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Book ; Online: Propuesta pedagógica de Laboratorio de Innovación en Tecnología Educativa LITE para creación de contenido educativo, para la licenciatura en innovación educativa de la UCEMICH

Ortiz Soriano, Agustina / Villa Fajardo, Moisés Ramón / Instituto de Investigación y Capacitación Profesional del Pacífico / Instituto de Investigación y Capacitación Profesional del Pacífico

(Calidad de la educación superior: gestión estratégica, formación integral y soporte institucional ; 1)

2023

Series title	Calidad de la educación superior: gestión estratégica, formación integral y soporte institucional ; 1
Keywords	Education ; Tecnología educativa
Language	Spanish
Size	1 electronic resource (31 - 45 pages)
Publisher	Instituto de Investigación y Capacitación Profesional del Pacífico - IDICAP PACÍFICO
Publishing place	Puno - Perú
Document type	Book ; Online
Note	Spanish
HBZ-ID	HT030376424
ISBN	9786124881657 ; 6124881659
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Tutoría universitaria y el desempeño académico en los estudiantes del programa de Lengua, Literatura, Psicología y Filosofía

Coila Torres, Abraham / Condori Castillo, Wido Willam / Ruelas Vargas, Ronal / Suaña Calsín, Milciades Conrado / Condori Palomino, Juan Alexander / Instituto de Investigación y Capacitación Profesional del Pacífico / Editorial Idicap Pacífico / Instituto de Investigación y Capacitación Profesional del Pacífico

(Desafíos y perspectivas de la educación (tomo 2) ; 2)

2023

Series title	Desafíos y perspectivas de la educación (tomo 2) ; 2
Keywords	Education ; Acompañamiento ; desempeño académico ; educación y tutoría universitaria
Language	Spanish
Size	1 electronic resource (185-200 pages)
Publisher	Instituto de Investigación y Capacitación Profesional del Pacífico - IDICAP PACÍFICO
Publishing place	Puno - Perú
Document type	Book ; Online
Note	Spanish
HBZ-ID	HT030378296
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Obesity and labour market outcomes in Italy: a dynamic panel data evidence with correlated random effects.

Pacifico, Antonio

The European journal of health economics : HEPAC : health economics in prevention and care

2022 Volume 24, Issue 4, Page(s) 557–574

Abstract: This paper investigates the effects of obesity, socio-economic variables, and individual-specific factors on work productivity across Italian regions. A dynamic panel data with correlated random effects is used to jointly deal with incidental parameters, ...

Abstract	This paper investigates the effects of obesity, socio-economic variables, and individual-specific factors on work productivity across Italian regions. A dynamic panel data with correlated random effects is used to jointly deal with incidental parameters, endogeneity issues, and functional forms of misspecification. Methodologically, a hierarchical semiparametric Bayesian approach is involved in shrinking high dimensional model classes, and then obtaining a subset of potential predictors affecting outcomes. Monte Carlo designs are addressed to construct exact posterior distributions and then perform accurate forecasts. Cross-sectional Heterogeneity is modelled nonparametrically allowing for correlation between heterogeneous parameters and initial conditions as well as individual-specific regressors. Prevention policies and strategies to handle health and labour market prospects are also discussed.
MeSH term(s)	Humans ; Bayes Theorem ; Cross-Sectional Studies ; Markov Chains ; Algorithms ; Monte Carlo Method ; Italy ; Obesity/epidemiology
Language	English
Publishing date	2022-07-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2045253-6
ISSN	1618-7601 ; 1618-7598
ISSN (online)	1618-7601
ISSN	1618-7598
DOI	10.1007/s10198-022-01493-3
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Zs.A 5475: Show issues

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Article ; Online: Classification of Breast Implant Malposition.

Pacifico, Marc D / Goddard, Naveen V / Harris, Paul A

Aesthetic surgery journal

2024

Abstract: Background: Implant malposition is a well-recognized complication when using prosthetic implants in the breast for both reconstructive and aesthetic indications. However, to date, no objective classification system has been described.: Objectives: ... ...

