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Article ; Online: Analysis of high risk factors of pathological escalation after LEEP in CIN2 diagnosed by colposcopic biopsy

Ma Xiaoli, Meng Ge, Duan Hua

Xin yixue, Vol 54, Iss 12, Pp 895-

2023 Volume 901

Abstract: Objective To investigate the risk factors associated with pathological escalation to cervical intraepithelial neoplasia grade 2 （CIN2） or above （CIN2+） in patients with CIN2 confirmed by colposcopic biopsy， aiming to provide evidence for the stratified ... ...

Abstract	Objective To investigate the risk factors associated with pathological escalation to cervical intraepithelial neoplasia grade 2 （CIN2） or above （CIN2+） in patients with CIN2 confirmed by colposcopic biopsy， aiming to provide evidence for the stratified management of CIN2 patients. Methods Clinical data of 210 patients who underwent LEEP surgery after pathological diagnosis of cervical CIN2 by colposcopic biopsy were retrospectively analyzed. Pathological diagnosis of patients before and after LEEP surgery was observed. The relationship between pathological escalation after LEEP， and age，results of primary liquid-based thin-layer cytology （TCT）， typing of high-risk human papillomavirus （HPV）， the number of affected quadrants of lesions under colposcopy， the proportion of visible lesion area to cervical surface area， the longest linear length of the lesion， the type of transformation zone （TZ）， whether the lesion was involved with glands and the characteristics of colposcopic images was assessed by univariate and multivariate Logistic regression analyses. Results Among 210 cases of cervical CIN2 diagnosed by colposcopic biopsy， 37 cases （17.6%） were pathologically diagnosed with CIN2+ after LEEP， and 1 case was diagnosed with cervical squamous cell carcinoma stage IB1. Univariate analysis showed that pathological escalation after LEEP was associated with the age of patients， the number of affected quadrants of lesions under colposcopy， the proportion of visible lesion area to cervical surface area， the longest linear length of visible lesions， the type of transformation zone，and the characteristics of colposcoic images （all P < 0.05）. Multivariate analysis showed that the number （>1） of affected quadrants of lesions under colposcopy，the proportion （≥1/3） of visible lesion area to cervical surface area， TZ3 type and the characteristics （≥2） of colposcopic images were the high-risk factors for pathological escalation after LEEP （all P < 0.05）. For patients aged 26-50 years， the proportion （≥1/3） of lesion ...
Keywords	colposcopy\|cervical intraepithelial neoplasia\|loop resection of the cervix\|pathological escalation\|influencing factor\|thin-prep cytology test ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2023-12-01T00:00:00Z
Publisher	Editorial Office of Journal of New Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Diagnosis and prognostic predictive value of delineation methods from

Hu, Fan / Zhang, Xiao / Shu, Hua / Wang, Xiaoli / Feng, Shuqian / Hu, Mengmeng / Lan, Xiaoli / Qin, Chunxia

American journal of nuclear medicine and molecular imaging

2023 Volume 13, Issue 6, Page(s) 269–278

Abstract: The aim was to utilize three segmentation methods ... ...

Abstract	The aim was to utilize three segmentation methods on
Language	English
Publishing date	2023-12-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2623515-8
ISSN	2160-8407
ISSN	2160-8407
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Optic nerve head injury and optical coherence tomography angiography.

Ma, Xiaoli / Hua, Rui

Quantitative imaging in medicine and surgery

2021 Volume 11, Issue 10, Page(s) 4497–4503

Language	English
Publishing date	2021-09-16
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-20-1218
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Article ; Online: Changes in intestinal microbiota of HBV-associated liver cirrhosis with/without hepatic encephalopathy.

Hua, Xiaoli / Feng, Hao

Medicine

2022 Volume 101, Issue 33, Page(s) e29935

Abstract: The compositional balance of intestinal microbiota plays an important role in maintaining homeostasis. This study aimed to investigate the intestinal flora of hepatitis B virus-associated liver cirrhosis (HBV-LC) with or without hepatic encephalopathy ( ... ...

