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  1. Article: Vittaliana mangrovei Devadatha, Nikita, A.Baghela & V.V.Sarma, gen. nov, sp. nov. (Phaeosphaeriaceae), from Mangroves Near Pondicherry (India), Based on Morphology and Multigene Phylogeny

    Devadatha, Bandarupalli / Mehta, Nikita / Wanasinghe, Dhanushka N / Baghela, Abhishek / Sarma, V. Venkateswara

    Cryptogamie. 2019 Nov. 8, v. 40, no. 7

    2019  

    Abstract: ... mangrovei Devadatha, Nikita, A.Baghela & V.V.Sarma, gen. nov., sp. nov., such as semi-immersed, globose ... Devadatha, Nikita, A.Baghela & V.V.Sarma, gen. nov., is saprobic and occurs in marine environment ...

    Abstract Collection and examination of decaying wood samples of Avicennia marina (Forssk.) Vierh. from Pondicherry mangroves, India, resulted in the discovery of a novel monotypic genus Vittaliana, based on the type species V. mangrovei, which shares close morphological affinities with Italica Wanas., Camporesi & K.D.Hyde and Phaeosphaeriopsis M.P.S. Câmara, M.E. Palm & A.W. Ramaley. The concatenated LSU, SSU, TEF1α and ITS multigene phylogenetic analyses revealed that the new genus clustered together with Italica as a sister clade but forms a separate branch. In addition, morphological variations in Vittaliana mangrovei Devadatha, Nikita, A.Baghela & V.V.Sarma, gen. nov., sp. nov., such as semi-immersed, globose to subglobose ascomata, 5-6 distoseptate, phragmosporous, yellow to golden-yellow ascospores lacking a mucilaginous sheath and any type of ornamentation, and which are strongly constricted at the 4th septum, clearly delineate the new genus from the other genera in Phaeosphaeriaceae. Furthermore, Vittaliana Devadatha, Nikita, A.Baghela & V.V.Sarma, gen. nov., is saprobic and occurs in marine environment. Morphological characteristics and phylogenetic relation of our new species are discussed by comparing with closely related genera in Phaeosphaeriaceae.
    Keywords Avicennia marina ; Phaeosphaeriaceae ; ascomata ; ascospores ; decayed wood ; internal transcribed spacers ; marine environment ; new genus ; new species ; phylogeny ; ribosomal DNA ; saprophytes ; India
    Language English
    Dates of publication 2019-1108
    Size p. 117-132.
    Publishing place Association des Amis des Cryptogames
    Document type Article
    ISSN 1776-100X
    DOI 10.5252/cryptogamiemycologie2019v40a7
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Distributed Discrete-time Exponential Sliding Mode Consensus Protocol for Discrete Multi-Agent System Comprise of Multiple Robotic Arms.

    Joshi, Nikita / Mehta, Axaykumar

    ISA transactions

    2024  

    Abstract: In this paper, a Distributed Discrete-time Exponential Sliding Mode Consensus (DDESMC) protocol is proposed for the leader-follower consensus of a Discrete Multi-Agent System (DMAS). The proposed protocol ensures not only the minimal consensus effort and ...

    Abstract In this paper, a Distributed Discrete-time Exponential Sliding Mode Consensus (DDESMC) protocol is proposed for the leader-follower consensus of a Discrete Multi-Agent System (DMAS). The proposed protocol ensures not only the minimal consensus effort and reaching time for the consensus among the agents but also the minimum consensus deviation in the order of O(T
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2012746-7
    ISSN 1879-2022 ; 0019-0578
    ISSN (online) 1879-2022
    ISSN 0019-0578
    DOI 10.1016/j.isatra.2024.02.027
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  3. Article ; Online: Robust discrete-time super twisting formation protocol for a 6-DOF Quadcopter swarm.