Abstract	Background: Implant malposition is a well-recognized complication when using prosthetic implants in the breast for both reconstructive and aesthetic indications. However, to date, no objective classification system has been described. Objectives: This study presents a prospective trial of an objective and reproducible classification system for implant malposition formulated using retrospective data from a large cohort of patients with implant malposition. Methods: The authors retrospectively analyzed the degree of medial/lateral and inferior/superior implant malposition relative to their optimal position within the breast footprint in a series of 189 breasts (n = 100 patients). An objective classification system for implant malposition was devised and then applied to a prospective cohort of 53 breasts in 28 patients with implant malposition. Results: The degree of malposition in a single or combination of axes was categorised according to the distance from the ideal breast footprint and measured in centimeters (cms). The classification system incorporated the axis of malposition and distance to generate a treatment decision-making guide. Cases of Grade 1 malposition did not warrant surgical intervention, whilst surgical correction was warranted in all Grade 3 cases.In the combined patient cohort (n = 242 breasts, 128 patients), lateral, inferior, medial and superior displacement ranged between grades 1-3. There was no inter-observer variability in the grades assigned to nine out of ten patients in the prospective group. Conclusions: We have created a simple and reproducible classification system for implant malposition that allows surgeons to objectively record the extent of malposition, guides surgical decision-making and can be used to document the results of any intervention.
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjae084
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Zs.A 5721: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 570: Show issues

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Article ; Online: Feeding dairy cows bakery by-products enhanced nutrient digestibility, but affected fecal microbial composition and pH in a dose-dependent manner.

Kaltenegger, A / Humer, E / Pacífico, C / Zebeli, Q

Journal of dairy science

2021 Volume 104, Issue 7, Page(s) 7781–7793

Abstract: We reported recently that adding bakery by-products (BP) to the diets of dairy cows up to 30% improved performance and rumen pH, but caused major shifts in the nutrient profile and availability, likely modifying nutrient degradation patterns throughout ... ...

Abstract	We reported recently that adding bakery by-products (BP) to the diets of dairy cows up to 30% improved performance and rumen pH, but caused major shifts in the nutrient profile and availability, likely modifying nutrient degradation patterns throughout the gastrointestinal tract. The aim of this study was to investigate the effects of the gradual replacement of cereals by BP on the apparent total-tract digestibility (ATTD), the fermentation patterns, and the microbial community in feces of dairy cows. Twenty-four mid-lactating Simmental cows (149 ± 22.3 days in milk, 756 ± 89.6 kg of initial body weight) were fed a total mixed ration ad libitum (fresh feed was offered twice per day) containing a 50:50 ratio of forage to concentrate (dry matter basis) throughout the experiment. The trial lasted 5 wk, whereby the first week was used for baseline measurements, in which all cows received the same diet, without BP. Cows were then randomly allocated into 3 groups differing in the BP content of diets (0% BP, 15% BP, and 30% BP on a DM basis) and fed for 4 wk. Fecal samples were taken for analysis of pH, volatile fatty acids (VFA), and 16S rRNA gene sequencing. The inclusion of BP resulted in an increase of ether extract and sugars, and a reduction of starch and neutral detergent fiber in the diet. Feeding BP linearly increased the ATTD of almost all nutrients resulting in up to 2 kg more digestible organic matter intake (DOMI). Increasing BP level up to 30% increased fecal total VFA concentration and decreased the pH. The proportion of butyrate in feces increased linearly, but the proportion of all other VFA was not affected by BP-feeding. The richness and diversity indices of the fecal microbiota linearly declined by the inclusion of BP. The cellulolytic phyla Fibrobacteres decreased, whereas amylolytic phyla, such as Proteobacteria, increased. Overall, results showed that feeding BP linearly increased ATTD and DOMI, but impaired fecal microbial diversity and pH. In the interest of the optimization of BP inclusion in the dairy cows' feeding, a dietary level between 15 to 30% of BP might be a better compromise than 30% in terms of an enhanced DOMI and performance with still lowered risk of hindgut dysbiosis, but this will require further investigations.
MeSH term(s)	Animal Feed/analysis ; Animals ; Cattle ; Diet/veterinary ; Dietary Fiber/metabolism ; Digestion ; Feces ; Female ; Fermentation ; Hydrogen-Ion Concentration ; Lactation ; Milk ; Nutrients ; RNA, Ribosomal, 16S/metabolism ; Rumen/metabolism
Chemical Substances	Dietary Fiber ; RNA, Ribosomal, 16S
Language	English
Publishing date	2021-04-15
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial, Veterinary
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2020-19998
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Zs.B 810: Show issues

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Article ; Online: Sigla storax (Liquidambar orientalis) mitigates in vitro methane production without disturbances in rumen microbiota and nutrient fermentation in comparison to monensin.

