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  1. Article ; Online: A Guide to the Repair of Traumatic Cyclodialysis Clefts: Medical, Laser, and Surgical Treatment.

    Castillejos, Alexandra G / Chen, Teresa C

    International ophthalmology clinics

    2024  Volume 64, Issue 2, Page(s) 75–87

    MeSH term(s) Humans ; Cyclodialysis Clefts/surgery ; Intraocular Pressure ; Lasers ; Eye Injuries/surgery
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207382-1
    ISSN 1536-9617 ; 0020-8167
    ISSN (online) 1536-9617
    ISSN 0020-8167
    DOI 10.1097/IIO.0000000000000497
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Speckle tracking echocardiography: too much granularity?

    Chen, Robert / Fottinger, Alexandra / Tousignant, Claude

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2024  Volume 71, Issue 5, Page(s) 565–569

    Title translation L’échocardiographie de suivi des marqueurs acoustiques : trop de granularité?
    MeSH term(s) Humans ; Echocardiography ; Image Interpretation, Computer-Assisted ; Reproducibility of Results ; Ventricular Dysfunction, Left
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-024-02714-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Minimally Invasive Chevron Akin Osteotomy for Hallux Valgus Correction.

    Flaherty, Alexandra / Chen, Jie

    JBJS essential surgical techniques

    2024  Volume 14, Issue 1

    Abstract: Background: The minimally invasive chevron Akin osteotomy technique is indicated for the treatment of symptomatic mild to moderate hallux valgus deformities. The aim of the procedure is to restore alignment of the first ray while minimizing soft-tissue ... ...

