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  1. Article ; Online: Minimal residual disease in Philadelphia-positive acute lymphoblastic leukemia: Maximizing the clinical yield of testing.

    Saliba, Antoine N / Foà, Robin

    American journal of hematology

    2023  Volume 98, Issue 8, Page(s) 1168–1170

    MeSH term(s) Humans ; Neoplasm, Residual/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Philadelphia Chromosome ; Acute Disease ; Hematopoietic Stem Cell Transplantation
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1251: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Measurable residual disease in chronic lymphocytic leukemia. Where do we stand?

    Del Giudice, Ilaria / Foà, Robin

    Leukemia

    2023  Volume 37, Issue 12, Page(s) 2339–2342

    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Antineoplastic Combined Chemotherapy Protocols ; Neoplasm, Residual/drug therapy
    Language English
    Publishing date 2023-10-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-023-02066-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2295: Show issues Location:
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  3. Article ; Online: Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.

    Foà, Robin / Chiaretti, Sabina

    The New England journal of medicine

    2022  Volume 386, Issue 25, Page(s) 2399–2411

    MeSH term(s) Acute Disease ; Humans ; Philadelphia Chromosome ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra2113347
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  4. Article ; Online: The evolution of frontline therapy for adult Philadelphia-positive acute lymphoblastic leukemia: Giant strides and ongoing challenges.

    Saliba, Antoine N / Foà, Robin

    American journal of hematology

    2022  Volume 98, Issue 3, Page(s) 374–376

    MeSH term(s) Adult ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Cyclophosphamide ; Longitudinal Studies ; Philadelphia Chromosome
    Chemical Substances Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2022-12-31
    Publishing country United States
    Document type Editorial
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Role of the Microenvironment and Cell Adhesion Molecules in Chronic Lymphocytic Leukemia.

    Cerreto, Marina / Foà, Robin / Natoni, Alessandro

    Cancers

    2023  Volume 15, Issue 21

    Abstract: Chronic lymphocytic leukemia (CLL) is a B-cell malignancy whose progression largely depends on the lymph node and bone marrow microenvironment. Indeed, CLL cells actively proliferate in specific regions of these anatomical compartments, known as ... ...

    Abstract Chronic lymphocytic leukemia (CLL) is a B-cell malignancy whose progression largely depends on the lymph node and bone marrow microenvironment. Indeed, CLL cells actively proliferate in specific regions of these anatomical compartments, known as proliferation centers, while being quiescent in the blood stream. Hence, CLL cell adhesion and migration into these protective niches are critical for CLL pathophysiology. CLL cells are lodged in their microenvironment through a series of molecular interactions that are mediated by cellular adhesion molecules and their counter receptors. The importance of these adhesion molecules in the clinic is demonstrated by the correlation between the expression levels of some of them, in particular CD49d, and the prognostic likelihood. Furthermore, novel therapeutic agents, such as ibrutinib, impair the functions of these adhesion molecules, leading to an egress of CLL cells from the lymph nodes and bone marrow into the circulation together with an inhibition of homing into these survival niches, thereby preventing disease progression. Several adhesion molecules have been shown to participate in CLL adhesion and migration. Their importance also stems from the observation that they are involved in promoting, directly or indirectly, survival signals that sustain CLL proliferation and limit the efficacy of standard and novel chemotherapeutic drugs, a process known as cell adhesion-mediated drug resistance. In this respect, many studies have elucidated the molecular mechanisms underlying cell adhesion-mediated drug resistance, which have highlighted different signaling pathways that may represent potential therapeutic targets. Here, we review the role of the microenvironment and the adhesion molecules that have been shown to be important in CLL and their impact on transendothelial migration and cell-mediated drug resistance. We also discuss how novel therapeutic compounds modulate the function of this important class of molecules.
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15215160
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  6. Article ; Online: Introduction Chronic Lymphocytic Leukemia. Where Do We Stand, Where Do We Go.

    Foà, Robin / Montserrat, Emili

    Cancer journal (Sudbury, Mass.)

    2021  Volume 27, Issue 4, Page(s) 257–258

    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy
    Language English
    Publishing date 2021-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2018400-1
    ISSN 1540-336X ; 1528-9117 ; 1081-4442
    ISSN (online) 1540-336X
    ISSN 1528-9117 ; 1081-4442
    DOI 10.1097/PPO.0000000000000539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4470: Show issues Location:
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    Zs.MO 163: Show issues

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  7. Article ; Online: Dasatinib-Blinatumomab for Ph-Positive ALL. Reply.

    Foà, Robin / Chiaretti, Sabina

    The New England journal of medicine

    2021  Volume 384, Issue 4, Page(s) 384

    MeSH term(s) Antibodies, Bispecific ; Dasatinib ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Chemical Substances Antibodies, Bispecific ; blinatumomab (4FR53SIF3A) ; Dasatinib (RBZ1571X5H)
    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2033785
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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: PSGL-1 decorated with sialyl Lewis

    O'Dwyer, Michael / Kirkham-McCarthy, Lucy / Cerreto, Marina / Foà, Robin / Natoni, Alessandro

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1756

    Abstract: Dissemination of multiple myeloma into the bone marrow proceeds through sequential steps mediated by a variety of adhesion molecules and chemokines that eventually results in the extravasation of malignant plasma cells into this protective niche. ... ...

    Abstract Dissemination of multiple myeloma into the bone marrow proceeds through sequential steps mediated by a variety of adhesion molecules and chemokines that eventually results in the extravasation of malignant plasma cells into this protective niche. Selectins are a class of C-type lectins that recognize carbohydrate structures exposed on blood borne cells and participate in the first step of the extravasation cascade, serving as brakes to slow down circulating cells enabling them to establish firm adhesion onto the endothelium. Myeloma cells enriched for the expression of selectin ligands present an aggressive disease in vivo that is refractory to bortezomib treatment and can be reverted by small molecules targeting E-selectin. In this study, we have defined the molecular determinants of the selectin ligands expressed on myeloma cells. We show that PSGL-1 is the main protein carrier of sialyl Lewis
    MeSH term(s) Humans ; Cell Adhesion ; E-Selectin/metabolism ; Ligands ; Multiple Myeloma/metabolism ; P-Selectin/metabolism ; Sialyl Lewis X Antigen ; Membrane Glycoproteins/metabolism ; Cell Line, Tumor
    Chemical Substances E-Selectin ; Ligands ; P-Selectin ; Sialyl Lewis X Antigen ; P-selectin ligand protein ; Membrane Glycoproteins
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52212-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: First-line dasatinib discontinuation in chronic myeloid leukaemia: another step towards an "operational cure".

    Breccia, Massimo / Foà, Robin

    The Lancet. Haematology

    2020  Volume 7, Issue 3, Page(s) e182–e183

    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Dasatinib/pharmacology ; Dasatinib/therapeutic use ; Female ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Male ; Middle Aged ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; Dasatinib (RBZ1571X5H)
    Language English
    Publishing date 2020-01-21
    Publishing country England
    Document type Journal Article
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(19)30251-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Response to Comment by Amato T.

    Giudice, Ilaria Del / Foà, Robin

    Haematologica

    2019  Volume 104, Issue 11, Page(s) e541

    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell ; Mutation
    Language English
    Publishing date 2019-10-30
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2019.224303
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