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  1. Article: TMEM16A Plays an Insignificant Role in Myocardium Remodeling but May Promote Angiogenesis of Heart During Pressure-overload.

    Zhang, Yaofang / Ye, Lingyu / Duan, Dayue Darrel / Yang, Hong / Ma, Tonghui

    Frontiers in physiology

    2022  Volume 13, Page(s) 897619

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.897619
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  2. Article ; Online: Calm down when the heart is stressed: Inhibiting calmodulin-dependent protein kinase II for antiarrhythmias.

    Duan, Dayue Darrel

    Trends in cardiovascular medicine

    2015  Volume 25, Issue 5, Page(s) 398–400

    Abstract: Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) plays a pivotal role in many regulatory processes of cellular functions ranging from membrane potentials and electric-contraction (E-C) coupling to mitochondrial integrity and survival of ... ...

    Abstract Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) plays a pivotal role in many regulatory processes of cellular functions ranging from membrane potentials and electric-contraction (E-C) coupling to mitochondrial integrity and survival of cardiomyocytes. The review article by Hund and Mohler in this issue of Trends in Cardiovascular Medicine highlights the importance of the elevated CaMKII signaling pathways under stressed conditions such as myocardial hypertrophy and ischemia in the detrimental remodeling of ion channels and in the genesis of cardiac arrhythmias. Down-regulation of the elevated CaMKII is now emerging as a powerful therapeutic strategy for the treatment of cardiac arrhythmias and other forms of heart disease such as hypertrophic and ischemic heart failure. The development of new specific and effective CaMKII inhibitors as therapeutic agents for cardiac arrhythmias is challenged by the tremendous complexity of CaMKII expression and distribution of multi isoforms, as well as the multitude of downstream targets in the CaMKII signaling pathways and regulatory processes. A systematic understanding of the structure and regulation of the CaMKII signaling and functional network under the scope of genome and phenome may improve and extend our knowledge about the role of CaMKII in cardiac health and disease and accelerate the discovery of new CaMKII inhibitors that target not only the ATP-binding site but also the regulation sites in the CaMKII signaling and functional network.
    MeSH term(s) Arrhythmias, Cardiac/enzymology ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Humans
    Chemical Substances Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17)
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2015.01.016
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    Zs.A 3419: Show issues Location:
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  3. Article ; Online: New omic and network paradigms for deep understanding of therapeutic mechanisms for Fangji of traditional Chinese medicine.

    Duan, Dayue Darrel / Wang, Zhong / Wang, Yong-Yan

    Acta pharmacologica Sinica

    2018  Volume 39, Issue 6, Page(s) 903–905

    MeSH term(s) Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional/methods
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2018-06-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 1360774-1
    ISSN 1745-7254 ; 0253-9756 ; 1671-4083
    ISSN (online) 1745-7254
    ISSN 0253-9756 ; 1671-4083
    DOI 10.1038/aps.2018.42
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    Zs.A 1904: Show issues Location:
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  4. Article ; Online: Phenomics of cardiac chloride channels.

    Duan, Dayue Darrel

    Comprehensive Physiology

    2013  Volume 3, Issue 2, Page(s) 667–692

    Abstract: Forward genetic studies have identified several chloride (Cl-) channel genes, including CFTR, ClC-2, ClC-3, CLCA, Bestrophin, and Ano1, in the heart. Recent reverse genetic studies using gene targeting and transgenic techniques to delineate the ... ...

