LIVIVO - Search results -

Search results

Result 1 - 10 of total 136

Search options

Article ; Online: Reimagining Critical Care Delivery Mechanisms in Global Surgery: The Frontiers of Telemedicine.

Ehsan, Anam N / Ranganathan, Kavitha / Raghavendran, Krishnan

2023 Volume 47, Issue 7, Page(s) 1631–1632

MeSH term(s)	Humans ; Telemedicine ; Delivery of Health Care ; Critical Care
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Editorial
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-023-06907-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1336: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Book: ALI and ARDS

Raghavendran, Krishnan / Napolitano, Lena M.

challenges and advances

(Critical care clinics ; 27,3)

2011

Author's details	guest ed. Krishnan Raghavendran ; Lena M. Napolitano
Series title	Critical care clinics ; 27,3
Collection
Language	English
Size	XIV S., S. 429 - 764 : Ill., graph. Darst.
Publisher	Saunders an imprint of Elseveir
Publishing place	Philadelphia, Pa
Publishing country	United States
Document type	Book
HBZ-ID	HT016925471
ISBN	978-1-4557-1037-9 ; 1-4557-1037-7
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Se 990 -27,3-	verfügbar in Königswinter	Königswinter

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The Intersection of Pulmonary Vascular Disease and Hypoxia-Inducible Factors.

Suresh, Madathilparambil V / Aggarwal, Vikas / Raghavendran, Krishnan

Interventional cardiology clinics

2023 Volume 12, Issue 3, Page(s) 443–452

Abstract: Hypoxia-inducible factors (HIFs) are a family of nuclear transcription factors that serve as the master regulator of the adaptive response to hypoxia. In the lung, HIFs orchestrate multiple inflammatory pathways and signaling. They have been reported to ... ...

Abstract	Hypoxia-inducible factors (HIFs) are a family of nuclear transcription factors that serve as the master regulator of the adaptive response to hypoxia. In the lung, HIFs orchestrate multiple inflammatory pathways and signaling. They have been reported to have a major role in the initiation and progression of acute lung injury, chronic obstructive pulmonary disease, pulmonary fibrosis, and pulmonary hypertension. Although there seems to be a clear mechanistic role for both HIF 1α and 2α in pulmonary vascular diseases including PH, a successful translation into a definitive therapeutic modality has not been accomplished to date.
MeSH term(s)	Humans ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Lung/metabolism ; Hypertension, Pulmonary ; Hypoxia
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors
Language	English
Publishing date	2023-04-28
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2211-7466
ISSN (online)	2211-7466
DOI	10.1016/j.iccl.2023.03.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: What's New in Shock, November 2014?

Raghavendran, Krishnan

Shock (Augusta, Ga.)

2014 Volume 42, Issue 5, Page(s) 381–382

MeSH term(s)	Animals ; Disease Models, Animal ; Humans ; Resuscitation/methods ; Shock, Septic/physiopathology ; Shock, Septic/therapy
Language	English
Publishing date	2014-10-01
Publishing country	United States
Document type	Editorial ; Introductory Journal Article
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000000256
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3985: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Polymer Lung Surfactants Attenuate Direct Lung Injury in Mice.

Fesenmeier, Daniel J / Suresh, Madathilparambil V / Kim, Seyoung / Park, Sungwan / Raghavendran, Krishnan / Won, You-Yeon

ACS biomaterials science & engineering

2023 Volume 9, Issue 5, Page(s) 2716–2730

Abstract: If not properly managed, acute lung injuries, either through direct or indirect causes, have the potential to present serious risk for many patients worldwide. One of the mechanisms for the transition from acute lung injury (ALI) to the more serious ... ...

