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  1. Book ; Online ; E-Book: Discoidin domain receptors in health and disease

    Fridman, Rafael / Huang, Paul H.

    2016  

    Author's details Rafael Fridman, Paul H. Huang editors
    Keywords Medicine ; Cancer research ; Medical microbiology ; Medical biochemistry ; Cell biology
    Subject code 614.5999
    Language English
    Size 1 Online-Ressource (XIV, 355 Seiten), Illustrationen
    Publisher Springer
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019442021
    ISBN 978-1-4939-6383-6 ; 9781493963812 ; 1-4939-6383-X ; 1493963813
    DOI 10.1007/978-1-4939-6383-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Kinase signaling networks

    Tan, Aik-Choon / Huang, Paul H.

    (Methods in molecular biology ; 1636 ; Springer protocols)

    2017  

    Author's details edited by Aik-Choon Tan, Paul H. Huang
    Series title Methods in molecular biology ; 1636
    Springer protocols
    Collection
    Keywords Protein science ; Synthetic biology ; Screening approaches ; Mass spectrometry ; Computational analysis ; Chemical biology ; Drug development
    Subject code 570
    Language English
    Size xvii, 537 Seiten, Illustrationen, 25.4 cm x 17.8 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019375663
    ISBN 978-1-4939-7152-7 ; 1-4939-7152-2 ; 9781493971541 ; 1493971549
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1636- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Investigating the Effects of Intensity and Frequency on Vibrotactile Spatial Acuity.

    Huang, Bingjian / Dietz, Paul H / Wigdor, Daniel

    IEEE transactions on haptics

    2024  Volume PP

    Abstract: Vibrotactile devices are commonly used in applications for sensory substitution or to provide feedback in virtual reality. An important aspect of vibrotactile perception is spatial acuity, which determines the resolutions of vibrotactile displays on the ... ...

    Abstract Vibrotactile devices are commonly used in applications for sensory substitution or to provide feedback in virtual reality. An important aspect of vibrotactile perception is spatial acuity, which determines the resolutions of vibrotactile displays on the skin. However, the complex vibration characteristics of vibrotactile actuators make it challenging for researchers to reference and compare previous study results. This is because the effects of typical characteristics, such as intensity and frequency, are not well understood. In this study, we investigated the effects of intensity and frequency on vibrotactile spatial acuity. Using Linear Resonant Actuators (LRAs), we conducted relative point localization experiments to measure spatial acuity under different conditions. In the first experiment, we found that intensity had a significant effect on spatial acuity, with higher intensity leading to better acuity. In the second experiment, using a carefully designed intensity calibration procedure, we did not find a significant effect of frequency on spatial acuity. These findings provide a better understanding of vibrotactile spatial acuity, allow for comparisons to previous research, and provide insights into the design of future tactile devices.
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 2329-4051
    ISSN (online) 2329-4051
    DOI 10.1109/TOH.2024.3350929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular Heterogeneity in Leiomyosarcoma and Implications for Personalised Medicine.

    Arfan, Sara / Thway, Khin / Jones, Robin L / Huang, Paul H

    Current treatment options in oncology

    2024  

    Abstract: Opinion statement: Leiomyosarcoma (LMS) is one of the more common subtypes of soft tissue sarcomas (STS), accounting for about 20% of cases. Differences in anatomical location, risk of recurrence and histomorphological variants contribute to the ... ...

    Abstract Opinion statement: Leiomyosarcoma (LMS) is one of the more common subtypes of soft tissue sarcomas (STS), accounting for about 20% of cases. Differences in anatomical location, risk of recurrence and histomorphological variants contribute to the substantial clinical heterogeneity in survival outcomes and therapy responses observed in patients. There is therefore a need to move away from the current one-size-fits-all treatment approach towards a personalised strategy tailored for individual patients. Over the past decade, tissue profiling studies have revealed key genomic features and an additional layer of molecular heterogeneity among patients, with potential utility for optimal risk stratification and biomarker-matched therapies. Furthermore, recent studies investigating intratumour heterogeneity and tumour evolution patterns in LMS suggest some key features that may need to be taken into consideration when designing treatment strategies and clinical trials. Moving forward, national and international collaborative efforts to aggregate expertise, data, resources and tools are needed to achieve a step change in improving patient survival outcomes in this disease of unmet need.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-024-01204-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5523: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Proteomic and Metabolomic Profiling in Soft Tissue Sarcomas.

