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  1. Article ; Online: Investigating morphological changes in the brain in relation to etiology and duration of olfactory dysfunction with voxel-based morphometry.

    Postma, E M / Smeets, P A M / Boek, W M / Boesveldt, S

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 12704

    Abstract: Olfactory loss (OL) affects up to 20% of the general population and is related to changes in olfaction-related brain regions. This study investigated the effect of etiology and duration of OL on gray matter volume (GMV) of these regions in 257 patients. ... ...

    Abstract Olfactory loss (OL) affects up to 20% of the general population and is related to changes in olfaction-related brain regions. This study investigated the effect of etiology and duration of OL on gray matter volume (GMV) of these regions in 257 patients. Voxel-based morphometry was applied to measure GMV in brain regions of interest to test the effects of etiology and duration on regional GMV and the relation between olfactory function and regional GMV. Etiology of OL had a significant effect on GMV in clusters representing the gyrus rectus and orbitofrontal cortex (OFC), bilaterally. Patients with congenital anosmia had reduced GMV in the gyrus rectus and an increased OFC volume compared to patients with acquired OL. There was a significant association between volume of the left OFC and olfactory function. This implies that changes in GMV in patients with acquired OL are mainly reflected in the OFC and depend on olfactory function. Morphology of olfactory areas in the brain therefore seems to relate to olfactory function and the subsequent degree of exposure to olfactory input in patients with acquired OL. Differences in GMV in congenital anosmia are most likely due to the fact that patients were never able to smell.
    MeSH term(s) Adult ; Female ; Gray Matter/diagnostic imaging ; Gray Matter/pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Olfaction Disorders/congenital ; Olfaction Disorders/diagnostic imaging ; Olfaction Disorders/etiology ; Olfaction Disorders/pathology ; Prefrontal Cortex/diagnostic imaging ; Prefrontal Cortex/pathology ; Smell
    Language English
    Publishing date 2021-06-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-92224-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: IGF-1 as screening tool for acromegaly and adult-onset growth hormone deficiency in the Netherlands.

    Postma, Mark R / van Beek, André P / van der Klauw, Melanie M / Lentjes, Eef G W M / Muller Kobold, Anneke C

    Clinical endocrinology

    2023  Volume 100, Issue 3, Page(s) 260–268

    Abstract: Objective: Insulin-like growth factor 1 (IGF-1) measurements play a central role in the diagnosis and follow-up of acromegaly and growth hormone deficiency. However, improving health care outcomes for these patients involves an intricate process of ... ...

    Abstract Objective: Insulin-like growth factor 1 (IGF-1) measurements play a central role in the diagnosis and follow-up of acromegaly and growth hormone deficiency. However, improving health care outcomes for these patients involves an intricate process of laboratory diagnostics and skilled health care professionals. The integrated effects of IGF-1 reports on diagnosis and treatment decisions are yet unknown.
    Design, patients and measurements: Extended quality assessment, distributing the description of five (real) patient cases with accompanying blood samples. Patients suspected or during follow up for acromegaly or adult onset of growth hormone deficiency were included. Laboratory specialists and endocrinologists in the same centre were asked to interpret their centre-specific IGF-1 results by using a laboratory and medical questionnaire. This way, insight could be obtained into the combined effects of different assays, assay harmonisation, reference value sets, and individual physician interpretation in relation to guidelines, thus reviewing the entire diagnostic and management process.
    Results: Limited variation (CV 13.8 ± 2.8) was found in IGF-1 concentrations despite different use of the harmonization sample and factor among laboratories. This interlaboratory variation increased upon conversion to SD scores (CV 15.7 ± 40.7) as a consequence of the use of different reference value sets. Furthermore, there was a lack of adherence to international guidelines among endocrinologists.
    Conclusions: Highly variable diagnostic and treatment outcomes in acromegaly and AGHD in the Netherlands can be attributed to increased variability of IGF-1 upon conversion to SD scores and low adherence to clinical guidelines.
    MeSH term(s) Adult ; Humans ; Acromegaly ; Insulin-Like Growth Factor I/metabolism ; Human Growth Hormone/therapeutic use ; Netherlands ; Dwarfism, Pituitary/drug therapy ; Growth Hormone/therapeutic use
    Chemical Substances Insulin-Like Growth Factor I (67763-96-6) ; Human Growth Hormone (12629-01-5) ; Growth Hormone (9002-72-6)
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.15000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rice increases phosphorus uptake in strongly sorbing soils by intra-root facilitation.