    Modi, Akash / Joshi, Nikita / Mehta, Axaykumar

    ISA transactions

    2023  Volume 143, Page(s) 177–187

    Abstract: This paper contains a discrete-time higher-order sliding mode control for achieving the formation of a 6-Degrees of Freedom (DOF) Quadcopter swarm using the concept of a discrete Multi-agent system (DMAS). A graph theory is used to represent the ... ...

    Abstract This paper contains a discrete-time higher-order sliding mode control for achieving the formation of a 6-Degrees of Freedom (DOF) Quadcopter swarm using the concept of a discrete Multi-agent system (DMAS). A graph theory is used to represent the communication between the Quadcopters and a leader-follower approach of DMAS is used to design the discrete super-twisting (DST) protocol for the formation of a 6-DOF Quadcopter swarm. The DST protocol not only ensures robustness but also reduces the convergence time and the chattering during the formation process of Quadcopters in a swarm. The stability condition of the formation is also derived using the Lyapunov function. The protocol is validated for the formation of 5 Quadcopters in the given pattern. The simulation results show that the formation is achieved in a finite time. Further to show the efficacy of the DST formation protocol, the results are compared with the first-order discrete-time sliding mode controllers designed by switching type reaching law and non-switching type of reaching law. As the first-order discrete-time sliding mode controllers have a significant amount of quasi-sliding mode band (QSMB) in the sliding surface during the operations, the DST protocol of higher-order discrete-time sliding mode control is preferred. From the comparative analysis, it is inferred that the DST protocol performs better for the formation of a 6-DOF Quadcopter swarm.
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2012746-7
    ISSN 1879-2022 ; 0019-0578
    ISSN (online) 1879-2022
    ISSN 0019-0578
    DOI 10.1016/j.isatra.2023.09.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correspondence on "Standards for the classification of pathogenicity of somatic variants in cancer (oncogenicity): Joint recommendations of Clinical Genome Resource (ClinGen), Cancer Genomics Consortium (CGC), and Variant Interpretation for Cancer Consortium (VICC)" by Horak et al.

    Mehta, Nikita / He, Rong / Viswanatha, David S

    Genetics in medicine : official journal of the American College of Medical Genetics

    2022  Volume 24, Issue 9, Page(s) 1986–1988

    MeSH term(s) Genetic Testing ; Genetic Variation/genetics ; Genome, Human/genetics ; Genomics ; Humans ; Neoplasms/genetics ; Virulence
    Language English
    Publishing date 2022-07-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1455352-1
    ISSN 1530-0366 ; 1098-3600
    ISSN (online) 1530-0366
    ISSN 1098-3600
    DOI 10.1016/j.gim.2022.05.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Assessing the impact of COVID-19 on STEM (science, technology, engineering, mathematics) researchers in India.

    Mehta, Nikita / Inamdar, Vedika / Puthillam, Arathy / Chunekar, Shivani / Kapoor, Hansika / Tagat, Anirudh / Subramanyam, Deepa

    Wellcome open research

    2023  Volume 7, Page(s) 157

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.17853.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Quorum sensing-mediated inter-specific conidial anastomosis tube fusion between Colletotrichum gloeosporioides and C. siamense.

    Mehta, Nikita / Baghela, Abhishek

    IMA fungus

    2021  Volume 12, Issue 1, Page(s) 7

    Abstract: Many plant pathogenic filamentous fungi undergo fusion of conidia through conidial anastomosis tubes (CATs), which is believed to facilitate horizontal gene transfer between species. We discovered a remarkable inter-specific CAT fusion between two ... ...