Abstract	If not properly managed, acute lung injuries, either through direct or indirect causes, have the potential to present serious risk for many patients worldwide. One of the mechanisms for the transition from acute lung injury (ALI) to the more serious acute respiratory distress syndrome (ARDS) is the deactivation of the native lung surfactant by injury-induced infiltrates to the alveolar space. Currently, there are no surfactant replacement therapies that are used to treat ALI and subsequent ARDS. In this paper, we present an indepth efficacy study of using a novel polymer lung surfactant (PLS, composed of poly(styrene-
MeSH term(s)	Mice ; Animals ; Polymers/pharmacology ; Polymers/therapeutic use ; Lung ; Pulmonary Surfactants/pharmacology ; Pulmonary Surfactants/therapeutic use ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/etiology ; Acute Lung Injury/drug therapy ; Acute Lung Injury/complications
Chemical Substances	Polymers ; Pulmonary Surfactants ; styrene glycol (2ZAC511UK8)
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2373-9878
ISSN (online)	2373-9878
DOI	10.1021/acsbiomaterials.3c00061
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Prehospital hemorrhage management in low- and middle-income countries: A scoping review.

Kulkarni, Ashwin J / Batra, Amber / Eisner, Zachary J / Delaney, Peter G / Pine, Haleigh / Klapow, Maxwell C / Raghavendran, Krishnan

World journal of surgery

2024 Volume 48, Issue 3, Page(s) 547–559

Abstract: Introduction: Low- and middle-income countries (LMICs) account for 90% of deaths due to injury, largely due to hemorrhage. The increased hemorrhage mortality burden in LMICs is exacerbated by absent or ineffective prehospital care. Hemorrhage management ...

Abstract	Introduction: Low- and middle-income countries (LMICs) account for 90% of deaths due to injury, largely due to hemorrhage. The increased hemorrhage mortality burden in LMICs is exacerbated by absent or ineffective prehospital care. Hemorrhage management (HM) is an essential component of prehospital care in LMICs, yet current practices for prehospital HM and outcomes from first responder HM training have yet to be summarized. Methods: This review describes the current literature on prehospital HM and the impact of first responder HM training in LMICs. Articles published between January 2000 and January 2023 were identified using PMC, MEDLINE, and Scopus databases following PRISMA-ScR guidelines. Inclusion criteria spanned first responder training programs delivering prehospital care for HM. Relevant articles were assessed for quality using the Newcastle-Ottawa scale. Results: Of the initial 994 articles, 20 met inclusion criteria representing 16 countries. Studies included randomized control trials, cohort studies, case control studies, reviews, and epidemiological studies. Basic HM curricula were found in 15 studies and advanced HM curricula were found in six studies. Traumatic hemorrhage was indicated in 17 studies while obstetric hemorrhage was indicated in three studies. First responders indicated HM use in 55%-76% of encounters, the most frequent skill they reported using. Mean improvements in HM knowledge acquisition post-course ranged from 23 to 58 percentage points following training for pressure and elevation, gauze application, and tourniquet application. Conclusions: Our study summarizes the current literature on prehospital HM in LMICs pertaining to epidemiology, interventions, and outcomes. HM resources should be a priority for further development.
MeSH term(s)	Humans ; Emergency Medical Services ; Developing Countries ; Hemorrhage/etiology ; Hemorrhage/therapy ; Curriculum ; Emergency Responders
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Systematic Review ; Review ; Journal Article
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1002/wjs.12054
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1336: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Therapeutic potential of curcumin in ARDS and COVID-19.

Suresh, Madathilparambil V / Francis, Sairah / Aktay, Sinan / Kralovich, Georgia / Raghavendran, Krishnan

Clinical and experimental pharmacology & physiology

2023 Volume 50, Issue 4, Page(s) 267–276

Abstract: Curcumin is a safe, non-toxic, readily available and naturally occurring compound, an active constituent of Curcuma longa (turmeric). Curcumin could potentially treat diseases, but faces poor physicochemical and pharmacological characteristics. To ... ...

