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  1. Article ; Online: Ionic channels in nerve membranes, 50 years on.

    Hille, Bertil

    Progress in biophysics and molecular biology

    2021  Volume 169-170, Page(s) 12–20

    Abstract: ... in this journal (Hille, B., 1970, Prog. Biophys. Mol. Biol. 21, 1-32) to its realization today in biophysical ...

    Abstract This retrospective traces the hypothesis of ion channels from an early statement in a 1970 essay in this journal (Hille, B., 1970, Prog. Biophys. Mol. Biol. 21, 1-32) to its realization today in biophysical, molecular, biochemical, and structural terms. The Na
    MeSH term(s) Ion Channels/physiology ; Ions/metabolism ; Potassium/metabolism ; Retrospective Studies ; Sodium/metabolism
    Chemical Substances Ion Channels ; Ions ; Sodium (9NEZ333N27) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2021-11-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209302-9
    ISSN 1873-1732 ; 0079-6107
    ISSN (online) 1873-1732
    ISSN 0079-6107
    DOI 10.1016/j.pbiomolbio.2021.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Life of Biophysics.

    Hille, Bertil

    Annual review of biophysics

    2021  Volume 51, Page(s) 1–17

    Abstract: Biophysics is a way of approaching biological problems through numbers, physical laws, models, and quantitative logic. In a long scientific career, I have seen the formation and fruition of the ion channel concept through biophysical study. Marvelous ... ...

    Abstract Biophysics is a way of approaching biological problems through numbers, physical laws, models, and quantitative logic. In a long scientific career, I have seen the formation and fruition of the ion channel concept through biophysical study. Marvelous discoveries were made as our instruments evolved from vacuum tubes to transistors; computers evolved from the size of an entire building to a few chips inside our instruments; and genome sequencing, gene expression, and atom-level structural biology became accessible to all laboratories. Science is rewarding and exhilarating.
    MeSH term(s) Biophysical Phenomena ; Biophysics ; Ion Channels
    Chemical Substances Ion Channels
    Language English
    Publishing date 2021-12-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2434725-5
    ISSN 1936-1238 ; 1936-122X
    ISSN (online) 1936-1238
    ISSN 1936-122X
    DOI 10.1146/annurev-biophys-120121-074034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The founding of

    Hille, Bertil

    The Journal of general physiology

    2018  Volume 150, Issue 3, Page(s) 389–400

    Abstract: This essay begins with a description of the founding years ... ...

    Abstract This essay begins with a description of the founding years of
    MeSH term(s) Anniversaries and Special Events ; History, 20th Century ; History, 21st Century ; Membrane Potentials ; Periodicals as Topic/history ; Physiology/history
    Language English
    Publishing date 2018-01-23
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 3118-5
    ISSN 1540-7748 ; 0022-1295
    ISSN (online) 1540-7748
    ISSN 0022-1295
    DOI 10.1085/jgp.201711937
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  4. Book: Ion channels of excitable membranes

    Hille, Bertil

    2001  

    Author's details Bertil Hille
    Keywords Cell Membrane / physiology ; Ion Channels / physiology ; Ionenkanal ; Nervenzelle
    Subject Ganglienzelle ; Neurozyt ; Neuron
    Language English
    Size XVIII, 814 S. : Ill., graph. Darst.
    Edition 3. ed.
    Publisher Sinauer
    Publishing place Sunderland, Mass
    Publishing country United States
    Document type Book
    Old title Frühere Aufl. u.d.T. Hille, Bertil: Ionic channels of excitable membranes
    HBZ-ID HT013175424
    ISBN 0-87893-321-2 ; 978-0-87893-321-1
    Database Catalogue ZB MED Medicine, Health

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    2003 A 2529 order for loan Magazin

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  5. Book: Ionic channels of excitable membranes

    Hille, Bertil

    1992  

    Author's details Bertil Hille
    Keywords Ion Channels ; Cell Membrane ; Neurons ; Ionenkanal ; Nervenzelle
    Subject Ganglienzelle ; Neurozyt ; Neuron
    Language English
    Size XIII, 607 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Sinauer
    Publishing place Sunderland, Mass
    Publishing country United States
    Document type Book
    New title 3. Aufl. u.d.T. Hille, Bertil: Ion channels of excitable membranes
    HBZ-ID HT004155072
    ISBN 0-87893-323-9 ; 978-0-87893-323-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1992 A 1587 order for loan Magazin

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  6. Article ; Online: Serotonin modulates melatonin synthesis as an autocrine neurotransmitter in the pineal gland.

