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Article: Effectiveness of palpation technique training and practice using a muscle-nodule-palpation simulator.

Isogai, Kaoru / Noda, Asuka / Matsuzawa, Ayumi / Okamoto, Shogo

2024 Volume 36, Issue 4, Page(s) 195–201

Abstract: Purpose] Extant techniques for palpating nodules, a diagnostic criterion of myofascial trigger points, lack high reliability. Therefore, this study aimed to investigate the effects of training and practice using a novel muscle-nodule-palpation simulator. ...

Abstract	[Purpose] Extant techniques for palpating nodules, a diagnostic criterion of myofascial trigger points, lack high reliability. Therefore, this study aimed to investigate the effects of training and practice using a novel muscle-nodule-palpation simulator. [Participants and Methods] Sixteen university students (age range: 19-22 years) were randomly assigned to the training (
Language	English
Publishing date	2024-04-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038898-6
ISSN	0915-5287
ISSN	0915-5287
DOI	10.1589/jpts.36.195
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Heterogeneous treatment effect of dose-dense paclitaxel plus carboplatin therapy for advanced ovarian cancer.

Taguchi, Ayumi / Kato, Kosuke / Furusawa, Akiko / Hara, Konan / Sone, Kenbun / Yamada, Kyosuke / Kajiyama, Hiroaki / Shimada, Muneaki / Okamoto, Aikou

International journal of cancer

2024

Abstract: A Japanese clinical trial (JGOG3016) showed that dose-dense weekly paclitaxel in combination with carboplatin extensively prolonged overall survival (OS) in patients with advanced ovarian cancer. However, in other clinical trials, dose-dense paclitaxel ... ...

Abstract	A Japanese clinical trial (JGOG3016) showed that dose-dense weekly paclitaxel in combination with carboplatin extensively prolonged overall survival (OS) in patients with advanced ovarian cancer. However, in other clinical trials, dose-dense paclitaxel regimens were not superior to triweekly paclitaxel regimens. In this study, causal tree analysis was applied to explore subpopulations with different treatment effects of dose-dense paclitaxel in a data-driven approach. The 587 participants with stage II-IV ovarian cancer in the JGOG3016 trial were used for model development. The primary endpoint was treatment effect in terms of 3-year OS in patients receiving dose-dense vs. conventional paclitaxel therapies. In patients <50 years, the 3-year OS was similar in both groups; however, it was higher in the dose-dense group in patients ≥50 years. Dose-dense paclitaxel showed strong positive treatment effects in patients ≥50 years with stage II/III disease, BMI <23 kg/m
Language	English
Publishing date	2024-05-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.34996
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 576: Show issues

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Article: Inhibitory Effect of Resveratrol on Candida albicans Biofilm Formation.

Okamoto-Shibayama, Kazuko / Yoshida, Ayumi / Ishihara, Kazuyuki

The Bulletin of Tokyo Dental College

2021 Volume 62, Issue 1, Page(s) 1–6

Abstract: Candida albicans is the primary candidiasis-causing fungal pathogen in humans, and one of its most important virulence factors is the ability to form biofilms. Moreover, these biofilms are often resistant to antifungal agents, so there is a need to ... ...

Abstract	Candida albicans is the primary candidiasis-causing fungal pathogen in humans, and one of its most important virulence factors is the ability to form biofilms. Moreover, these biofilms are often resistant to antifungal agents, so there is a need to develop alternative elimination strategies and therapeutic agents for such infections. The antifungal activity of resveratrol, a phytoalexin polyphenolic compound, impairs the morphological transition of C. albicans under various hypha-inducing conditions and inhibits growth of the yeast-form and mycelia. The purpose of this study was to investigate the effect of resveratrol against C. albicans biofilm formation. The developmental, sustained, and mature stages of biofilm formation were affected or inhibited by resveratrol. Exposure to resveratrol at the developmental stage inhibited growth of C. albicans in a dose-dependent manner. A >30% reduction was observed in sustained biofilm growth in the presence of 200 μg/ml resveratrol in comparison with in its absence. In terms of disruption of matured biofilm, 6.25-100 μg/ml resveratrol significantly reduced cell viability of C. albicans compared with in a control sample (p<0.05). The present results indicate that resveratrol has the potential to serve as an anti-Candida treatment and preventive tool which functions by inhibiting existing or under-forming C. albicans biofilms.
MeSH term(s)	Biofilms ; Candida albicans ; Candidiasis ; Humans ; Hyphae ; Resveratrol/pharmacology
Chemical Substances	Resveratrol (Q369O8926L)
Language	English
Publishing date	2021-02-15
Publishing country	Japan
Document type	Journal Article
ZDB-ID	968071-8
ISSN	0040-8891
ISSN	0040-8891
DOI	10.2209/tdcpublication.2020-0023
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Zs.A 1011: Show issues

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Article ; Online: A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity.