Demirtas, Ahu / Pacífico, Cátia / Gruber, Theresa / Chizzola, Remigius / Zebeli, Qendrim / Khiaosa-Ard, Ratchaneewan

Journal of applied microbiology

2023 Volume 134, Issue 8

Abstract: Aim: The aim of this study was to investigate the in vitro dose-dependent effects of sigla storax (Styrax liquidus) on rumen microbiota and rumen microbial fermentation in comparison to monensin as a positive control.: Methods and results: This study ...

Abstract	Aim: The aim of this study was to investigate the in vitro dose-dependent effects of sigla storax (Styrax liquidus) on rumen microbiota and rumen microbial fermentation in comparison to monensin as a positive control. Methods and results: This study was carried out using a rumen simulation model (Rusitec). Treatments consisted of no additive (control), 10 mg l-1 of monensin sodium salt, 100 mg l-1 (Low-Sigla), and 500 mg l-1 (High-Sigla) of sigla storax (n = 6/treatment). In addition to rumen fermentation characteristics, rumen microbial composition was investigated using 16S rRNA sequencing. The methane variables and the acetate to propionate ratio decreased in the both High-Sigla and monensin groups (P < 0.05). High-Sigla had no effect on ammonia, total SCFA and nutrition degradation, while monensin decreased these parameters (P < 0.05). Unlike monensin, the sigla storax treatments did not affect the alpha or beta diversity indexes of the microbiota. The relative abundance of Methanomethylophilaceae and Ruminococcaceae decreased with High-Sigla and monensin (P < 0.05), and Atopobiaceae and Eggerthellaceae decreased with the both doses of sigla storax as well as monensin treatments (P < 0.05). Syntrophococcus, DNF00809, and Kandleria were among the genera that most decreased with High-Sigla and monensin (Q < 0.07) and were strongly positively correlated with methane production (r = 0.52-0.56). Conclusions: The high dose of sigla storax (500 mg l-1) decreased methane in the rumen ecosystem without adverse effects on nutrient degradation and SCFA production, and without dramatically impacting the microbial composition. Sigla storax might be a novel feed additive to mitigate methane in cattle.
MeSH term(s)	Animals ; Cattle ; Monensin/pharmacology ; Monensin/metabolism ; Fermentation ; Liquidambar/metabolism ; Rumen/metabolism ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/metabolism ; Styrax/metabolism ; Microbiota ; Methane/metabolism ; Nutrients ; Diet/veterinary ; Animal Feed
Chemical Substances	Monensin (906O0YJ6ZP) ; RNA, Ribosomal, 16S ; storax ; Methane (OP0UW79H66)
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1093/jambio/lxad154
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Zs.A 259: Show issues

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Article ; Online: Dietary carbohydrate sources differently prime the microbial ecosystem but not the epithelial gene expression profile along the complete gut of young calves.

Hartinger, Thomas / Pacífico, Cátia / Sener-Aydemir, Arife / Poier, Gregor / Kreuzer-Redmer, Susanne / Terler, Georg / Klevenhusen, Fenja / Zebeli, Qendrim

Animal microbiome

2024 Volume 6, Issue 1, Page(s) 12

Abstract: Background: Recent data indicated similar growth performance of young calves fed solely high-quality hay instead of a starter diet based on starchy ingredients. Yet, providing exclusively such distinct carbohydrate sources during early life might ... ...

Abstract	Background: Recent data indicated similar growth performance of young calves fed solely high-quality hay instead of a starter diet based on starchy ingredients. Yet, providing exclusively such distinct carbohydrate sources during early life might specifically prime the microbiota and gene expression along the gut of young calves, which remains to be explored. We investigated the effects of starter diets differing in carbohydrate composition, that is medium- or high-quality hay and without or with 70% concentrate supplementation (on fresh matter basis), across the gastrointestinal tract (GIT) of weaned Holstein calves (100 ± 4 days of age) using 16 S rRNA gene sequencing and analyses of short-chain fatty acids and host epithelial gene expressions. Results: The concentrate supplementation drastically decreased microbial diversity throughout the gut, which was also true to a much lesser extent for high-quality hay when compared to medium-quality hay in the foregut. Similarly, the factor concentrate strongly shaped the diet-associated common core microbiota, which was substantially more uniform along the gut with concentrate supplementation. The fermentation profile shifted towards less acetate but more propionate with concentrate supplementation in almost all gut sections, corresponding with higher abundances of starch-utilizing bacteria, while major fibrolytic clusters declined. Noteworthy, the n-butyrate proportion decreased in the rumen and increased in the colon with concentrate, showing an opposite, gut site-dependent effect. Both dietary factors modestly influenced the host epithelial gene expression. Conclusions: Concentrate supplementation clearly primed the microbial ecosystem on a starch-targeted fermentation with characteristic genera occupying this niche along the entire GIT of calves, whereas the microbial differentiation due to hay quality was less distinct. Overall, changes in the microbial ecosystem were only marginally reflected in the targeted transcriptional profile of the host epithelium.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ISSN	2524-4671
ISSN (online)	2524-4671
DOI	10.1186/s42523-024-00297-5
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Article ; Online: Glutamine Metabolism in Cancer Stem Cells: A Complex Liaison in the Tumor Microenvironment.

