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  1. Article ; Online: Diabetes-induced peripheral neuropathy: Is prescribing physical exercise the answer?

    Akhtar, Saghir

    Biomolecules & biomedicine

    2024  

    Abstract: Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia, has become a global health concern with an increasing prevalence worldwide. The International Diabetes Federation (IDF) estimates that over 537 million adults currently have ... ...

    Abstract Diabetes mellitus, a chronic metabolic disorder characterized by hyperglycemia, has become a global health concern with an increasing prevalence worldwide. The International Diabetes Federation (IDF) estimates that over 537 million adults currently have diabetes, and they project that this figure will likely exceed 780 million by 2045. In addition, a further 541 million adults are thought to exhibit impaired glucose tolerance/prediabetes. Among its many complications, diabetic peripheral neuropathy (DPN) affects up to 50% of sufferers, with some studies showing that its prevalence, even in prediabetes, may be as high as 77%. Read more in the PDF.
    Language English
    Publishing date 2024-01-11
    Publishing country Bosnia and Herzegovina
    Document type Editorial
    ISSN 2831-090X
    ISSN (online) 2831-090X
    DOI 10.17305/bb.2023.10188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: In honour of Professor Jackie Ying, recipient of the

    Akhtar, Saghir

    Journal of drug targeting

    2020  Volume 28, Issue 7-8, Page(s) 681–682

    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country England
    Document type Editorial
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2020.1798585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: In honour of Professor Patrick Couvreur, recipient of the Journal Of Drug Targeting's Lifetime Achievement Award For 2019.

    Akhtar, Saghir

    Journal of drug targeting

    2019  Volume 27, Issue 5-6, Page(s) 467–468

    MeSH term(s) Awards and Prizes ; Drug Delivery Systems/methods ; History, 21st Century ; Humans
    Language English
    Publishing date 2019-02-28
    Publishing country England
    Document type Editorial ; Historical Article
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2019.1589139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: COVID-19 and Alzheimer's disease: Impact of lockdown and other restrictive measures during the COVID-19 pandemic.

    Nawaz, Ahmed Daniyal / Haider, Mohammad Zulqurnain / Akhtar, Saghir

    Biomolecules & biomedicine

    2024  Volume 24, Issue 2, Page(s) 219–229

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection initially results in respiratory distress symptoms but can also lead to central nervous system (CNS) and neurological manifestations, significantly impacting coronavirus disease 2019 ( ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection initially results in respiratory distress symptoms but can also lead to central nervous system (CNS) and neurological manifestations, significantly impacting coronavirus disease 2019 (COVID-19) patients with neurodegenerative diseases. Additionally, strict lockdown measures introduced to curtail the spread of COVID-19 have raised concerns over the wellbeing of patients with dementia and/or Alzheimer's disease. The aim of this review was to discuss the overlapping molecular pathologies and the potential bidirectional relationship between COVID-19 and Alzheimer's dementia, as well as the impact of lockdown/restriction measures on the neuropsychiatric symptoms (NPS) of patients with Alzheimer's dementia. Furthermore, we aimed to assess the impact of lockdown measures on the NPS of caregivers, exploring its potential effects on the quality and extent of care they provide to dementia patients.We utilized the PubMed and Google Scholar databases to search for articles on COVID-19, dementia, Alzheimer's disease, lockdown, and caregivers. Our review highlights that patients with Alzheimer's disease face an increased risk of COVID-19 infection and complications. Additionally, these patients are likely to experience greater cognitive decline. It appears that these issues are primarily caused by the SARS-CoV-2 infection and appear to be further exacerbated by restrictive/lockdown measures. Moreover, lockdown measures introduced during the pandemic have negatively impacted both the NPSs of caregivers and their perception of the wellbeing of their Alzheimer's patients. Thus, additional safeguard measures, along with pharmacological and non-pharmacological approaches, are needed to protect the wellbeing of dementia patients and their caregivers in light of this and possible future pandemics.
    MeSH term(s) Humans ; COVID-19 ; Alzheimer Disease/psychology ; Pandemics ; SARS-CoV-2 ; Communicable Disease Control
    Language English
    Publishing date 2024-03-11
    Publishing country Bosnia and Herzegovina
    Document type Journal Article ; Review
    ISSN 2831-090X
    ISSN (online) 2831-090X
    DOI 10.17305/bb.2023.9680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: In honour of Professor Leaf Huang, recipient of the Journal of Drug Targeting's life-time achievement award for 2018.

