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  1. Article ; Online: Laquinimod, Huntington's disease, and disease modification.

    Mestre, Tiago A

    The Lancet. Neurology

    2024  Volume 23, Issue 3, Page(s) 220–221

    MeSH term(s) Humans ; Huntington Disease/drug therapy ; Quinolones/pharmacology ; Quinolones/therapeutic use
    Chemical Substances laquinimod (908SY76S4G) ; Quinolones
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(24)00001-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5955: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Using Big Data in Movement Disorders: Disease States and Progression in Huntington's Disease.

    Mestre, Tiago A

    Movement disorders : official journal of the Movement Disorder Society

    2022  Volume 37, Issue 3, Page(s) 441–443

    MeSH term(s) Big Data ; Disease Progression ; Humans ; Huntington Disease ; Movement Disorders
    Language English
    Publishing date 2022-03-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28943
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    Zs.A 2555: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 238: Show issues

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  3. Article ; Online: α-synuclein seed amplification in Parkinson's disease.

    Mestre, Tiago A / Kalia, Lorraine V

    The Lancet. Neurology

    2023  Volume 22, Issue 11, Page(s) 984–985

    MeSH term(s) Humans ; alpha-Synuclein/genetics ; Parkinson Disease/genetics
    Chemical Substances alpha-Synuclein
    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00374-5
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    Zs.A 5955: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Target-Specific Strategies to Modify the Course of Parkinson's: Is Iron Chelation Safe?

    Mestre, Tiago A / Schlossmacher, Michael G

    Movement disorders : official journal of the Movement Disorder Society

    2023  Volume 38, Issue 5, Page(s) 740–741

    MeSH term(s) Humans ; Parkinson Disease/drug therapy ; Iron Chelating Agents/adverse effects ; Iron
    Chemical Substances Iron Chelating Agents ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29382
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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 238: Show issues

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  5. Article ; Online: Motor band sign in a Huntington disease phenocopy.

    Dash, Deepa / Mestre, Tiago A

    Parkinsonism & related disorders

    2023  Volume 109, Page(s) 105333

    Abstract: We report a 68-year-old lady who presented with Huntington phenocopy with generalized chorea and was genetically proven to have Spinocerebellar ataxia (SCA)17. MRI Brain demonstrated motor band sign, which is most commonly reported in motor neuron ... ...

    Abstract We report a 68-year-old lady who presented with Huntington phenocopy with generalized chorea and was genetically proven to have Spinocerebellar ataxia (SCA)17. MRI Brain demonstrated motor band sign, which is most commonly reported in motor neuron disease. This is the first case of motor band sign with SCA 17 and highlights the widening spectrum of radiological signs in SCA 17.
    MeSH term(s) Female ; Humans ; Aged ; Huntington Disease/complications ; Huntington Disease/diagnostic imaging ; Spinocerebellar Ataxias/diagnosis ; Chorea/diagnostic imaging ; Chorea/etiology ; Motor Neuron Disease/diagnostic imaging
    Language English
    Publishing date 2023-02-20
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2023.105333
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    Zs.A 4553: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 420: Show issues

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  6. Article: The Disease Modification Conundrum in Parkinson's Disease: Failures and Hopes.

    Mari, Zoltan / Mestre, Tiago A

    Frontiers in aging neuroscience

    2022  Volume 14, Page(s) 810860

    Abstract: In the last half-century, Parkinson's disease (PD) has played a historical role in demonstrating our ability to translate preclinical scientific advances in pathology and pharmacology into highly effective clinical therapies. Yet, as highly efficacious ... ...

    Abstract In the last half-century, Parkinson's disease (PD) has played a historical role in demonstrating our ability to translate preclinical scientific advances in pathology and pharmacology into highly effective clinical therapies. Yet, as highly efficacious symptomatic treatments were successfully developed and adopted in clinical practice, PD remained a progressive disease without a cure. In contrast with the success story of symptomatic therapies, the lack of translation of disease-modifying interventions effective in preclinical models into clinical success has continued to accumulate failures in the past two decades. The ability to stop, prevent or mitigate progression in PD remains the "holy grail" in PD science at the present time. The large number of high-quality disease modification clinical trials in the past two decades with its lessons learned, as well as the growing knowledge of PD molecular pathology should enable us to have a deeper understanding of the reasons for past failures and what we need to do to reach better outcomes. Periodic reviews and mini-reviews of the unsolved disease modification conundrum in PD are important, considering how this field is rapidly evolving along with our views and understanding of the possible explanations.
    Language English
    Publishing date 2022-02-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.810860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Genetic Testing in Clinical Movement Disorders: A Case-Based Review.

    Kalia, Lorraine V / Nimmo, Graeme A M / Mestre, Tiago A

    Seminars in neurology

    2023  Volume 43, Issue 1, Page(s) 147–155

    Abstract: Genetics are fundamental to understanding the pathophysiology of neurological disease, including movement disorders. Genetic testing in clinical practice has changed dramatically over the last few decades. While the likelihood of establishing an ... ...