Abstract	The compositional balance of intestinal microbiota plays an important role in maintaining homeostasis. This study aimed to investigate the intestinal flora of hepatitis B virus-associated liver cirrhosis (HBV-LC) with or without hepatic encephalopathy (HE) and how it relates to the disease. A total of 20 patients with HBV-LC were enrolled in this study, along with 10 healthy adults. The participants were divided into HE group, non-HE group, and control group. Fecal samples were collected under the condition of patients' daily diet, and the 16S rRNA test was performed for each fecal sample. The relative abundance of Bacteroidia, Streptococcaceae, Streptococcus, Veillonella, Bacteroidales, Lactobacillales, Pasteurellales, and Veillonella parvula increased in the HBV-LC group. Meanwhile, the relative weights of Pasteurellales, Pasteurellaceae, Haemophilus, and Selenomonas significantly increased in the HE group. Furthermore, in the non-HE group, the relative abundance of Veillonella increased. Intestinal microbiota was significantly different from controls with respect to a lack of potentially beneficial autochthonous bacteria and overgrowth of potentially pathogenic genera in patients with HBV-LC. Moreover, there was a greater change in the relative abundance of intestinal flora when complicated with HE.
MeSH term(s)	Adult ; Gastrointestinal Microbiome ; Hepatic Encephalopathy/etiology ; Hepatitis B virus/genetics ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/microbiology ; RNA, Ribosomal, 16S/genetics
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2022-08-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000029935
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Article ; Online: Construction and validation of a nomogram model to predict the poor prognosis in patients with pulmonary cryptococcosis.

Tan, Xiaoli / Zhang, Yingqing / Zhou, Jianying / Chen, Wenyu / Zhou, Hua

PeerJ

2024 Volume 12, Page(s) e17030

Abstract: Background: Patients with poor prognosis of pulmonary cryptococcosis (PC) are prone to other complications such as meningeal infection, recurrence or even death. Therefore, this study aims to analyze the influencing factors in the poor prognosis of ... ...

Abstract	Background: Patients with poor prognosis of pulmonary cryptococcosis (PC) are prone to other complications such as meningeal infection, recurrence or even death. Therefore, this study aims to analyze the influencing factors in the poor prognosis of patients with PC, so as to build a predictive nomograph model of poor prognosis of PC, and verify the predictive performance of the model. Methods: This retrospective study included 410 patients (78.1%) with improved prognosis of PC and 115 patients (21.9%) with poor prognosis of PC. The 525 patients with PC were randomly divided into the training set and validation set according to the ratio of 7:3. The Least Absolute Shrinkage and Selection Operator (LASSO) algorithm was used to screen the demographic information, including clinical characteristics, laboratory test indicators, comorbidity and treatment methods of patients, and other independent factors that affect the prognosis of PC. These factors were included in the multivariable logistic regression model to build a predictive nomograph. The receiver operating characteristic curve (ROC), calibration curve and decision curve analysis (DCA) were used to verify the accuracy and application value of the model. Results: It was finally confirmed that psychological symptoms, cytotoxic drugs, white blood cell count, hematocrit, platelet count, CRP, PCT, albumin, and CD4/CD8 were independent predictors of poor prognosis of PC patients. The area under the curve (AUC) of the predictive model for poor prognosis in the training set and validation set were 0.851 (95% CI: 0.818-0.881) and 0.949, respectively. At the same time, calibration curve and DCA results confirmed the excellent performance of the nomogram in predicting poor prognosis of PC. Conclusion: The nomograph model for predicting the poor prognosis of PC constructed in this study has good prediction ability, which is helpful for improving the prognosis of PC and further optimizing the clinical management strategy.
MeSH term(s)	Humans ; Nomograms ; Retrospective Studies ; Albumins ; Algorithms ; Cryptococcosis/diagnosis
Chemical Substances	Albumins
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.17030
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Corrigendum: Reconstruction and Analysis of the lncRNA-miRNA-mRNA Network Based on Competitive Endogenous RNA Reveal Functional lncRNAs in Dilated Cardiomyopathy.

Tao, Lichan / Yang, Ling / Huang, Xiaoli / Hua, Fei / Yang, Xiaoyu

Frontiers in genetics

2022 Volume 13, Page(s) 896402

Abstract: This corrects the article DOI: 10.3389/fgene.2019.01149.]. ...

Abstract	[This corrects the article DOI: 10.3389/fgene.2019.01149.].
Language	English
Publishing date	2022-04-25
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.896402
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Article: [Correlation of early neurodevelopmental features of children with SYNGAP1 variants and their genotypes].

