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  1. Article ; Online: Controlled Ring-Opening Polymerization of Macrocyclic Monomers Based on Ring-Opening/Ring-Closing Cascade Reaction.

    Chen, Wensen / Guo, Changjuan / Ding, Hao / Yang, Xingyu / Zhang, Ke

    Journal of the American Chemical Society

    2023  

    Abstract: The development of a controlled ring-opening polymerization (ROP) method for synthesizing backbone-functionalized and sequence-controlled polymers with well-defined architectures from macrocyclic monomers is highly desirable in polymer chemistry. Herein, ...

    Abstract The development of a controlled ring-opening polymerization (ROP) method for synthesizing backbone-functionalized and sequence-controlled polymers with well-defined architectures from macrocyclic monomers is highly desirable in polymer chemistry. Herein, we developed a novel general controlled ROP of macrocycles for producing backbone functional and sequence-controlled polyurethanes and polyamides with controlled molecular weights and narrow dispersities (
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c10765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Armillariella tabescens polysaccharide treated rats with oral ulcers through modulation of oral microbiota and activation of the Nrf2/HO-1 pathway.

    Zhang, Kunfeng / Chen, Hao / Hao, Yunbo / Li, Wensen / Li, Yong / Zhang, Wenna / Chen, Yan

    International journal of biological macromolecules

    2024  Volume 261, Issue Pt 1, Page(s) 129697

    Abstract: We identified Armillariella tabescens polysaccharide (PAT-W), a compound isolated from a Chinese medicinal mushroom, as a potential novel oral ulcer (OU) drug. In treating OU rats with PAT-W, especially in the high-dose group, oral mucous tissue TNF-α, ... ...

    Abstract We identified Armillariella tabescens polysaccharide (PAT-W), a compound isolated from a Chinese medicinal mushroom, as a potential novel oral ulcer (OU) drug. In treating OU rats with PAT-W, especially in the high-dose group, oral mucous tissue TNF-α, IL-1β, and IL-6 levels were markedly reduced, and pathological morphology and oxidative stress were effectively improved. Western blot analysis showed that the PAT-W channel ameliorated OU mucous tissue damage, which depends on the activation of the Nrf2/HO-1 antioxidant signaling pathway. Furthermore, high-throughput sequencing results showed that PAT-W regulated the maladjustment of the oral microbiota caused by OU. Therefore, based on the new viewpoint of activating the Nrf2/HO-1 pathway and regulating oral microbiota, PAT-W is expected to become a new natural drug for treating oral ulcers and improving patients' quality of life.
    MeSH term(s) Rats ; Animals ; Humans ; Oral Ulcer/drug therapy ; NF-E2-Related Factor 2/metabolism ; Quality of Life ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Oxidative Stress ; Microbiota ; Armillaria
    Chemical Substances NF-E2-Related Factor 2 ; Polysaccharides
    Language English
    Publishing date 2024-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129697
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  3. Article ; Online: Reconstruction of the Deformed Tragus Accompanied by Accessory Auricle.

    Chen, Yongjun / Wei, Siming / Hao, Dongyue / Xia, Wensen / Ma, Xianjie / Dong, Liwei

    Aesthetic surgery journal

    2023  Volume 43, Issue 9, Page(s) NP687–NP695

    MeSH term(s) Humans ; Plastic Surgery Procedures/adverse effects ; Retrospective Studies ; Ear, External/surgery ; Ear, External/abnormalities ; Ear Auricle/surgery ; Esthetics
    Language English
    Publishing date 2023-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2087022-X
    ISSN 1527-330X ; 1090-820X ; 1084-0761
    ISSN (online) 1527-330X
    ISSN 1090-820X ; 1084-0761
    DOI 10.1093/asj/sjad146
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  4. Article: Renal artery pseudoaneurysm formation and rupture induced by renal abscess: A case report.

    Liao, Hai / Yang, Yong / Zhang, Wensen / Zhang, Senlin / Dai, Hang / Chen, Fubing

    Urology case reports

    2023  Volume 51, Page(s) 102547

    Abstract: Severe consequences can ensue from the rupture and hemorrhage of a renal artery pseudoaneurysm, necessitating immediate intervention upon detection. To date, no reports exist on the development of renal artery pseudoaneurysms as a result of renal ... ...

    Abstract Severe consequences can ensue from the rupture and hemorrhage of a renal artery pseudoaneurysm, necessitating immediate intervention upon detection. To date, no reports exist on the development of renal artery pseudoaneurysms as a result of renal abscesses. This document introduces the first reported case of this occurrence.
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2023.102547
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  5. Article ; Online: SPS: Accurate and Real-Time Semantic Positioning System Based on Low-Cost DEM Maps.

