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  1. Article: Editorial on the special issue on brain physiology meets complex systems.

    Semyachkina-Glushkovskaya, Oxana / Pavlov, Alexey / Karavaev, Anatoly / Penzel, Thomas / Myllylä, Teemu

    The European physical journal. Special topics

    2023  Volume 232, Issue 5, Page(s) 469–473

    Language English
    Publishing date 2023-04-17
    Publishing country France
    Document type Editorial
    ZDB-ID 2267176-6
    ISSN 1951-6401 ; 1951-6355
    ISSN (online) 1951-6401
    ISSN 1951-6355
    DOI 10.1140/epjs/s11734-023-00828-2
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  2. Article: Transcranial photobiomodulation for brain diseases: review of animal and human studies including mechanisms and emerging trends.

    Lin, Hao / Li, Dongyu / Zhu, Jingtan / Liu, Shaojun / Li, Jingting / Yu, Tingting / Tuchin, Valery V / Semyachkina-Glushkovskaya, Oxana / Zhu, Dan

    Neurophotonics

    2024  Volume 11, Issue 1, Page(s) 10601

    Abstract: The brain diseases account for 30% of all known diseases. Pharmacological treatment is hampered by the blood-brain barrier, limiting drug delivery to the central nervous system (CNS). Transcranial photobiomodulation (tPBM) is a promising technology for ... ...

    Abstract The brain diseases account for 30% of all known diseases. Pharmacological treatment is hampered by the blood-brain barrier, limiting drug delivery to the central nervous system (CNS). Transcranial photobiomodulation (tPBM) is a promising technology for treating brain diseases, due to its effectiveness, non-invasiveness, and affordability. tPBM has been widely used in pre-clinical experiments and clinical trials for treating brain diseases, such as stroke and Alzheimer's disease. This review provides a comprehensive overview of tPBM. We summarize emerging trends and new discoveries in tPBM based on over one hundred references published in the past 20 years. We discuss the advantages and disadvantages of tPBM and highlight successful experimental and clinical protocols for treating various brain diseases. A better understanding of tPBM mechanisms, the development of guidelines for clinical practice, and the study of dose-dependent and personal effects hold great promise for progress in treating brain diseases.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2781943-7
    ISSN 2329-4248 ; 2329-423X
    ISSN (online) 2329-4248
    ISSN 2329-423X
    DOI 10.1117/1.NPh.11.1.010601
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  3. Article ; Online: Transcranial photobiomodulation improves insulin therapy in diabetic microglial reactivity and the brain drainage system.

    Liu, Shaojun / Li, Dongyu / Yu, Tingting / Zhu, Jingtan / Semyachkina-Glushkovskaya, Oxana / Zhu, Dan

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 1239

    Abstract: The dysfunction of microglia in the development of diabetes is associated with various diabetic complications, while traditional insulin therapy is insufficient to rapidly restore the function of microglia. Therefore, the search for new alternative ... ...

    Abstract The dysfunction of microglia in the development of diabetes is associated with various diabetic complications, while traditional insulin therapy is insufficient to rapidly restore the function of microglia. Therefore, the search for new alternative methods of treating diabetes-related dysfunction of microglia is urgently needed. Here, we evaluate the effects of transcranial photobiomodulation (tPBM) on microglial function in diabetic mice and investigate its mechanism. We find tPBM treatment effectively improves insulin therapy on microglial morphology and reactivity. We also show that tPBM stimulates brain drainage system through activation of meningeal lymphatics, which contributes to the removal of inflammatory factor, and increase of microglial purinergic receptor P2RY12. Besides, the energy expenditure and locomotor activity of diabetic mice are also improved by tPBM. Our results demonstrate that tPBM can be an efficient, non-invasive method for the treatment of microglial dysfunction caused by diabetes, and also has the potential to prevent diabetic physiological disorders.
    MeSH term(s) Mice ; Animals ; Microglia ; Insulin ; Diabetes Mellitus, Experimental/therapy ; Low-Level Light Therapy/methods ; Brain
    Chemical Substances Insulin
    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05630-3
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  4. Article ; Online: Mechanisms of Activation of Brain's Drainage during Sleep: The Nightlife of Astrocytes.

