of CYP450 isoenzymes. This narrative systematic review aimed to systematize the available information regarding clinical relevance of cannabis-drug interactions. We utilized the PubMed/Medline database for this systematic review, using the terms drug interactions and cannabis, between June 2011 and June 2021. Articles with cannabis-drug interactions in humans, in English or Spanish, with full-text access were selected. Two researchers evaluated the article's inclusion. The level of clinical relevance was determined according to the severity and probability of the interaction. Ninety-five articles were identified and twenty-six were included. Overall, 19 pairs of drug interactions with medicinal or recreational cannabis were identified in humans. According to severity and probability, 1, 2, 12, and 4 pairs of cannabis-drug interactions were classified at levels 1 (very high risk), 2 (high risk), 3 (medium risk), and 5 (without risk), respectively. Cannabis-warfarin was classified at level 1, and cannabis-buprenorphine and tacrolimus at level 2. This review provides evidence for both the low probability of the occurrence of clinically relevant drug interactions and the lack of evidence regarding cannabis-drug interactions.
    Language English
    Publishing date 2022-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11051154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Relevancia clínica de las interacciones medicamentosas: Propuesta de actualización de la clasificación, acorde con su gravedad y probabilidad.

    Amariles, Pedro / Madrigal-Cadavid, Juliana / Giraldo, Newar A

    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia

    2021  Volume 38, Issue 2, Page(s) 304–305

    Title translation Clinical relevance of drug interactions: Proposal to update the classification based on the severity and probability of its occurrence.
    MeSH term(s) Drug Interactions ; Pharmaceutical Preparations ; Probability
    Chemical Substances Pharmaceutical Preparations
    Language Spanish
    Publishing date 2021-06-29
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 2048815-4
    ISSN 0717-6341 ; 0716-1018
    ISSN (online) 0717-6341
    ISSN 0716-1018
    DOI 10.4067/S0716-10182021000200304
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  7. Article ; Online: Proposed Individual Risk Score for Educational Institutions: The Role of Health Surveillance for the SARS-CoV-2 Risk Assessment in the Schools.

    Granados, Johan / Ceballos, Mauricio / Amariles, Pedro

    Journal of occupational and environmental medicine

    2021  Volume 63, Issue 4, Page(s) e257–e258

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Colombia/epidemiology ; Humans ; Morbidity ; Occupational Exposure ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Schools ; Transportation
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Letter
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002171
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 155: Show issues Location:
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  8. Article ; Online: Clinical Relevance of Drug Interactions with Cannabis

    Valentina Lopera / Adriana Rodríguez / Pedro Amariles

    Journal of Clinical Medicine, Vol 11, Iss 1154, p

    A Systematic Review

    2022  Volume 1154

    Abstract: Concomitant use of cannabis with other drugs may lead to cannabis–drug interactions, mainly due to the pharmacokinetic mechanism involving the family of CYP450 isoenzymes. This narrative systematic review aimed to systematize the available information ... ...

    Abstract Concomitant use of cannabis with other drugs may lead to cannabis–drug interactions, mainly due to the pharmacokinetic mechanism involving the family of CYP450 isoenzymes. This narrative systematic review aimed to systematize the available information regarding clinical relevance of cannabis–drug interactions. We utilized the PubMed/Medline database for this systematic review, using the terms drug interactions and cannabis, between June 2011 and June 2021. Articles with cannabis–drug interactions in humans, in English or Spanish, with full-text access were selected. Two researchers evaluated the article’s inclusion. The level of clinical relevance was determined according to the severity and probability of the interaction. Ninety-five articles were identified and twenty-six were included. Overall, 19 pairs of drug interactions with medicinal or recreational cannabis were identified in humans. According to severity and probability, 1, 2, 12, and 4 pairs of cannabis–drug interactions were classified at levels 1 (very high risk), 2 (high risk), 3 (medium risk), and 5 (without risk), respectively. Cannabis–warfarin was classified at level 1, and cannabis–buprenorphine and tacrolimus at level 2. This review provides evidence for both the low probability of the occurrence of clinically relevant drug interactions and the lack of evidence regarding cannabis–drug interactions.
    Keywords drug interactions ; medicinal cannabis ; recreational cannabis ; clinical relevance ; severity ; probability ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Pharmacotherapy for hospitalized patients with COVID-19: Waiting or doing?

    Amariles, Pedro / Hincapie-García, Jaime / Julio Montoya, Carlos

    Research in social & administrative pharmacy : RSAP

    2020  Volume 17, Issue 1, Page(s) 2049

    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/epidemiology ; Clinical Decision-Making/methods ; Hospitalization/trends ; Humans ; Randomized Controlled Trials as Topic/methods
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-05-13
    Publishing country United States
    Document type Letter
    ZDB-ID 2192059-X
    ISSN 1934-8150 ; 1551-7411
    ISSN (online) 1934-8150
    ISSN 1551-7411
    DOI 10.1016/j.sapharm.2020.05.010
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  10. Article ; Online: Proposed Individual Risk Score for Educational Institutions Utilizing Risk of Morbidity/Mortality by SARS-CoV-2, Occupational Exposure, and Type of Transportation.

    Granados, Johan / Ceballos, Mauricio / Amariles, Pedro

    Journal of occupational and environmental medicine

    2020  Volume 62, Issue 12, Page(s) e770–e772

    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/epidemiology ; COVID-19/etiology ; COVID-19/prevention & control ; COVID-19/transmission ; Clinical Decision Rules ; Colombia/epidemiology ; Comorbidity ; Female ; Humans ; Male ; Middle Aged ; Occupational Diseases/epidemiology ; Occupational Diseases/etiology ; Occupational Diseases/prevention & control ; Occupational Exposure/prevention & control ; Occupational Exposure/statistics & numerical data ; Risk Assessment ; Risk Factors ; Transportation/methods ; Universities ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-10-19
    Publishing country United States
    Document type Letter
    ZDB-ID 1223932-x
    ISSN 1536-5948 ; 1076-2752
    ISSN (online) 1536-5948
    ISSN 1076-2752
    DOI 10.1097/JOM.0000000000002032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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