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  1. Article ; Online: Les lymphocytes T CD8

    Gensous, Noémie / White, Eoghann / Appay, Victor

    Medecine sciences : M/S

    2023  Volume 39, Issue 8-9, Page(s) 609–611

    Title translation Do T cells have a potentially unlimited replication capacity?
    MeSH term(s) Humans ; T-Lymphocytes ; Virus Replication
    Language French
    Publishing date 2023-09-11
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2023100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2872: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Assessing immune aging in HIV-infected patients.

    Appay, Victor / Sauce, Delphine

    Virulence

    2017  Volume 8, Issue 5, Page(s) 529–538

    Abstract: Many of the alterations that affect innate and adaptive immune cell compartments in HIV-infected patients are reminiscent of the process of immune aging, characteristic of old age. These alterations define the immunological age of individuals and are ... ...

    Abstract Many of the alterations that affect innate and adaptive immune cell compartments in HIV-infected patients are reminiscent of the process of immune aging, characteristic of old age. These alterations define the immunological age of individuals and are likely to participate to the decline of immune competence with HIV disease progression. It is therefore important to characterize these changes, which point toward the accumulation of highly differentiated immunocompetent cells, associated with overall telomere length shortening, as well as understanding their etiology, especially related to the impact of chronic immune activation. Particular attention should be given to the exhaustion of primary immune resources, including haematopoietic progenitors and naïve cells, which holds the key for effective hematopoiesis and immune response induction, respectively. The alteration of these compartments during HIV infection certainly represents the foundation of the immune parallel with aging.
    Language English
    Publishing date 2017-07-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2016.1195536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Immunological considerations regarding parental concerns on pediatric immunizations.

    Nicoli, Francesco / Appay, Victor

    Vaccine

    2017  Volume 35, Issue 23, Page(s) 3012–3019

    Abstract: Despite the fundamental role of vaccines in the decline of infant mortality, parents may decide to decline vaccination for their own children. Many factors may influence this decision, such as the belief that the infant immune system is weakened by ... ...

    Abstract Despite the fundamental role of vaccines in the decline of infant mortality, parents may decide to decline vaccination for their own children. Many factors may influence this decision, such as the belief that the infant immune system is weakened by vaccines, and concerns have been raised about the number of vaccines and the early age at which they are administered. Studies focused on the infant immune system and its reaction to immunizations, summarized in this review, show that vaccines can overcome those suboptimal features of infant immune system that render them more at risk of infections and of their severe manifestations. In addition, many vaccines have been shown to improve heterologous innate and adaptive immunity resulting in lower mortality rates for fully vaccinated children. Thus, multiple vaccinations are necessary and not dangerous, as infants can respond to several antigens as well as when responding to single stimuli. Current immunization schedules have been developed and tested to avoid vaccine interference, improve benefits and reduce side effects compared to single administrations. The infant immune system is therefore capable, early after birth, of managing several antigenic challenges and exploits them to prompt its development.
    Language English
    Publishing date 2017-05-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2017.04.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1930: Show issues Location:
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    Zs.MO 458: Show issues

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  4. Article ; Online: 25 years of HIV research! ... and what about a vaccine?

    Appay, Victor

    European journal of immunology

    2009  Volume 39, Issue 8, Page(s) 1999–2003

    Abstract: Over the past quarter century, colossal progress in our understanding of HIV pathogenesis has been achieved. Yet, we have no solution to the pandemic; the search for an HIV vaccine remains among the highest public health priorities. Identifying ... ...

    Abstract Over the past quarter century, colossal progress in our understanding of HIV pathogenesis has been achieved. Yet, we have no solution to the pandemic; the search for an HIV vaccine remains among the highest public health priorities. Identifying correlates of immune protection in humans, inducing effective immunity through immunization, and overcoming virus and host diversity represent the major obstacles in vaccine development. HIV vaccine research discovery may only be at its dawn.
    MeSH term(s) AIDS Vaccines/immunology ; AIDS Vaccines/therapeutic use ; Acquired Immunodeficiency Syndrome/drug therapy ; Acquired Immunodeficiency Syndrome/immunology ; Acquired Immunodeficiency Syndrome/virology ; Animals ; Antibody Formation/drug effects ; Antibody Formation/immunology ; Antiviral Agents/therapeutic use ; Biomedical Research/methods ; Biomedical Research/trends ; Disease Models, Animal ; HIV-1/drug effects ; HIV-1/immunology ; Humans ; Macaca/immunology ; Macaca/virology ; Simian Acquired Immunodeficiency Syndrome/drug therapy ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/drug effects ; Simian Immunodeficiency Virus/immunology ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Treatment Outcome
    Chemical Substances AIDS Vaccines ; Antiviral Agents
    Language English
    Publishing date 2009-08
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.200939551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 489: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 85: Show issues

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  5. Article ; Online: Immune activation and immune aging in HIV infection.

    Appay, Victor / Kelleher, Anthony D

    Current opinion in HIV and AIDS

    2016  Volume 11, Issue 2, Page(s) 242–249

    Abstract: Purpose of review: The development of serious non-AIDS-related pathologies typically associated with aging, and the premature immune aging that characterizes HIV-1-infected patients, even with suppressive antiretroviral therapy, have raised increasing ... ...

