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  1. Article ; Online: Isatin Hybrids and Their Pharmacological Investigations.

    Varpe, Bhushan D / Kulkarni, Amol A / Jadhav, Shailaja B / Mali, Anil S / Jadhav, Shravan Y

    Mini reviews in medicinal chemistry

    2020  Volume 21, Issue 10, Page(s) 1182–1225

    Abstract: Hybridization is an important strategy to design molecules that can be effectively used to treat fatal diseases known to mankind. Molecular hybrids and their pharmacological investigations aided in discovering several potent isatin (Indole 2, 3 dione) ... ...

    Abstract Hybridization is an important strategy to design molecules that can be effectively used to treat fatal diseases known to mankind. Molecular hybrids and their pharmacological investigations aided in discovering several potent isatin (Indole 2, 3 dione) derivatives with anti-HIV, antimalarial, antitubercular, antibacterial, and anticancer activities. Indole-2,3-dione and their derivatives have diverse pharmacological properties and have a prominent role in the discovery of new drugs. To understand the various approaches for designing new molecules based on isatin nucleus analysis of various pharmacophore hybrids, spacers/linkers between pharmacophores and isatin for hybridization and their biological activities are important. This review discusses the progress in developing isatin hybrids as biologically effective agents and their crucial aspects of design and structure-activity relationships.
    MeSH term(s) Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-HIV Agents/chemical synthesis ; Anti-HIV Agents/chemistry ; Anti-HIV Agents/pharmacology ; Antimalarials/chemical synthesis ; Antimalarials/chemistry ; Antimalarials/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antitubercular Agents/chemical synthesis ; Antitubercular Agents/chemistry ; Antitubercular Agents/pharmacology ; Humans ; Isatin/chemical synthesis ; Isatin/chemistry ; Isatin/pharmacology ; Molecular Structure
    Chemical Substances Anti-Bacterial Agents ; Anti-HIV Agents ; Antimalarials ; Antineoplastic Agents ; Antitubercular Agents ; Isatin (82X95S7M06)
    Language English
    Publishing date 2020-12-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2104081-3
    ISSN 1875-5607 ; 1389-5575
    ISSN (online) 1875-5607
    ISSN 1389-5575
    DOI 10.2174/1389557520999201209213029
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  2. Article ; Online: Chitosan scaffolds: Expanding horizons in biomedical applications.

    Gholap, Amol D / Rojekar, Satish / Kapare, Harshad S / Vishwakarma, Nikhar / Raikwar, Sarjana / Garkal, Atul / Mehta, Tejal A / Jadhav, Harsh / Prajapati, Mahendra Kumar / Annapure, Uday

    Carbohydrate polymers

    2023  Volume 323, Page(s) 121394

    Abstract: Chitosan, a natural polysaccharide from chitin, shows promise as a biomaterial for various biomedical applications due to its biocompatibility, biodegradability, antibacterial activity, and ease of modification. This review overviews "chitosan scaffolds" ...

    Abstract Chitosan, a natural polysaccharide from chitin, shows promise as a biomaterial for various biomedical applications due to its biocompatibility, biodegradability, antibacterial activity, and ease of modification. This review overviews "chitosan scaffolds" use in diverse biomedical applications. It emphasizes chitosan's structural and biological properties and explores fabrication methods like gelation, electrospinning, and 3D printing, which influence scaffold architecture and mechanical properties. The review focuses on chitosan scaffolds in tissue engineering and regenerative medicine, highlighting their role in bone, cartilage, skin, nerve, and vascular tissue regeneration, supporting cell adhesion, proliferation, and differentiation. Investigations into incorporating bioactive compounds, growth factors, and nanoparticles for improved therapeutic effects are discussed. The review also examines chitosan scaffolds in drug delivery systems, leveraging their prolonged release capabilities and ability to encapsulate medicines for targeted and controlled drug delivery. Moreover, it explores chitosan's antibacterial activity and potential for wound healing and infection management in biomedical contexts. Lastly, the review discusses challenges and future objectives, emphasizing the need for improved scaffold design, mechanical qualities, and understanding of interactions with host tissues. In summary, chitosan scaffolds hold significant potential in various biological applications, and this review underscores their promising role in advancing biomedical science.
    MeSH term(s) Chitosan/chemistry ; Tissue Scaffolds/chemistry ; Biocompatible Materials/pharmacology ; Biocompatible Materials/therapeutic use ; Tissue Engineering ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Chitosan (9012-76-4) ; Biocompatible Materials ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-09-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1501516-6
    ISSN 1879-1344 ; 0144-8617
    ISSN (online) 1879-1344
    ISSN 0144-8617
    DOI 10.1016/j.carbpol.2023.121394
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  3. Article ; Online: NLOphoric 3,6-di(substituted quinoxalin) Carbazoles - Synthesis, Photophysical Properties and DFT Studies.