    Kuppe, Christian W / Kirk, Guy J D / Wissuwa, Matthias / Postma, Johannes A

    Plant, cell & environment

    2022  Volume 45, Issue 3, Page(s) 884–899

    Abstract: Upland rice (Oryza sativa) is adapted to strongly phosphorus (P) sorbing soils. The mechanisms ... underlying P acquisition, however, are not well understood, and models typically underestimate uptake ... model, which correctly simulates the P uptake by a P-efficient rice genotype measured over 48 days ...

    Abstract Upland rice (Oryza sativa) is adapted to strongly phosphorus (P) sorbing soils. The mechanisms underlying P acquisition, however, are not well understood, and models typically underestimate uptake. This complicates root ideotype development and trait-based selection for further improvement. We present a novel model, which correctly simulates the P uptake by a P-efficient rice genotype measured over 48 days of growth. The model represents root morphology at the local rhizosphere scale, including root hairs and fine S-type laterals. It simulates fast- and slowly reacting soil P and the P-solubilizing effect of root-induced pH changes in the soil. Simulations predict that the zone of pH changes and P solubilization around a root spreads further into the soil than the zone of P depletion. A root needs to place laterals outside its depletion- but inside its solubilization zone to maximize P uptake. S-type laterals, which are short but hairy, appear to be the key root structures to achieve that. Thus, thicker roots facilitate the P uptake by fine lateral roots. Uptake can be enhanced through longer root hairs and greater root length density but was less sensitive to total root length and root class proportions.
    MeSH term(s) Oryza/genetics ; Phosphorus ; Plant Roots ; Rhizosphere ; Soil/chemistry
    Chemical Substances Soil ; Phosphorus (27YLU75U4W)
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391893-2
    ISSN 1365-3040 ; 0140-7791
    ISSN (online) 1365-3040
    ISSN 0140-7791
    DOI 10.1111/pce.14285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correlates of physical activity in ambulatory people with spinal cord injury during the first year after inpatient rehabilitation.

    Postma, Karin / van Diemen, Tijn / Post, Marcel W M / Stolwijk-Swüste, Janneke M / van den Berg-Emons, Rita J G / Osterthun, Rutger

    Spinal cord

    2024  

    Abstract: ... Results: Mobility was longitudinally associated with level of PA (beta: 4.5, P < 0.001, R: Conclusions ...

    Abstract Study design: Longitudinal cohort study.
    Objectives: Examine the longitudinal association between mobility and level of physical activity (PA) and explore which other factors are also associated with level of PA in ambulatory people with Spinal Cord Injury (SCI) during the first-year post-inpatient rehabilitation.
    Setting: Three SCI-specialized rehabilitation centers and the Dutch community.
    Methods: Forty-seven adults with recent SCI and ambulatory function were included. All had motor incomplete lesions, 49% had tetraplegia, and the mean age was 55 ± 13 years. Duration of accelerometry-based all-day PA and self-reported level of mobility, exertion of walking, pain, fatigue, depressive mood symptoms, fear of falling, exercise self-efficacy, and attitude toward PA were measured just before discharge from inpatient rehabilitation and 6 and 12 months after discharge. All data were longitudinally analyzed using generalized estimating equations analyses. Models were corrected for age, lesion level, and time since injury.
    Results: Mobility was longitudinally associated with level of PA (beta: 4.5, P < 0.001, R
    Conclusions: Mobility, exertion of walking, fear of falling, and exercise self-efficacy seem to be correlates of level of PA in ambulatory people with SCI during the first year after inpatient rehabilitation. Targeting these factors using an interdisciplinary approach may enhance levels of PA in this population.
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1316161-1
    ISSN 1476-5624 ; 1362-4393
    ISSN (online) 1476-5624
    ISSN 1362-4393
    DOI 10.1038/s41393-024-00982-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The association between radiological spreading pattern and clinical outcomes in necrotizing external otitis.

    van der Meer, W Leentje / Bayoumy, Ahmed B / Otten, Josje J / Waterval, Jerome J / Kunst, Henricus P M / Postma, Alida A

    Journal of otology

    2022  Volume 17, Issue 3, Page(s) 156–163

    Abstract: ... Higher rates of N.VII (42.9% vs 14.8% P = 0.047) and N. IX palsies were found in group B compared ... to group A (28.6% vs 3.7%, P = 0.039). The median duration of antibiotic use was significantly different ...