Okamoto, Masaaki / Sasai, Miwa / Kuratani, Ayumi / Okuzaki, Daisuke / Arai, Masaya / Wing, James B / Sakaguchi, Shimon / Yamamoto, Masahiro

Cell reports

2023 Volume 42, Issue 7, Page(s) 112813

Abstract: Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs shared by T helper (Th) subsets under certain conditions. Here, to determine the roles of T-bet-expressing Treg cells, we generate a mouse strain, called ... ...

Abstract	Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs shared by T helper (Th) subsets under certain conditions. Here, to determine the roles of T-bet-expressing Treg cells, we generate a mouse strain, called VeDTR, in which T-bet/Foxp3 double-positive cells are engineered to be specifically labeled and depleted by a combination of Cre- and Flp-recombinase-dependent gene expression control. Characterization of T-bet
MeSH term(s)	Animals ; Mice ; T-Lymphocytes, Regulatory ; Th1 Cells ; T-Box Domain Proteins/metabolism ; Autoimmunity ; Forkhead Transcription Factors/metabolism
Chemical Substances	T-Box Domain Proteins ; Forkhead Transcription Factors
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112813
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Article: Individual Learning Needs of Japanese Public Health Dietitians by Years of Experience in Health Promotion.

Kushida, Osamu / Iida, Ayaka / Arai, Yusuke / Koyama, Tatsuya / Tanaka, Kazumi / Morooka, Ayumi / Isobe, Sumie / Okamoto, Rie / Yoshita, Katsushi

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 12

Abstract: Lifelong education for dietitians in Japan is based mainly on competencies according to years of experience. Because learning content differs depending on the desired position and specialty, training programs that reflect the individual learning needs of ...

Abstract	Lifelong education for dietitians in Japan is based mainly on competencies according to years of experience. Because learning content differs depending on the desired position and specialty, training programs that reflect the individual learning needs of public health dietitians are needed. This study aimed to assess the individual learning needs of public health dietitians via years of experience in health promotion. In 2021, an online survey of public health dietitians involved in health promotion in prefectures, designated cities, and other municipalities throughout Japan was conducted. Years of experience in health promotion were categorized as early (<10 years), mid-career (10-19 years), and leadership (≥20 years) periods. To ascertain individual learning needs, the survey asked about respondents' desired final position, career path, and skills they felt they needed to improve in the future. Of the 1649 public health dietitians analyzed, all administrative categories preferred to work as public health generalists in mid-career or leadership periods rather than in the early period. In municipalities, more public health dietitians across all experience categories selected "professional competence", such as knowledge in specialized areas and nutritional guidance techniques. It was suggested that public health dietitians in the mid-career and leadership periods have individual learning needs, in both nutrition specialists and public health generalists.
Language	English
Publishing date	2023-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11121765
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Article ; Online: Gold Nanoparticles Produced by Low-temperature Heating of the Dry Residue of a Droplet of an HCl Acidic Solution of HAuCl

Umeda, Hiroki / Mezaki, Yuya / Oshio, Ayumi / Kaneko, Yasunori / Okamoto, Ryota / Kusumoto, Sakuya / Kunimura, Shinsuke

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

2021 Volume 37, Issue 10, Page(s) 1427–1432

Abstract: An easy method is presented for producing gold nanoparticles. We show that by performing simultaneous low-temperature heating of a quartz glass substrate on which the dry residue of a 10 μL droplet of an HCl acidic solution of ... ...

Abstract	An easy method is presented for producing gold nanoparticles. We show that by performing simultaneous low-temperature heating of a quartz glass substrate on which the dry residue of a 10 μL droplet of an HCl acidic solution of HAuCl
Language	English
Publishing date	2021-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1483376-1
ISSN	1348-2246 ; 1348-2246
ISSN (online)	1348-2246
ISSN	1348-2246
DOI	10.2116/analsci.20P458
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Article: [Gender differences in cardiovascular surgery].

Fukui, Toshihiro / Okamoto, Ken / Tazume, Hirokazu / Koga, Ayumi

Nihon rinsho. Japanese journal of clinical medicine

2018 Volume 74 Suppl 6, Page(s) 563–567

MeSH term(s)	Cardiovascular Diseases/surgery ; Humans ; Sex Characteristics
Language	Japanese
Publishing date	2018-12-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 429: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The vision for public health dietitians’ skill improvement over the next 10 years in Japan

Tatsuya Koyama / Yusuke Arai / Ayaka Iida / Sumie Isobe / Okamoto Rie / Izumi Shibuya / Kazumi Tanaka / Ayumi Morooka / Katsushi Yoshita

Public Health in Practice, Vol 5, Iss , Pp 100392- (2023)

A qualitative study

2023

Abstract: Objectives: To obtain the basis for developing a new human resource development program. We examined the association between their position type and their vision for skill improvement in the profession in the next 10 years. Study design: This was a ... ...