    Abstract Forward genetic studies have identified several chloride (Cl-) channel genes, including CFTR, ClC-2, ClC-3, CLCA, Bestrophin, and Ano1, in the heart. Recent reverse genetic studies using gene targeting and transgenic techniques to delineate the functional role of cardiac Cl- channels have shown that Cl- channels may contribute to cardiac arrhythmogenesis, myocardial hypertrophy and heart failure, and cardioprotection against ischemia reperfusion. The study of physiological or pathophysiological phenotypes of cardiac Cl- channels, however, is complicated by the compensatory changes in the animals in response to the targeted genetic manipulation. Alternatively, tissue-specific conditional or inducible knockout or knockin animal models may be more valuable in the phenotypic studies of specific Cl- channels by limiting the effect of compensation on the phenotype. The integrated function of Cl- channels may involve multiprotein complexes of the Cl- channel subproteome. Similar phenotypes can be attained from alternative protein pathways within cellular networks, which are influenced by genetic and environmental factors. The phenomics approach, which characterizes phenotypes as a whole phenome and systematically studies the molecular changes that give rise to particular phenotypes achieved by modifying the genotype under the scope of genome/proteome/phenome, may provide more complete understanding of the integrated function of each cardiac Cl- channel in the context of health and disease.
    MeSH term(s) Animals ; Chloride Channels/physiology ; Heart/physiology ; Humans ; Phenotype
    Chemical Substances Chloride Channels
    Language English
    Publishing date 2013-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2040-4603
    ISSN (online) 2040-4603
    DOI 10.1002/cphy.c110014
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  5. Article ; Online: CFTR plays an important role in the regulation of vascular resistance and high-fructose/salt-diet induced hypertension in mice.

    Zhang, Ya-Ping / Ye, Lingyu Linda / Yuan, Hong / Duan, Dayue Darrel

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2020  Volume 20, Issue 3, Page(s) 516–524

    Abstract: ... continuously monitored from unrestricted conscious wild-type (cftr: Results: The aortic stiffness, daytime and ...

    Abstract Background: The pathophysiological roles of cystic fibrosis transmembrane-conductance regulator (CFTR) Cl
    Methods: The systolic, diastolic and mean BP (SBP, DBP and MBP, respectively) were continuously monitored from unrestricted conscious wild-type (cftr
    Results: The aortic stiffness, daytime and nighttime SBP, DBP, and MBP of the cftr
    Conclusions: CFTR regulates peripheral arterial resistance and BP in vivo. HFSD-induced CFTR downregulation specifically in the arteries may be a novel mechanism for hypertension.
    MeSH term(s) Animals ; Blood Pressure/physiology ; Cystic Fibrosis/physiopathology ; Cystic Fibrosis Transmembrane Conductance Regulator/physiology ; Diet, High-Fat ; Dietary Carbohydrates/administration & dosage ; Down-Regulation ; Fructose/administration & dosage ; Male ; Mice ; Ultrasonography, Doppler ; Vascular Resistance/physiology
    Chemical Substances Dietary Carbohydrates ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Fructose (30237-26-4)
    Language English
    Publishing date 2020-12-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2020.11.014
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    Zs.A 6028: Show issues Location:
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    Zs.MO 459: Show issues

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  6. Article ; Online: Novel Biomarkers and Treatments of Cardiac Diseases

    Hua Zhu / Renzhi Han / Dayue Darrel Duan

    BioMed Research International, Vol

    2016  Volume 2016

    Keywords Medicine ; R
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D

    Fei Liu / Chao Song / Weiye Cai / Jingwen Chen / Kang Cheng / Daru Guo / Dayue Darrel Duan / Zongchao Liu

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 16

    Abstract: Abstract Recently accumulated evidence implicates a close association of vitamin D (VitD) insufficiency to the incidence and clinical manifestations of the COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). Populations with ... ...

