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Article ; Online: Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk.

Regan, Jessica A / Shah, Svati H

2020 Volume 22, Issue 12, Page(s) 174

Abstract: Purpose of review: Obesity is a significant international public health epidemic with major downstream consequences on morbidity and mortality. While lifestyle factors contribute, there is an evolving understanding of genomic and metabolomic pathways ... ...

Abstract	Purpose of review: Obesity is a significant international public health epidemic with major downstream consequences on morbidity and mortality. While lifestyle factors contribute, there is an evolving understanding of genomic and metabolomic pathways involved with obesity and its relationship with cardiometabolic risk. This review will provide an overview of some of these important findings from both a biologic and clinical perspective. Recent findings: Recent studies have identified polygenic risk scores and metabolomic biomarkers of obesity and related outcomes, which have also highlighted biological pathways, such as the branched-chain amino acid (BCAA) pathway that is dysregulated in this disease. These biomarkers may help in personalizing obesity interventions and for mitigation of future cardiometabolic risk. A multifaceted approach is necessary to impact the growing epidemic of obesity and related diseases. This will likely include incorporating precision medicine approaches with genomic and metabolomic biomarkers to personalize interventions and improve risk prediction.
MeSH term(s)	Amino Acids, Branched-Chain ; Biomarkers ; Cardiovascular Diseases/genetics ; Genomics ; Humans ; Metabolomics ; Obesity/genetics
Chemical Substances	Amino Acids, Branched-Chain ; Biomarkers
Language	English
Publishing date	2020-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2055373-0
ISSN	1534-3170 ; 1523-3782
ISSN (online)	1534-3170
ISSN	1523-3782
DOI	10.1007/s11886-020-01422-x
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Article ; Online: Attitudes, barriers, and facilitators to adherent completion of the recombinant zoster vaccine regimen in Canada: Qualitative interviews with healthcare providers and patients.

George, Sydney / Regan, Jessica / Awan, Amnah / O'Connor, Meaghan / Foster, April / Raymond, Kimberly / Gorfinkel, Iris / McNeil, Shelly A

Human vaccines & immunotherapeutics

2024 Volume 20, Issue 1, Page(s) 2317595

Abstract: This qualitative, cross-sectional study aimed to understand the barriers and facilitators related to the adherence and completion of the recombinant zoster vaccine (RZV) two-dose series in Canada, as perceived by healthcare providers (HCPs) and patients. ...

Abstract	This qualitative, cross-sectional study aimed to understand the barriers and facilitators related to the adherence and completion of the recombinant zoster vaccine (RZV) two-dose series in Canada, as perceived by healthcare providers (HCPs) and patients. Data collection occurred via 60-minute concept elicitation interviews with 12 HCPs (4 physicians, 2 nurse practitioners, 6 pharmacists) who had prescribed and/or administered RZV in Canada, and 21 patients aged ≥50 years who had received ≥1 dose of RZV. Patients were categorized as adherent (received both doses within the recommended 2-to-6-month timeframe;
MeSH term(s)	Adult ; Humans ; Herpes Zoster Vaccine ; Cross-Sectional Studies ; Herpes Zoster/prevention & control ; Herpesvirus 3, Human ; Vaccines, Synthetic ; Health Personnel ; Canada
Chemical Substances	Herpes Zoster Vaccine ; Vaccines, Synthetic
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2024.2317595
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Article ; Online: Updated Public Health Impact and Cost Effectiveness of Recombinant Zoster Vaccine in Canadian Adults Aged 50 Years and Older.

George, Sydney / Carrico, Justin / Hicks, Katherine A / Loukov, Dessi / Ng, Cheryl / Regan, Jessica / Giannelos, Nikolaos

PharmacoEconomics - open

2024

Abstract: Objectives: The aim of this study was to update previously estimated public health impact and cost effectiveness of recombinant zoster vaccine (RZV) for the prevention of herpes zoster (HZ) in Canadians aged ≥50 years using longer-term RZV efficacy and ... ...

