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  1. Book ; Online: Phospholipases: From Structure to Biological Function

    Balboa, María A. / Balsinde, Jesús / Balsinde, Jesús

    2022  

    Keywords Research & information: general ; Biology, life sciences ; inhibitor ; metabolic stability ; α-methylation ; oxoesters ; phospholipase A2 ; adrenic acid ; arachidonic acid ; mass spectrometry ; lipid signaling ; inflammation ; monocytes/macrophages ; crotoxin ; snake venom ; lung impairment ; inflammatory response ; lipid mediators ; neuromuscular blocker ; lipidomics ; PAP-2 ; autotaxin ; lysophosphatidate ; G protein-coupled receptor ; PLA2G6 ; fatty liver ; phospholipid remodeling ; diet-induced obesity ; morbidly obesity ; choline and methionine deficiency ; glioblastoma ; sphingolipid ; sphingosine-1-phosphate ; sphingomyelinase ; sphingomyelin ; metastasis ; phosphatidic acid ; diacylglycerol ; lipin ; signaling ; cPLA2α ; psoriasis ; proliferation ; anti-inflammatory ; atherosclerosis ; phospholipases ; macrophages ; T cells ; lipins ; pancreatic islets ; β-cells ; insulin secretion ; glucose tolerance ; insulin resistance ; group VIA phospholipase A2 ; fatty acid ; knockout mouse ; lipid mediator ; lysophospholipid ; membrane ; phospholipid ; ceramide ; acidic sphingomyelinase ; neutral sphingomyelinase ; hepatocellular carcinoma ; alcoholic and nonalcoholic steatohepatitis ; preadipocytes ; prostaglandins ; adipokines ; cytokines ; EP receptors ; Group V phospholipase A2 ; lipids ; majeed syndrome ; LPIN2 ; LIPIN2 ; chronic non-bacterial osteomyelitis ; chronic recurrent multifocal osteomyelitis ; autoinflammatory ; inflammasome ; macrophage ; osteoclast ; n/a
    Language 0|e
    Size 1 electronic resource (348 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021610523
    ISBN 9783036540634 ; 3036540636
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Phospholipases: From Structure to Biological Function.

    Balboa, María A / Balsinde, Jesús

    Biomolecules

    2021  Volume 11, Issue 3

    Abstract: Phospholipases are enzymes that cleave ester bonds within phospholipids [ ... ]. ...

    Abstract Phospholipases are enzymes that cleave ester bonds within phospholipids [...].
    MeSH term(s) Animals ; Calcium/metabolism ; Humans ; Phospholipases/chemistry ; Phospholipases/metabolism ; Phospholipids/metabolism
    Chemical Substances Phospholipids ; Phospholipases (EC 3.1.-) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-03-15
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11030428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Phosphorylation of cPLA

    Casas, Javier / Balsinde, Jesús / Balboa, María A

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 7

    Abstract: Group IVA cytosolic phospholipase ... ...

    Abstract Group IVA cytosolic phospholipase A
    MeSH term(s) Arachidonic Acid/metabolism ; Cytosol/metabolism ; Eicosanoids/metabolism ; Group IV Phospholipases A2/genetics ; Group IV Phospholipases A2/metabolism ; Humans ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Phosphorylation
    Chemical Substances Eicosanoids ; Phosphatidylinositol 4,5-Diphosphate ; Arachidonic Acid (27YG812J1I) ; Group IV Phospholipases A2 (EC 3.1.1.4)
    Language English
    Publishing date 2022-04-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27072347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  4. Article ; Online: Compartmentalized regulation of lipid signaling in oxidative stress and inflammation: Plasmalogens, oxidized lipids and ferroptosis as new paradigms of bioactive lipid research.

    Astudillo, Alma M / Balboa, María A / Balsinde, Jesús

    Progress in lipid research

    2022  Volume 89, Page(s) 101207

    Abstract: Perturbations in lipid homeostasis combined with conditions favoring oxidative stress constitute a hallmark of the inflammatory response. In this review we focus on the most recent results concerning lipid signaling in various oxidative stress-mediated ... ...