    Abstract Background: The minimally invasive chevron Akin osteotomy technique is indicated for the treatment of symptomatic mild to moderate hallux valgus deformities. The aim of the procedure is to restore alignment of the first ray while minimizing soft-tissue disruption.
    Description: Prior to the procedure, radiographs are utilized to characterize the patient's hallux valgus deformity by determining the hallux valgus angle and intermetatarsal angle. The metatarsal rotation is also assessed via the lateral round sign and sesamoid view. To begin, a stab incision is made over the lateral aspect of the first metatarsophalangeal (MTP) joint and a lateral release is completed by percutaneous fenestration of the lateral capsule. Next, the chevron osteotomy of the first metatarsal is performed. To begin this step, a Kirschner wire is inserted in an anterograde fashion from the medial base of the first metatarsal to the lateral aspect of the metatarsal neck. The wire is then withdrawn just proximal to the osteotomy site. A stab incision is made at the medial aspect of the metatarsal neck, and periosteal elevation is utilized for soft-tissue dissection. A minimally invasive burr is utilized to complete the osteotomy cuts. With the osteotomy complete, the first metatarsal translator is utilized to lever the metatarsal head laterally. Once satisfactory alignment has been achieved, the Kirschner wire is advanced into the metatarsal head. A cannulated depth gauge is utilized to measure the length of the screw. The near cortex is drilled, and the screw is inserted over the Kirschner wire, which is then removed. The next step is the Akin osteotomy of the proximal phalanx. Again, a Kirschner wire is placed in an anterograde fashion from the medial base of the proximal phalanx to the lateral neck. The Kirschner wire is then withdrawn until the tip is just proximal to the osteotomy site. A stab incision is made over the medial aspect of the proximal phalangeal neck, and periosteal elevation is carried out. The burr is utilized to complete the osteotomy; however, care is taken not to cut the far cortex. The great toe is then rotated medially, collapsing on the osteotomy site and hinging on the intact far cortex. When satisfactory alignment has been achieved, the Kirschner wire is advanced across the osteotomy and far cortex. A cannulated depth gauge is utilized to measure the length of the screw, and the wire is then driven through the lateral skin and clamped. The near cortex is drilled, the cannulated screw is inserted, and the Kirschner wire is then removed. Final fluoroscopy is performed to assess adequate correction, alignment, and hardware placement. The stab incisions are closed with use of simple interrupted 3-0 nylon. A tongue-depressor bunion dressing is applied. The patient is discharged to home with this dressing, as well as with an offloading postoperative shoe.
    Alternatives: Surgical alternatives include open distal chevron osteotomy, open Akin osteotomy, MTP joint arthrodesis, Lapidus fusion, and Scarf osteotomy
    Rationale: The minimally invasive chevron Akin technique for hallux valgus correction provides alignment restoration of the first ray with less soft-tissue trauma than conventional open surgical procedures. This technique utilizes dorsal and medial stab incisions, instead of a more extensive open dorsal incision. These smaller incisions minimize the soft-tissue disruption, which has been reported to improve postoperative range of motion and to reduce loss of postoperative dorsiflexion related to scar tissue formation. Even while minimizing soft-tissue disruption, this technique still enables adequate correction and reliably stable fixation.
    Expected outcomes: The expected outcome of this procedure is a return to normal activities following the recovery period. Prior to correction, the patient is counseled regarding the risk of persistent or recurrent deformity postoperatively. The patient is also informed regarding potential postoperative stiffness. According to the literature, outcomes following minimally invasive chevron Akin hallux valgus correction have been shown to be equivalent to traditional open correction, with reported recurrence rates of <1% and excellent or good patient satisfaction in >90% of patients
    Important tips: If the chevron osteotomy cut accidentally turns into a transverse cut, then add a second screw to provide rotational stability.Obtain a perfect lateral view after placing the Kirschner wire in order to ensure satisfactory trajectory of the Kirschner wire in all planes.Drive the Akin Kirschner wire through the skin distally and clamp with a mosquito to prevent pullout after drilling.If the Akin Kirschner wire is too flimsy to get a good starting point and trajectory, exchange it for the chevron Kirschner wire and use the drill to exchange back just prior to screw insertion.Subtract approximately 4 mm from the measured screw length in order to ensure that the screw is not too long; otherwise, it may create a gap in the osteotomy site.
    Acronyms and abbreviations: NSAIDs = nonsteroidal anti-inflammatory drugsK-wire = Kirschner wireHVA = hallux valgus angleIMA = intermetatarsal angleMIS = minimally invasive surgeryAP = anteroposteriorOR = operating roomMTP = metatarsophalangealVAS = visual analog scaleMOXFQ = Manchester-Oxford Foot Questionnaire.
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747088-X
    ISSN 2160-2204
    ISSN 2160-2204
    DOI 10.2106/JBJS.ST.22.00021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Second Metatarsal Fracture During Lapidus Hallux Valgus Correction: A Case Report.

    Flaherty, Alexandra F / Chen, Jie

    JBJS case connector

    2023  Volume 13, Issue 1

    Abstract: Case: A 67-year-old woman with rheumatoid arthritis underwent Lapidus hallux valgus correction. Initial realignment was unsatisfactory, so the K-wire through the first and second metatarsals was removed. As the clamp was repositioned, the second ... ...

    Abstract Case: A 67-year-old woman with rheumatoid arthritis underwent Lapidus hallux valgus correction. Initial realignment was unsatisfactory, so the K-wire through the first and second metatarsals was removed. As the clamp was repositioned, the second metatarsal fractured through the K-wire hole. The Lapidus procedure was completed, and then, the fracture was fixed with a percutaneous K-wire. The tarsometatarsal fusion and second metatarsal fracture healed.
    Conclusion: Because second metatarsal structural integrity is imperative for use of the clamp, bone quality and K-wire holes from re-reduction should be considered. Although technically challenging, this case demonstrates percutaneous fracture reduction after Lapidus hallux valgus correction.
    MeSH term(s) Female ; Humans ; Aged ; Metatarsal Bones/surgery ; Hallux Valgus/diagnostic imaging ; Hallux Valgus/surgery ; Arthrodesis/adverse effects ; Arthrodesis/methods ; Bone Wires ; Arthritis, Rheumatoid
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI e22.00639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hyperthermic intraperitoneal chemotherapy for gastric cancer: a narrative review.

    Chen, Courtney / Justo, Monica / Gangi, Alexandra

    Chinese clinical oncology

    2024  Volume 12, Issue 6, Page(s) 68

    Abstract: Background and objective: Gastric cancer (GC) is the 5th most common malignancy globally, and although there have been modest gains in improving survival rates, it remains a leading cause of death. A component contributing to the poor survival rates ... ...

    Abstract Background and objective: Gastric cancer (GC) is the 5th most common malignancy globally, and although there have been modest gains in improving survival rates, it remains a leading cause of death. A component contributing to the poor survival rates includes advanced disease stage at presentation. Approximately 30-40% of GC patients present with metastases at diagnosis, with poorer outcomes when peritoneal metastases are present. However, recent studies have demonstrated potential utility of hyperthermic intraperitoneal chemotherapy (HIPEC) for GC with peritoneal carcinomatosis (GCPC) and for prevention of peritoneal carcinomatosis in high-risk patients. HIPEC for GC is highly debated. It is currently not recommended as part of standard of care for GC. The objective of this study is to discuss the various factors influencing the success of HIPEC, current intraperitoneal (IP) chemotherapy treatment regimens, timing of HIPEC administration, major randomized controlled trials (RCTs) and non-RCTs (NRCTs), and meta-analyses in GC patients.
    Methods: A review of the Library of Congress, the Cochrane Review, Google Scholar, PubMed, and ClinicalTrials.gov was performed. All articles and trials with available data in English with full text were considered. Necessary keywords used to search included "gastric cancer" and/or "HIPEC". Included articles were independently reviewed by authors.
    Key content and findings: Optimal HIPEC administration timing is unclear, but many utilize it in a neoadjuvant or prophylactic setting. Signet ring pathology and epithelial mesenchymal transition (EMT) cell histologic subtypes may have more aggressive pathology, limiting HIPEC success rates. Patients who receive complete cytoreduction and have low peritoneal carcinomatosis index (PCI) burden have been shown to have improved median overall survival (OS) after HIPEC. The data suggests in GCPC, HIPEC can modestly improve recurrence-free and OS. The data regarding benefits of prophylactic HIPEC in advanced GC (AGC) remains mixed.
    Conclusions: HIPEC for GC is controversial. Much of the literature is exploratory in nature or difficult to compare, as many outcomes are novel/not cross validated against substantial preceding data, with highly variable patient populations and study designs. However, in certain clinical scenarios in high volume centers, some patients with non-metastatic or low burden disease who undergo prophylactic or intraoperative HIPEC may benefit with improved overall and recurrence free survival (RFS).
    MeSH term(s) Humans ; Stomach Neoplasms/drug therapy ; Hyperthermic Intraperitoneal Chemotherapy ; Peritoneal Neoplasms/drug therapy ; Cytoreduction Surgical Procedures ; Neoadjuvant Therapy ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2024-01-10
    Publishing country China
    Document type Review ; Journal Article
    ZDB-ID 2828547-5
    ISSN 2304-3873 ; 2304-3873
    ISSN (online) 2304-3873
    ISSN 2304-3873
    DOI 10.21037/cco-23-90
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Publisher Correction: Age-related changes in the zebrafish and killifish inner ear and lateral line.

    Coffin, Allison B / Dale, Emily / Molano, Olivia / Pederson, Alexandra / Costa, Emma K / Chen, Jingxun

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9327

    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59895-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Cryogenic Ion Vibrational Predissociation (CIVP) Spectroscopy of Aryl Cobinamides in the Gas Phase: How Good Are the Calculations for Vitamin B

    Tsybizova, Alexandra / Fritsche, Lukas / Miloglyadova, Larisa / Kräutler, Bernhard / Chen, Peter

    Journal of the American Chemical Society

    2023  Volume 145, Issue 36, Page(s) 19561–19570

    Abstract: Aryl corrins represent a novel class of designed ... ...

    Abstract Aryl corrins represent a novel class of designed B
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c03001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Characterization of Novel Human β-glucocerebrosidase Antibodies for Parkinson's Disease Research.

    Jong, Tiffany / Gehrlein, Alexandra / Sidransky, Ellen / Jagasia, Ravi / Chen, Yu

    Journal of Parkinson's disease

    2024  Volume 14, Issue 1, Page(s) 65–78

    Abstract: Background: Mutations in GBA1, which encodes the lysosome enzyme β-glucocerebrosidase (also referred to as acid β-glucosidase or GCase), are the most common genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Evidence ... ...

    Abstract Background: Mutations in GBA1, which encodes the lysosome enzyme β-glucocerebrosidase (also referred to as acid β-glucosidase or GCase), are the most common genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Evidence also suggests that loss of GCase activity is implicated in PD without GBA1 mutations. Consequently, therapies targeting GCase are actively being pursued as potential strategies to modify the progression of PD and related synucleinopathies. Despite this significant interest in GCase as a therapeutic target, the lack of well-characterized GCase antibodies continues to impede progress in the development of GCase-targeted therapies.
    Objective: This study aims to independently evaluate human GCase (hGCase) antibodies to provide recommendations for western blot, immunofluorescence, immunoprecipitation, and AlphaLISA (Amplified Luminescent Proximity Homogeneous Assay) assays.
    Methods: Two mouse monoclonal antibodies, hGCase-1/17 and hGCase-1/23, were raised against hGCase using imiglucerase, the recombinant enzyme developed to treat patients, as the antigen. These novel antibodies, alongside commonly used antibodies in the field, underwent evaluation in a variety of assays.
    Results: The characterization of hGCase-1/17 and hGCase-1/23 using genetic models including GBA1 loss-of-function human neuroglioma H4 line and neurons differentiated from human embryonic stem cells revealed their remarkable specificity and potency in immunofluorescence and immunoprecipitation assays. Furthermore, a hGCase AlphaLISA assay with excellent sensitivity, a broad dynamic range, and suitability for high throughput applications was developed using hGCase-1/17 and hGCase-1/23, which enabled a sandwich assay configuration.
    Conclusions: The hGCase immunofluorescence, immunoprecipitation, and AlphaLISA assays utilizing hGCase-1/17 and hGCase-1/23 will not only facilitate improved investigations of hGCase biology, but can also serve as tools to assess the distribution and effectiveness of GCase-targeted therapies for PD and related synucleinopathies.
    MeSH term(s) Animals ; Mice ; Humans ; Parkinson Disease/drug therapy ; Glucosylceramidase/genetics ; Synucleinopathies/genetics ; Neurons ; Cell Differentiation ; Mutation ; alpha-Synuclein/genetics ; Lysosomes/genetics
    Chemical Substances Glucosylceramidase (EC 3.2.1.45) ; alpha-Synuclein
    Language English
    Publishing date 2024-02-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-230295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Progressive

    Tzioni, Maria-Myrsini / Clipson, Alexandra / Chen, Zi / Cucco, Francesco / Wotherspoon, Andrew / Dojcinov, Stefan / Du, Ming-Qing

    Leukemia & lymphoma

    2024  , Page(s) 1–5

    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2024.2332508
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  10. Article ; Online: Effects of Addition of Lanthanum and Zinc Oxides on the Biological Properties of TiO

    Lyutova, Ekaterina S / Tkachuk, Valeriya A / Zakharkiva, Alexandra M / Borilo, Lyudmila P / Buzaev, Aleksandr A / Chen, Yu-Wen

    ACS omega

    2024  Volume 9, Issue 6, Page(s) 6880–6887

    Abstract: The spherical materials ... ...

    Abstract The spherical materials TiO
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08268
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