    Abstract Genetics are fundamental to understanding the pathophysiology of neurological disease, including movement disorders. Genetic testing in clinical practice has changed dramatically over the last few decades. While the likelihood of establishing an etiological diagnosis is greater now with increased access to testing and more advanced technologies, clinicians face challenges when deciding whether to test, then selecting the appropriate test, and ultimately interpreting and sharing the results with patients and families. In this review, we use a case-based approach to cover core aspects of genetic testing for the neurologist, namely, genetic testing in Parkinson's disease, interpretation of inconclusive genetic test reports, and genetic testing for repeat expansion disorders using Huntington disease as a prototype.
    MeSH term(s) Humans ; Genetic Testing/methods ; Movement Disorders/diagnosis ; Movement Disorders/genetics ; Parkinson Disease/genetics
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0043-1763507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1737: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Canadian Healthcare Access in Parkinson's Disease and COVID-19: A Cross-Sectional Survey.

    McKeown, Monica D / Crighton, Eric / Mestre, Tiago A

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2023  , Page(s) 1–6

    Abstract: Background: Parkinson's disease (PD) is a common chronic neurodegenerative condition. As a result of the COVID-19 pandemic, healthcare provision faced challenges worldwide. We aimed to explore how the COVID-19 pandemic changed healthcare experiences for ...

    Abstract Background: Parkinson's disease (PD) is a common chronic neurodegenerative condition. As a result of the COVID-19 pandemic, healthcare provision faced challenges worldwide. We aimed to explore how the COVID-19 pandemic changed healthcare experiences for people living with Parkinson's disease (PwP) in Canada.
    Methods: We conducted a national cross-sectional online survey about healthcare access for PwP in 2020. Participants (n = 298) were recruited through Parkinson Canada, the national patient association and its provincial partners, that advertised the study in a monthly newsletter. We used descriptive statistics and multivariate regression modelling to test associations of interest. A P < 0.05 was deemed statistically significant.
    Results: During the COVID-19 pandemic, PwP reported greater difficulty obtaining PD-related healthcare services and lesser satisfaction with healthcare provision compared to pre-pandemic experiences. Dissatisfaction with care was associated with the presence of barriers to access services, a lack of confidence in accessing services remotely, pre-pandemic care dissatisfaction, and difficulty in obtaining care during the COVID-19 pandemic. Unmet care needs were associated with a lack of confidence in accessing services remotely, dissatisfaction with pre-pandemic care, difficulty obtaining pre-pandemic care, and communication challenges.
    Conclusion: Our results suggest that healthcare experiences for PwP significantly changed during the COVID-19 pandemic, with challenges in access to virtual care. Poorer pre-pandemic care experiences were amplified during the pandemic.
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2023.275
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  9. Article ; Online: Assessing and managing Parkinson's disease from home: A 21st century vision closer to reality.

    Mestre, Tiago A

    Movement disorders : official journal of the Movement Disorder Society

    2018  Volume 33, Issue 9, Page(s) 1407

    MeSH term(s) Humans ; Machine Learning ; Parkinson Disease ; Smartphone
    Language English
    Publishing date 2018-09-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 238: Show issues

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  10. Article ; Online: Nocebo and lessebo effects.

    A Mestre, Tiago

    International review of neurobiology

    2020  Volume 153, Page(s) 121–146

    Abstract: The power of placebos is commonly associated with the placebo effect. In contrast, detrimental effects related to the use of a placebo are little studied and less well recognized. This chapter covers the nocebo and lessebo effects defined, respectively, ... ...

    Abstract The power of placebos is commonly associated with the placebo effect. In contrast, detrimental effects related to the use of a placebo are little studied and less well recognized. This chapter covers the nocebo and lessebo effects defined, respectively, as expectation of harm in the form of adverse events in a placebo arm and reduction of therapeutic benefit due to the uncertainty of being allocated to placebo. The lessebo effect is a more recent concept and has been described only in depression, schizophrenia and Parkinson's disease. The nocebo response was evaluated in many neurological diseases, including epilepsy, multiple sclerosis, Parkinson's disease, Alzheimer's disease, restless leg syndrome, among others. Meta-analyses of randomized controlled trials in these conditions reveal a significant variability of the magnitude of the nocebo response and that factors related to study design, study participants or neurological disease can be associated with a nocebo response, although with the opposing findings across conditions. The knowledge about neurobiological mechanisms of the nocebo effect is poor for neurological diseases, and most of the information has been generated in pain. Functional neuroimaging suggests the existence of a distinct network for the anticipation and the experience of a hyperalgesia nocebo response. Different types of neurotransmitters have been involved, including cholecystokinin, dopamine and opioids. Recognizing the potential impact of nocebo and lessebo effects, mitigating strategies are in development with application to clinical research and clinical practice, such as a contextualized informed consent process, alternative study designs and enhancement of patient-physician communication.
    MeSH term(s) Anticipation, Psychological/physiology ; Conditioning, Psychological/physiology ; Controlled Clinical Trials as Topic/standards ; Humans ; Informed Consent/standards ; Nervous System Diseases/therapy ; Nocebo Effect ; Patient Selection ; Placebo Effect ; Placebos/therapeutic use
    Chemical Substances Placebos
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 209876-3
    ISSN 2162-5514 ; 0074-7742
    ISSN (online) 2162-5514
    ISSN 0074-7742
    DOI 10.1016/bs.irn.2020.04.005
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