    Abstract Perturbations in lipid homeostasis combined with conditions favoring oxidative stress constitute a hallmark of the inflammatory response. In this review we focus on the most recent results concerning lipid signaling in various oxidative stress-mediated responses and inflammation. These include phagocytosis and ferroptosis. The best characterized event, common to these responses, is the synthesis of oxygenated metabolites of arachidonic acid and other polyunsaturated fatty acids. Major developments in this area have highlighted the importance of compartmentalization of the enzymes and lipid substrates in shaping the appropriate response. In parallel, other relevant lipid metabolic pathways are also activated and, until recently, there has been a general lack of knowledge on the enzyme regulation and molecular mechanisms operating in these pathways. Specifically, data accumulated in recent years on the regulation and biological significance of plasmalogens and oxidized phospholipids have expanded our knowledge on the involvement of lipid metabolism in the progression of disease and the return to homeostasis. These recent major developments have helped to establish the concept of membrane phospholipids as cellular repositories for the compartmentalized production of bioactive lipids involved in cellular regulation. Importantly, an enzyme classically described as being involved in regulating the homeostatic turnover of phospholipids, namely the group VIA Ca
    MeSH term(s) Humans ; Plasmalogens/metabolism ; Ferroptosis ; Phospholipids/metabolism ; Phospholipases A2/metabolism ; Oxidative Stress ; Inflammation
    Chemical Substances Plasmalogens ; Phospholipids ; Phospholipases A2 (EC 3.1.1.4)
    Language English
    Publishing date 2022-12-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 282560-0
    ISSN 1873-2194 ; 0079-6832 ; 0163-7827
    ISSN (online) 1873-2194
    ISSN 0079-6832 ; 0163-7827
    DOI 10.1016/j.plipres.2022.101207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 298: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Phosphorylation of cPLA 2 α at Ser 505 Is Necessary for Its Translocation to PtdInsP 2 -Enriched Membranes

    Javier Casas / Jesús Balsinde / María A. Balboa

    Molecules, Vol 27, Iss 2347, p

    2022  Volume 2347

    Abstract: Group IVA cytosolic phospholipase A 2 α (cPLA 2 α) is a key enzyme in physiology and pathophysiology because it constitutes a rate-limiting step in the pathway for the generation of pro- and anti-inflammatory eicosanoid lipid mediators. cPLA 2 α activity ...

    Abstract Group IVA cytosolic phospholipase A 2 α (cPLA 2 α) is a key enzyme in physiology and pathophysiology because it constitutes a rate-limiting step in the pathway for the generation of pro- and anti-inflammatory eicosanoid lipid mediators. cPLA 2 α activity is tightly regulated by multiple factors, including the intracellular Ca 2+ concentration, phosphorylation reactions, and cellular phosphatidylinositol (4,5) bisphosphate levels (PtdInsP 2 ). In the present work, we demonstrate that phosphorylation of the enzyme at Ser 505 is an important step for the translocation of the enzyme to PtdInsP 2 –enriched membranes in human cells. Constructs of eGFP-cPLA 2 mutated in Ser 505 to Ala (S505A) exhibit a delayed translocation in response to elevated intracellular Ca 2+ , and also in response to increases in intracellular PtdInsP 2 levels. Conversely, translocation of a phosphorylation mimic mutant (S505E) is fully observed in response to cellular increases in PtdInsP 2 levels. Collectively, these results suggest that phosphorylation of cPLA 2 α at Ser 505 is necessary for the enzyme to translocate to internal membranes and mobilize arachidonic acid for eicosanoid synthesis.
    Keywords cytosolic phospholipase A 2 α ; arachidonic acid ; membrane translocation ; phosphorylation ; phosphatidylinositol bisphosphate ; Organic chemistry ; QD241-441
    Subject code 333 ; 290
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Lipid Droplets, Phospholipase A

    Bermúdez, Miguel A / Balboa, María A / Balsinde, Jesús

    Biomedicines

    2021  Volume 9, Issue 12

    Abstract: Lipid droplets, classically regarded as static storage organelles, are currently considered as dynamic structures involved in key processes of lipid metabolism, cellular homeostasis and signaling. Studies on the inflammatory state of atherosclerotic ... ...