Abstract	Objectives: The aim of this study was to update previously estimated public health impact and cost effectiveness of recombinant zoster vaccine (RZV) for the prevention of herpes zoster (HZ) in Canadians aged ≥50 years using longer-term RZV efficacy and waning data and real-world coverage and completion. Methods: A multicohort Markov model was used to conduct a cost-utility analysis comparing RZV with no HZ vaccination among Canadians aged ≥50 years. Real-world data were used for first-dose coverage (17.5%) and second-dose completion (65%). Vaccine efficacy and waning data were applied from up to 8-year follow-up from the ZOE-50 and ZOE-70 clinical trials. Incremental costs and benefits were calculated using a lifetime horizon from the healthcare payer (base case) and societal perspectives. A discount rate of 1.5% was applied to costs and quality-adjusted life-years (QALYs). Results: The model estimated that RZV would prevent 303,835 HZ cases, 83,256 post-herpetic neuralgia (PHN) cases, 39,653 other complications, and 99 HZ-related deaths compared with no HZ vaccination. Incremental cost-effectiveness ratios (ICERs) were estimated to be $27,486 and $22,097 per QALY (2022 Canadian dollars [CAN$]) from the healthcare payer and societal perspectives, respectively. The base-case ICER was most sensitive to a lower percentage of initial HZ cases with PHN. Almost all probabilistic sensitivity analysis simulations (98.1%) resulted in ICERs <CAN$50,000 per QALY.<br />Conclusions: RZV is expected to remain a cost-effective option for Canadian adults aged ≥50 years when using longer-term RZV efficacy and waning estimates, although the estimated public health impact was smaller than in the previous analysis (due to lower coverage/completion estimates).
Language	English
Publishing date	2024-04-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2874287-4
ISSN	2509-4254 ; 2509-4262
ISSN (online)	2509-4254
ISSN	2509-4262
DOI	10.1007/s41669-024-00483-w
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Article ; Online: Virtual Obstetric Hospitalist Support for Obstetric Emergencies and Deliveries: The Mayo Clinic Experience.

Theiler, Regan N / Torbenson, Vanessa / Schoen, Jessica C / Stegemann, Hollie / Heaton, Heather A / Kozhimannil, Katy B / Fang, Jennifer L / Sadosty, Annie

Telemedicine journal and e-health : the official journal of the American Telemedicine Association

2024

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2035659-6
ISSN	1556-3669 ; 1530-5627
ISSN (online)	1556-3669
ISSN	1530-5627
DOI	10.1089/tmj.2023.0358
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Article: The atypical antipsychotic aripiprazole alters the outcome of disseminated

Reitler, Parker / Regan, Jessica / DeJarnette, Christian / Srivastava, Ashish / Carnahan, Jen / Tucker, Katie M / Meibohm, Bernd / Peters, Brian M / Palmer, Glen E

bioRxiv : the preprint server for biology

2024

Abstract: Invasive fungal infections (IFIs) impose an enormous clinical, social, and economic burden on humankind. For many IFIs, ≥ 30% of patients fail therapy with existing antifungal drugs, including the widely used azole class. We previously identified a ... ...

Abstract	Invasive fungal infections (IFIs) impose an enormous clinical, social, and economic burden on humankind. For many IFIs, ≥ 30% of patients fail therapy with existing antifungal drugs, including the widely used azole class. We previously identified a collection of 13 approved medications that antagonize azole activity. While gain-of-function mutants resulting in antifungal resistance are often associated with reduced fitness and virulence, it is currently unknown how exposure to azole antagonistic drugs impact
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.13.580133
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Article ; Online: Clinician Perspectives on Managing Chronic Pain After Curative-Intent Cancer Treatment.

Check, Devon K / Jones, Katie F / Fish, Laura J / Dinan, Michaela A / Dunbar, T Kayla / Farley, Samantha / Ma, Jessica / Merlin, Jessica S / O'Regan, Amy / Oeffinger, Kevin C

JCO oncology practice

2023 Volume 19, Issue 4, Page(s) e484–e491

Abstract: Purpose: Among cancer survivors who have completed curative-intent treatment, the high prevalence and adverse consequences of chronic pain are well documented. Yet, research on clinicians' experiences with and perspectives on managing chronic pain among ...