Abstract	Curcumin is a safe, non-toxic, readily available and naturally occurring compound, an active constituent of Curcuma longa (turmeric). Curcumin could potentially treat diseases, but faces poor physicochemical and pharmacological characteristics. To overcome these limitations, we developed a stable, water-soluble formulation of curcumin called cyclodextrin-complexed curcumin (CDC). We have previously shown that direct delivery of CDC to the lung following lipopolysaccharides exposure reduces acute lung injury (ALI) and effectively reduces lung injury, inflammation and mortality in mice following Klebsiella pneumoniae. Recently, we found that administration of CDC led to a significant reduction in angiotensin-converting enzyme 2 and signal transducer and activator of transcription 3 expression in gene and protein levels following pneumonia, indicating its potential in treating coronavirus disease 2019 (COVID-19). In this review, we consider the clinical features of ALI and acute respiratory distress syndrome (ARDS) and the role of curcumin in modulating the pathogenesis of bacterial/viral-induced ARDS and COVID-19.
MeSH term(s)	Mice ; Animals ; Curcumin/pharmacology ; COVID-19/pathology ; Lung ; Respiratory Distress Syndrome/pathology ; Acute Lung Injury/pathology
Chemical Substances	Curcumin (IT942ZTH98)
Language	English
Publishing date	2023-01-10
Publishing country	Australia
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	189277-0
ISSN	1440-1681 ; 0305-1870 ; 0143-9294
ISSN (online)	1440-1681
ISSN	0305-1870 ; 0143-9294
DOI	10.1111/1440-1681.13744
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 990: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Developing a Sustaining Program of Surgical Care in the Developing World.

Ranganathan, Kavitha / Raghavendran, Krishnan

Hand clinics

2019 Volume 35, Issue 4, Page(s) 391–395

Abstract: The development of sustainable surgical systems in low- and middle-income countries is imperative given the rising burden of surgical disease processes. Surgical conditions now account for more than 11% of the overall burden of disease. Although the ... ...

Abstract	The development of sustainable surgical systems in low- and middle-income countries is imperative given the rising burden of surgical disease processes. Surgical conditions now account for more than 11% of the overall burden of disease. Although the administration of surgical care has historically taken a variety of forms, a sustainable surgical model requires the utilization of robust clinical infrastructure, curricula for educating future staff and trainees, and research to promote quality improvement. Increasing the number of trained anesthesia providers, surgeons, and nurses is of utmost importance; task shifting may be necessary to most efficiently offset the shortage of health care providers.
MeSH term(s)	Delivery of Health Care/organization & administration ; Developing Countries ; Global Health ; Health Services Research ; Humans ; Surgical Procedures, Operative/education
Language	English
Publishing date	2019-10-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1315374-2
ISSN	1558-1969 ; 0749-0712
ISSN (online)	1558-1969
ISSN	0749-0712
DOI	10.1016/j.hcl.2019.07.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 989: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Leveraging transportation providers to deploy lay first responder (LFR) programs in three sub-Saharan African countries without formal emergency medical services: Evaluating longitudinal impact and cost-effectiveness.

Delaney, Peter G / Eisner, Zachary J / Pine, Haleigh / Klapow, Max / Thullah, Alfred Harun / Bamuleke, Richard / Nuur, Issa Mohamet / Raghavendran, Krishnan

Injury

2024 Volume 55, Issue 5, Page(s) 111505

Abstract: Introduction: In 2019, the World Health Assembly declared emergency care essential to achieve the 2030 Sustainable Development Goals. Few sub-Saharan African (SSA) countries have developed robust approaches to sustainably deliver emergency medical ... ...