    Telore, Rahul D / Jadhav, Amol G / Sekar, Nagaiyan

    Journal of fluorescence

    2017  Volume 27, Issue 4, Page(s) 1531–1540

    Abstract: Synthesis of novel 3,6-di(substituted quinoxalin) carbazole fluorophores by the condensation of 1,1'-(9-ethyl-9H-carbazole-3,6-diyl)bis(2-bromoethanone) with methyl, chloro and unsubstituted o-phenylenediamine is presented. Synthesized derivatives are ... ...

    Abstract Synthesis of novel 3,6-di(substituted quinoxalin) carbazole fluorophores by the condensation of 1,1'-(9-ethyl-9H-carbazole-3,6-diyl)bis(2-bromoethanone) with methyl, chloro and unsubstituted o-phenylenediamine is presented. Synthesized derivatives are well characterized by
    Language English
    Publishing date 2017-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2016892-5
    ISSN 1573-4994 ; 1053-0509
    ISSN (online) 1573-4994
    ISSN 1053-0509
    DOI 10.1007/s10895-017-2092-4
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  4. Article ; Online: Unraveling the Function of Metal-Amorphous Support Interactions in Single-Atom Electrocatalytic Hydrogen Evolution.

    Liu, Yang / Liu, Xinghui / Jadhav, Amol R / Yang, Taehun / Hwang, Yosep / Wang, Hongdan / Wang, Lingling / Luo, Yongguang / Kumar, Ashwani / Lee, Jinsun / Bui, Huong T D / Gyu Kim, Min / Lee, Hyoyoung

    Angewandte Chemie (International ed. in English)

    2021  , Page(s) e202114160

    Abstract: Amorphization of the support in single-atom catalysts is a less researched concept for promoting catalytic kinetics through modulating the metal-support interaction (MSI). We modeled single-atom ruthenium ( ... ...

    Abstract Amorphization of the support in single-atom catalysts is a less researched concept for promoting catalytic kinetics through modulating the metal-support interaction (MSI). We modeled single-atom ruthenium (Ru
    Language English
    Publishing date 2021-12-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202114160
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  5. Article ; Online: Compartmentalized Platforms for Neuro-Pharmacological Research.

    Jadhav, Amol D / Wei, Li / Shi, Peng

    Current neuropharmacology

    2015  Volume 14, Issue 1, Page(s) 72–86

    Abstract: Dissociated primary neuronal cell culture remains an indispensable approach for neurobiology research in order to investigate basic mechanisms underlying diverse neuronal functions, drug screening and pharmacological investigation. Compartmentalization, ... ...

    Abstract Dissociated primary neuronal cell culture remains an indispensable approach for neurobiology research in order to investigate basic mechanisms underlying diverse neuronal functions, drug screening and pharmacological investigation. Compartmentalization, a widely adopted technique since its emergence in 1970s enables spatial segregation of neuronal segments and detailed investigation that is otherwise limited with traditional culture methods. Although these compartmental chambers (e.g. Campenot chamber) have been proven valuable for the investigation of Peripheral Nervous System (PNS) neurons and to some extent within Central Nervous System (CNS) neurons, their utility has remained limited given the arduous manufacturing process, incompatibility with high-resolution optical imaging and limited throughput. The development in the area of microfabrication and microfluidics has enabled creation of next generation compartmentalized devices that are cheap, easy to manufacture, require reduced sample volumes, enable precise control over the cellular microenvironment both spatially as well as temporally, and permit highthroughput testing. In this review we briefly evaluate the various compartmentalization tools used for neurobiological research, and highlight application of the emerging microfluidic platforms towards in vitro single cell neurobiology.
    MeSH term(s) Animals ; Biomedical Research/methods ; Biomedical Research/trends ; Cell Culture Techniques/methods ; Cell Culture Techniques/trends ; Drug Evaluation, Preclinical/methods ; Drug Evaluation, Preclinical/trends ; Humans ; Microfluidics/methods ; Microfluidics/trends ; Neurons/drug effects ; Neurons/physiology ; Pharmaceutical Preparations/administration & dosage
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2015-04-01
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159x13666150516000957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Efficient Rapid Access to Biginelli for the Multicomponent Synthesis of 1,2,3,4-Tetrahydropyrimidines in Room-Temperature Diisopropyl Ethyl Ammonium Acetate

