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  1. Book ; Collection: Cutaneous melanoma

    Balch, Charles M. / Atkins, Michael B. / Garbe, Claus / Gershenwald, Jeffrey E. / Halpern, Allan C. / Kirkwood, John M.

    (Springer reference)

    2020  

    Author's details Charles M. Balch, Michael B. Atkins, Claus Garbe, Jeffrey E. Gershenwald, Allan C. Halpern, John M. Kirkwood [und 3 weitere] editors
    Series title Springer reference
    Language English
    Dates of publication 2020-9999
    Edition Sixth edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Collection (display volumes)
    HBZ-ID HT020364139
    ISBN 978-3-030-05068-9 ; 9783030050702 ; 3-030-05068-8 ; 303005070X
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Cutaneous melanoma / Volume 1

    Balch, Charles M. / Atkins, Michael B. / Garbe, Claus / Gershenwald, Jeffrey E. / Halpern, Allan C. / Kirkwood, John M.

    2020  

    Author's details Charles M. Balch, Michael B. Atkins, Claus Garbe, Jeffrey E. Gershenwald, Allan C. Halpern, John M. Kirkwood [und 3 weitere] editors
    Collection Cutaneous melanoma
    Language English
    Size xxix, 894 Seiten, Illustrationen, Diagramme
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020400491
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 384 available for loan (reading room) Lesesaal EG

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  3. Book: Cutaneous melanoma / Volume 2

    Balch, Charles M. / Atkins, Michael B. / Garbe, Claus / Gershenwald, Jeffrey E. / Halpern, Allan C. / Kirkwood, John M.

    2020  

    Author's details Charles M. Balch, Michael B. Atkins, Claus Garbe, Jeffrey E. Gershenwald, Allan C. Halpern, John M. Kirkwood [und 3 weitere] editors
    Collection Cutaneous melanoma
    Language English
    Size xxix Seiten, Seite 897 - 1510, Illustrationen
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT020400498
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 385 available for loan (reading room) Lesesaal EG

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  4. Book ; Conference proceedings: Integrins in cancer: novel therapeutic approaches

    Kirkwood, John M.

    [... based on the symposium presented to the 31st congress of the European Society of Medical Oncology on September 29, 2006, in Istanbul]

    (Oncology ; 21,9, Suppl. 3)

    2007  

    Author's details guest ed. John M. Kirkwood
    Series title Oncology ; 21,9, Suppl. 3
    Collection
    Language English
    Size 24 S. : Ill.
    Publisher PRR
    Publishing place Melville, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT015292944
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3168 -21,Suppl.3- not available for loan Zeitschriften-Lesesaal

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  5. Article: Immunotherapy in Melanoma: Recent Advances and Future Directions.

    Knight, Andrew / Karapetyan, Lilit / Kirkwood, John M

    Cancers

    2023  Volume 15, Issue 4

    Abstract: The use of immunotherapy in the treatment of advanced and high-risk melanoma has led to a striking improvement in outcomes. Although the incidence of melanoma has continued to rise, median survival has improved from approximately 6 months to nearly 6 ... ...

    Abstract The use of immunotherapy in the treatment of advanced and high-risk melanoma has led to a striking improvement in outcomes. Although the incidence of melanoma has continued to rise, median survival has improved from approximately 6 months to nearly 6 years for patients with advanced inoperable stage IV disease. Recent understanding of the tumor microenvironment and its interplay with the immune system has led to the explosive development of novel immunotherapy treatments. Since the approval of the therapeutic cytokines interleukin-2 and interferon alfa-2 in the 1990s, the development of novel immune checkpoint inhibitors (ICIs), oncolytic virus therapy, and modulators of the tumor microenvironment have given way to a new era in melanoma treatment. Monoclonal antibodies directed at programmed cell death protein 1 receptor (PD-1) and its ligand (PDL-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), and lymphocyte-activation gene 3 (LAG-3) have provided robust activation of the adaptive immune system, restoring immune surveillance leading to host tumor recognition and destruction. Multiple other immunomodulatory therapeutics are under investigation to overcome resistance to ICI therapy, including the toll-like receptor-9 (TLR-9) and 7/8 (TLR-7/8) agonists, stimulator of interferon genes (STING) agonists, and fecal microbiota transplantation. In this review, we focus on the recent advances in immunotherapy for the treatment of melanoma and provide an update on novel therapies currently under investigation.
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Beyond PD-1: The Next Frontier for Immunotherapy in Melanoma.

    Rohatgi, Anjali / Kirkwood, John M

    Frontiers in oncology

    2021  Volume 11, Page(s) 640314

    Abstract: The advent of first and second-generation immune checkpoint blockade (ICI) has resulted in improved survival of patients with metastatic melanoma over the past decade. However, the majority of patients ultimately progress despite these treatments, which ... ...