    Akhtar, Saghir

    Journal of drug targeting

    2018  Volume 26, Issue 5-6, Page(s) 383

    MeSH term(s) Awards and Prizes ; Drug Delivery Systems/history ; History, 20th Century ; History, 21st Century ; Humans
    Language English
    Publishing date 2018-02-15
    Publishing country England
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2018.1440923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  7. Article ; Online: In honour of Professor Ruth Duncan, recipient of the Journal of Drug Targeting's Lifetime Achievement Award for 2017.

    Akhtar, Saghir

    Journal of drug targeting

    2017  Volume 25, Issue 9-10, Page(s) 755–756

    MeSH term(s) Awards and Prizes ; Drug Delivery Systems ; History, 21st Century ; Humans
    Language English
    Publishing date 2017-10-09
    Publishing country England
    Document type Editorial ; Historical Article
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2017.1379225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: In honour of Professor Pieter R Cullis, recipient of the Journal of Drug Targeting's Lifetime Achievement Award for 2016.

    Akhtar, Saghir

    Journal of drug targeting

    2016  Volume 24, Issue 9, Page(s) 759–760

    MeSH term(s) Awards and Prizes ; Biophysics/history ; British Columbia ; Drug Delivery Systems ; History, 20th Century ; History, 21st Century ; Nanomedicine/history ; Nanotechnology/history
    Language English
    Publishing date 2016-09-27
    Publishing country England
    Document type Biography ; Editorial ; Historical Article ; Portraits
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2016.1241511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4481: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  9. Book: Delivery strategies for antisense oligonucleotide therapeutics

    Akhtar, Saghir

    1995  

    Author's details ed. by Saghir Akhtar
    Keywords Oligonucleotides, Antisense / administration & dosage ; Oligonucleotides, Antisense / pharmacokinetics ; Oligonucleotides, Antisense / therapeutic use ; Drug Delivery Systems ; Antisense-Oligonucleotide ; Heilmittel
    Subject Therapeutikum ; Therapeutische Leistung ; Triplex-Bildner ; Antisense-Pharmakon ; Antisense-Oligomere ; Antisense-Oligodeoxynucleotide ; Phosphorothioat-Oligonucleotide ; S-Oligos ; Antisense-Oligonukleotide
    Language German
    Size 305 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton
    Publishing country United States
    Document type Book
    HBZ-ID HT006837033
    ISBN 0-8493-4778-5 ; 978-0-8493-4778-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 323 order for loan Magazin

    Order via subito

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  10. Article: An Updated Review of the Biomarkers of Response to Immune Checkpoint Inhibitors in Merkel Cell Carcinoma: Merkel Cell Carcinoma and Immunotherapy.

    Fojnica, Adnan / Ljuca, Kenana / Akhtar, Saghir / Gatalica, Zoran / Vranic, Semir

    Cancers

    2023  Volume 15, Issue 20

    Abstract: Merkel cell carcinoma (MCC) is primarily a disease of the elderly Caucasian, with most cases occurring in individuals over 50. Immune checkpoint inhibitors (ICI) treatment has shown promising results in MCC patients. Although ~34% of MCC patients are ... ...

    Abstract Merkel cell carcinoma (MCC) is primarily a disease of the elderly Caucasian, with most cases occurring in individuals over 50. Immune checkpoint inhibitors (ICI) treatment has shown promising results in MCC patients. Although ~34% of MCC patients are expected to exhibit at least one of the predictive biomarkers (PD-L1, high tumor mutational burden/TMB-H/, and microsatellite instability), their clinical significance in MCC is not fully understood. PD-L1 expression has been variably described in MCC, but its predictive value has not been established yet. Our literature survey indicates conflicting results regarding the predictive value of TMB in ICI therapy for MCC. Avelumab therapy has shown promising results in Merkel cell polyomavirus (MCPyV)-negative MCC patients with TMB-H, while pembrolizumab therapy has shown better response in patients with low TMB. A study evaluating neoadjuvant nivolumab therapy found no significant difference in treatment response between the tumor etiologies and TMB levels. In addition to ICI therapy, other treatments that induce apoptosis, such as milademetan, have demonstrated positive responses in MCPyV-positive MCC, with few somatic mutations and wild-type
    Language English
    Publishing date 2023-10-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15205084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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