    Chetan K. Jadhav / Amol S. Nipate / Asha V. Chate / Vishal D. Songire / Anil P. Patil / Charansingh. H. Gill

    ACS Omega, Vol 4, Iss 27, Pp 22313-

    2019  Volume 22324

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2019-12-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
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  7. Article ; Online: Efficient Rapid Access to Biginelli for the Multicomponent Synthesis of 1,2,3,4-Tetrahydropyrimidines in Room-Temperature Diisopropyl Ethyl Ammonium Acetate.

    Jadhav, Chetan K / Nipate, Amol S / Chate, Asha V / Songire, Vishal D / Patil, Anil P / Gill, Charansingh H

    ACS omega

    2019  Volume 4, Issue 27, Page(s) 22313–22324

    Abstract: The diisopropyl ethyl ammonium acetate (DIPEAc)-promoted Biginelli protocol has been developed for the first time by a successive one-pot three-component reaction of aldehydes, ethylcyanoacetate/ethyl acetoacetate, and thiourea/urea to afford ... ...

    Abstract The diisopropyl ethyl ammonium acetate (DIPEAc)-promoted Biginelli protocol has been developed for the first time by a successive one-pot three-component reaction of aldehydes, ethylcyanoacetate/ethyl acetoacetate, and thiourea/urea to afford pharmacologically promising 1,2,3,4-tetrahydropyrimidines in high yields at room temperature. The key benefits of the present scheme are the capability to allow a variability of functional groups, short reaction times, easy workup, high yields, recyclability of the catalyst, and solvent-free conditions, thus providing economic and environmental advantages. In addition, a series of 4-oxo-6-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles analogues were synthesized and selected for their in vitro antifungal and antibacterial activities.
    Language English
    Publishing date 2019-12-17
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.9b02286
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  8. Article ; Online: Moving beyond bimetallic-alloy to single-atom dimer atomic-interface for all-pH hydrogen evolution

    Ashwani Kumar / Viet Q. Bui / Jinsun Lee / Lingling Wang / Amol R. Jadhav / Xinghui Liu / Xiaodong Shao / Yang Liu / Jianmin Yu / Yosep Hwang / Huong T. D. Bui / Sara Ajmal / Min Gyu Kim / Seong-Gon Kim / Gyeong-Su Park / Yoshiyuki Kawazoe / Hyoyoung Lee

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 10

    Abstract: While single, dispersed atoms enable efficient atomic utilization, controllably preparing single-atom dimers remains challenging. Here, authors prepare nickel-cobalt single-atom dimers as high-performance pH-universal H2 evolution electrocatalysts. ...

    Abstract While single, dispersed atoms enable efficient atomic utilization, controllably preparing single-atom dimers remains challenging. Here, authors prepare nickel-cobalt single-atom dimers as high-performance pH-universal H2 evolution electrocatalysts.
    Keywords Science ; Q
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
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  9. Article ; Online: Salacia spp.: recent insights on biotechnological interventions and future perspectives.

    Chavan, Jaykumar / Patil, Priyanka / Patil, Avdhoot / Deshmukh, Akshay / Panari, Pallavi / Mohite, Ashwini / Lawand, Pramod / Yadav, Pradnya / Bodhe, Minal / Kadam, Abhijit / Namdas, Dada / Pawar, Bandu / Jadhav, Amol / Shekhawat, Mahipal / Santa-Catarina, Claudette

    Applied microbiology and biotechnology

    2024  Volume 108, Issue 1, Page(s) 200

    Abstract: The plants of the genus Salacia L. are the storehouse of several bioactive compounds, and are involved in treating human diseases and disorders. Hitherto, a number of reports have been published on in vitro biotechnology as well as microbial involvement ... ...