Liu, Haoran / Yang, Shenghai / Li, Jiayi / Xie, Hua / Chen, Xiaoli

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

2024 Volume 41, Issue 1, Page(s) 25–31

Abstract: Objective: To explore the early neurodevelopmental features of young children with SYNGAP1 variants and their genotype-phenotype correlation.: Methods: Young children with neurodevelopmental disorders (NDDs) (< 5 years old) who were referred to the ... ...

Abstract	Objective: To explore the early neurodevelopmental features of young children with SYNGAP1 variants and their genotype-phenotype correlation. Methods: Young children with neurodevelopmental disorders (NDDs) (< 5 years old) who were referred to the Children's Hospital Affiliated to the Capital Institute of Pediatrics between January 2019 and July 2022 were selected as the study subjects. All children had undergone whole-exome sequencing, comprehensive pediatric neuropsychological assessment, familial segregation analysis, and pathogenicity classification. Meanwhile, young Chinese NDD children (< 5 years old) with pathogenic/likely pathogenic SYNGAP1 variants were retrieved from the literature, with information including detailed clinical and genetic testing, neurodevelopmental quotient (DQ) of the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). Children who did not have a detailed DQ but had their developmental status assessed by a medical professional were also included. The correlation between neurodevelopmental severity, comorbidity and SYNGAP1 variants were summarized. Results: Four young NDD children carrying SYNGAP1 variants were recruited (1 male and 3 females, with a mean age of 34.0 ± 18.2 months), among whom one harboring a novel variant (c.437C>G, p.S146). Combined with 19 similar cases retrieved from the literature, 23 Chinese NDD young children were included in our study (8 males and 10 females, 5 with unknown sex, with a mean age of 37.1 ± 14.2 months). A loss of function (LOF) variant was found in 19 (82.6%) children. All of the children had presented global developmental delay (GDD) before the age of two. In addition, 16 (69.6%) had seizure/epilepsy at the age of 27.0 ± 12.1 months, among whom 15 had occurred independent of the global developmental delay. Myoclonic and absence were common types of seizures. Compared with those with variants of exons 8 to 15, the severity of developmental delay was milder among children with variants in exons 1 to 5. Conclusion:* The early neurodevelopment features of the SYNGAP1 variants for young children (< 5 years old) have included global developmental delay and seizure/epilepsy. All of the children may present GDD before the age of two. The severity of developmental delay may be related to the type and location of the SYNGAP1 variants.
MeSH term(s)	Child, Preschool ; Female ; Humans ; Infant ; Male ; Epilepsy/genetics ; Genetic Testing ; Genotype ; Neurodevelopmental Disorders/genetics ; ras GTPase-Activating Proteins/genetics ; Seizures/genetics
Chemical Substances	ras GTPase-Activating Proteins ; SYNGAP1 protein, human
Language	Chinese
Publishing date	2024-01-01
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1003-9406
ISSN	1003-9406
DOI	10.3760/cma.j.cn511374-20230214-00074
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Article ; Online: Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages.

Yang, Fengbo / Jia, Xiaoli / Hua, Chao / Zhou, Feifan / Hua, Jianing / Ji, Yuting / Zhao, Peng / Yuan, Quan / Xing, Malcolm / Lyu, Guozhong

Bioactive materials

2024 Volume 36, Page(s) 30–47

Abstract: Nature makes the most beautiful solution to involuted problems. Among them, the parallel tubular structures are capable of transporting fluid quickly in plant trunks and leaf stems, which demonstrate an ingenious evolutionary design. This study develops ... ...

Abstract	Nature makes the most beautiful solution to involuted problems. Among them, the parallel tubular structures are capable of transporting fluid quickly in plant trunks and leaf stems, which demonstrate an ingenious evolutionary design. This study develops a mini-thermoelectric semiconductor P-N module to create gradient and parallel channeled hydrogels. The modules decrease quickly the temperature of polymer solution from 20 °C to -20 °C within 5 min. In addition to the exceptional liquid absorption rate, the foams exhibited shape memory mechanics. Our mini device universally makes the inspired structure in such as chitosan, gelatin, alginate and polyvinyl alcohol. Non-compressible hemorrhages are the primary cause of death in emergency. The rapid liquid absorption leads to fast activation of coagulation, which provides an efficient strategy for hemostasis management. We demonstrated this by using our semiconductor modules on collagen-kaolin parallel channel foams with their high porosity (96.43%) and rapid expansion rate (2934%). They absorb liquid with 37.25 times of the own weight, show 46.5-fold liquid absorption speed and 24-fold of blood compared with random porous foams. These superior properties lead to strong hemostatic performance in vitro and in vivo.
Language	English
Publishing date	2024-02-23
Publishing country	China
Document type	Journal Article
ISSN	2452-199X
ISSN (online)	2452-199X
DOI	10.1016/j.bioactmat.2024.02.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Developing a risk assessment tool for cancer-related venous thrombosis in China: a modified Delphi-analytic hierarchy process study.