    Abstract Lipid droplets, classically regarded as static storage organelles, are currently considered as dynamic structures involved in key processes of lipid metabolism, cellular homeostasis and signaling. Studies on the inflammatory state of atherosclerotic plaques suggest that circulating monocytes interact with products released by endothelial cells and may acquire a foamy phenotype before crossing the endothelial barrier and differentiating into macrophages. One such compound released in significant amounts into the bloodstream is arachidonic acid, the common precursor of eicosanoids, and a potent inducer of neutral lipid synthesis and lipid droplet formation in circulating monocytes. Members of the family of phospholipase A
    Language English
    Publishing date 2021-12-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9121891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Differential Mobilization of the Phospholipid and Triacylglycerol Pools of Arachidonic Acid in Murine Macrophages.

    Bermúdez, Miguel A / Rubio, Julio M / Balboa, María A / Balsinde, Jesús

    Biomolecules

    2022  Volume 12, Issue 12

    Abstract: Innate immune cells such as monocytes and macrophages contain high levels of arachidonic acid (AA), part of which can be mobilized during cellular activation for the formation of a vast array of bioactive oxygenated metabolites. Monocytes and macrophages ...

    Abstract Innate immune cells such as monocytes and macrophages contain high levels of arachidonic acid (AA), part of which can be mobilized during cellular activation for the formation of a vast array of bioactive oxygenated metabolites. Monocytes and macrophages present in inflammatory foci typically incorporate large amounts of AA, not only in membrane phospholipids, but also in neutral lipids such as triacylglycerol. Thus, it was of interest to investigate the metabolic fate of these two AA pools in macrophages. Utilizing a variety of radiolabeling techniques to distinguish the phospholipid and triacylglycerol pools, we show in this paper that during an acute stimulation of the macrophages with yeast-derived zymosan, the membrane phospholipid AA pool acts as the major, if not the only, source of releasable AA. On the contrary, the AA pool in triacylglycerol appears to be used at a later stage, when the zymosan-stimulated response has declined, as a source to replenish the phospholipid pools that were consumed during the activation process. Thus, phospholipids and triacylglycerol play different in roles AA metabolism and dynamics during macrophage activation.
    Language English
    Publishing date 2022-12-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12121851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dynamics of Docosahexaenoic Acid Utilization by Mouse Peritoneal Macrophages.

    Monge, Patricia / Astudillo, Alma M / Pereira, Laura / Balboa, María A / Balsinde, Jesús

    Biomolecules

    2023  Volume 13, Issue 11

    Abstract: In this work, the incorporation of docosahexaenoic acid (DHA) in mouse resident peritoneal macrophages and its redistribution within the various phospholipid classes were investigated. Choline glycerophospholipids (PC) behaved as the major initial ... ...

    Abstract In this work, the incorporation of docosahexaenoic acid (DHA) in mouse resident peritoneal macrophages and its redistribution within the various phospholipid classes were investigated. Choline glycerophospholipids (PC) behaved as the major initial acceptors of DHA. Prolonged incubation with the fatty acid resulted in the transfer of DHA from PC to ethanolamine glycerophospholipids (PE), reflecting phospholipid remodeling. This process resulted in the cells containing similar amounts of DHA in PC and PE in the resting state. Mass spectrometry-based lipidomic analyses of phospholipid molecular species indicated a marked abundance of DHA in ether phospholipids. Stimulation of the macrophages with yeast-derived zymosan resulted in significant decreases in the levels of all DHA-containing PC and PI species; however, no PE or PS molecular species were found to decrease. In contrast, the levels of an unusual DHA-containing species, namely PI(20:4/22:6), which was barely present in resting cells, were found to markedly increase under zymosan stimulation. The levels of this phospholipid also significantly increased when the calcium-ionophore A23187 or platelet-activating factor were used instead of zymosan to stimulate the macrophages. The study of the route involved in the synthesis of PI(20:4/22:6) suggested that this species is produced through deacylation/reacylation reactions. These results define the increases in PI(20:4/22:6) as a novel lipid metabolic marker of mouse macrophage activation, and provide novel information to understand the regulation of phospholipid fatty acid turnover in activated macrophages.
    MeSH term(s) Mice ; Animals ; Macrophages, Peritoneal/metabolism ; Docosahexaenoic Acids ; Zymosan ; Phospholipids/metabolism ; Fatty Acids/metabolism
    Chemical Substances Docosahexaenoic Acids (25167-62-8) ; Zymosan (9010-72-4) ; Phospholipids ; Fatty Acids
    Language English
    Publishing date 2023-11-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13111635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Lipid Droplets, Phospholipase A 2 , Arachidonic Acid, and Atherosclerosis

    Miguel A. Bermúdez / María A. Balboa / Jesús Balsinde

    Biomedicines, Vol 9, Iss 1891, p

    2021  Volume 1891

    Abstract: Lipid droplets, classically regarded as static storage organelles, are currently considered as dynamic structures involved in key processes of lipid metabolism, cellular homeostasis and signaling. Studies on the inflammatory state of atherosclerotic ... ...

