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Article ; Online: Examining emergency departments practices on advance care directives and medical treatment decision making using the victorian emergency minimum dataset.

Osman, Abdi D / Howell, Jocelyn / Yates, Paul / Jones, Daryl / Braitberg, George

Australasian emergency care

2024

Abstract: Introduction: Existence of Advance Care Planning (ACP) documents including contact details of Medical Treatment Decision Makers (MTDM), are essential patient care records that support Emergency Department (ED) clinicians in implementing treatment ... ...

Abstract	Introduction: Existence of Advance Care Planning (ACP) documents including contact details of Medical Treatment Decision Makers (MTDM), are essential patient care records that support Emergency Department (ED) clinicians in implementing treatment concordant with patients' expressed wishes. Based upon previous findings, we conducted a statewide study to evaluate the performance of Victorian public hospital emergency departments on reporting of availability of records for ACP. Method: The study is a quantitative retrospective observational comparative design based upon ED tier levels as defined by the Australasian College for Emergency Medicine (ACEM) for the calendar year 2021. Results: Of 1.8 million total Victorian ED attendances, 15,222 patients had an ACP alert status recorded. Of these, 7296 were aged ≥ 65 years (study group). Of the thirty-one public EDs that submitted data, 65 % were accredited and assigned a level of service tier. The presence of ACP alerts positively correlated to location, tier level, age and gender (MANOVA wilk's; p < 0.001, value=.981, F = (12, 15,300), partial ƞ Conclusion: The identified rate of ACP reporting is low. Strategies to improve the result include synchronising ACP (generated at different points) electronically, staff education, training and further validation of the data at the sending and receiving agencies.
Language	English
Publishing date	2024-01-22
Publishing country	Australia
Document type	Journal Article
ISSN	2588-994X
ISSN (online)	2588-994X
DOI	10.1016/j.auec.2024.01.001
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Article ; Online: Comet Assay Profiling of FLASH-Induced Damage: Mechanistic Insights into the Effects of FLASH Irradiation.

Cooper, Christian R / Jones, Donald J L / Jones, George D D / Petersson, Kristoffer

International journal of molecular sciences

2023 Volume 24, Issue 8

Abstract: Numerous studies have demonstrated the normal tissue-sparing effects of ultra-high dose rate 'FLASH' irradiation in vivo, with an associated reduction in damage burden being reported in vitro. Towards this, two key radiochemical mechanisms have been ... ...

Abstract	Numerous studies have demonstrated the normal tissue-sparing effects of ultra-high dose rate 'FLASH' irradiation in vivo, with an associated reduction in damage burden being reported in vitro. Towards this, two key radiochemical mechanisms have been proposed: radical-radical recombination (RRR) and transient oxygen depletion (TOD), with both being proposed to lead to reduced levels of induced damage. Previously, we reported that FLASH induces lower levels of DNA strand break damage in whole-blood peripheral blood lymphocytes (WB-PBL) ex vivo, but our study failed to distinguish the mechanism(s) involved. A potential outcome of RRR is the formation of crosslink damage (particularly, if any organic radicals recombine), whilst a possible outcome of TOD is a more anoxic profile of induced damage resulting from FLASH. Therefore, the aim of the current study was to profile FLASH-induced damage via the Comet assay, assessing any DNA crosslink formation as a putative marker of RRR and/or anoxic DNA damage formation as an indicative marker of TOD, to determine the extent to which either mechanism contributes to the "FLASH effect". Following FLASH irradiation, we see no evidence of any crosslink formation; however, FLASH irradiation induces a more anoxic profile of induced damage, supporting the TOD mechanism. Furthermore, treatment of WB-PBLs pre-irradiation with BSO abrogates the reduced strand break damage burden mediated by FLASH exposures. In summary, we do not see any experimental evidence to support the RRR mechanism contributing to the reduced damage burden induced by FLASH. However, the observation of a greater anoxic profile of damage following FLASH irradiation, together with the BSO abrogation of the reduced strand break damage burden mediated by FLASH, lends further support to TOD being a driver of the reduced damage burden plus a change in the damage profile mediated by FLASH.
MeSH term(s)	Comet Assay ; DNA Damage ; Lymphocytes/radiation effects ; Oxygen ; DNA
Chemical Substances	Oxygen (S88TT14065) ; DNA (9007-49-2)
Language	English
Publishing date	2023-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24087195
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Article ; Online: Differences between brachial and aortic blood pressure in adolescence and their implications for diagnosis of hypertension.

Hughes, Alun D / Davey Smith, George / Howe, Laura D / Lawlor, Deborah / Jones, Siana / Park, Chloe M / Chaturvedi, Nish

Journal of hypertension

2024

Abstract: Objectives: Blood pressure (BP) is the leading global cause of mortality, and its prevalence is increasing in children and adolescents. Aortic BP is lower than brachial BP in adults. We aimed to assess the extent of this difference and its impact on the ...

Abstract	Objectives: Blood pressure (BP) is the leading global cause of mortality, and its prevalence is increasing in children and adolescents. Aortic BP is lower than brachial BP in adults. We aimed to assess the extent of this difference and its impact on the diagnosis of hypertension among adolescents. Methods: We used data from 3850 participants from a UK cohort of births in the early 1990s in the Southwest of England, who attended their ∼17-year follow-up and had valid measures of brachial and aortic BP at that clinic [mean (SD) age 17.8 (0.4) years, 66% female individuals]. Data are presented as mean differences [95% prediction intervals] for both sexes. Results: Aortic systolic BP (SBP) was lower than brachial SBP [male, -22.3 (-31.2, -13.3) mmHg; female, -17.8 (-25.5, -10.0) mmHg]. Differences between aortic and brachial diastolic BP (DBP) were minimal. Based on brachial BP measurements, 101 male individuals (6%) and 22 female individuals (1%) were classified as hypertensive. In contrast, only nine male individuals (<1%) and 14 female individuals (<1%) met the criteria for hypertension based on aortic BP, and the predictive value of brachial BP for aortic hypertension was poor (positive-predictive value = 13.8%). Participants with aortic hypertension had a higher left ventricular mass index than those with brachial hypertension. Conclusion: Brachial BP substantially overestimates aortic BP in adolescents because of marked aortic-to-brachial pulse pressure amplification. The use of brachial BP measurement may result in an overdiagnosis of hypertension during screening in adolescence.
Language	English
Publishing date	2024-04-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000003743
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Article ; Online: Novel trial designs for patients with gastrointestinal stromal tumor.

Serrano, C / Rothschild, S / Villacampa, G / Heinrich, M C / George, S / Blay, J-Y / Sicklick, J K / Schwartz, G K / Rastogi, S / Jones, R L / Rutkowski, P / Somaiah, N / Navarro, V / Evans, D / Trent, J C

ESMO open

2024 Volume 9, Issue 1, Page(s) 102218

MeSH term(s)	Humans ; Gastrointestinal Stromal Tumors ; Patients
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Letter
ISSN	2059-7029
ISSN (online)	2059-7029
DOI	10.1016/j.esmoop.2023.102218
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Article ; Online: The effects of exercise training in the cold on cerebral blood flow and cerebrovascular function in young healthy individuals.

Miller, G D / Maxwell, J D / Thompson, A / Cable, N T / Low, D A / George, K P / Jones, H

Autonomic neuroscience : basic & clinical

2022 Volume 238, Page(s) 102945

Abstract: Exercise elicits acute increases in cerebral blood flow velocity (CBFv) and provokes long-term beneficial effects on CBFv, thereby reducing cerebrovascular risk. Acute exposure to a cold stimulus also increases CBFv. We compared the impact of exercise ... ...

Abstract	Exercise elicits acute increases in cerebral blood flow velocity (CBFv) and provokes long-term beneficial effects on CBFv, thereby reducing cerebrovascular risk. Acute exposure to a cold stimulus also increases CBFv. We compared the impact of exercise training in cold and thermoneutral environments on CFBv, cerebrovascular function and peripheral endothelial function. Twenty-one (16 males, 22 ± 5 years) individuals were randomly allocated to either a cold (5 °C) or thermoneutral (15 °C) exercise intervention. Exercise consisted of 50-min cycling at 70% heart rate max, three times per week for eight weeks. Transcranial Doppler was used to determine pre and post intervention CBFv, dynamic cerebral autoregulation (dCA) and cerebrovascular reactivity (CVR
Language	English
Publishing date	2022-01-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2020105-9
ISSN	1872-7484 ; 1566-0702
ISSN (online)	1872-7484
ISSN	1566-0702
DOI	10.1016/j.autneu.2022.102945
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Article ; Online: Intestinal

Price, Courtney E / Valls, Rebecca A / Ramsey, Alexis R / Loeven, Nicole A / Jones, Jane T / Barrack, Kaitlyn E / Schwartzman, Joseph D / Royce, Darlene B / Cramer, Robert A / Madan, Juliette C / Ross, Benjamin D / Bliska, James / O'Toole, George A

mBio

2024 Volume 15, Issue 2, Page(s) e0314423

Abstract: Persons with cystic fibrosis (CF), starting in early life, show intestinal microbiome dysbiosis characterized in part by a decreased relative abundance of the ... ...

Abstract	Persons with cystic fibrosis (CF), starting in early life, show intestinal microbiome dysbiosis characterized in part by a decreased relative abundance of the genus
MeSH term(s)	Child ; Infant ; Humans ; Mice ; Animals ; Cystic Fibrosis/complications ; Cystic Fibrosis Transmembrane Conductance Regulator ; Propionates ; Bacteroides/genetics ; Caco-2 Cells ; Inflammation/complications ; Disease Models, Animal ; Dysbiosis/complications ; Escherichia coli
Chemical Substances	Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Propionates
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.03144-23
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Article ; Online: Quality improvement project to improve providers' goal-setting activity for chronic disease self-management.

Krishnappa, V / George, E / Oravec, M / Jones, R / Lee, A / Sweet, D

Journal of healthcare quality research

2021 Volume 37, Issue 2, Page(s) 79–84

Abstract: Background: Patient-centered medical home (PCMH) places patients at the center of care and actively considers patients' goals, preferences and skill levels in caring for their disease while developing a care plan. We implemented a quality improvement ( ... ...

