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  1. Article ; Online: Hydrocortisone rapidly and significantly reduces the IL-6 level in blood and lungs of patients with COVID-19-related ARDS.

    Guillon, Antoine / Jouan, Youenn / Kassa-Sombo, Arthur / Paget, Christophe / Dequin, Pierre-François

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 101

    MeSH term(s) Humans ; COVID-19/complications ; Interleukin-6 ; Hydrocortisone/therapeutic use ; Lung ; Respiratory Distress Syndrome/drug therapy
    Chemical Substances Interleukin-6 ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-024-04887-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
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  2. Article: The positive impact of COVID-19 on critical care: from unprecedented challenges to transformative changes, from the perspective of young intensivists.

    Hermann, Bertrand / Benghanem, Sarah / Jouan, Youenn / Lafarge, Antoine / Beurton, Alexandra

    Annals of intensive care

    2023  Volume 13, Issue 1, Page(s) 28

    Abstract: Over the past 2 years, SARS-CoV-2 infection has resulted in numerous hospitalizations and deaths worldwide. As young intensivists, we have been at the forefront of the fight against the COVID-19 pandemic and it has been an intense learning experience ... ...

    Abstract Over the past 2 years, SARS-CoV-2 infection has resulted in numerous hospitalizations and deaths worldwide. As young intensivists, we have been at the forefront of the fight against the COVID-19 pandemic and it has been an intense learning experience affecting all aspects of our specialty. Critical care was put forward as a priority and managed to adapt to the influx of patients and the growing demand for beds, financial and material resources, thereby highlighting its flexibility and central role in the healthcare system. Intensivists assumed an essential and unprecedented role in public life, which was important when claiming for indispensable material and human investments. Physicians and researchers around the world worked hand-in-hand to advance research and better manage this disease by integrating a rapidly growing body of evidence into guidelines. Our daily ethical practices and communication with families were challenged by the massive influx of patients and restricted visitation policies, forcing us to improve our collaboration with other specialties and innovate with new communication channels. However, the picture was not all bright, and some of these achievements are already fading over time despite the ongoing pandemic and hospital crisis. In addition, the pandemic has demonstrated the need to improve the working conditions and well-being of critical care workers to cope with the current shortage of human resources. Despite the gloomy atmosphere, we remain optimistic. In this ten-key points review, we outline our vision on how to capitalize on the lasting impact of the pandemic to face future challenges and foster transformative changes of critical care for the better.
    Language English
    Publishing date 2023-04-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-023-01118-9
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  3. Article ; Online: Lung compartmentalization of inflammatory biomarkers in COVID-19-related ARDS.

    Jouan, Youenn / Baranek, Thomas / Si-Tahar, Mustapha / Paget, Christophe / Guillon, Antoine

    Critical care (London, England)

    2021  Volume 25, Issue 1, Page(s) 120

    MeSH term(s) Biomarkers ; COVID-19 ; Humans ; Lung ; Pneumonia ; Respiratory Distress Syndrome ; SARS-CoV-2
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-03-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-021-03513-9
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  4. Article ; Online: Nosocomial herpes simplex encephalitis: Does it really exist?

    Jouan, Youenn / Grammatico-Guillon, Leslie / Guillon, Antoine

    Journal of infection and public health

    2017  Volume 11, Issue 1, Page(s) 142

    MeSH term(s) Acyclovir ; Child ; Cross Infection ; Encephalitis, Herpes Simplex ; Haemophilus influenzae type b ; Humans ; Meningitis
    Chemical Substances Acyclovir (X4HES1O11F)
    Language English
    Publishing date 2017-02-10
    Publishing country England
    Document type Letter ; Comment
    ISSN 1876-035X
    ISSN (online) 1876-035X
    DOI 10.1016/j.jiph.2016.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Critically ill SARS-CoV-2-infected patients are not stratified as sepsis by the qSOFA.

    Ferreira, Marion / Blin, Timothee / Collercandy, Nived / Szychowiak, Piotr / Dequin, Pierre-François / Jouan, Youenn / Guillon, Antoine

    Annals of intensive care

    2020  Volume 10, Issue 1, Page(s) 43

    Keywords covid19
    Language English
    Publishing date 2020-04-19
    Publishing country Germany
    Document type Letter
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-020-00664-w
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  6. Article ; Online: The proteolytic airway environment associated with pneumonia acts as a barrier for treatment with anti-infective antibodies.

    Blin, Timothée / Parent, Christelle / Pichon, Gabrielle / Guillon, Antoine / Jouan, Youenn / Allouchi, Hassan / Aubrey, Nicolas / Boursin, Fanny / Domain, Roxane / Korkmaz, Baris / Sécher, Thomas / Heuzé-Vourc'h, Nathalie

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

    2023  Volume 195, Page(s) 114163

    Abstract: Like pneumonia, coronavirus disease 2019 (COVID-19) is characterized by a massive infiltration of innate immune cells (such as polymorphonuclear leukocytes) into the airways and alveolar spaces. These cells release proteases that may degrade therapeutic ... ...