    Chadha, Madhumeeta / Huang, Paul H

    Current treatment options in oncology

    2022  Volume 23, Issue 1, Page(s) 78–88

    Abstract: Opinion statement: Advances in proteomic and metabolomic technologies have accelerated our understanding of multiple aspects of cancer biology across distinct tumour types. Here we review the current state-of-the-art in the use of proteomics and ... ...

    Abstract Opinion statement: Advances in proteomic and metabolomic technologies have accelerated our understanding of multiple aspects of cancer biology across distinct tumour types. Here we review the current state-of-the-art in the use of proteomics and metabolomics in soft tissue sarcomas. We highlight the utility of these Omics-based methodologies to identify new drug targets, synthetic lethal interactions, candidate therapeutics and novel biomarkers to facilitate patient stratification. Due to the unbiased and global nature of these profiling methods to assess the levels of protein expression, post-translational modifications such as phosphorylation and glycosylation as well as key metabolites, many of these findings have broad applications not just in specific histotypes but across multiple STS subtypes. Specific examples of proteomic and metabolomic findings that have led to the development of early phase clinical trials of investigational agents will be discussed. While promising, the use of these technologies in the study of sarcoma is still limited, and there is a need for further research in this area. In particular, it would be important to integrate these approaches with other Omics strategies such as genomics and epigenomics as well as implement these tools alongside clinical trials in order to maximize the impact of these tools on our biological understanding and treatment of this group of rare diseases of unmet need.
    MeSH term(s) Epigenomics/methods ; Genomics/methods ; Humans ; Metabolomics/methods ; Proteomics/methods ; Sarcoma/drug therapy ; Sarcoma/genetics ; Soft Tissue Neoplasms
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-022-00947-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5523: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Molecular profiling in desmoplastic small round cell tumours.

    Tam, Yuen Bun / Jones, Robin L / Huang, Paul H

    The international journal of biochemistry & cell biology

    2023  Volume 157, Page(s) 106383

    Abstract: Desmoplastic small round cell tumour (DSRCT) is an ultra-rare soft tissue sarcoma that is characterised by aggressive disease and dismal patient outcomes. Despite multi-modal therapy, prognosis remains poor and there are currently no effective targeted ... ...

    Abstract Desmoplastic small round cell tumour (DSRCT) is an ultra-rare soft tissue sarcoma that is characterised by aggressive disease and dismal patient outcomes. Despite multi-modal therapy, prognosis remains poor and there are currently no effective targeted therapies available for patients with this disease. Advances in comprehensive molecular profiling approaches including next generation sequencing and proteomics hold the promise of identifying new therapeutic targets and biomarkers. In this review, we provide an overview of the current status of molecular profiling studies in DSRCT patient specimens and cell lines, highlighting the key genomic, epigenetic and proteomic findings that have contributed to our biological knowledge base of this recalcitrant disease. In-depth analysis of these molecular profiles has led to the identification of promising novel and repurposed candidate therapies that are suitable for translation into clinical trials. We further provide a perspective on how future integrated studies including proteogenomics could further enrich our understanding of this ultra-rare entity and deliver progress that will ultimately impact the outcomes of patients with DSRCT.
    MeSH term(s) Humans ; Desmoplastic Small Round Cell Tumor/genetics ; Desmoplastic Small Round Cell Tumor/drug therapy ; Desmoplastic Small Round Cell Tumor/pathology ; Proteomics ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-02-01
    Publishing country Netherlands
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2023.106383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 431: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: The effect of charge and albumin on cellular uptake of supramolecular polymer nanostructures.

    Song, Jiankang / Fransen, Peter-Paul K H / Bakker, Maarten H / Wijnands, Sjors P W / Huang, Jingyi / Guo, Shuaiqi / Dankers, Patricia Y W

    Journal of materials chemistry. B

    2024  

    Abstract: Intracellular delivery of functional biomolecules by using supramolecular polymer nanostructures has gained significant interest. Here, various charged supramolecular ureido-pyrimidinone (UPy)-aggregates were designed and ... ...

    Abstract Intracellular delivery of functional biomolecules by using supramolecular polymer nanostructures has gained significant interest. Here, various charged supramolecular ureido-pyrimidinone (UPy)-aggregates were designed and formulated
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb02631k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: EGFR

    Pacini, Laura / Cabal, Virginia N / Hermsen, Mario A / Huang, Paul H

    Cancers

    2022  Volume 14, Issue 2

    Abstract: Recurrent epidermal growth factor receptor ( ...

