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Article ; Online: The Influence of Nutritional Status at Diagnosis of Childhood B-Cell Acute Lymphoblastic Leukemia on Survival Rates: Data from a Hispanic Cohort.

Jaime-Pérez, José C / Turrubiates-Hernández, Grecia A / García-Salas, Gerardo / de la Torre-Salinas, Anel M / Áncer-Rodríguez, Patricia / Villarreal-Martínez, Laura / Gómez-Almaguer, David

Nutrition and cancer

2021 Volume 74, Issue 3, Page(s) 889–895

Abstract: The impact of nutritional status at diagnosis of childhood acute lymphoblastic leukemia (ALL) on survival rates was assessed in a Hispanic cohort. Children <16 years with newly diagnosed ALL-B from 2011 to 2019 were studied. Overweight and obesity were ... ...

Abstract	The impact of nutritional status at diagnosis of childhood acute lymphoblastic leukemia (ALL) on survival rates was assessed in a Hispanic cohort. Children <16 years with newly diagnosed ALL-B from 2011 to 2019 were studied. Overweight and obesity were classified by body mass index (BMI) and Z-score according to WHO and CDC criteria. BMI, weight percentiles for age and Z-Score were assessed using the WHO Anthro (0-5 years) and AnthroPlus (5-19 years) programs. Cox model was used to estimate risk factors for relapse and death; differences between groups were assessed with Student's T test for parametric and Mann-Whitney U test for non-parametric variables. Disease-free survival (DFS) and overall survival (OS) were determined by the Kaplan-Meier method, calculating time, status, cumulative survival and standard error with a 95% confidence interval. Equal data distribution was estimated with the log-rank test. One-hundred and seventy-two B-ALL children were studied. The overweight-obese group had a non-significant lower DFS (CDC: 54% vs. 60%,
MeSH term(s)	Body Mass Index ; Child ; Disease-Free Survival ; Hispanic or Latino ; Humans ; Nutritional Status ; Obesity/complications ; Overweight/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Retrospective Studies ; Survival Rate
Language	English
Publishing date	2021-06-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581.2021.1934042
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Article ; Online: New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent.

Alvarez-Salas, Elena / García-Luna, Cinthia / de Gortari, Patricia

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: Thyrotropin-releasing hormone (TRH) is a tripeptide that regulates the neuroendocrine thyroid axis. Moreover, its widespread brain distribution has indicated that it is a relevant neuromodulator of behaviors such as feeding, arousal, anxiety, and ... ...

Abstract	Thyrotropin-releasing hormone (TRH) is a tripeptide that regulates the neuroendocrine thyroid axis. Moreover, its widespread brain distribution has indicated that it is a relevant neuromodulator of behaviors such as feeding, arousal, anxiety, and locomotion. Importantly, it is also a neurotrophic peptide, and thus may halt the development of neurodegenerative diseases and improve mood-related disorders. Its neuroprotective actions on those pathologies and behaviors have been limited due to its poor intestinal and blood-brain barrier permeability, and because it is rapidly degraded by a serum enzyme. As new strategies such as TRH intranasal delivery emerge, a renewed interest in the peptide has arisen. TRH analogs have proven to be safe in animals and humans, while not inducing alterations in thyroid hormones' levels. In this review, we integrate research from different approaches, aiming to demonstrate the therapeutic effects of TRH, and to summarize new efforts to prolong and facilitate the peptide's actions to improve symptoms and the progression of several pathologies.
MeSH term(s)	Animals ; Humans ; Thyrotropin-Releasing Hormone/therapeutic use ; Thyrotropin-Releasing Hormone/metabolism ; Brain/metabolism ; Thyroid Gland/metabolism ; Peptides/metabolism ; Thyroid Hormones/metabolism
Chemical Substances	Thyrotropin-Releasing Hormone (5Y5F15120W) ; Peptides ; Thyroid Hormones
Language	English
Publishing date	2023-07-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241311047
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Article ; Online: New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent

Elena Alvarez-Salas / Cinthia García-Luna / Patricia de Gortari

International Journal of Molecular Sciences, Vol 24, Iss 11047, p

2023 Volume 11047

Abstract	Thyrotropin-releasing hormone (TRH) is a tripeptide that regulates the neuroendocrine thyroid axis. Moreover, its widespread brain distribution has indicated that it is a relevant neuromodulator of behaviors such as feeding, arousal, anxiety, and locomotion. Importantly, it is also a neurotrophic peptide, and thus may halt the development of neurodegenerative diseases and improve mood-related disorders. Its neuroprotective actions on those pathologies and behaviors have been limited due to its poor intestinal and blood–brain barrier permeability, and because it is rapidly degraded by a serum enzyme. As new strategies such as TRH intranasal delivery emerge, a renewed interest in the peptide has arisen. TRH analogs have proven to be safe in animals and humans, while not inducing alterations in thyroid hormones’ levels. In this review, we integrate research from different approaches, aiming to demonstrate the therapeutic effects of TRH, and to summarize new efforts to prolong and facilitate the peptide’s actions to improve symptoms and the progression of several pathologies.
Keywords	thyrotropin-releasing hormone ; therapeutic factor ; neuromodulator ; TRH analogs ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Influence of Nutritional Status at Diagnosis of Childhood B-Cell Acute Lymphoblastic Leukemia on Survival Rates: Data from a Hispanic Cohort

Jaime-Pérez, José C. / Turrubiates-Hernández, Grecia A. / García-Salas, Gerardo / de la Torre-Salinas, Anel M. / Áncer-Rodríguez, Patricia / Villarreal-Martínez, Laura / Gómez-Almaguer, David

Nutrition and cancer. 2022 Mar. 24, v. 74, no. 3

2022

Abstract	The impact of nutritional status at diagnosis of childhood acute lymphoblastic leukemia (ALL) on survival rates was assessed in a Hispanic cohort. Children <16 years with newly diagnosed ALL-B from 2011 to 2019 were studied. Overweight and obesity were classified by body mass index (BMI) and Z-score according to WHO and CDC criteria. BMI, weight percentiles for age and Z-Score were assessed using the WHO Anthro (0-5 years) and AnthroPlus (5-19 years) programs. Cox model was used to estimate risk factors for relapse and death; differences between groups were assessed with Student’s T test for parametric and Mann-Whitney U test for non-parametric variables. Disease-free survival (DFS) and overall survival (OS) were determined by the Kaplan-Meier method, calculating time, status, cumulative survival and standard error with a 95% confidence interval. Equal data distribution was estimated with the log-rank test. One-hundred and seventy-two B-ALL children were studied. The overweight-obese group had a non-significant lower DFS (CDC: 54% vs. 60%, p = 0.80; WHO: 57% vs. 64%, p = 0.89) and OS rate (CDC:76% vs. 82%, p = 0.38; WHO:65% vs. 81%, p = 0.13). An association between nutritional status determined by CDC and WHO criteria at diagnosis of B-cell ALL and survival rates was not documented.
Keywords	B-lymphocytes ; body mass index ; childhood ; confidence interval ; death ; lymphocytic leukemia ; models ; nutritional status ; obesity ; relapse ; risk estimate
Language	English
Dates of publication	2022-0324
Size	p. 889-895.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581.2021.1934042
Database	NAL-Catalogue (AGRICOLA)

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Article: Determination of lipid composition of the two principal cherimoya cultivars grown in Andalusian Region

García-Salas, Patricia / Alberto Fernández-Gutiérrez / Alessandro Gori / Antonio Segura-Carretero / Maria Fiorenza Caboni / Vito Verardo

Lebensmittel-Wissenschaft + [i.e. und] Technologie. 2016 Jan., v. 65

2016

Abstract: Cherimoya (Annona cherimola) is a tropical fruit, native to inter-Andean valleys from Peru and Ecuador. The main cherimoya growing in the Mediterranean basin is the coast of Granada–Malaga (Spain), the so-called Costa Tropical.Recently, the number of ... ...

Abstract	Cherimoya (Annona cherimola) is a tropical fruit, native to inter-Andean valleys from Peru and Ecuador. The main cherimoya growing in the Mediterranean basin is the coast of Granada–Malaga (Spain), the so-called Costa Tropical.Recently, the number of studies related to economic exploitation of seeds and other by-products proceeding from new oleaginous vegetable sources has increased. Therefore, the aim of this work was to characterize the lipid fraction of the edible portion of the cherimoya and its by-products.Different fatty acids were identified in pulp, seed, and skin. The major fatty acids were palmitic, oleic, linoleic, and α-linolenic. On the other hand, α-tocopherol was identified in seeds and peel. Moreover, three different phospholipids were identified. Finally, β-sitosterol was the principle sterol in all samples and, to our knowledge, γ-sitosterol was identified only in pulp and peel of cherimoya for the first time.
Keywords	alpha-tocopherol ; Annona cherimola ; basins ; beta-sitosterol ; byproducts ; cherimoyas ; coasts ; cultivars ; lipid composition ; palmitic acid ; phospholipids ; pulp ; seeds ; valleys ; vegetables ; Ecuador ; Peru ; Spain
Language	English
Dates of publication	2016-01
Size	p. 390-397.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	241369-3
ISSN	0460-1173 ; 0023-6438
ISSN	0460-1173 ; 0023-6438
DOI	10.1016/j.lwt.2015.08.004
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Near-Infrared Fluorescence Imaging in Preclinical Models of Glioblastoma.