    Abstract The advent of first and second-generation immune checkpoint blockade (ICI) has resulted in improved survival of patients with metastatic melanoma over the past decade. However, the majority of patients ultimately progress despite these treatments, which has served as an impetus to consider a range of subsequent therapies. Many of the next generation of immunotherapeutic agents focus on modifying the immune system to overcome resistance to checkpoint blockade. ICI resistance can be understood as primary, or acquired-where the latter is the most common scenario. While there are several postulated mechanisms by which resistance, particularly acquired resistance, occurs, the predominant escape mechanisms include T cell exhaustion, upregulation of alternative inhibitory checkpoint receptors, and alteration of the tumor microenvironment (TME) into a more suppressive, anti-inflammatory state. Therapeutic agents in development are designed to work by combating one or more of these resistance mechanisms. These strategies face the added challenge of minimizing immune-related toxicities, while improving antitumor efficacy. This review focuses upon the following categories of novel therapeutics: 1) alternative inhibitory receptor pathways; 2) damage- or pathogen-associated molecular patterns (DAMPs/PAMPs); and 3) immune cell signaling mediators. We present the current state of these therapies, including preclinical and clinical data available for these targets under development.
    Language English
    Publishing date 2021-03-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.640314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Strategies in adjuvant therapy

    Kirkwood, John M.

    2000  

    Author's details ed. by John M. Kirkwood
    Language English
    Size XI, 255 S. : graph. Darst.
    Publisher Dunitz
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT012743663
    ISBN 1-85317-317-7 ; 978-1-85317-317-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2000 A 2248 order for loan Magazin

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  8. Article ; Online: Cancer vaccine induces potent T cell responses - but is it enough?

    Rohatgi, Anjali / Kirkwood, John M

    Nature reviews. Clinical oncology

    2020  Volume 17, Issue 12, Page(s) 721–722

    MeSH term(s) CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cancer Vaccines/therapeutic use ; Humans ; Melanoma ; RNA
    Chemical Substances Cancer Vaccines ; RNA (63231-63-0)
    Language English
    Publishing date 2020-09-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-020-00437-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6029: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 103: Show issues

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  9. Article ; Online: Developing agents for the therapeutic prevention of melanoma: can the assessment of cutaneous precursor lesions help?

    Maguire, William F / Kirkwood, John M

    Future oncology (London, England)

    2020  Volume 16, Issue 9, Page(s) 413–415

    MeSH term(s) Anticarcinogenic Agents/therapeutic use ; Biomarkers, Tumor ; Chemoprevention ; Clinical Trials as Topic ; Drug Development ; Humans ; Melanoma/pathology ; Melanoma/prevention & control ; Nevus/pathology ; Patient Selection ; Skin Neoplasms/pathology ; Skin Neoplasms/prevention & control
    Chemical Substances Anticarcinogenic Agents ; Biomarkers, Tumor
    Language English
    Publishing date 2020-02-26
    Publishing country England
    Document type Editorial
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2020-0012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6478: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Waiting Times for Cataract Surgery in Scotland since 2002 and the Effect of Austerity: An Interrupted Time Series Analysis.

    Kirkwood, Graham / Buchan, John / Pollock, Allyson M

    Ophthalmic epidemiology

    2022  , Page(s) 1–8

    Abstract: Purpose: In Scotland, in 2002, the National Waiting Times Unit was launched to reduce NHS waiting times. This was accompanied by a series of waiting time targets across the NHS in Scotland. The purpose of this study is to analyse changes in equality of ... ...

    Abstract Purpose: In Scotland, in 2002, the National Waiting Times Unit was launched to reduce NHS waiting times. This was accompanied by a series of waiting time targets across the NHS in Scotland. The purpose of this study is to analyse changes in equality of access to treatment by socioeconomic deprivation associated with this initiative.
    Methods: Trends in annual cataract rates were calculated using secondary care admissions' Scottish Morbidity Record (SMR01) data on NHS funded elective cataract procedures for patients treated in Scotland from 01 April 1997 to 31 March 2019. An interrupted time series model was used to analyse socioeconomic differences in waiting times by deprivation quintile over three time periods; pre and post waiting time initiative, and post austerity.
    Results: Cataract Surgical Rates more than doubled from 3,723 per million population in 1997/1998 to 7,896 per million population in 2018/2019. Mean waiting time fell from 129.5 days in 1997/1998 to 87.7 days in 2018/2019. Inequality in mean waiting time between most and least deprived cataract patients increased by 1.34 days per quarter between 01 April 1997 and 30 June 2002 and following the waiting time initiative fell by 0.41 days per quarter through to 31 March 2010; and then decreased by 0.002 days per quarter between 01 April 2010 and 31 March 2019.
    Conclusion: The waiting time initiative had a major impact on reducing inequality in waiting times between socioeconomic groups. The onset of austerity in 2010 was associated with a very small and insignificant increase in inequality.
    Language English
    Publishing date 2022-06-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1213070-9
    ISSN 1744-5086 ; 0928-6586
    ISSN (online) 1744-5086
    ISSN 0928-6586
    DOI 10.1080/09286586.2022.2075900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4138: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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