    Abstract Recurrent epidermal growth factor receptor (
    Language English
    Publishing date 2022-01-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14020394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2.

    Watts, Norman R / Eren, Elif / Palmer, Ira / Huang, Paul L / Huang, Philip Lin / Shoemaker, Robert H / Lee-Huang, Sylvia / Wingfield, Paul T

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0286370

    Abstract: The continuing emergence of SARS-CoV-2 variants has highlighted the need to identify additional points for viral inhibition. Ribosome inactivating proteins (RIPs), such as MAP30 and Momordin which are derived from bitter melon (Momordica charantia), have ...

    Abstract The continuing emergence of SARS-CoV-2 variants has highlighted the need to identify additional points for viral inhibition. Ribosome inactivating proteins (RIPs), such as MAP30 and Momordin which are derived from bitter melon (Momordica charantia), have been found to inhibit a broad range of viruses. MAP30 has been shown to potently inhibit HIV-1 with minimal cytotoxicity. Here we show that MAP30 and Momordin potently inhibit SARS-CoV-2 replication in A549 human lung cells (IC50 ~ 0.2 μM) with little concomitant cytotoxicity (CC50 ~ 2 μM). Both viral inhibition and cytotoxicity remain unaltered by appending a C-terminal Tat cell-penetration peptide to either protein. Mutation of tyrosine 70, a key residue in the active site of MAP30, to alanine completely abrogates both viral inhibition and cytotoxicity, indicating the involvement of its RNA N-glycosylase activity. Mutation of lysine 171 and lysine 215, residues corresponding to those in Ricin which when mutated prevented ribosome binding and inactivation, to alanine in MAP30 decreased cytotoxicity (CC50 ~ 10 μM) but also the viral inhibition (IC50 ~ 1 μM). Unlike with HIV-1, neither Dexamethasone nor Indomethacin exhibited synergy with MAP30 in the inhibition of SARS-CoV-2. From a structural comparison of the two proteins, one can explain their similar activities despite differences in both their active-sites and ribosome-binding regions. We also note points on the viral genome for potential inhibition by these proteins.
    MeSH term(s) Humans ; COVID-19 ; Lysine ; SARS-CoV-2 ; Alanine ; HIV Seropositivity ; HIV-1 ; Momordica charantia ; Ribosome Inactivating Proteins/pharmacology ; Ribosomes ; COVID-19 Drug Treatment
    Chemical Substances momordin ; Lysine (K3Z4F929H6) ; Alanine (OF5P57N2ZX) ; Ribosome Inactivating Proteins (EC 3.2.2.22)
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0286370
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Amivantamab for the treatment of

    Vyse, Simon / Huang, Paul H

    Expert review of anticancer therapy

    2021  Volume 22, Issue 1, Page(s) 3–16

    Abstract: Introduction: Amivantamab is a monoclonal bispecific anti-EGFR-MET antibody that is the first targeted therapy to be approved for non-small cell lung cancer (NSCLC) patients harboring : Areas covered: In this article, we outline the drug profile of ... ...

    Abstract Introduction: Amivantamab is a monoclonal bispecific anti-EGFR-MET antibody that is the first targeted therapy to be approved for non-small cell lung cancer (NSCLC) patients harboring
    Areas covered: In this article, we outline the drug profile of amivantamab compared with EGFR kinase inhibitors under evaluation in
    Expert opinion: Unlike small molecule EGFR kinase inhibitors, amivantamab has an extracellular mode of action and dual activity against EGFR and MET. It remains to be determined what role MET inhibition plays in toxicity and efficacy and whether dual target inhibition can delay the onset of drug resistance in these cancers. Due to its large molecular size, amivantamab is expected to have poor activity to treat brain metastases. Building on the clinical data so far, future trials that will evaluate combination treatments with brain-penetrant EGFR kinase inhibitors will be critical to move the drug toward a first-line treatment.
    MeSH term(s) Antibodies, Bispecific ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; ErbB Receptors/genetics ; Exons ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mutation ; Protein Kinase Inhibitors/adverse effects
    Chemical Substances Antibodies, Bispecific ; Protein Kinase Inhibitors ; amivantamab-vmjw ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2021-12-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1080/14737140.2022.2016397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5907: Show issues Location:
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