Abstract	Introduction: In 2019, the World Health Assembly declared emergency care essential to achieve the 2030 Sustainable Development Goals. Few sub-Saharan African (SSA) countries have developed robust approaches to sustainably deliver emergency medical services (EMS) at scale, as high-income country models are financially impractical. Innovative reassessment of EMS delivery in resource-limited settings is necessary as timely emergency care access can substantially reduce mortality. Materials and methods: We developed the Lay First Responder (LFR) program by training 1,291 pre-existing motorcycle taxi drivers, a predominant form of short-distance transport in sub-Saharan Africa, to provide trauma care and transport for road traffic injuries. Three pilot programs were launched in staggered fashion between 2016 and 2019 in West, Central, and East Africa and a 5.5 h curriculum was iteratively developed to train first responders. Longitudinal data on patient impact (patient demographics, injury characteristics, and treatment rendered), emergency care knowledge acquisition/retention, and social/financial effects of LFR training were collected and pooled across three sites for collective analysis. Novel cost-effectiveness ratios were calculated based on prospective cost data from each site. Previously projected aggregate disability-adjusted life years (DALYs) addressable by LFRs were used to inform cost-effectiveness ratios($USD cost per DALY averted). Cost-effectiveness ratios were then compared against African per capita gross domestic product (GDP), following WHOCHOICE guidelines, which state ratios less than GDP per capita are "very cost-effective." Results: In 2,171 total patient encounters across all three pilot sites, LFRs most frequently provided hemorrhage control in 61 % of patient encounters and patient transport by motorcycle in 98.5 %. Median pre-/post-test scores improved by 34.1 percentage points (39.5% vs.73.6 %, p < 0.0001) with significant knowledge retention at six months. 75 % of initial participants remain voluntarily involved 3 years post-course, reporting increased local stature and customer acquisition(income 32.0 % greater than non-trained counterparts). Locally sourced first-aid materials cost $6.54USD/participant. Cost-effectiveness analysis demonstrated cost per DALY averted=$51.65USD. Conclusion: LFR training is highly cost-effective according to WHOCHOICE guidelines and expands emergency care access. The LFR program may be an alternative approach to formal ambulance-reliant EMS that are cost-prohibitive in resource-limited, sub-Saharan African settings. A novel social/financial mechanism appears to incentivize long-term voluntary LFR involvement, which may sustain programs in resource-limited settings.
MeSH term(s)	Humans ; Cost-Benefit Analysis ; Cost-Effectiveness Analysis ; Prospective Studies ; Emergency Medical Services ; Africa South of the Sahara ; Emergency Responders
Language	English
Publishing date	2024-03-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2024.111505
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 778: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 10: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Emerging Promise of Phytochemicals in Ameliorating Neurological Disorders.

Jayaraman, Megala / Dutta, Parijat / Krishnan, Sabari / Arora, Khyati / Sivakumar, Diveyaa / Raghavendran, Hanumanth Rao Balaji

CNS & neurological disorders drug targets

2022

Abstract: Background: The field of medicine and synthetic drug development have advanced rapidly over the past few decades. However, research on alternative medicine such as phytochemicals cannot be ignored. The main reason for prominent curiosity about ... ...

Abstract	Background: The field of medicine and synthetic drug development have advanced rapidly over the past few decades. However, research on alternative medicine such as phytochemicals cannot be ignored. The main reason for prominent curiosity about phytochemicals stems from the belief that usage of natural compounds is safer and has lesser detrimental side effects. Objective: The aim of the present review was to discuss in detail with several phytochemicals that have been studied or are being studied in the context of various neurological disorders including depression, Alzheimer's disease, Huntington's disease and even neuroinflammatory disorders such as encephalitis. Methods: The potential role of phytochemicals in the treatment or management of symptoms associated with neurological disorders have been included in this article. All data included in this paper has been pooled from various databases including Google Scholar, PubMed, Science Direct, Springer and Wiley Online Library. Results: Phytochemicals have been widely studied for their therapeutic properties associated with neurological disorders. Using various experimental techniques for both in vivo and in vitro experiments, studies have shown that phytochemicals do have antioxidant, anti-inflammatory and neuroprotective activities which play major roles in the treatment of neurological diseases. Conclusion: Even though there has been compelling evidence of the therapeutic role of phytochemicals, further research is still required to evaluate the safety and efficacy of these medicines. Using previously published papers as foundation for additional research such as preclinical studies and clinical trials, phytochemicals can become a safer alternative to synthetic drugs for treating a spectrum of neurological diseases.
Language	English
Publishing date	2022-07-01
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2228394-8
ISSN	1996-3181 ; 1871-5273
ISSN (online)	1996-3181
ISSN	1871-5273
DOI	10.2174/1871527321666220701153926
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5892: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito