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  1. Book: Meconium aspiration syndrome

    Mokra, Daniela / Mokry, Juraj

    from pathomechanisms to treatment

    (Pregnancy & infants : medical, psychological and social issues ; Nova biomedical)

    2010  

    Author's details Daniela Mokra and Juraj Mokry
    Series title Pregnancy & infants : medical, psychological and social issues
    Nova biomedical
    Keywords Neoplasms / etiology ; Cell Transformation, Neoplastic ; Cell Division ; Cell Fusion ; Acquired Immunodeficiency Syndrome / etiology
    Language English
    Size 130 S. : Ill., graph. Darst., 23 cm
    Publisher Nova Biomed. Books
    Publishing place New York
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT016255095
    ISBN 978-1-60876-944-5 ; 1-60876-944-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 3788 order for loan Magazin

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  2. Article: Advances in the Use of

    Mokra, Daniela / Mokry, Juraj / Barosova, Romana / Hanusrichterova, Juliana

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: ... ...

    Abstract N
    Language English
    Publishing date 2023-09-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12091713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Anti-inflammatory activity of non-selective PDE inhibitor aminophylline on the lung tissue and respiratory parameters in animal model of ARDS.

    Kosutova, Petra / Mikolka, Pavol / Mokra, Daniela / Calkovska, Andrea

    Journal of inflammation (London, England)

    2023  Volume 20, Issue 1, Page(s) 10

    Abstract: Acute respiratory distress syndrome (ARDS) is a common complication of critical illness characterized by lung inflammation, epithelial and endothelial dysfunction, alveolar-capillary leakage, and worsening respiratory failure. The present study aimed to ... ...

    Abstract Acute respiratory distress syndrome (ARDS) is a common complication of critical illness characterized by lung inflammation, epithelial and endothelial dysfunction, alveolar-capillary leakage, and worsening respiratory failure. The present study aimed to investigate the anti-inflammatory effects of non-selective phosphodiesterase (PDE) inhibitor aminophylline. New Zealand white rabbits were randomly divided into 3 groups: animals with respiratory failure defined as PaO
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2164385-4
    ISSN 1476-9255
    ISSN 1476-9255
    DOI 10.1186/s12950-023-00337-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics.

    Barosova, Romana / Baranovicova, Eva / Hanusrichterova, Juliana / Mokra, Daniela

    International journal of molecular sciences

    2023  Volume 25, Issue 1

    Abstract: Bronchial asthma is an extremely heterogenous chronic respiratory disorder with several distinct endotypes and phenotypes. These subtypes differ not only in the pathophysiological changes and/or clinical features but also in their response to the ... ...

    Abstract Bronchial asthma is an extremely heterogenous chronic respiratory disorder with several distinct endotypes and phenotypes. These subtypes differ not only in the pathophysiological changes and/or clinical features but also in their response to the treatment. Therefore, precise diagnostics represent a fundamental condition for effective therapy. In the diagnostic process, metabolomic approaches have been increasingly used, providing detailed information on the metabolic alterations associated with human asthma. Further information is brought by metabolomic analysis of samples obtained from animal models. This article summarizes the current knowledge on metabolomic changes in human and animal studies of asthma and reveals that alterations in lipid metabolism, amino acid metabolism, purine metabolism, glycolysis and the tricarboxylic acid cycle found in the animal studies resemble, to a large extent, the changes found in human patients with asthma. The findings indicate that, despite the limitations of animal modeling in asthma, pre-clinical testing and metabolomic analysis of animal samples may, together with metabolomic analysis of human samples, contribute to a novel way of personalized treatment of asthma patients.
    MeSH term(s) Animals ; Humans ; Metabolomics ; Models, Animal ; Asthma ; Citric Acid Cycle ; Glycolysis
    Language English
    Publishing date 2023-12-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: New Insights into Pathomechanisms and Treatment Possibilities for Lung Silicosis.

    Adamcakova, Jana / Mokra, Daniela

    International journal of molecular sciences

    2021  Volume 22, Issue 8

    Abstract: Inhalation of silica particles is an environmental and occupational cause of silicosis, a type of pneumoconiosis. Development of the lung silicosis is a unique process in which the vicious cycle of ingestion of inhaled silica particles by alveolar ... ...

    Abstract Inhalation of silica particles is an environmental and occupational cause of silicosis, a type of pneumoconiosis. Development of the lung silicosis is a unique process in which the vicious cycle of ingestion of inhaled silica particles by alveolar macrophages and their release triggers inflammation, generation of nodular lesions, and irreversible fibrosis. The pathophysiology of silicosis is complex, and interactions between the pathomechanisms have not been completely understood. However, elucidation of silica-induced inflammation cascades and inflammation-fibrosis relations has uncovered several novel possibilities of therapeutic targeting. This article reviews new information on the pathophysiology of silicosis and points out several promising treatment approaches targeting silicosis-related pathways.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Antioxidants/therapeutic use ; Cytokines/genetics ; Cytokines/metabolism ; Humans ; Inflammasomes/drug effects ; Inflammasomes/metabolism ; Macrophages/drug effects ; Macrophages/metabolism ; Silicosis/drug therapy ; Silicosis/metabolism
    Chemical Substances Anti-Inflammatory Agents ; Antioxidants ; Cytokines ; Inflammasomes
    Language English
    Publishing date 2021-04-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22084162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Phosphodiesterase Inhibitors in Acute Lung Injury: What Are the Perspectives?

    Mokra, Daniela / Mokry, Juraj

    International journal of molecular sciences

    2021  Volume 22, Issue 4

    Abstract: Despite progress in understanding the pathophysiology of acute lung damage, currently approved treatment possibilities are limited to lung-protective ventilation, prone positioning, and supportive interventions. Various pharmacological approaches have ... ...

    Abstract Despite progress in understanding the pathophysiology of acute lung damage, currently approved treatment possibilities are limited to lung-protective ventilation, prone positioning, and supportive interventions. Various pharmacological approaches have also been tested, with neuromuscular blockers and corticosteroids considered as the most promising. However, inhibitors of phosphodiesterases (PDEs) also exert a broad spectrum of favorable effects potentially beneficial in acute lung damage. This article reviews pharmacological action and therapeutical potential of nonselective and selective PDE inhibitors and summarizes the results from available studies focused on the use of PDE inhibitors in animal models and clinical studies, including their adverse effects. The data suggest that xanthines as representatives of nonselective PDE inhibitors may reduce acute lung damage, and decrease mortality and length of hospital stay. Various (selective) PDE3, PDE4, and PDE5 inhibitors have also demonstrated stabilization of the pulmonary epithelial-endothelial barrier and reduction the sepsis- and inflammation-increased microvascular permeability, and suppression of the production of inflammatory mediators, which finally resulted in improved oxygenation and ventilatory parameters. However, the current lack of sufficient clinical evidence limits their recommendation for a broader use. A separate chapter focuses on involvement of cyclic adenosine monophosphate (cAMP) and PDE-related changes in its metabolism in association with coronavirus disease 2019 (COVID-19). The chapter illuminates perspectives of the use of PDE inhibitors as an add-on treatment based on actual experimental and clinical trials with preliminary data suggesting their potential benefit.
    MeSH term(s) Acute Lung Injury/drug therapy ; Acute Lung Injury/metabolism ; Acute Lung Injury/physiopathology ; Animals ; COVID-19/metabolism ; COVID-19/physiopathology ; Cyclic AMP/metabolism ; Disease Models, Animal ; Humans ; Phosphodiesterase Inhibitors/pharmacology ; Phosphodiesterase Inhibitors/therapeutic use ; Phosphoric Diester Hydrolases/metabolism ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome/metabolism ; Respiratory Distress Syndrome/physiopathology ; Sepsis/drug therapy ; Sepsis/metabolism ; Sepsis/physiopathology ; COVID-19 Drug Treatment
    Chemical Substances Phosphodiesterase Inhibitors ; Cyclic AMP (E0399OZS9N) ; Phosphoric Diester Hydrolases (EC 3.1.4.-)
    Language English
    Publishing date 2021-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22041929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics

    Romana Barosova / Eva Baranovicova / Juliana Hanusrichterova / Daniela Mokra

    International Journal of Molecular Sciences, Vol 25, Iss 1, p

    2023  Volume 459

    Abstract: Bronchial asthma is an extremely heterogenous chronic respiratory disorder with several distinct endotypes and phenotypes. These subtypes differ not only in the pathophysiological changes and/or clinical features but also in their response to the ... ...

    Abstract Bronchial asthma is an extremely heterogenous chronic respiratory disorder with several distinct endotypes and phenotypes. These subtypes differ not only in the pathophysiological changes and/or clinical features but also in their response to the treatment. Therefore, precise diagnostics represent a fundamental condition for effective therapy. In the diagnostic process, metabolomic approaches have been increasingly used, providing detailed information on the metabolic alterations associated with human asthma. Further information is brought by metabolomic analysis of samples obtained from animal models. This article summarizes the current knowledge on metabolomic changes in human and animal studies of asthma and reveals that alterations in lipid metabolism, amino acid metabolism, purine metabolism, glycolysis and the tricarboxylic acid cycle found in the animal studies resemble, to a large extent, the changes found in human patients with asthma. The findings indicate that, despite the limitations of animal modeling in asthma, pre-clinical testing and metabolomic analysis of animal samples may, together with metabolomic analysis of human samples, contribute to a novel way of personalized treatment of asthma patients.
    Keywords metabolomics ; bronchial asthma ; animal model ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases?

    Mokra, Daniela / Adamcakova, Jana / Mokry, Juraj

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 8

    Abstract: Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a wide variety of actions. EGCG acts as a strong antioxidant which effectively scavenges reactive oxygen species (ROS), inhibits pro-oxidant enzymes including NADPH ... ...

    Abstract (-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a wide variety of actions. EGCG acts as a strong antioxidant which effectively scavenges reactive oxygen species (ROS), inhibits pro-oxidant enzymes including NADPH oxidase, activates antioxidant systems including superoxide dismutase, catalase, or glutathione, and reduces abundant production of nitric oxide metabolites by inducible nitric oxide synthase. ECGC also exerts potent anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, and metabolic effects via modulation of a variety of intracellular signaling cascades. Based on this knowledge, the use of EGCG could be of benefit in respiratory diseases with acute or chronic inflammatory, oxidative, and fibrotizing processes in their pathogenesis. This article reviews current information on the biological effects of EGCG in those respiratory diseases or animal models in which EGCG has been administered, i.e., acute respiratory distress syndrome, respiratory infections, COVID-19, bronchial asthma, chronic obstructive pulmonary disease, lung fibrosis, silicosis, lung cancer, pulmonary hypertension, and lung embolism, and critically discusses effectiveness of EGCG administration in these respiratory disorders. For this review, articles in English language from the PubMed database were used.
    Language English
    Publishing date 2022-08-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11081566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Editorial: Phosphodiesterases as Drug Targets in Airway and Inflammatory Diseases.

    Mokry, Juraj / Giembycz, Mark / Mokra, Daniela

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 657596

    Language English
    Publishing date 2021-04-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.657596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases?

    Mokra, Daniela / Adamcakova, Jana / Mokry, Juraj

    Antioxidants. 2022 Aug. 13, v. 11, no. 8

    2022  

    Abstract: Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a wide variety of actions. EGCG acts as a strong antioxidant which effectively scavenges reactive oxygen species (ROS), inhibits pro-oxidant enzymes including NADPH ... ...

    Abstract (-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a wide variety of actions. EGCG acts as a strong antioxidant which effectively scavenges reactive oxygen species (ROS), inhibits pro-oxidant enzymes including NADPH oxidase, activates antioxidant systems including superoxide dismutase, catalase, or glutathione, and reduces abundant production of nitric oxide metabolites by inducible nitric oxide synthase. ECGC also exerts potent anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, and metabolic effects via modulation of a variety of intracellular signaling cascades. Based on this knowledge, the use of EGCG could be of benefit in respiratory diseases with acute or chronic inflammatory, oxidative, and fibrotizing processes in their pathogenesis. This article reviews current information on the biological effects of EGCG in those respiratory diseases or animal models in which EGCG has been administered, i.e., acute respiratory distress syndrome, respiratory infections, COVID-19, bronchial asthma, chronic obstructive pulmonary disease, lung fibrosis, silicosis, lung cancer, pulmonary hypertension, and lung embolism, and critically discusses effectiveness of EGCG administration in these respiratory disorders. For this review, articles in English language from the PubMed database were used.
    Keywords COVID-19 infection ; NAD(P)H oxidase (H2O2-forming) ; acute respiratory distress syndrome ; animals ; apoptosis ; asthma ; catalase ; databases ; embolism ; epigallocatechin gallate ; glutathione ; green tea ; hypertension ; inducible nitric oxide synthase ; lung neoplasms ; lungs ; metabolites ; nitric oxide ; pathogenesis ; polyphenols ; pulmonary fibrosis ; reactive oxygen species ; superoxide dismutase
    Language English
    Dates of publication 2022-0813
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11081566
    Database NAL-Catalogue (AGRICOLA)

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