Pacifico, Francesco / Leonardi, Antonio / Crescenzi, Elvira

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: In this review we focus on the role of glutamine in control of cancer stem cell (CSC) fate. We first provide an overview of glutamine metabolism, and then summarize relevant studies investigating how glutamine metabolism modulates the CSC compartment, ... ...

Abstract	In this review we focus on the role of glutamine in control of cancer stem cell (CSC) fate. We first provide an overview of glutamine metabolism, and then summarize relevant studies investigating how glutamine metabolism modulates the CSC compartment, concentrating on solid tumors. We schematically describe how glutamine in CSC contributes to several metabolic pathways, such as redox metabolic pathways, ATP production, non-essential aminoacids and nucleotides biosynthesis, and ammonia production. Furthermore, we show that glutamine metabolism is a key regulator of epigenetic modifications in CSC. Finally, we briefly discuss how cancer-associated fibroblasts, adipocytes, and senescent cells in the tumor microenvironment may indirectly influence CSC fate by modulating glutamine availability. We aim to highlight the complexity of glutamine's role in CSC, which supports our knowledge about metabolic heterogeneity within the CSC population.
MeSH term(s)	Humans ; Glutamine/metabolism ; Tumor Microenvironment ; Neoplasms/metabolism ; Metabolic Networks and Pathways ; Neoplastic Stem Cells/metabolism
Chemical Substances	Glutamine (0RH81L854J)
Language	English
Publishing date	2023-01-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032337
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Article: Iron Metabolism in Cancer and Senescence: A Cellular Perspective.

Crescenzi, Elvira / Leonardi, Antonio / Pacifico, Francesco

Biology

2023 Volume 12, Issue 7

Abstract: Iron participates in a number of biological processes and plays a crucial role in cellular homeostasis. Alterations in iron metabolism are considered hallmarks of cancer and drivers of aggressive behaviors, such as uncontrolled proliferation, resistance ... ...

Abstract	Iron participates in a number of biological processes and plays a crucial role in cellular homeostasis. Alterations in iron metabolism are considered hallmarks of cancer and drivers of aggressive behaviors, such as uncontrolled proliferation, resistance to apoptosis, enhanced metastatic ability, increased cell plasticity and stemness. Furthermore, a dysregulated iron metabolism has been associated with the development of an adverse tumor microenvironment. Alterations in iron metabolism have been described in cellular senescence and in aging. For instance, iron has been shown to accumulate in aged tissues and in age-related diseases. Furthermore, in vitro studies demonstrate increases in iron content in both replicative and stress-induced senescent cells. However, the role, the mechanisms of regulation and dysregulation and the effects of iron metabolism on senescence remain significantly less characterized. In this review, we first provide an overview of iron metabolism and iron regulatory proteins. Then, we summarize alterations in iron homeostasis in cancer and senescence from a cellular point of view.
Language	English
Publishing date	2023-07-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12070989
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Article ; Online: Acrodermatitis continua of Hallopeau in an elderly patient successfully and rapidly treated with risankizumab: a case report.

Orsini, Diego / Iacovelli, Paolo / Frascione, Pasquale / Pacifico, Alessia

The Journal of dermatological treatment

2023 Volume 34, Issue 1, Page(s) 2229468

MeSH term(s)	Aged ; Humans ; Acrodermatitis/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Exanthema ; Psoriasis/drug therapy ; Skin Diseases, Vesiculobullous
Chemical Substances	risankizumab (90ZX3Q3FR7) ; Antibodies, Monoclonal
Language	English
Publishing date	2023-06-28
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2023.2229468
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