Llaguno-Munive, Monserrat / Villalba-Abascal, Wilberto / Avilés-Salas, Alejandro / Garcia-Lopez, Patricia

Journal of imaging

2023 Volume 9, Issue 10

Abstract: Cancer is a public health problem requiring ongoing research to improve current treatments and discover novel therapies. More accurate imaging would facilitate such research. Near-infrared fluorescence has been developed as a non-invasive imaging ... ...

Abstract	Cancer is a public health problem requiring ongoing research to improve current treatments and discover novel therapies. More accurate imaging would facilitate such research. Near-infrared fluorescence has been developed as a non-invasive imaging technique capable of visualizing and measuring biological processes at the molecular level in living subjects. In this work, we evaluate the tumor activity in two preclinical glioblastoma models by using fluorochrome (IRDye 800CW) coupled to different molecules: tripeptide Arg-Gly-Asp (RGD), 2-amino-2-deoxy-D-glucose (2-DG), and polyethylene glycol (PEG). These molecules interact with pathological conditions of tumors, including their overexpression of αvβ3 integrins (RGD), elevated glucose uptake (2-DG), and enhanced permeability and retention effect (PEG). IRDye 800CW RGD gave the best in vivo fluorescence signal from the tumor area, which contrasted well with the low fluorescence intensity of healthy tissue. In the ex vivo imaging (dissected tumor), the accumulation of IRDye 800CW RGD could be appreciated at the tumor site. Glioblastoma tumors were presently detected with specificity and sensitivity by utilizing IRDye 800CW RGD, a near-infrared fluorophore combined with a marker of αvβ3 integrin expression. Further research is needed on its capacity to monitor tumor growth in glioblastoma after chemotherapy.
Language	English
Publishing date	2023-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2824270-1
ISSN	2313-433X ; 2313-433X
ISSN (online)	2313-433X
ISSN	2313-433X
DOI	10.3390/jimaging9100212
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Article ; Online: New local ganirelix sustained release therapy for uterine leiomyoma. Evaluation in a preclinical organ model.

Salas, Ana / García-García, Patricia / Díaz-Rodríguez, Patricia / Évora, Carmen / Almeida, Teresa A / Delgado, Araceli

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 156, Page(s) 113909

Abstract: Currently, there is a limited number of treatment options available for patients with symptomatic leiomyomas, and surgical removal is by far the most frequent procedure. Previous studies found that GnRH agonists and antagonists acting through GnRH ... ...

Abstract	Currently, there is a limited number of treatment options available for patients with symptomatic leiomyomas, and surgical removal is by far the most frequent procedure. Previous studies found that GnRH agonists and antagonists acting through GnRH receptors led to cell death and decreased extracellular synthesis in cultured leiomyoma cells. In this study, we encapsulated the GnRH antagonist ganirelix in PLGA microspheres contained in an alginate scaffold that also supports a leiomyoma ex vivo tissue explant. Microspheres maintained ganirelix concentration stably during six days of culture, inducing significant cell death in 50-55% of tumor cells. Although no changes were observed in the expression of extracellular matrix genes, a decreased expression of the Nuclear Factor of Activated T cells 5, a transcription factor involved in osmotic stress and tumor size. Interestingly, all tumors analyzed experienced apoptosis independently of the original driver mutation. These data indicate that local therapy of ganirelix would induce tumor reduction in a wide range of uterine leiomyomas.
MeSH term(s)	Humans ; Female ; Delayed-Action Preparations ; Leiomyoma/metabolism ; Gonadotropin-Releasing Hormone/pharmacology ; Hormone Antagonists/pharmacology ; Hormone Antagonists/therapeutic use ; Uterine Neoplasms/pathology
Chemical Substances	ganirelix (IX503L9WN0) ; Delayed-Action Preparations ; Gonadotropin-Releasing Hormone (33515-09-2) ; Hormone Antagonists
Language	English
Publishing date	2022-10-21
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113909
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Article ; Online: Efficacy of the use of video games on mood, anxiety and depression in stroke patients: preliminary findings of a randomised controlled trial.