    Abstract Objectives: Necrotizing external otitis (NEO) is a rare infectious disease of the skull base. The purpose of this study was to determine whether clinical outcomes of NEO can be correlated to different infectious spread patterns.
    Methods: Retrospective chart review from 2010 to 2019 with NEO patients, who were divided into two cohorts: single spreading patterns (group A) or complex spreading patterns (group B) as diagnosed by CT. Clinical symptoms, diagnostic and treatment delay, course of disease, complications, and duration of antibiotic exposure were retrospectively collected from patient records.
    Results: 41 NEO patients were included, of which 27 patients belonged to group A (66%). The disease-related mortality rate was 12.2% among the entire cohort, no differences were found between group A and B. Higher rates of N.VII (42.9% vs 14.8% P = 0.047) and N. IX palsies were found in group B compared to group A (28.6% vs 3.7%, P = 0.039). The median duration of antibiotic use was significantly different for a complex spreading pattern, clinical recovery and hospitalizations. Complications were associated with higher diagnostic delay and with a complex spread pattern. The median duration of follow-up was 12.0 (IQR 6.0-19.5) months.
    Conclusion: NEO is a severe disease, with significant mortality and morbidity (cranial nerve palsies). The radiological spread pattern may assist in predicting clinical outcome. Furthermore, complex spread patterns are associated with higher rates of clinical nerve palsies (N. VII and N.IX), complications, surgery rates and longer duration of antibiotic use. Diagnostic delay was associated with mortality, complications and facial palsies.
    Level of evidence: Level IV.
    Language English
    Publishing date 2022-06-03
    Publishing country China
    Document type Journal Article
    ZDB-ID 2621477-5
    ISSN 2524-1753 ; 1672-2930
    ISSN (online) 2524-1753
    ISSN 1672-2930
    DOI 10.1016/j.joto.2022.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Antibiotic Use in European Pig Production: Less Is More.

    Dewulf, Jeroen / Joosten, Philip / Chantziaras, Ilias / Bernaerdt, Elise / Vanderhaeghen, Wannes / Postma, Merel / Maes, Dominiek

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 11

    Abstract: The goal of this study is to describe the current use of antibiotics in the European pig industry based on an extensive literature review. To achieve this, an overview of results from national ( ...

    Abstract The goal of this study is to describe the current use of antibiotics in the European pig industry based on an extensive literature review. To achieve this, an overview of results from national (
    Language English
    Publishing date 2022-10-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11111493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Assessment of the clinical feasibility of detecting subtle blood-brain barrier leakage in cerebral small vessel disease using dynamic susceptibility contrast MRI.

    Elschot, Elles P / Backes, Walter H / de Jong, Joost J A / Drenthen, Gerhard S / Wong, Sau May / Staals, Julie / Postma, Alida A / Rouhl, Rob P W / van Oostenbrugge, Robert J / Jansen, Jacobus F A

    Magnetic resonance imaging

    2023  Volume 102, Page(s) 55–61

    Abstract: ... leakage rate K: Results: K2 showed significant differences between tissue regions (P < 0.001 for CGM-NAWM ... and CGM-WMH, and P = 0.001 for NAWM-WMH). Conversely, according to the computer simulations the DSC ...

    Abstract Purpose: Cerebral small vessel disease (cSVD) involves several pathologies affecting the small vessels, including blood-brain barrier (BBB) impairment. Dynamic susceptibility contrast (DSC) MRI is sensitive to both blood perfusion and BBB leakage, and correction methods may be crucial for obtaining reliable perfusion measures. These methods might also be applicable to detect BBB leakage itself. This study investigated to what extent DSC-MRI can measure subtle BBB leakage in a clinical feasibility setting.
    Methods: In vivo DCE and DSC data were collected from fifteen cSVD patients (71 (±10) years, 6F/9M) and twelve elderly controls (71 (±10) years, 4F/8M). DSC-derived leakage fractions were obtained using the Boxerman-Schmainda-Weisskoff method (K2). K2 was compared with the DCE-derived leakage rate K
    Results: K2 showed significant differences between tissue regions (P < 0.001 for CGM-NAWM and CGM-WMH, and P = 0.001 for NAWM-WMH). Conversely, according to the computer simulations the DSC sensitivity was insufficient to measure subtle BBB leakage, as the K2 values were below the derived limit of quantification (4∙10
    Conclusions: Although clinical DSC-MRI seems capable to detect subtle BBB leakage differences between WMH and normal-appearing brain tissue it is not recommended. K2 as a direct measure for subtle BBB leakage remains ambiguous as its signal effects are due to mixed T
    MeSH term(s) Humans ; Aged ; Blood-Brain Barrier/diagnostic imaging ; Feasibility Studies ; Contrast Media/pharmacology ; Magnetic Resonance Imaging/methods ; Cerebral Small Vessel Diseases/diagnostic imaging ; White Matter
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-05-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604885-7
    ISSN 1873-5894 ; 0730-725X
    ISSN (online) 1873-5894
    ISSN 0730-725X
    DOI 10.1016/j.mri.2023.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Effectiviteit van inundatie voor de bestrijding van Meloidogyne chitwoodi

