LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 2113

Search options

  1. Article ; Online: Deep brain stimulation of thalamus for epilepsy.

    Fisher, Robert S

    Neurobiology of disease

    2023  Volume 179, Page(s) 106045

    Abstract: Neuromodulation (neurostimulation) is a relatively new and rapidly growing treatment for refractory epilepsy. Three varieties are approved in the US: vagus nerve stimulation (VNS), deep brain stimulation (DBS) and responsive neurostimulation (RNS). This ... ...

    Abstract Neuromodulation (neurostimulation) is a relatively new and rapidly growing treatment for refractory epilepsy. Three varieties are approved in the US: vagus nerve stimulation (VNS), deep brain stimulation (DBS) and responsive neurostimulation (RNS). This article reviews thalamic DBS for epilepsy. Among many thalamic sub-nuclei, DBS for epilepsy has been targeted to the anterior nucleus (ANT), centromedian nucleus (CM), dorsomedial nucleus (DM) and pulvinar (PULV). Only ANT is FDA-approved, based upon a controlled clinical trial. Bilateral stimulation of ANT reduced seizures by 40.5% at three months in the controlled phase (p = .038) and 75% by 5 years in the uncontrolled phase. Side effects related to paresthesias, acute hemorrhage, infection, occasional increased seizures, and usually transient effects on mood and memory. Efficacy was best documented for focal onset seizures in temporal or frontal lobe. CM stimulation may be useful for generalized or multifocal seizures and PULV for posterior limbic seizures. Mechanisms of DBS for epilepsy are largely unknown, but animal work points to changes in receptors, channels, neurotransmitters, synapses, network connectivity and neurogenesis. Personalization of therapies, in terms of connectivity of the seizure onset zone to the thalamic sub- nucleus and individual characteristics of the seizures, might lead to improved efficacy. Many questions remain about DBS, including the best candidates for different types of neuromodulation, the best targets, the best stimulation parameters, how to minimize side effects and how to deliver current noninvasively. Despite the questions, neuromodulation provides useful new opportunities to treat people with refractory seizures not responding to medicines and not amenable to resective surgery.
    MeSH term(s) Animals ; Deep Brain Stimulation ; Epilepsy/therapy ; Thalamus ; Seizures/therapy ; Drug Resistant Epilepsy
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2023.106045
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4444: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Neuromodulatory Focused Ultrasound for Epilepsy: Are Animal Models Useful?

    Chu, Po-Chun / Yu, Hsiang-Yu / Fisher, Robert S / Liu, Hao-Li

    ACS chemical neuroscience

    2024  

    Abstract: Ultrasound neuromodulation is a potential alternative therapy for suppressing epileptic discharges. Recently, several human clinical trials have reported promising results from repeated focused ultrasound (FUS) treatments for temporal lobe epilepsy. In ... ...

    Abstract Ultrasound neuromodulation is a potential alternative therapy for suppressing epileptic discharges. Recently, several human clinical trials have reported promising results from repeated focused ultrasound (FUS) treatments for temporal lobe epilepsy. In this Viewpoint, we highlight the valuable guidance of preclinical validation methods for choosing the optimal FUS parameters, thus ensuring consistency with the outcomes of clinical trials and leading human trials to the safest and most effective approaches.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.4c00198
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Intravascular stimulation of the motor cortex.

    Fisher, Robert S

    Nature biomedical engineering

    2018  Volume 2, Issue 12, Page(s) 883–884

    MeSH term(s) Animals ; Electric Stimulation ; Electrodes ; Motor Cortex ; Sheep ; Stents
    Language English
    Publishing date 2018-10-29
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2157-846X
    ISSN (online) 2157-846X
    DOI 10.1038/s41551-018-0330-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book ; Conference proceedings ; Online: Petrography and geochemical composition of the Atlantis II Fracture Zone, supplementary data to: Dick, Henry JB; Schouten, Hans; Meyer, Peter S; Gallo, David G; Bergh, Hugh; Tyce, Robert; Patriat, Phillipe; Johnson, Kevin TM; Snow, Jon; Fisher, Andrew T (1991): Tectonic evolution of the Atlantis II fracture zone. In: Von Herzen, RP; Robinson, PT; et al. (eds.), Proceedings of the Ocean Drilling Program, Scientific Results, College Station, TX (Ocean Drilling Program), 118, 359-398

    Dick, Henry JB / Bergh, Hugh / Fisher, Andrew T / Gallo, David G / Johnson, Kevin TM / Meyer, Peter S / Patriat, Phillipe / Schouten, Hans / Snow, Jon / Tyce, Robert

    1991  

    Abstract: SeaBeam echo sounding, seismic reflection, magnetics, and gravity profiles were run along closely spaced tracks (5 km) parallel to the Atlantis II Fracture Zone on the Southwest Indian Ridge, giving 80% bathymetric coverage of a 30- * 170-nmi strip ... ...

    Abstract SeaBeam echo sounding, seismic reflection, magnetics, and gravity profiles were run along closely spaced tracks (5 km) parallel to the Atlantis II Fracture Zone on the Southwest Indian Ridge, giving 80% bathymetric coverage of a 30- * 170-nmi strip centered over the fracture zone. The southern and northern rift valleys of the ridge were clearly defined and offset north-south by 199 km. The rift valleys are typical of those found elsewhere on the Southwest Indian Ridge, with relief of more than 2200 m and widths from 22 to 38 km. The ridge-transform intersections are marked by deep nodal basins lying on the transform side of the neovolcanic zone that defines the present-day spreading axis. The walls of the transform generally are steep (25?-40?), although locally, they can be more subdued. The deepest point in the transform is 6480 m in the southern nodal basin, and the shallowest is an uplifted wave-cut terrace that exposes plutonic rocks from the deepest layer of the ocean crust at 700 m. The transform valley is bisected by a 1.5-km-high median tectonic ridge that extends from the northern ridge-transform intersection to the midpoint of the active transform. The seismic survey showed that the floor of the transform contains up to 0.5 km of sediment. Piston-coring at two locations on the transform floor recovered more than 1 m of sand and gravel, which appears to be turbidites shed from the walls of the fracture zone. Extensive dredging showed that more than two-thirds of the crust exposed in the transform valley and its walls were plutonic rocks, principally gabbros and residual mantle peridotites. In contrast, based on dredging and seafloor morphology, only relatively undisrupted pillow basalt flows have been exposed on crust of the same age spreading away from the transform.
    Magnetic anomalies are well defined out to 11 m.y. over the flanking transverse ridges and transform valley, even where layer 2 appears to be absent. The total opening rate is 1.6 cm/yr, but the arrangement of the anomalies indicates that the spreading for each ridge is asymmetric, with the ridge flanks facing the transform spreading at a rate of 1.0 cm/yr. Such an asymmetric spreading pattern requires that both the northern and southern ridges migrate away from each other at 0.2 cm/yr, thus lengthening the transform at 0.4 cm/yr for the last 11 m.y.
    To the north, the fracture zone valley is oriented differently from the present-day transform, indicating a paleospreading direction change at 17 m.y. from N10?E to due north-south. This change placed the transform into extension for the 11-m.y. period required for simple orthogonal ridge-transform geometry to be reestablished and produced a large transtensional basin within the transform valley. This basin was split by continued transform slip after 11 m.y., with the larger half moving to the north with the African Plate.
    Language English
    Dates of publication 1991-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Conference proceedings ; Online
    Note This dataset is supplement to doi:10.2973/odp.proc.sr.118.156.1991
    DOI 10.1594/PANGAEA.757822
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: An overview of the 2017 ILAE operational classification of seizure types.

    Fisher, Robert S

    Epilepsy & behavior : E&B

    2017  Volume 70, Issue Pt A, Page(s) 271–273

    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2017.03.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5289: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Bad information in epilepsy care.

    Fisher, Robert S

    Epilepsy & behavior : E&B

    2017  Volume 67, Page(s) 133–134

    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2016.10.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5289: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Serum prolactin in seizure diagnosis: Glass half-full or half-empty?

    Fisher, Robert S

    Neurology. Clinical practice

    2017  Volume 6, Issue 2, Page(s) 100–101

    Language English
    Publishing date 2017-11-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000000228
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Fecal metabarcoding of the endangered Pacific pocket mouse (

    Vandergast, Amy G / Brehme, Cheryl S / Iwanowicz, Deborah / Cornman, Robert S / Adsit-Morris, Devin / Fisher, Robert N

    Ecology and evolution

    2023  Volume 13, Issue 9, Page(s) e10460

    Abstract: Information on diet breadth and preference can assist in understanding links between food resources and population growth and inform habitat restoration for rare herbivores. We assessed the diet of the endangered Pacific pocket mouse using metabarcoding ... ...

    Abstract Information on diet breadth and preference can assist in understanding links between food resources and population growth and inform habitat restoration for rare herbivores. We assessed the diet of the endangered Pacific pocket mouse using metabarcoding of fecal samples and compared it to plant community composition in long-term study plots in two populations on Marine Corps Base Camp Pendleton, San Diego County, CA. Fecal samples (
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10460
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: The New Classification of Seizures by the International League Against Epilepsy 2017.

    Fisher, Robert S

    Current neurology and neuroscience reports

    2017  Volume 17, Issue 6, Page(s) 48

    Abstract: Purpose of review: This review presents the newly developed International League Against Epilepsy (ILAE) 2017 classification of seizure types.: Recent findings: The fundamental distinction is between seizures that begin focally in one hemisphere of ... ...

    Abstract Purpose of review: This review presents the newly developed International League Against Epilepsy (ILAE) 2017 classification of seizure types.
    Recent findings: The fundamental distinction is between seizures that begin focally in one hemisphere of the brain, generalized onset seizures that apparently originate in both hemispheres, and seizures of unknown onset. Focal seizures optionally can be subclassified according to whether awareness (a surrogate marker for consciousness) is intact or impaired. The next level of classification for focal seizures is motor (with subgroups automatisms, atonic, clonic, epileptic spasms, hyperkinetic, myoclonic, tonic), non-motor (with subgroups autonomic, behavior arrest, cognitive, emotional, sensory), and focal to bilateral tonic-clonic. Generalized seizures are categorized as motor (tonic-clonic, clonic, tonic, myoclonic, myoclonic-tonic-clonic, myoclonic-atonic, atonic, epileptic spasms) and non-motor/absence (typical, atypical, myoclonic, eyelid myoclonia). The classification allows new types of focal seizures and a few new generalized seizures, and clarifies terms used to name seizures.
    MeSH term(s) Consciousness/classification ; Dominance, Cerebral ; Humans ; Seizures/classification ; Societies, Medical
    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-017-0758-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5549: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book: The clinician’s guide to acid peptic disorders and motility disorders of the gastrointestinal tract

    Parkman, Henry P. / Fisher, Robert S.

    2006  

    Title variant Acid peptic disorders and motility disorders of the gastrointestinal tract
    Author's details Henry P. Parkman ; Robert S. Fisher
    Keywords Gastrointestinal Diseases ; Gastroesophageal Reflux
    Language English
    Size XIII, 458 S. : Ill., graph. Darst.
    Publisher Slack
    Publishing place Thorofare, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015278391
    ISBN 978-1-55642-716-9 ; 1-55642-716-6
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 43 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top