    Postnov, Dmitry / Semyachkina-Glushkovskaya, Oxana / Litvinenko, Elena / Kurths, Jürgen / Penzel, Thomas

    Cells

    2023  Volume 12, Issue 22

    Abstract: The study of functions, mechanisms of generation, and pathways of movement of cerebral fluids has a long history, but the last decade has been especially productive. The proposed glymphatic hypothesis, which suggests a mechanism of the brain waste ... ...

    Abstract The study of functions, mechanisms of generation, and pathways of movement of cerebral fluids has a long history, but the last decade has been especially productive. The proposed glymphatic hypothesis, which suggests a mechanism of the brain waste removal system (BWRS), caused an active discussion on both the criticism of some of the perspectives and our intensive study of new experimental facts. It was especially found that the intensity of the metabolite clearance changes significantly during the transition between sleep and wakefulness. Interestingly, at the cellular level, a number of aspects of this problem have been focused on, such as astrocytes-glial cells, which, over the past two decades, have been recognized as equal partners of neurons and perform many important functions. In particular, an important role was assigned to astrocytes within the framework of the glymphatic hypothesis. In this review, we return to the "astrocytocentric" view of the BWRS function and the explanation of its activation during sleep from the viewpoint of new findings over the last decade. Our main conclusion is that the BWRS's action may be analyzed both at the systemic (whole-brain) and at the local (cellular) level. The local level means here that the neuro-glial-vascular unit can also be regarded as the smallest functional unit of sleep, and therefore, the smallest functional unit of the BWRS.
    MeSH term(s) Astrocytes/metabolism ; Brain/metabolism ; Sleep/physiology ; Neuroglia ; Wakefulness/physiology
    Language English
    Publishing date 2023-11-20
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12222667
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  5. Article ; Online: Transcranial photobiomodulation improves insulin therapy in diabetic microglial reactivity and the brain drainage system

    Shaojun Liu / Dongyu Li / Tingting Yu / Jingtan Zhu / Oxana Semyachkina-Glushkovskaya / Dan Zhu

    Communications Biology, Vol 6, Iss 1, Pp 1-

    2023  Volume 16

    Abstract: Abstract The dysfunction of microglia in the development of diabetes is associated with various diabetic complications, while traditional insulin therapy is insufficient to rapidly restore the function of microglia. Therefore, the search for new ... ...

    Abstract Abstract The dysfunction of microglia in the development of diabetes is associated with various diabetic complications, while traditional insulin therapy is insufficient to rapidly restore the function of microglia. Therefore, the search for new alternative methods of treating diabetes-related dysfunction of microglia is urgently needed. Here, we evaluate the effects of transcranial photobiomodulation (tPBM) on microglial function in diabetic mice and investigate its mechanism. We find tPBM treatment effectively improves insulin therapy on microglial morphology and reactivity. We also show that tPBM stimulates brain drainage system through activation of meningeal lymphatics, which contributes to the removal of inflammatory factor, and increase of microglial purinergic receptor P2RY12. Besides, the energy expenditure and locomotor activity of diabetic mice are also improved by tPBM. Our results demonstrate that tPBM can be an efficient, non-invasive method for the treatment of microglial dysfunction caused by diabetes, and also has the potential to prevent diabetic physiological disorders.
    Keywords Biology (General) ; QH301-705.5
    Subject code 616
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Phototherapy of Alzheimer's Disease: Photostimulation of Brain Lymphatics during Sleep: A Systematic Review.

    Semyachkina-Glushkovskaya, Oxana / Penzel, Thomas / Poluektov, Mikhail / Fedosov, Ivan / Tzoy, Maria / Terskov, Andrey / Blokhina, Inna / Sidorov, Viktor / Kurths, Jürgen

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: The global number of people with Alzheimer's disease (AD) doubles every 5 years. It has been established that unless an effective treatment for AD is found, the incidence of AD will triple by 2060. However, pharmacological therapies for AD have failed to ...