    Abstract Purpose of review: The development of serious non-AIDS-related pathologies typically associated with aging, and the premature immune aging that characterizes HIV-1-infected patients, even with suppressive antiretroviral therapy, have raised increasing concerns in recent years. Deciphering the causes of these phenomena is key for our understanding of HIV pathogenesis and for the clinical care of patients living with the virus.
    Recent findings: An important basis for the immune parallels between HIV infection and aging lies in the exhaustion of the lymphopoietic capacity of infected individuals, which eventually affects all compartments of the immune system. The alleged cause for these immune alterations, and the onset of age-related comorbidities, is the systemic chronic immune activation that is established in patients. However, there is a multiplicity of contributors to this immune activation.
    Summary: Our understanding of the precise link between immune activation and aging in HIV infection is complicated by the influence of coinfections and life style factors. Developing rational interventions to reduce the hyper-inflammatory status of HIV-1-infected patients requires a clearer delineation of the factors contributing to the increased levels of systemic immune activation.
    MeSH term(s) Aging/immunology ; Comorbidity ; HIV Infections/complications ; HIV Infections/immunology ; HIV-1/immunology ; Humans ; Inflammation/immunology
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6812: Show issues Location:
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  6. Article: Ageing Curtails the Diversity and Functionality of Nascent CD8

    Proietto, Davide / Dallan, Beatrice / Gallerani, Eleonora / Albanese, Valentina / Llewellyn-Lacey, Sian / Price, David A / Appay, Victor / Pacifico, Salvatore / Caputo, Antonella / Nicoli, Francesco / Gavioli, Riccardo

    Vaccines

    2023  Volume 11, Issue 1

    Abstract: Age-related changes in the immune system are thought to underlie the vulnerability of elderly individuals to emerging viral diseases, such as coronavirus disease 2019 (COVID-19). In this study, we used a fully ... ...

    Abstract Age-related changes in the immune system are thought to underlie the vulnerability of elderly individuals to emerging viral diseases, such as coronavirus disease 2019 (COVID-19). In this study, we used a fully validated
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11010154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Does Inflammation Contribute to Cancer Incidence and Mortality during Aging? A Conceptual Review.

    Guerville, Florent / Bourdel-Marchasson, Isabelle / Déchanet-Merville, Julie / Pellegrin, Isabelle / Soubeyran, Pierre / Appay, Victor / Lemoine, Maël

    Cancers

    2022  Volume 14, Issue 7

    Abstract: Aging is associated with chronic low-grade inflammation, cancer incidence and mortality. As inflammation contributes to cancer initiation and progression, one could hypothesize that age-associated chronic low-grade inflammation contributes to the ... ...

    Abstract Aging is associated with chronic low-grade inflammation, cancer incidence and mortality. As inflammation contributes to cancer initiation and progression, one could hypothesize that age-associated chronic low-grade inflammation contributes to the increase in cancer incidence and/or mortality observed during aging. Here, we review the evidence supporting this hypothesis: (1) epidemiological associations between biomarkers of systemic inflammation and cancer incidence and mortality in older people, (2) therapeutic clues suggesting that targeting inflammation could reduce cancer incidence and mortality and (3) experimental evidence from animal models highlighting inflammation as a link between various mechanisms of aging and cancer initiation and progression. Despite a large body of literature linking aging, inflammation and cancer, convincing evidence for the clear implication of specific inflammatory pathways explaining cancer incidence or mortality during aging is still lacking. Further dedicated research is needed to fill these gaps in evidence and pave the way for the development of applications in clinical care.
    Language English
    Publishing date 2022-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14071622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Harnessing the Induction of CD8

    Nicoli, Francesco / Paul, Stéphane / Appay, Victor

    Frontiers in immunology

    2018  Volume 9, Page(s) 2372

    Abstract: Cytotoxic ... ...

    Abstract Cytotoxic CD8
    MeSH term(s) Animals ; Antigen-Presenting Cells/immunology ; Antigen-Presenting Cells/metabolism ; Autophagy ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Energy Metabolism ; Fatty Acids/metabolism ; Host-Pathogen Interactions/immunology ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Membrane Proteins/metabolism ; Protein Binding ; Receptors, Pattern Recognition/metabolism ; Toll-Like Receptor 4/metabolism ; Toll-Like Receptor 9/metabolism
    Chemical Substances Fatty Acids ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Membrane Proteins ; Receptors, Pattern Recognition ; STING1 protein, human ; Toll-Like Receptor 4 ; Toll-Like Receptor 9
    Language English
    Publishing date 2018-10-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.02372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Accelerated immune senescence in HIV infection

    Appay Victor

    Retrovirology, Vol 7, Iss Suppl 1, p I

    2010  Volume 30

    Keywords Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Immunologic diseases. Allergy ; RC581-607
    Language English
    Publishing date 2010-05-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Hepatitis B surface antigen reduction is associated with hepatitis B core-specific CD8

    Takahama, Shokichi / Yoshio, Sachiyo / Masuta, Yuji / Murakami, Hirotomo / Sakamori, Ryotaro / Kaneko, Shun / Honda, Takashi / Murakawa, Miyako / Sugiyama, Masaya / Kurosaki, Masayuki / Asahina, Yasuhiro / Takehara, Tetsuo / Appay, Victor / Kanto, Tatsuya / Yamamoto, Takuya

    Frontiers in immunology

    2023  Volume 14, Page(s) 1257113

    Abstract: Despite treatment, hepatitis B surface antigen (HBsAg) persists in patients with chronic hepatitis B (CHB), suggesting the likely presence of the virus in the body. ... ...

    Abstract Despite treatment, hepatitis B surface antigen (HBsAg) persists in patients with chronic hepatitis B (CHB), suggesting the likely presence of the virus in the body. CD8
    MeSH term(s) Humans ; Hepatitis B Surface Antigens ; CD8-Positive T-Lymphocytes ; Hepatitis B virus ; Leukocytes, Mononuclear ; Hepatitis B, Chronic/drug therapy
    Chemical Substances Hepatitis B Surface Antigens
    Language English
    Publishing date 2023-10-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1257113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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