    Abstract Many plant pathogenic filamentous fungi undergo fusion of conidia through conidial anastomosis tubes (CATs), which is believed to facilitate horizontal gene transfer between species. We discovered a remarkable inter-specific CAT fusion between two important plant fungal pathogens Colletotrichum gloeosporioides and C. siamense. In an invitro assay, under no selection pressure, the inter-specific CAT fusion was preferred with higher frequency (25% ± 5%) than intra-specific CAT fusion (11% ± 3.6%). Different stages of CAT fusion viz. CAT induction, homing, and fusion were observed during this inter-specific CAT fusion. The CAT fusion was found to be higher in absence of nutrients and under physiological stresses. This CAT fusion involved a quorum sensing phenomenon, wherein the CAT induction was dependent on conidial density and the putative quorum sensing molecule was extractable in chloroform. Movement of nuclei, mitochondria, and lipid droplets were observed during the CAT fusion. Post CAT fusion, the resulting conidia gave rise to putative heterokaryotic progenies with variable colony characteristics as compared to their parental strains. Few heterokaryons showed variable AFLP banding pattern compared to their parental strains, thereby suggesting a possible genetic exchange between the two species through CAT fusion. The heterokaryotic progenies exhibited varied fitness under different stress conditions. Our study illustrated a possible role of inter-specific CAT fusion in generation of genetic and phenotypic diversity in these fungal pathogens.
    Language English
    Publishing date 2021-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2666116-0
    ISSN 2210-6359 ; 2210-6340
    ISSN (online) 2210-6359
    ISSN 2210-6340
    DOI 10.1186/s43008-021-00058-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Differential Physiological Prerequisites and Gene Expression Profiles of Conidial Anastomosis Tube and Germ Tube Formation in

    Mehta, Nikita / Patil, Ravindra / Baghela, Abhishek

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 7

    Abstract: The conidia of a hemibiotrophic fungus, ...

    Abstract The conidia of a hemibiotrophic fungus,
    Language English
    Publishing date 2021-06-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7070509
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  8. Article: Outcomes Following Abiraterone versus Enzalutamide for Prostate Cancer: A Scoping Review.

    Shah, Yash B / Shaver, Amy L / Beiriger, Jacob / Mehta, Sagar / Nikita, Nikita / Kelly, William Kevin / Freedland, Stephen J / Lu-Yao, Grace

    Cancers

    2022  Volume 14, Issue 15

    Abstract: Abiraterone acetate (AA) and enzalutamide (ENZ) are commonly used for metastatic prostate cancer. It is unclear how their outcomes and toxicities vary with patient-specific factors because clinical trials typically exclude patients with significant ... ...

    Abstract Abiraterone acetate (AA) and enzalutamide (ENZ) are commonly used for metastatic prostate cancer. It is unclear how their outcomes and toxicities vary with patient-specific factors because clinical trials typically exclude patients with significant comorbidities. This study aims to fill this knowledge gap and facilitate informed treatment decision making. A registered protocol utilizing PRISMA scoping review methodology was utilized to identify real-world studies. Of 433 non-duplicated publications, 23 were selected by three independent reviewers. ENZ offered a faster and more frequent biochemical response (30-50% vs. 70-75%), slowed progression (HR 0.66; 95% CI 0.50-0.88), and improved overall survival versus AA. ENZ was associated with more fatigue and neurological adverse effects. Conversely, AA increased risk of cardiovascular- (HR 1.82; 95% CI 1.09-3.05) and heart failure-related (HR 2.88; 95% CI 1.09-7.63) hospitalizations. Ultimately, AA was associated with increased length of hospital stay, emergency department visits, and hospitalizations (HR 1.26; 95% CI 1.04-1.53). Accordingly, total costs were higher for AA, although pharmacy costs alone were higher for ENZ. Existing data suggest that AA and ENZ have important differences in outcomes including toxicities, response, disease progression, and survival. Additionally, adherence, healthcare utilization, and costs differ. Further investigation is warranted to inform treatment decisions which optimize patient outcomes.
    Language English
    Publishing date 2022-08-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14153773
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  9. Article ; Online: A practical guide to interpreting germline variants that drive hematopoietic malignancies, bone marrow failure, and chronic cytopenias.

    Feurstein, Simone / Hahn, Christopher N / Mehta, Nikita / Godley, Lucy A

    Genetics in medicine : official journal of the American College of Medical Genetics

    2022  Volume 24, Issue 4, Page(s) 931–954

    Abstract: Purpose: The American College of Medical Genetics and Genomics and the Association for Molecular Pathology guidelines for germline variant interpretation are implemented as a broad framework by standardizing variant interpretation. These rules were ... ...