Qin, Xiaoli / Gao, Xiurong / Yang, Yujie / Ou, Shunlong / Luo, Jing / Wei, Hua / Jiang, Qian

BMC cancer

2024 Volume 24, Issue 1, Page(s) 120

Abstract: Objective: To develop a Risk Assessment Tool for Cancer-related Venous Thrombosis in China.: Methods: A modified two-round Delphi method was employed to establish consensus within a field to reach an agreement via a questionnaire or by interviewing a ...

Abstract	Objective: To develop a Risk Assessment Tool for Cancer-related Venous Thrombosis in China. Methods: A modified two-round Delphi method was employed to establish consensus within a field to reach an agreement via a questionnaire or by interviewing a multidisciplinary panel of experts by collecting their feedback to inform the next round, exchanging their knowledge, experience, and opinions anonymously, and resolving uncertainties. Furthermore, The AHP (Analytic Hierarchy Process) was used to determine the final quality indicators' relative importance. Results: The expert's positive coefficient was 85.19% in the first round and 82.61% in the second round, with authoritative coefficients of 0.89 and 0.92 in the respective surveys. The P-value of Kendall's W test was all less than 0.001 for each round, and the W-value for concordance at the end of the two rounds was 0.115. The final Risk Assessment Tool for Cancer-related Venous Thrombosis consisted of three domains, ten subdomains, and 39 indicators, with patient factors weighing 0.1976, disease factors weighing 0.4905, and therapeutic factors weighing 0.3119. Conclusion: The tool is significantly valid and reliable with a strong authority and coordination degree, and it can be used to assess the risk of cancer-related VTE and initiate appropriate thrombophylactic interventions in China.
MeSH term(s)	Humans ; Analytic Hierarchy Process ; Neoplasms ; China ; Risk Assessment ; Venous Thrombosis
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-11877-8
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Article ; Online: Information-based monitoring platform for rational use of antibiotics at a Chinese university hospital.

Hua, Xiaoli

European journal of hospital pharmacy : science and practice

2016 Volume 23, Issue 5, Page(s) 257–265

Abstract: Background: This study aims to describe the implementation of an information-based monitoring platform for rational use of antibiotics (IMPUA) in a Chinese university hospital, and to test the effectiveness of pharmacists' interventions in the ... ...

Abstract	Background: This study aims to describe the implementation of an information-based monitoring platform for rational use of antibiotics (IMPUA) in a Chinese university hospital, and to test the effectiveness of pharmacists' interventions in the electronic prescription with the help of IMPUA. Methods: A computerised supervision system integrated with such new features as hierarchical management in terms of risks involved, limiting rights of antibiotic prescription, electronic control of drug prescribing, online acquisition of all antibiotic-related data, setting special prescriptions, and restricting the maximum dose and days of a single prescription. To test the effects of new features proposed by participating pharmacists, the number of high-risk warnings at different stages of IMPUA were statistically analysed. Results: Our preliminary study showed that IMPUA was feasible and effective for preventing or limiting irrational use of antibiotics. In particular, the number of high-risk warnings were substantially decreased after the options of 'intervention' and 'interception,' as proposed by participating pharmacists, were included in the system. There was a significant difference in percentage of level-4 (red) warnings between the non-intervention and intervention group (p<0.01). Conclusions: Professional information pharmacists, via participatory development, were able to help to improve or perfect the IMPUA. With active involvement of professional pharmacists, the IMPUA can help to reduce irrational antibiotic use and minimise the risk involved.
Language	English
Publishing date	2016-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2650179-X
ISSN	2047-9964 ; 2047-9956
ISSN (online)	2047-9964
ISSN	2047-9956
DOI	10.1136/ejhpharm-2015-000731
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