    Cai, Jun-Xiong / Feng, Wensen / Chen, Hao-Xiang / Mu, Tai-Jiang

    IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

    2023  Volume 32, Page(s) 6401–6412

    Abstract: This paper presents a Semantic Positioning System (SPS) to enhance the accuracy of mobile device geo-localization in outdoor urban environments. Although the traditional Global Positioning System (GPS) can offer a rough localization, it lacks the ... ...

    Abstract This paper presents a Semantic Positioning System (SPS) to enhance the accuracy of mobile device geo-localization in outdoor urban environments. Although the traditional Global Positioning System (GPS) can offer a rough localization, it lacks the necessary accuracy for applications such as Augmented Reality (AR). Our SPS integrates Geographic Information System (GIS) data, GPS signals, and visual image information to estimate the 6 Degree-of-Freedom (DoF) pose through cross-view semantic matching. This approach has excellent scalability to support GIS context with Levels of Detail (LOD). The map data representation is Digital Elevation Model (DEM), a cost-effective aerial map that allows for fast deployment for large-scale areas. However, the DEM lacks geometric and texture details, making it challenging for traditional visual feature extraction to establish pixel/voxel level cross-view correspondences. To address this, we sample observation pixels from the query ground-view image using predicted semantic labels. We then propose an iterative homography estimation method with semantic correspondences. To improve the efficiency of the overall system, we further employ a heuristic search to speedup the matching process. The proposed method is robust, real-time, and automatic. Quantitative experiments on the challenging Bund dataset show that we achieve a positioning accuracy of 73.24%, surpassing the baseline skyline-based method by 20%. Compared with the state-of-the-art semantic-based approach on the Kitti dataset, we improve the positioning accuracy by an average of 5%.
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0042
    ISSN (online) 1941-0042
    DOI 10.1109/TIP.2023.3332212
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  6. Article ; Online: Prediction and evaluation of a nomogram model for recurrent acute pancreatitis.

    Chen, Yuan / Huang, Shu / Luo, Bei / Jiang, Jiao / Ren, Wensen / Zou, Kang / Zhong, Xiaolin / Lü, Muhan / Tang, Xiaowei

    European journal of gastroenterology & hepatology

    2024  Volume 36, Issue 5, Page(s) 554–562

    Abstract: Objective: The purpose of this study was to investigate the influencing factors for recurrent acute pancreatitis and construct the nomogram model to predict the risk of recurrent acute pancreatitis.: Methods: Patients diagnosed with acute ... ...

    Abstract Objective: The purpose of this study was to investigate the influencing factors for recurrent acute pancreatitis and construct the nomogram model to predict the risk of recurrent acute pancreatitis.
    Methods: Patients diagnosed with acute pancreatitis in the Affiliated Hospital of Southwest Medical University were enrolled. We collected these patients' basic information, laboratory data, imaging information. Using Logistic regression and least absolute shrinkage and selection operator regression to select risk factor for Cross-Validation Criterion. To create nomogram and validated by receiver operator characteristic curve, calibration curves and decision curve analysis.
    Results: A total of 533 patients with acute pancreatitis were included, including 99 recurrent acute pancreatitis patients. The average age of recurrent acute pancreatitis patients was 49.69 years old, and 67.7% of them were male. At the same time, in all recurrent acute pancreatitis patients, hypertriglyceridemic pancreatitis is the most important reason (54.5%). Regression analysis and least absolute shrinkage and selection operator regression showed that smoking history, acute necrotic collection, triglyceride, and alcohol etiology for acute pancreatitis were identified and entered into the nomogram. The area under the receiver operator characteristic curve of the training set was 0.747. The calibration curve showed the consistency between the nomogram model and the actual probability.
    Conclusion: In conclusion, some high-risk factors like smoking history, acute necrotic collection, triglyceride, and alcohol etiology for acute pancreatitis may predict recurrent pancreatitis and their incorporation into a nomogram has high accuracy in predicting recurrence.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Acute Disease ; Nomograms ; Pancreatitis, Chronic ; Ethanol ; Triglycerides
    Chemical Substances Ethanol (3K9958V90M) ; Triglycerides
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/MEG.0000000000002732
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    Zs.A 2932: Show issues Location:
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  7. Article: Optimized clinical randomized controlled trials designed for biomarker-guided antibiotics stewardship.

    Chen, Wensen / Zhang, Kai / Liu, Yun

    Annals of translational medicine

    2020  Volume 8, Issue 4, Page(s) 144

    Language English
    Publishing date 2020-02-26
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2020.01.67
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  8. Article ; Online: impHFrEF trial: study protocol for an open-label, multicentre study of improvement the outcome of patients with heart failure in China using a mobile hEalth-supported platForm.