    Abstract Like pneumonia, coronavirus disease 2019 (COVID-19) is characterized by a massive infiltration of innate immune cells (such as polymorphonuclear leukocytes) into the airways and alveolar spaces. These cells release proteases that may degrade therapeutic antibodies and thus limit their effectiveness. Here, we investigated the in vitro and ex vivo impact on anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) IgG1s and other IgG subclasses (IgG2 and IgG4) of the neutrophil elastase, proteinase 3 and cathepsin G (the three main neutrophil serine proteases) found in endotracheal aspirates from patients with severe COVID-19. Although the IgGs were sensitive to neutrophil serine proteases, IgG2 was most resistant to proteolytic degradation. The two anti-SARS CoV2 antibodies (casirivimab and imdevimab) were sensitive to the lung's proteolytic environment, although neutrophil serine protease inhibitors only partly limited the degradation. Overall, our results show that the pneumonia-associated imbalance between proteases and their inhibitors in the airways contributes to degradation of antiviral antibodies.
    MeSH term(s) Humans ; RNA, Viral ; Serine Proteases/metabolism ; Neutrophils/metabolism ; Pneumonia/metabolism ; COVID-19/metabolism ; Immunoglobulin G/metabolism
    Chemical Substances RNA, Viral ; Serine Proteases (EC 3.4.-) ; Immunoglobulin G
    Language English
    Publishing date 2023-12-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1065368-5
    ISSN 1873-3441 ; 0939-6411
    ISSN (online) 1873-3441
    ISSN 0939-6411
    DOI 10.1016/j.ejpb.2023.12.003
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    Zs.B 1651: Show issues Location:
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  7. Article ; Online: Preoperative Chemerin Level Is Predictive of Inflammatory Status 1 Year After Bariatric Surgery.

    Jouan, Youenn / Blasco, Hélène / Bongrani, Alice / Couet, Charles / Dupont, Joëlle / Maillot, François

    Obesity surgery

    2020  Volume 30, Issue 10, Page(s) 3852–3861

    Abstract: Background: Obesity is associated with chronic low-grade inflammation, which has been linked to increased morbidity. However, inflammation variably and unpredictably improves after bariatric surgery. This study aimed at (1) evaluating the relationship ... ...

    Abstract Background: Obesity is associated with chronic low-grade inflammation, which has been linked to increased morbidity. However, inflammation variably and unpredictably improves after bariatric surgery. This study aimed at (1) evaluating the relationship between amplitude of weight loss and variation of inflammatory parameters after bariatric surgery, and (2) identifying, among clinical and biological baseline parameters, predictive factors of variation in inflammatory parameters.
    Methods: In a prospective cohort of patients who underwent bariatric surgery, serum concentrations of interleukin (IL)-6, IL-10, resistin, leptin, adiponectin chemerin, and C-reactive protein (CRP) were measured preoperatively and 1 year after surgery, and routine clinical and biochemical parameters were retrieved. Univariate and multivariate analyses (partial least square method) were performed to assess how parameters were associated with weight loss and to predict improvement of inflammatory parameters.
    Results: Eighty-seven patients were included (mean weight ± SD 136.3 ± 3.2 kg, 35 gastric bypasses, 52 sleeve gastrectomies). In parallel with weight loss (39.5 ± 13.8 kg), pro-inflammatory markers (IL-6, CRP, leptin, resistin) significantly decreased, and anti-inflammatory markers (IL-10, adiponectin) increased. Multivariate analysis revealed a significant association between weight loss and improvement in inflammatory parameters. Among all the clinical and biological preoperative parameters, baseline chemerin level was the only parameter that was significantly associated with global improvement of the inflammatory status after surgery.
    Conclusion: The amplitude of weight loss 1 year after bariatric surgery was strongly correlated with improvement of inflammatory profile, which could be predicted by baseline plasma level of chemerin. This suggests a key role of chemerin in obesity-driven inflammation, and a potential use as a biomarker.
    MeSH term(s) Adipokines ; Adiponectin ; Bariatric Surgery ; Biomarkers ; Chemokines ; Humans ; Inflammation ; Obesity, Morbid/surgery ; Prospective Studies ; Weight Loss
    Chemical Substances Adipokines ; Adiponectin ; Biomarkers ; Chemokines ; RARRES2 protein, human
    Language English
    Publishing date 2020-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-020-04584-3
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    Zs.A 3381: Show issues Location:
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  8. Article: Correction to: Energetic dysfunction in sepsis: a narrative review.

    Preau, Sebastien / Vodovar, Dominique / Jung, Boris / Lancel, Steve / Zafrani, Lara / Flatres, Aurelien / Oualha, Mehdi / Voiriot, Guillaume / Jouan, Youenn / Joffre, Jeremie / Uhel, Fabrice / De Prost, Nicolas / Silva, Stein / Azabou, Eric / Radermacher, Peter

    Annals of intensive care

    2021  Volume 11, Issue 1, Page(s) 185

    Language English
    Publishing date 2021-12-29
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-021-00970-x
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  9. Article ; Online: Proteinase release from activated neutrophils in mechanically ventilated patients with non-COVID-19 and COVID-19 pneumonia.

    Seren, Seda / Derian, Lohann / Keleş, Irem / Guillon, Antoine / Lesner, Adam / Gonzalez, Loïc / Baranek, Thomas / Si-Tahar, Mustapha / Marchand-Adam, Sylvain / Jenne, Dieter E / Paget, Christophe / Jouan, Youenn / Korkmaz, Brice

    The European respiratory journal

    2021  Volume 57, Issue 4

    MeSH term(s) COVID-19 ; Humans ; Neutrophils ; Peptide Hydrolases ; Respiration, Artificial ; SARS-CoV-2
    Chemical Substances Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2021-04-29
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.03755-2020
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  10. Article ; Online: Critically ill SARS-CoV-2-infected patients are not stratified as sepsis by the qSOFA

    Marion Ferreira / Timothee Blin / Nived Collercandy / Piotr Szychowiak / Pierre-François Dequin / Youenn Jouan / Antoine Guillon

    Annals of Intensive Care, Vol 10, Iss 1, Pp 1-

    2020  Volume 3

    Keywords Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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