    Lee, Bo Hyun / Hille, Bertil / Koh, Duk-Su

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 43

    Abstract: The pineal gland secretes melatonin principally at night. Regulated by norepinephrine released from sympathetic nerve terminals, adrenergic receptors on pinealocytes activate ... ...

    Abstract The pineal gland secretes melatonin principally at night. Regulated by norepinephrine released from sympathetic nerve terminals, adrenergic receptors on pinealocytes activate aralkylamine
    MeSH term(s) Animals ; Exocytosis ; GTP-Binding Proteins/metabolism ; Ion Channel Gating ; Ligands ; Male ; Melatonin/biosynthesis ; Neurotransmitter Agents/physiology ; Pineal Gland/cytology ; Pineal Gland/metabolism ; Rats ; Rats, Sprague-Dawley ; Serotonin/physiology ; Signal Transduction ; Up-Regulation
    Chemical Substances Ligands ; Neurotransmitter Agents ; Serotonin (333DO1RDJY) ; GTP-Binding Proteins (EC 3.6.1.-) ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2113852118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Conference proceedings: Proteins of excitable membranes

    Hille, Bertil

    [based on a symposium held in 1985]

    (Society of General Physiologists series ; 41)

    1987  

    Author's details ed.: Bertil Hille
    Series title Society of General Physiologists series ; 41
    Collection
    Keywords Membrane Proteins / physiology / congresses ; Membranproteine
    Subject Biomembran
    Size XIV, 331 S. : Ill., graph. Darst.
    Edition 1. [Dr.]
    Publisher Wiley
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003155879
    ISBN 0-471-01150-9 ; 978-0-471-01150-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1988 A 3088 order for loan Magazin

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  8. Article ; Online: Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids.

    Dickson, Eamonn J / Hille, Bertil

    The Biochemical journal

    2019  Volume 476, Issue 1, Page(s) 1–23

    Abstract: Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically ... ...

    Abstract Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death. They do so by recruiting cytoplasmic proteins/effectors or by interacting with cytoplasmic domains of membrane proteins at the membrane-cytoplasm interface to organize and mold organelle identity. The present study summarizes aspects of our current understanding concerning the metabolism, manipulation, measurement, and intimate roles these lipids play in regulating membrane homeostasis and vital cell signaling reactions in health and disease.
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Humans ; Membrane Proteins/metabolism ; Phosphatidylinositols/metabolism ; Signal Transduction
    Chemical Substances Membrane Proteins ; Phosphatidylinositols
    Language English
    Publishing date 2019-01-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
    ISSN (online) 1470-8728
    ISSN 0006-2936 ; 0306-3275 ; 0264-6021
    DOI 10.1042/BCJ20180022
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  9. Book: Ionic channels of excitable membranes

    Hille, Bertil

    1984  

    Author's details Bertil Hille
    Keywords Cell Membrane / physiology ; Ion Channels / physiology ; Ionenkanal ; Nervenzelle
    Subject Ganglienzelle ; Neurozyt ; Neuron
    Language English
    Size 426 S. : Ill., graph. Darst.
    Publisher Sinauer
    Publishing place Sunderland, Massachusetts
    Publishing country United States
    Document type Book
    HBZ-ID HT003926581
    ISBN 0-87893-322-0 ; 978-0-87893-322-8
    Database Catalogue ZB MED Medicine, Health

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    1991 A 5226 order for loan Magazin

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  10. Article: Optical approaches for visualization of arrestin binding to muscarinic receptor.

    Jung, Seung-Ryoung / Hille, Bertil

    Methods in cell biology

    2018  Volume 149, Page(s) 1–18

    Abstract: G protein-coupled seven-transmembrane receptors (GPCRs) mediate responses to hormones, metabolites, lipids, and neurotransmitters at the cell membrane, and so they are prominent drug targets. Although many structural, biochemical, cell biological, and ... ...

    Abstract G protein-coupled seven-transmembrane receptors (GPCRs) mediate responses to hormones, metabolites, lipids, and neurotransmitters at the cell membrane, and so they are prominent drug targets. Although many structural, biochemical, cell biological, and biophysical studies made remarkable progress to understand mechanisms of GPCR signaling, there still are many unanswered questions about arrestin-dependent GPCR signaling. In this chapter, we focus on optical assays to see muscarinic receptor-arrestin interactions with ensemble FRET and single-molecule TIRF imaging in live cells and finally to integrate the information to simulate hypothesized steps in Virtual Cell.
    MeSH term(s) Arrestins/metabolism ; Biosensing Techniques ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Fluorescence Resonance Energy Transfer/methods ; HEK293 Cells ; Humans ; Kinetics ; Protein Binding ; Receptors, Muscarinic/metabolism
    Chemical Substances Arrestins ; Receptors, Muscarinic ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2018-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2017.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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