Abstract	Objectives: To obtain the basis for developing a new human resource development program. We examined the association between their position type and their vision for skill improvement in the profession in the next 10 years. Study design: This was a qualitative study. Methods: In 2021, we conducted an exhaustive survey of Japanese public health dietitians working in Japanese local governments. Using qualitative content analysis, we analyzed the participants’ descriptions of how the profession could improve their skills over the next 10 years. Results: Regardless of the participants’ organization of employment or their target position type, seven common categories were extracted; [goals], [health promotion activities], [organizational activities], [evaluation from others], [cooperation], [skills to be acquired], and [means for improving skills]. Depending on the organization type, 35–40 subcategories were extracted from those who wanted to be staff, 35–38 subcategories from those who wanted to be supervisors, and 20–37 subcategories from those who wanted to be managers. Different subcategories were extracted to describe the difference between specialists and generalists in [goals]. Participants described challenges with [evaluation from others] and [collaboration], regardless of the target position type or [goals]. Conclusion: The vision for Japanese public health dietitians’ skill improvement to achieve in the next 10 years describes challenges with business evaluation and collaborative work. However, participants differed across what skills they wanted to improve based on the direction of their careers. To offer public health dietitians learning content that connects with their desired direction, a new human resource development program needs to be considered.
Keywords	Public health dietitian ; Goal ; Skill improvement ; Position ; Human resource development ; Public aspects of medicine ; RA1-1270
Subject code	306
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Individual Learning Needs of Japanese Public Health Dietitians by Years of Experience in Health Promotion

Osamu Kushida / Ayaka Iida / Yusuke Arai / Tatsuya Koyama / Kazumi Tanaka / Ayumi Morooka / Sumie Isobe / Rie Okamoto / Katsushi Yoshita

Healthcare, Vol 11, Iss 1765, p

2023 Volume 1765

Abstract	Lifelong education for dietitians in Japan is based mainly on competencies according to years of experience. Because learning content differs depending on the desired position and specialty, training programs that reflect the individual learning needs of public health dietitians are needed. This study aimed to assess the individual learning needs of public health dietitians via years of experience in health promotion. In 2021, an online survey of public health dietitians involved in health promotion in prefectures, designated cities, and other municipalities throughout Japan was conducted. Years of experience in health promotion were categorized as early (<10 years), mid-career (10–19 years), and leadership (≥20 years) periods. To ascertain individual learning needs, the survey asked about respondents’ desired final position, career path, and skills they felt they needed to improve in the future. Of the 1649 public health dietitians analyzed, all administrative categories preferred to work as public health generalists in mid-career or leadership periods rather than in the early period. In municipalities, more public health dietitians across all experience categories selected “professional competence”, such as knowledge in specialized areas and nutritional guidance techniques. It was suggested that public health dietitians in the mid-career and leadership periods have individual learning needs, in both nutrition specialists and public health generalists.
Keywords	dietitians ; administration ; public health nutrition ; training program ; learning needs ; Medicine ; R
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity

Masaaki Okamoto / Miwa Sasai / Ayumi Kuratani / Daisuke Okuzaki / Masaya Arai / James B. Wing / Shimon Sakaguchi / Masahiro Yamamoto

Cell Reports, Vol 42, Iss 7, Pp 112813- (2023)

2023

Abstract: Summary: Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs shared by T helper (Th) subsets under certain conditions. Here, to determine the roles of T-bet-expressing Treg cells, we generate a mouse strain, ... ...

Abstract	Summary: Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs shared by T helper (Th) subsets under certain conditions. Here, to determine the roles of T-bet-expressing Treg cells, we generate a mouse strain, called VeDTR, in which T-bet/Foxp3 double-positive cells are engineered to be specifically labeled and depleted by a combination of Cre- and Flp-recombinase-dependent gene expression control. Characterization of T-bet+Foxp3+ cells using VeDTR mice reveals high resistance under oxidative stress, which is involved in accumulation of T-bet+Foxp3+ cells in tumor tissues. Moreover, short-term depletion of T-bet+Foxp3+ cells leads to anti-tumor immunity but not autoimmunity, whereas that of whole Treg cells does both. Although ablation of T-bet+Foxp3+ cells during Toxoplasma infection slightly enhances Th1 immune responses, it does not affect the course of the infection. Collectively, the intersectional genetic method reveals the specific roles of T-bet+Foxp3+ cells in suppressing tumor immunity.
Keywords	CP: Immunology ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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