    Abstract Lipid droplets, classically regarded as static storage organelles, are currently considered as dynamic structures involved in key processes of lipid metabolism, cellular homeostasis and signaling. Studies on the inflammatory state of atherosclerotic plaques suggest that circulating monocytes interact with products released by endothelial cells and may acquire a foamy phenotype before crossing the endothelial barrier and differentiating into macrophages. One such compound released in significant amounts into the bloodstream is arachidonic acid, the common precursor of eicosanoids, and a potent inducer of neutral lipid synthesis and lipid droplet formation in circulating monocytes. Members of the family of phospholipase A 2 , which hydrolyze the fatty acid present at the sn-2 position of phospholipids, have recently emerged as key controllers of lipid droplet homeostasis, regulating their formation and the availability of fatty acids for lipid mediator production. In this paper we discuss recent findings related to lipid droplet dynamics in immune cells and the ways these organelles are involved in regulating arachidonic acid availability and metabolism in the context of atherosclerosis.
    Keywords lipid droplet ; phospholipase A 2 ; arachidonic acid ; atherosclerosis ; lipid signaling ; lipid mediators ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Roles of Palmitoleic Acid and Its Positional Isomers, Hypogeic and Sapienic Acids, in Inflammation, Metabolic Diseases and Cancer.

    Bermúdez, Miguel A / Pereira, Laura / Fraile, Cristina / Valerio, Laura / Balboa, María A / Balsinde, Jesús

    Cells

    2022  Volume 11, Issue 14

    Abstract: In the last few years, the monounsaturated hexadecenoic fatty acids are being increasingly considered as biomarkers of health with key functions in physiology and pathophysiology. Palmitoleic acid (16:1n-7) and sapienic acid (16:1n-10) are synthesized ... ...

    Abstract In the last few years, the monounsaturated hexadecenoic fatty acids are being increasingly considered as biomarkers of health with key functions in physiology and pathophysiology. Palmitoleic acid (16:1n-7) and sapienic acid (16:1n-10) are synthesized from palmitic acid by the action of stearoyl-CoA desaturase-1 and fatty acid desaturase 2, respectively. A third positional isomer, hypogeic acid (16:1n-9) is produced from the partial β-oxidation of oleic acid. In this review, we discuss the current knowledge of the effects of palmitoleic acid and, where available, sapienic acid and hypogeic acid, on metabolic diseases such as diabetes, cardiovascular disease, and nonalcoholic fatty liver disease, and cancer. The results have shown diverse effects among studies in cell lines, animal models and humans. Palmitoleic acid was described as a lipokine able to regulate different metabolic processes such as an increase in insulin sensitivity in muscle, β cell proliferation, prevention of endoplasmic reticulum stress and lipogenic activity in white adipocytes. Numerous beneficial effects have been attributed to palmitoleic acid, both in mouse models and in cell lines. However, its role in humans is not fully understood, and is sometimes controversial. Regarding sapienic acid and hypogeic acid, studies on their biological effects are still scarce, but accumulating evidence suggests that they also play important roles in metabolic regulation. The multiplicity of effects reported for palmitoleic acid and the compartmentalized manner in which they often occur, may suggest the overlapping actions of multiple isomers being present at the same or neighboring locations.
    MeSH term(s) Animals ; Fatty Acids, Monounsaturated ; Humans ; Inflammation ; Insulin Resistance ; Mice ; Neoplasms ; Palmitic Acids
    Chemical Substances Fatty Acids, Monounsaturated ; Palmitic Acids ; delta(6)-hexadecenoic acid ; palmitoleic acid (209B6YPZ4I)
    Language English
    Publishing date 2022-07-08
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11142146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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