    Abstract The plants of the genus Salacia L. are the storehouse of several bioactive compounds, and are involved in treating human diseases and disorders. Hitherto, a number of reports have been published on in vitro biotechnology as well as microbial involvement in the improvement of Salacia spp. The present review provides comprehensive insights into biotechnological interventions such as tissue culture for plant propagation, in vitro cultures, and endophytic microbes for up-scaling the secondary metabolites and biological potential of Salacia spp. Other biotechnological interventions such as molecular markers and bio-nanomaterials for up-grading the prospective of Salacia spp. are also considered. The in vitro biotechnology of Salacia spp. is largely focused on plant regeneration, callus culture, cell suspension culture, somatic embryogenesis, and subsequent ex vitro establishment of the in vitro-raised plantlets. The compiled information on tissue cultural strategies, involvement of endophytes, molecular markers, and nanomaterials will assist the advanced research related to in vitro manipulation, domestication, and commercial cultivation of elite clones of Salacia spp. Moreover, the genetic diversity and other molecular-marker based assessments will aid in designing conservation policies as well as support upgrading and breeding initiatives for Salacia spp. KEY POINTS: • Salacia spp. plays a multifaceted role in human health and disease management. • Critical and updated assessment of tissue culture, endophytic microbes, metabolites, molecular markers, and bio-nanomaterials of Salacia spp. • Key shortcomings and future research directions for Salacia biotechnology.
    MeSH term(s) Humans ; Salacia ; Biotechnology ; Plants ; Cell Culture Techniques ; Endophytes
    Language English
    Publishing date 2024-02-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 392453-1
    ISSN 1432-0614 ; 0171-1741 ; 0175-7598
    ISSN (online) 1432-0614
    ISSN 0171-1741 ; 0175-7598
    DOI 10.1007/s00253-023-12998-z
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    Zs.A 2229: Show issues Location:
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  10. Article ; Online: Moving beyond bimetallic-alloy to single-atom dimer atomic-interface for all-pH hydrogen evolution.

    Kumar, Ashwani / Bui, Viet Q / Lee, Jinsun / Wang, Lingling / Jadhav, Amol R / Liu, Xinghui / Shao, Xiaodong / Liu, Yang / Yu, Jianmin / Hwang, Yosep / Bui, Huong T D / Ajmal, Sara / Kim, Min Gyu / Kim, Seong-Gon / Park, Gyeong-Su / Kawazoe, Yoshiyuki / Lee, Hyoyoung

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 6766

    Abstract: ... can upshift the d-band center, thereby, facilitate rapid water-dissociation and optimal proton adsorption ...

    Abstract Single-atom-catalysts (SACs) afford a fascinating activity with respect to other nanomaterials for hydrogen evolution reaction (HER), yet the simplicity of single-atom center limits its further modification and utilization. Obtaining bimetallic single-atom-dimer (SAD) structures can reform the electronic structure of SACs with added atomic-level synergistic effect, further improving HER kinetics beyond SACs. However, the synthesis and identification of such SAD structure remains conceptually challenging. Herein, systematic first-principle screening reveals that the synergistic interaction at the NiCo-SAD atomic interface can upshift the d-band center, thereby, facilitate rapid water-dissociation and optimal proton adsorption, accelerating alkaline/acidic HER kinetics. Inspired by theoretical predictions, we develop a facile strategy to obtain NiCo-SAD on N-doped carbon (NiCo-SAD-NC) via in-situ trapping of metal ions followed by pyrolysis with precisely controlled N-moieties. X-ray absorption spectroscopy indicates the emergence of Ni-Co coordination at the atomic-level. The obtained NiCo-SAD-NC exhibits exceptional pH-universal HER-activity, demanding only 54.7 and 61 mV overpotentials at -10 mA cm
    Language English
    Publishing date 2021-11-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-27145-3
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