Abstract	Purpose: Among cancer survivors who have completed curative-intent treatment, the high prevalence and adverse consequences of chronic pain are well documented. Yet, research on clinicians' experiences with and perspectives on managing chronic pain among cancer survivors is critically lacking. Methods: We conducted semistructured interviews with 17 clinicians (six oncology, three palliative care, and eight primary care) affiliated with an academic medical center. Interview questions addressed clinicians' experiences with and perspectives on managing chronic pain (with or without opioid therapy) during the transition from active treatment to survivorship. A multidisciplinary team conducted content analysis of interview transcripts to identify and refine themes related to current practices and challenges in managing chronic pain in this context. Results: Overall, clinicians perceived chronic pain to be relatively uncommon among cancer survivors. Identified challenges included a lack of clarity about which clinician (or clinicians) are best positioned to manage chronic pain among cancer survivors, and (relatedly) complexities introduced by long-term opioid management, with many clinicians describing this practice as outside their skill set. Additionally, although most clinicians recognized chronic pain as a biopsychosocial phenomenon, they described challenges with effectively managing psychosocial stressors, including difficulty accessing mental or behavioral health services for cancer survivors. Conclusion: Discovered challenges highlight unmet needs related to cancer survivor-clinician communication about chronic pain and the absence of a chronic pain management home for cancer survivors, including those requiring long-term opioid therapy. Research evaluating routine pain monitoring and accessible, tailored models of multimodal pain care in survivorship may help to address these challenges.
MeSH term(s)	Humans ; Pain Management ; Analgesics, Opioid/therapeutic use ; Chronic Pain/complications ; Chronic Pain/epidemiology ; Chronic Pain/therapy ; Neoplasms/complications ; Neoplasms/therapy ; Medical Oncology
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3028198-2
ISSN	2688-1535 ; 2688-1527
ISSN (online)	2688-1535
ISSN	2688-1527
DOI	10.1200/OP.22.00410
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Article ; Online: Phenome-Wide Association Study of Severe COVID-19 Genetic Risk Variants.

Regan, Jessica A / Abdulrahim, Jawan W / Bihlmeyer, Nathan A / Haynes, Carol / Kwee, Lydia Coulter / Patel, Manesh R / Shah, Svati H

Journal of the American Heart Association

2022 Volume 11, Issue 5, Page(s) e024004

MeSH term(s)	COVID-19/genetics ; Genetic Predisposition to Disease ; Genetic Variation ; Genome-Wide Association Study ; Humans ; Patient Acuity ; Phenotype ; SARS-CoV-2/genetics
Language	English
Publishing date	2022-02-18
Publishing country	England
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.024004
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Article ; Online: Identifying Specific Small Molecule-Protein Interactions Using Target Abundance-Based Fitness Screening (TAFiS).

Regan, Jessica / Palmer, Glen E

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2542, Page(s) 115–126

Abstract: Traditional small molecule antifungal discovery efforts often utilize high-throughput (HTP) biochemical or whole-cell phenotypic screens to identify novel candidates. However, both methods have limitations which hinder the rapid identification of ... ...

Abstract	Traditional small molecule antifungal discovery efforts often utilize high-throughput (HTP) biochemical or whole-cell phenotypic screens to identify novel candidates. However, both methods have limitations which hinder the rapid identification of physiologically active compounds that act via a defined mechanism of action. The method described herein is an efficient, sensitive, and HTP compatible approach that utilizes the principles of competitive fitness to rapidly identify small molecules that functionally interact with a specific target protein within whole cells.
MeSH term(s)	Antifungal Agents/pharmacology ; Biophysical Phenomena ; High-Throughput Screening Assays/methods ; Proteins
Chemical Substances	Antifungal Agents ; Proteins
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2549-1_8
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Article ; Online: Extra-articular arthroscopic release of lateral epicondylitis: a prospective study.