    Abstract Abstract Recently accumulated evidence implicates a close association of vitamin D (VitD) insufficiency to the incidence and clinical manifestations of the COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). Populations with insufficient VitD including patients with osteoporosis are more susceptible to SARS-COV-2 infection and patients with COVID-19 worsened or developed osteoporosis. It is currently unknown, however, whether osteoporosis and COVID-19 are linked by VitD insufficiency. In this study, 42 common targets for VitD on both COVID-19 and osteoporosis were identified among a total of 243 VitD targets. Further bioinformatic analysis revealed 8 core targets (EGFR, AR, ESR1, MAPK8, MDM2, EZH2, ERBB2 and MAPT) in the VitD-COVID-19-osteoporosis network. These targets are involved in the ErbB and MAPK signaling pathways critical for lung fibrosis, bone structural integrity, and cytokines through a crosstalk between COVID-19 and osteoporosis via the VitD-mediated conventional immune and osteoimmune mechanisms. Molecular docking confirmed that VitD binds tightly to the predicted targets. These findings support that VitD may target common signaling pathways in the integrated network of lung fibrosis and bone structural integrity as well as the immune systems. Therefore, VitD may serve as a preventive and therapeutic agent for both COVID-19 and osteoporosis.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Volume matters: novel roles of the volume-regulated CLC-3 channels in hypertension-induced cerebrovascular remodeling.

    Duan, Dayue Darrel

    Hypertension (Dallas, Tex. : 1979)

    2010  Volume 56, Issue 3, Page(s) 346–348

    MeSH term(s) Animals ; Cerebrovascular Circulation ; Chloride Channels/metabolism ; Hypertension/metabolism ; Hypertension/physiopathology ; Rats
    Chemical Substances Chloride Channels ; ClC-3 channel
    Language English
    Publishing date 2010-07-19
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.110.155770
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    Zs.A 1488: Show issues Location:
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  9. Article ; Online: Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D.

    Liu, Fei / Song, Chao / Cai, Weiye / Chen, Jingwen / Cheng, Kang / Guo, Daru / Duan, Dayue Darrel / Liu, Zongchao

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 18147

    Abstract: Recently accumulated evidence implicates a close association of vitamin D (VitD) insufficiency to the incidence and clinical manifestations of the COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). Populations with ... ...

    Abstract Recently accumulated evidence implicates a close association of vitamin D (VitD) insufficiency to the incidence and clinical manifestations of the COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). Populations with insufficient VitD including patients with osteoporosis are more susceptible to SARS-COV-2 infection and patients with COVID-19 worsened or developed osteoporosis. It is currently unknown, however, whether osteoporosis and COVID-19 are linked by VitD insufficiency. In this study, 42 common targets for VitD on both COVID-19 and osteoporosis were identified among a total of 243 VitD targets. Further bioinformatic analysis revealed 8 core targets (EGFR, AR, ESR1, MAPK8, MDM2, EZH2, ERBB2 and MAPT) in the VitD-COVID-19-osteoporosis network. These targets are involved in the ErbB and MAPK signaling pathways critical for lung fibrosis, bone structural integrity, and cytokines through a crosstalk between COVID-19 and osteoporosis via the VitD-mediated conventional immune and osteoimmune mechanisms. Molecular docking confirmed that VitD binds tightly to the predicted targets. These findings support that VitD may target common signaling pathways in the integrated network of lung fibrosis and bone structural integrity as well as the immune systems. Therefore, VitD may serve as a preventive and therapeutic agent for both COVID-19 and osteoporosis.
    MeSH term(s) Humans ; Vitamin D/therapeutic use ; COVID-19/complications ; Vitamin D Deficiency/epidemiology ; SARS-CoV-2 ; Molecular Docking Simulation ; Pulmonary Fibrosis/drug therapy ; Vitamins/therapeutic use ; Osteoporosis/drug therapy
    Chemical Substances Vitamin D (1406-16-2) ; Vitamins
    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-23143-7
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  10. Article ; Online: Novel Biomarkers and Treatments of Cardiac Diseases.

    Zhu, Hua / Han, Renzhi / Duan, Dayue Darrel

    BioMed research international

    2016  Volume 2016, Page(s) 1315627

    MeSH term(s) Biomarkers/blood ; Heart Diseases/blood ; Humans
    Chemical Substances Biomarkers
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2016/1315627
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