    Abstract The global number of people with Alzheimer's disease (AD) doubles every 5 years. It has been established that unless an effective treatment for AD is found, the incidence of AD will triple by 2060. However, pharmacological therapies for AD have failed to show effectiveness and safety. Therefore, the search for alternative methods for treating AD is an urgent problem in medicine. The lymphatic drainage and removal system of the brain (LDRSB) plays an important role in resistance to the progression of AD. The development of methods for augmentation of the LDRSB functions may contribute to progress in AD therapy. Photobiomodulation (PBM) is considered to be a non-pharmacological and safe approach for AD therapy. Here, we highlight the most recent and relevant studies of PBM for AD. We focus on emerging evidence that indicates the potential benefits of PBM during sleep for modulation of natural activation of the LDRSB at nighttime, providing effective removal of metabolites, including amyloid-β, from the brain, leading to reduced progression of AD. Our review creates a new niche in the therapy of brain diseases during sleep and sheds light on the development of smart sleep technologies for neurodegenerative diseases.
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Sleep/physiology ; Phototherapy
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310946
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  7. Article ; Online: Sleep as a Novel Biomarker and a Promising Therapeutic Target for Cerebral Small Vessel Disease: A Review Focusing on Alzheimer's Disease and the Blood-Brain Barrier.

    Semyachkina-Glushkovskaya, Oxana / Postnov, Dmitry / Penzel, Thomas / Kurths, Jürgen

    International journal of molecular sciences

    2020  Volume 21, Issue 17

    Abstract: Cerebral small vessel disease (CSVD) is a leading cause of cognitive decline in elderly people and development of Alzheimer's disease (AD). Blood-brain barrier (BBB) leakage is a key pathophysiological mechanism of amyloidal CSVD. Sleep plays a crucial ... ...

    Abstract Cerebral small vessel disease (CSVD) is a leading cause of cognitive decline in elderly people and development of Alzheimer's disease (AD). Blood-brain barrier (BBB) leakage is a key pathophysiological mechanism of amyloidal CSVD. Sleep plays a crucial role in keeping health of the central nervous system and in resistance to CSVD. The deficit of sleep contributes to accumulation of metabolites and toxins such as beta-amyloid in the brain and can lead to BBB disruption. Currently, sleep is considered as an important informative platform for diagnosis and therapy of AD. However, there are no effective methods for extracting of diagnostic information from sleep characteristics. In this review, we show strong evidence that slow wave activity (SWA) (0-0.5 Hz) during deep sleep reflects glymphatic pathology, the BBB leakage and memory deficit in AD. We also discuss that diagnostic and therapeutic targeting of SWA in AD might lead to be a novel era in effective therapy of AD. Moreover, we demonstrate that SWA can be pioneering non-invasive and bed-side technology for express diagnosis of the BBB permeability. Finally, we review the novel data about the methods of detection and enhancement of SWA that can be biomarker and a promising therapy of amyloidal CSVD and CSVD associated with the BBB disorders.
    MeSH term(s) Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Alzheimer Disease/therapy ; Animals ; Biomarkers/metabolism ; Blood-Brain Barrier/physiopathology ; Cerebral Small Vessel Diseases/metabolism ; Cerebral Small Vessel Diseases/pathology ; Cerebral Small Vessel Diseases/therapy ; Humans ; Sleep/physiology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-08-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21176293
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  8. Article: Photodynamic Opening of the Blood-Brain Barrier and the Meningeal Lymphatic System: The New Niche in Immunotherapy for Brain Tumors.

    Semyachkina-Glushkovskaya, Oxana / Terskov, Andrey / Khorovodov, Alexander / Telnova, Valeria / Blokhina, Inna / Saranceva, Elena / Kurths, Jürgen

    Pharmaceutics

    2022  Volume 14, Issue 12

    Abstract: Photodynamic therapy (PDT) is a promising add-on therapy to the current standard of care for patients with glioblastoma (GBM). The traditional explanation of the anti-cancer PDT effects involves the PDT-induced generation of a singlet oxygen in the GBM ... ...