Abstract	Background: Patient-centered medical home (PCMH) places patients at the center of care and actively considers patients' goals, preferences and skill levels in caring for their disease while developing a care plan. We implemented a quality improvement (QI) project to improve internal medicine resident goal-setting activity with patients for chronic disease self-management. Methods: The plan-do-study-act (PDSA) model was used and a root cause analysis was conducted with internal medicine residents (n=20) and faculty (n=7) to identify barriers to patient goal setting. Two main causes were identified - lack of awareness and lack of knowledge about where and how to set patient goals in the electronic medical record (EMR). Reminders during daily morning huddles, discussions with faculty, educational video presentation and organizational policy change interventions were implemented in four serial PDSA cycles. Results: The goal setting activity documentation rate by resident providers increased to 14% following inclusion of patient goal setting reminders during daily morning huddles. There was notable increase in the goal setting documentation rate to 29% following discussion in faculty meeting. The goal setting documentation rate remained the same (29%) despite educational video and policy change intervention. However, goal setting documentation rate increased to 33% by the end of the study. Conclusion: Our QI project resulted in a measurable increase in the use of methods of healthcare delivery associated with improved outcomes. This model worked well in our setting, and sharing our success may benefit others seeking to achieve similar goals.
MeSH term(s)	Chronic Disease ; Goals ; Humans ; Patient-Centered Care ; Quality Improvement ; Self-Management
Language	English
Publishing date	2021-11-27
Publishing country	Spain
Document type	Journal Article
ISSN	2603-6479
ISSN (online)	2603-6479
DOI	10.1016/j.jhqr.2021.10.003
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Article ; Online: Cupid, a cell permeable peptide derived from amoeba, capable of delivering GFP into a diverse range of species.

Fenton, Daniel / Phillips, Dylan / Maddison, Anne / H George, Christopher / Ryves, Jonathan / D Jones, Huw

Scientific reports

2020 Volume 10, Issue 1, Page(s) 13725

Abstract: Cell permeating peptides (CPPs) are attracting great interest for use as molecular delivery vehicles for the transport of biologically active cargo across the cell membrane. The sequence of a novel CPP sequence, termed 'Cupid', was identified from the ... ...

Abstract	Cell permeating peptides (CPPs) are attracting great interest for use as molecular delivery vehicles for the transport of biologically active cargo across the cell membrane. The sequence of a novel CPP sequence, termed 'Cupid', was identified from the genome of Dictyostelium discoideum. A Cupid-Green Fluorescent Protein (Cupid-GFP) fusion protein was tested on mammalian, whole plant cells, plant leaf protoplast and fungal cell cultures and observed using confocal microscopy. GFP fluorescence builds up within the cell cytosol in 60 min, demonstrating Cupid-GFP has permeated them and folded correctly into its fluorescent form. Our combined data suggest Cupid can act as a molecular vehicle capable of delivering proteins, such as GFP, into the cytosol of a variety of cells.
MeSH term(s)	Amoeba/metabolism ; Animals ; Cell Membrane/metabolism ; Cell-Penetrating Peptides/metabolism ; Cells, Cultured ; Cytosol/metabolism ; Dictyostelium/metabolism ; Fluorescence ; Green Fluorescent Proteins/metabolism ; Mice
Chemical Substances	Cell-Penetrating Peptides ; Green Fluorescent Proteins (147336-22-9)
Language	English
Publishing date	2020-08-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-70532-x
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Article: MYC is sufficient to generate mid-life high-grade serous ovarian and uterine serous carcinomas in a p53-R270H mouse model.

Blackman, Alexandra / Rees, Amy C / Bowers, Robert R / Jones, Christian M / Vaena, Silvia G / Clark, Madison A / Carter, Shelby / Villamor, Evan D / Evans, Della / Emanuel, Anthony J / Fullbright, George / Long, David T / Spruill, Laura / Romeo, Martin J / Helke, Kristi L / Delaney, Joe R

bioRxiv : the preprint server for biology

2024

Abstract: Genetically engineered mouse models (GEMM) have fundamentally changed how ovarian cancer etiology, early detection, and treatment is understood. However, previous GEMMs of high-grade serous ovarian cancer (HGSOC) have had to utilize genetics rarely or ... ...

Abstract	Genetically engineered mouse models (GEMM) have fundamentally changed how ovarian cancer etiology, early detection, and treatment is understood. However, previous GEMMs of high-grade serous ovarian cancer (HGSOC) have had to utilize genetics rarely or never found in human HGSOC to yield ovarian cancer within the lifespan of a mouse.
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.24.576924
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Article ; Online: Remote supervision for simulated cataract surgery.

Mamtora, Sunil / Jones, Rebecca / Rabiolo, Alessandro / Saleh, George M / Ferris, John D

Eye (London, England)

2021 Volume 36, Issue 6, Page(s) 1333–1334

MeSH term(s)	Cataract ; Cataract Extraction ; Humans ; Lens, Crystalline ; Ophthalmology
Language	English
Publishing date	2021-06-28
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-021-01638-3
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