    Chen, Fuzhong / Li, Guangjuan / Zhang, Xinxin / Shen, Qin / Wang, Fangfang / Dong, Xiaoyu / Zou, Yu / Chen, Wensen / Xu, Bing / Wang, Junhong

    BMJ open

    2024  Volume 14, Issue 3, Page(s) e081011

    Abstract: Background: Patients with chronic heart failure (CHF) often have a long duration of illness, difficulty in attending follow-up visits, and poor adherence to treatment. As a result, they frequently cannot receive guideline-directed medical therapy (GDMT) ...

    Abstract Background: Patients with chronic heart failure (CHF) often have a long duration of illness, difficulty in attending follow-up visits, and poor adherence to treatment. As a result, they frequently cannot receive guideline-directed medical therapy (GDMT) at the desired or maximum tolerable drug dosage. This leads to high hospitalisation and mortality rates for HF patients. Therefore, effective management and monitoring of patients with HF to ensure they receive GDMT is crucial for improving the prognosis.
    Design and methods: This is a multicentre, open-label, randomised, parallel-group study involving patients with CHF across five centres. The study aims to assess the impact of an optimised GDMT model for HF patients, established on a mobile health (mHealth) platform, compared with a control group. Patients must have a left ventricular ejection fraction of less than 50% and be receiving medication titration therapy that has not yet reached the target dose, with a modest increase in N-terminal pro-B-type natriuretic peptide level. The primary composite outcome is worsening HF events (hospitalisation or emergency treatment with intravenous fluids) or cardiovascular death.
    Ethics and dissemination: On 22 December 2021, this study received ethical approval from the Ethics Review Board of the First Affiliated Hospital of Nanjing Medical University, with the ethics number 2021-SR-530. All study participants will be informed of the research purpose and their participation will be voluntary. Informed consent will be obtained by providing and signing an informed consent form. We will ensure compliance with relevant laws and regulations regarding privacy and data protection. The results of this study will be published in a peer-reviewed academic journal. We will ensure that the dissemination of study results is accurate, clear and timely.
    Trial registration number: ChiCTR2200056527.
    MeSH term(s) Humans ; Stroke Volume ; Ventricular Function, Left ; Heart Failure ; Chronic Disease ; Telemedicine ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-081011
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  9. Article ; Online: Promising Roles of Circular RNAs as Biomarkers and Targets for Potential Diagnosis and Therapy of Tuberculosis.

    Huang, Yifan / Li, Ying / Lin, Wensen / Fan, Shuhao / Chen, Haorong / Xia, Jiaojiao / Pi, Jiang / Xu, Jun-Fa

    Biomolecules

    2022  Volume 12, Issue 9

    Abstract: Tuberculosis (TB), caused ... ...

    Abstract Tuberculosis (TB), caused by
    MeSH term(s) Biomarkers/metabolism ; Humans ; MicroRNAs/metabolism ; RNA Splicing ; RNA, Circular/genetics ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/genetics
    Chemical Substances Biomarkers ; MicroRNAs ; RNA, Circular
    Language English
    Publishing date 2022-09-04
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12091235
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  10. Article ; Online: Exenatide reduces atrial fibrillation susceptibility by inhibiting hKv1.5 and hNav1.5 channels.

    Zhou, Qian / Hao, Guoliang / Xie, Wensen / Chen, Bin / Lu, Wuguang / Wang, Gongxin / Zhong, Rongling / Chen, Jiao / Ye, Juan / Shen, Jianping / Cao, Peng

    The Journal of biological chemistry

    2024  , Page(s) 107294

    Abstract: Exenatide, a promising cardioprotective agent, protects against cardiac structural remodeling and diastolic dysfunction. Combined blockade of sodium and potassium channels is valuable for managing atrial fibrillation (AF). Here, we explored whether ... ...

    Abstract Exenatide, a promising cardioprotective agent, protects against cardiac structural remodeling and diastolic dysfunction. Combined blockade of sodium and potassium channels is valuable for managing atrial fibrillation (AF). Here, we explored whether exenatide displayed anti-AF effects by inhibiting human Kv1.5 and Nav1.5 channels. We used the whole-cell patch-clamp technique to investigate the effects of exenatide on hKv1.5 and hNav1.5 channels expressed in human embryonic kidney 293 cells and studied the effects of exenatide on action potential (AP) and other cardiac ionic currents in rat atrial myocytes. Additionally, an electrical mapping system was used to explore the effects of exenatide on electrical properties and AF activity in isolated rat hearts. Finally, a rat AF model, established using acetylcholine and calcium chloride, was employed to evaluate the anti-AF potential of exenatide in rats. Exenatide reversibly suppressed I
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.107294
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