Blázquez-González, Patricia / Mirón-González, Rubén / Lendínez-Mesa, Alejandro / Luengo-González, Raquel / Mancebo-Salas, Noelia / Camacho-Arroyo, María Teresa / Muriel-García, Alfonso / García-Sastre, María Montserrat

Journal of neurology

2024 Volume 271, Issue 3, Page(s) 1224–1234

Abstract: Background: In the different published studies, there is no consensus on the efficacy of virtual reality as an adjuvant treatment of mood states.: Aim: The aim of this study is to evaluate the impact of no immersive virtual reality with the Nintendo ... ...

Abstract	Background: In the different published studies, there is no consensus on the efficacy of virtual reality as an adjuvant treatment of mood states. Aim: The aim of this study is to evaluate the impact of no immersive virtual reality with the Nintendo Switch device in rehabilitation treatment on mood, anxiety and depression in stroke patients admitted to neurorehabilitation units. Methods: Fifty-eight patients admitted to neurorehabilitation units underwent a 1:3 multicentre randomised clinical trial. The intervention group consisted of 17 patients and the control group of 41 patients. The intervention group performed 6 virtual reality sessions together with the conventional treatment, and the control group performed only the conventional rehabilitation sessions. Primary and secondary clinical outcomes were measured before and six weeks after the intervention. Results: Comparing the intervention group and control group, the anxiety levels of the intervention group decreased compared to the results observed in the control group (p = 0.01), as did the dependence of the intervention group (0.015). On the other hand, the results obtained after the intervention by the control group for anxiety (0.479) and depression (0.292) were not statistically significant. Conclusion: Rehabilitation VR used as an adjuvant treatment to conventional treatment has a beneficial impact on the neurological status and state of anxiety of stroke patients admitted to neurorehabilitation units. Trial registration: Registered in the https://clinicaltrials.gov/ repository (NTC NCT05143385). Protocol registration date 7 October 2021, retrospectively registered.
MeSH term(s)	Humans ; Stroke Rehabilitation/methods ; Depression/etiology ; Depression/therapy ; Stroke/complications ; Stroke/therapy ; Video Games ; Anxiety/etiology ; Anxiety/therapy
Language	English
Publishing date	2024-01-10
Publishing country	Germany
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-023-12043-z
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Article ; Online: Identification and quantification of phenolic and other polar compounds in the edible part of Annona cherimola and its by-products by HPLC-DAD-ESI-QTOF-MS.

García-Salas, Patricia / Gómez-Caravaca, Ana María / Morales-Soto, Aránzazu / Segura-Carretero, Antonio / Fernández-Gutiérrez, Alberto

Food research international (Ottawa, Ont.)

2015 Volume 78, Page(s) 246–257

Language	English
Publishing date	2015-12
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2015.10.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Influence of an innovative and promising gas clarification process on the quality of stored extra virgin olive oils.

Valli, Enrico / Ayyad, Ziad / Garcia-Salas, Patricia / Cevoli, Chiara / Afaneh, Ibrahim Abdullah / Bendini, Alessandra / Gallina Toschi, Tullia

Food research international (Ottawa, Ont.)

2018 Volume 116, Page(s) 30–36

Abstract: Filtration of extra virgin olive oil is a process that may improve preservation of the quality during storage. In the current study, different aliquots of extra virgin olive oils were subjected to filtration with a traditional filter press or an ... ...

Abstract	Filtration of extra virgin olive oil is a process that may improve preservation of the quality during storage. In the current study, different aliquots of extra virgin olive oils were subjected to filtration with a traditional filter press or an innovative patented alternative process of clarification by insufflating inert gas such as nitrogen and argon; all treated samples and, as control unfiltered ones, were stored for one year to evaluate the effects of these technologies on the quality of oil during shelf-life. Basic quality indexes, diglycerides, phenolics and volatiles, as well as the sensory characteristics of samples, were determined at 4 month intervals during storage. According to the volatile compounds, phenolics and sensory analysis, the novel technique had a beneficial effect on the storage of extra virgin olive oils; accordingly, this process could be exploited by the olive oil industry.
MeSH term(s)	Filtration ; Food Handling ; Food Quality ; Food Storage ; Humans ; Iridoids/analysis ; Olive Oil/analysis ; Phenols/analysis ; Taste ; Volatile Organic Compounds/analysis ; Water/analysis
Chemical Substances	Iridoids ; Olive Oil ; Phenols ; Volatile Organic Compounds ; Water (059QF0KO0R)
Language	English
Publishing date	2018-12-25
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2018.12.050
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