    Visser, J.H.M. / Postma, J. / Brinkman, P. / van Geel, W. / Molendijk, L.P.G.

    Onderzoek naar de effectiviteit van inundatie op praktijkpercelen: Onderzoek naar effect van inundatie-duur, temperatuur en toevoegen van organisch materiaal op de effectiviteit van inundatie

    2021  

    Keywords Life Science
    Language Dutch
    Publisher Wageningen Plant Research
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Investigating morphological changes in the brain in relation to etiology and duration of olfactory dysfunction with voxel-based morphometry

    Postma, E.M. / Smeets, P.A.M. / Boek, W.M. / Boesveldt, S.

    Scientific Reports

    2021  Volume 11, Issue 1

    Abstract: Olfactory loss (OL) affects up to 20% of the general population and is related to changes in olfaction-related brain regions. This study investigated the effect of etiology and duration of OL on gray matter volume (GMV) of these regions in 257 patients. ... ...

    Abstract Olfactory loss (OL) affects up to 20% of the general population and is related to changes in olfaction-related brain regions. This study investigated the effect of etiology and duration of OL on gray matter volume (GMV) of these regions in 257 patients. Voxel-based morphometry was applied to measure GMV in brain regions of interest to test the effects of etiology and duration on regional GMV and the relation between olfactory function and regional GMV. Etiology of OL had a significant effect on GMV in clusters representing the gyrus rectus and orbitofrontal cortex (OFC), bilaterally. Patients with congenital anosmia had reduced GMV in the gyrus rectus and an increased OFC volume compared to patients with acquired OL. There was a significant association between volume of the left OFC and olfactory function. This implies that changes in GMV in patients with acquired OL are mainly reflected in the OFC and depend on olfactory function. Morphology of olfactory areas in the brain therefore seems to relate to olfactory function and the subsequent degree of exposure to olfactory input in patients with acquired OL. Differences in GMV in congenital anosmia are most likely due to the fact that patients were never able to smell.
    Keywords Life Science
    Subject code 610
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2615211-3
    ISSN 2045-2322
    ISSN 2045-2322
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: An unusual outbreak in the Netherlands: community-onset impetigo caused by a meticillin-resistant

    Vendrik, Karuna E W / Kuijper, Ed J / Dimmendaal, Marieke / Silvis, Welmoed / Denie-Verhaegh, Els / de Boer, Annemarie / Postma, Bent / Schoffelen, Annelot F / Ruijs, Wilhelmina L M / Koene, Fleur M H P A / Petrignani, Mariska / Hooiveld, Mariëtte / Witteveen, Sandra / Schouls, Leo M / Notermans, Daan W

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

    2023  Volume 27, Issue 49

    Abstract: In this retrospective observational study, we analysed a community outbreak of impetigo with meticillin- ... ...

    Abstract In this retrospective observational study, we analysed a community outbreak of impetigo with meticillin-resistant
    MeSH term(s) Child ; Humans ; Fusidic Acid/therapeutic use ; Fusidic Acid/pharmacology ; Methicillin-Resistant Staphylococcus aureus ; Impetigo/drug therapy ; Impetigo/epidemiology ; Methicillin ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Netherlands/epidemiology ; Staphylococcus aureus ; Disease Outbreaks ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Microbial Sensitivity Tests
    Chemical Substances Fusidic Acid (59XE10C19C) ; Methicillin (Q91FH1328A) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-24
    Publishing country Sweden
    Document type Observational Study ; Journal Article
    ZDB-ID 1338803-4
    ISSN 1560-7917 ; 1025-496X
    ISSN (online) 1560-7917
    ISSN 1025-496X
    DOI 10.2807/1560-7917.ES.2022.27.49.2200245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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