Baraza, Njalalle / Robinson, Mark P / Sakaleshpura Chandrashekar, Nanda Kumar / Perry, Jessica A / Regan, William D

JSES reviews, reports, and techniques

2021 Volume 1, Issue 4, Page(s) 398–401

Abstract: Background: Operative management of lateral epicondylitis can be managed with percutaneous, arthroscopic, or open surgical release. Extraarticular arthroscopic release is a new technique, and no study has compared its outcomes and risk profile.: ... ...

Abstract	Background: Operative management of lateral epicondylitis can be managed with percutaneous, arthroscopic, or open surgical release. Extraarticular arthroscopic release is a new technique, and no study has compared its outcomes and risk profile. Methods: A 26-patient cohort was reviewed before and after extraarticular arthroscopic release, which was performed by the senior author. The Mayo Elbow Performance Scores were used as a functional outcome score and obtained via a phone interview. Results were analyzed using a paired t-test with a statistical significance set at Results: Of the 26 patients, 10 were being treated under workers compensation. Preoperative Mayo Elbow Performance Score was 47.5, and the postoperative score was 90.2 with a significant difference of 42.7 ( Discussion and conclusion: The advantage of extraarticular arthroscopic release was better visualization of affected structures, which improved accuracy of debridement, and a small capsulotomy, which decreased the risk of a transient radial nerve palsy. Overall, extraarticular arthroscopic results were found to be good and comparable to the results of other operative techniques with the added advantage of a lower risk profile.
Language	English
Publishing date	2021-08-19
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-6391
ISSN (online)	2666-6391
DOI	10.1016/j.xrrt.2021.07.005
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Article ; Online: The influence of estrogen receptor α signaling independent of the estrogen response element on avoidance behavior, social interactions, and palatable ingestive behavior in female mice.

Wiersielis, Kimberly / Yasrebi, Ali / Ramirez, Patricia / Verpeut, Jessica / Regan, Daniel / Roepke, Troy A

Hormones and behavior

2021 Volume 136, Page(s) 105084

Abstract: Women are vulnerable to developing mental disorders that are associated with circulating estrogens. Estrogens, especially 17β-estradiol (E2), have a wide array of effects on the brain, affecting many behavioral endpoints associated with mental illness. ... ...

Abstract	Women are vulnerable to developing mental disorders that are associated with circulating estrogens. Estrogens, especially 17β-estradiol (E2), have a wide array of effects on the brain, affecting many behavioral endpoints associated with mental illness. By using a total estrogen receptor (ER) α knockout (KO), an ERα knock in/knock out (KIKO) that lacks a functional DNA-binding domain, and wild type (WT) controls treated with either oil or E2, we evaluated ERα signaling, dependent and independent of the estrogen response element (ERE), on avoidance behavior, social interactions and memory, and palatable ingestive behavior using the open field test, the elevated plus maze, the light dark box, the 3-chamber test, and palatable feeding. We found that ERα does not mediate control of anxiety-like behaviors but rather yielded differences in locomotor activity. In evaluating social preference and social recognition memory, we observed that E2 may modulate these measures in KIKO females but not KO females, suggesting that ERE-independent signaling is likely involved in sociability. Lastly, observations of palatable (high-fat) food intake suggested an increase in palatable eating behavior in oil-treated KIKO females. Oil-treated KO females had a longer latency to food intake, indicative of an anhedonic phenotype compared to oil-treated WT and KIKO females. We have observed that social-related behaviors are potentially influenced by ERE-independent ERα signaling and hedonic food intake requires signaling of ERα.
MeSH term(s)	Animals ; Avoidance Learning ; Behavior, Animal ; Estradiol/pharmacology ; Estradiol/physiology ; Estrogen Receptor alpha/genetics ; Estrogens/pharmacology ; Feeding Behavior ; Female ; Mice ; Mice, Knockout ; Response Elements ; Social Interaction
Chemical Substances	Estrogen Receptor alpha ; Estrogens ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2021-10-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	214409-8
ISSN	1095-6867 ; 0018-506X
ISSN (online)	1095-6867
ISSN	0018-506X
DOI	10.1016/j.yhbeh.2021.105084
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