    Abstract Purpose: The American College of Medical Genetics and Genomics and the Association for Molecular Pathology guidelines for germline variant interpretation are implemented as a broad framework by standardizing variant interpretation. These rules were designed to be specified, but this process has not been performed for most of the 200 genes associated with inherited hematopoietic malignancies, bone marrow failure, and cytopenias. Because guidelines on how to perform these gene specifications are lacking, variant interpretation is less reliable and reproducible.
    Methods: We have used a variety of methods such as calculations of minor allele frequencies, quasi-case-control studies to establish thresholds, proband counting, and plotting of receiver operating characteristic curves to compare different in silico prediction tools to design recommendations for variant interpretation.
    Results: We herein provide practical recommendations for the creation of thresholds for minor allele frequencies, in silico predictions, counting of probands, identification of functional domains with minimal benign variation, use of constraint Z-scores and functional evidence, prediction of nonsense-mediated decay, and assessment of phenotype specificity.
    Conclusion: These guidelines can be used by anyone interpreting variants associated with inherited hematopoietic malignancies, bone marrow failure, and cytopenias to develop criteria for reliable, accurate, and reproducible germline variant interpretation.
    MeSH term(s) Bone Marrow Failure Disorders/genetics ; Genetic Testing/methods ; Genetic Variation ; Genome, Human ; Germ Cells ; Hematologic Neoplasms/genetics ; Humans
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1455352-1
    ISSN 1530-0366 ; 1098-3600
    ISSN (online) 1530-0366
    ISSN 1098-3600
    DOI 10.1016/j.gim.2021.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Internal Standardization of the Interpretation and Reporting of Sequence Variants in Hematologic Neoplasms.

    Mehta, Nikita / He, Rong / Viswanatha, David S

    Molecular diagnosis & therapy

    2021  Volume 25, Issue 4, Page(s) 517–526

    Abstract: Introduction: Accurate classification of somatic genetic alterations detected by next-generation sequencing (NGS) assays is of paramount importance to ensure the provision of high-quality clinical data. Clinical significance of variants can be assessed ... ...

    Abstract Introduction: Accurate classification of somatic genetic alterations detected by next-generation sequencing (NGS) assays is of paramount importance to ensure the provision of high-quality clinical data. Clinical significance of variants can be assessed and tiered based on guidelines from the Association for Molecular Pathology (AMP), the American Society of Clinical Oncology, and the College of American Pathology for the interpretation of somatic sequence variants identified in cancer.
    Methods: We sought to develop a formal structured approach for the classification of somatic variants in hematologic neoplasms, to account for both a variant's clinical significance and its ability to drive tumorigenesis, by adapting elements from these existing guidelines. However, we additionally utilized key criteria from the American College of Medical Genetics/AMP standards for variant reporting to focus evaluation into specific categories of evidence and to gauge the effect of a given variant on tumorigenesis.
    Results: The combined approach was applied to the annotation of 87 variants identified by a targeted NGS panel for myeloid neoplasms. In the application of our variant evaluation, we classified 2/87 variants as benign, 6/87 as likely benign, 56/87 as variants of unknown significance (VUS), 13/87 variants as likely pathogenic, and 10/87 variants as pathogenic.
    Conclusion: Well-established oncogenic alterations were accurately classified as pathogenic. Although there is no defined benchmark for the remaining variants, drawing from two existing guidelines enabled the creation of a modified curation process for variant interpretation that emphasizes systematic review of relevant evidence.
    MeSH term(s) Algorithms ; Genetic Variation ; Guidelines as Topic ; Hematologic Neoplasms/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Research Design/standards ; Sequence Analysis, DNA
    Language English
    Publishing date 2021-06-14
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2232796-4
    ISSN 1179-2000 ; 1177-1062
    ISSN (online) 1179-2000
    ISSN 1177-1062
    DOI 10.1007/s40291-021-00540-8
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