    Abstract Photodynamic therapy (PDT) is a promising add-on therapy to the current standard of care for patients with glioblastoma (GBM). The traditional explanation of the anti-cancer PDT effects involves the PDT-induced generation of a singlet oxygen in the GBM cells, which causes tumor cell death and microvasculature collapse. Recently, new vascular mechanisms of PDT associated with opening of the blood-brain barrier (OBBB) and the activation of functions of the meningeal lymphatic vessels have been discovered. In this review, we highlight the emerging trends and future promises of immunotherapy for brain tumors and discuss PDT-OBBB as a new niche and an important informative platform for the development of innovative pharmacological strategies for the modulation of brain tumor immunity and the improvement of immunotherapy for GBM.
    Language English
    Publishing date 2022-11-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14122612
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  9. Article: Eye Tracking Parameters Correlate with the Level of Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Preliminary Study.

    Trofimov, Alexey O / Sofronova, Veronica / Trofimova, Ksenia / Dubrovin, Anton / Martynov, Dmitry / Lidji-Goryaev, Сyrill / Semyachkina-Glushkovskaya, Oxana / Bragin, Denis E

    Advances in experimental medicine and biology

    2022  Volume 1395, Page(s) 151–156

    Abstract: Aim: The aim of this study was to assess the relationship between oculomotor synergies and brain oxygen status at mild traumatic brain injury (mTBI) using simultaneous comparison of eye-tracking (ET) parameters and cerebral oxygen saturation.: ... ...

    Abstract Aim: The aim of this study was to assess the relationship between oculomotor synergies and brain oxygen status at mild traumatic brain injury (mTBI) using simultaneous comparison of eye-tracking (ET) parameters and cerebral oxygen saturation.
    Material and methods: This non-randomised single-centre prospective study included 77 patients with mTBI (mean age was 36.3 ± 4.8 years, 48 men, 29 women, median GCS 13.7 ± 0.7). Cerebral oximetry was used to detect oxygen saturation level (SctO
    Results: SctO
    Conclusions: VVx and HVx correlate with the SctO
    MeSH term(s) Male ; Humans ; Female ; Adult ; Oximetry ; Cerebrovascular Circulation ; Spectroscopy, Near-Infrared ; Eye-Tracking Technology ; Brain Concussion ; Prospective Studies ; Oxygen Saturation ; Oxygen ; Brain
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-12-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-14190-4_26
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: Blood⁻Brain Barrier, Lymphatic Clearance, and Recovery: Ariadne's Thread in Labyrinths of Hypotheses.

    Semyachkina-Glushkovskaya, Oxana / Postnov, Dmitry / Kurths, Jürgen

    International journal of molecular sciences

    2018  Volume 19, Issue 12

    Abstract: The peripheral lymphatic system plays a crucial role in the recovery mechanisms after many pathological changes, such as infection, trauma, vascular, or metabolic diseases. The lymphatic clearance of different tissues from waste products, viruses, ... ...

    Abstract The peripheral lymphatic system plays a crucial role in the recovery mechanisms after many pathological changes, such as infection, trauma, vascular, or metabolic diseases. The lymphatic clearance of different tissues from waste products, viruses, bacteria, and toxic proteins significantly contributes to the correspondent recovery processes. However, understanding of the cerebral lymphatic functions is a challenging problem. The exploration of mechanisms of lymphatic communication with brain fluids as well as the role of the lymphatic system in brain drainage, clearance, and recovery is still in its infancy. Here we review novel concepts on the anatomy and physiology of the lymphatics in the brain, which warrant a substantial revision of our knowledge about the role of lymphatics in the rehabilitation of the brain functions after neural pathologies. We discuss a new vision on the connective bridge between the opening of a blood⁻brain barrier and activation of the meningeal lymphatic clearance. The ability to stimulate the lymph flow in the brain, is likely to play an important role in developing future innovative strategies in neurorehabilitation therapy.
    MeSH term(s) Animals ; Blood-Brain Barrier/metabolism ; Humans ; Lymphatic System/metabolism ; Neurological Rehabilitation
    Language English
    Publishing date 2018-11-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19123818
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