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  1. Article: Development of gastro-food allergy model in shrimp allergen extract-induced sensitized mice promotes mast cell degranulation.

    Marhaeny, Honey Dzikri / Pratama, Yusuf Alif / Rohmah, Lutfiatur / Kasatu, Salsabilla Madudari / Miatmoko, Andang / Khotib, Junaidi

    Journal of public health in Africa

    2023  Volume 14, Issue Suppl 1, Page(s) 2512

    Abstract: Background: Food allergies have become more common in the last decade. Shrimp is one of the most dominant food allergy triggers in Asian countries, including Indonesia. After ingesting allergens, B cells will produce allergen-specific Immunoglobin E ( ... ...

    Abstract Background: Food allergies have become more common in the last decade. Shrimp is one of the most dominant food allergy triggers in Asian countries, including Indonesia. After ingesting allergens, B cells will produce allergen-specific Immunoglobin E (IgE). In the sensitization period, repeated allergen exposure promotes Mast Cell (MC) degranulation in intestinal tissue and releases several inflammatory mediators, thereby causing hypersensitivity reactions. Shrimp Allergen Extract (SAE) is an immunotherapy and diagnostic agent currently being developed in Indonesia. In this study, we investigated the effect of SAE administration on eliciting an MC immunological response.
    Methods: Mice were divided into a non-sensitized and sensitized group. The non-sensitized group only received 1 mg of alum (i.p), whereas the sensitized group received 1 mg of alum and 100 μg of SAE on days 0, 7, and 14. Then, both groups were challenged with 400 μg SAE (p.o) on days 21, 22, and 23 following systemic allergic symptom observation.
    Results: We showed that SAE was able to increase systemic allergic symptoms significantly in the sensitized mice through repeated challenge (1.33±0.21; 1.83±0.17; and 2.00±0.00), compared to non-sensitized mice (0.17±0.17). Moreover, histopathological analysis showed that the SAE administration causes an increase of MC degranulation in the ileum tissue of the sensitized mice (44.43%±0.01), compared to non-sensitized mice (35.45%±0.01).
    Conclusions: This study found that SAE could induce allergic reactions in mice by influencing critical effector cells, MCs.
    Language English
    Publishing date 2023-03-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2574977-8
    ISSN 2038-9930 ; 2038-9922
    ISSN (online) 2038-9930
    ISSN 2038-9922
    DOI 10.4081/jphia.2023.2512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development of gastro-food allergy model in shrimp allergen extract-induced sensitized mice promotes mast cell degranulation

    Honey Dzikri Marhaeny / Yusuf Alif Pratama / Lutfiatur Rohmah / Salsabilla Madudari Kasatu / Andang Miatmoko / Junaidi Khotib

    Journal of Public Health in Africa, Vol 14, Iss s

    2023  Volume 1

    Abstract: Background: Food allergies have become more common in the last decade. Shrimp is one of the most dominant food allergy triggers in Asian countries, including Indonesia. After ingesting allergens, B cells will produce allergen-specific Immunoglobin E (IgE) ...

    Abstract Background: Food allergies have become more common in the last decade. Shrimp is one of the most dominant food allergy triggers in Asian countries, including Indonesia. After ingesting allergens, B cells will produce allergen-specific Immunoglobin E (IgE). In the sensitization period, repeated allergen exposure promotes Mast Cell (MC) degranulation in intestinal tissue and releases several inflammatory mediators, thereby causing hypersensitivity reactions. Shrimp Allergen Extract (SAE) is an immunotherapy and diagnostic agent currently being developed in Indonesia. In this study, we investigated the effect of SAE administration on eliciting an MC immunological response. Methods: Mice were divided into a non-sensitized and sensitized group. The non-sensitized group only received 1 mg of alum (i.p), whereas the sensitized group received 1 mg of alum and 100 μg of SAE on days 0, 7, and 14. Then, both groups were challenged with 400 μg SAE (p.o) on days 21, 22, and 23 following systemic allergic symptom observation. Results: We showed that SAE was able to increase systemic allergic symptoms significantly in the sensitized mice through repeated challenge (1.33±0.21; 1.83±0.17; and 2.00±0.00), compared to non-sensitized mice (0.17±0.17). Moreover, histopathological analysis showed that the SAE administration causes an increase of MC degranulation in the ileum tissue of the sensitized mice (44.43%±0.01), compared to non-sensitized mice (35.45%±0.01) Conclusions: This study found that SAE could induce allergic reactions in mice by influencing critical effector cells, MCs.
    Keywords Mast cell degranulation ; immune response ; gastro-food allergy ; shrimp allergen extract ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Allergic rhinitis behavioral changes after Indonesian house dust mites allergenic extract administration as immunotherapy

    Yusuf Alif Pratama / Honey Dzikri Marhaeny / Lutfiatur Rohmah / Salsabilla Madudari Kasatu / Ahmad Dzulfikri Nurhan / Mahardian Rahmadi / Junaidi Khotib

    Journal of Public Health in Africa, Vol 14, Iss s

    2023  Volume 1

    Abstract: Background: Allergy is a hypersensitivity reaction that is generally mediated by Immunoglobulin E (IgE). More than 25% of the world’s population is suspected of having these various diseases, and the prevalence and progression of these diseases have ... ...

    Abstract Background: Allergy is a hypersensitivity reaction that is generally mediated by Immunoglobulin E (IgE). More than 25% of the world’s population is suspected of having these various diseases, and the prevalence and progression of these diseases have continued to increase significantly in recent years. Among these allergy-related diseases, allergic rhinitis and food allergy are the types of allergies with the highest prevalence. Clinical manifestations of allergic rhinitis include sneezing, rhinorrhea, nasal itching, and nasal congestion. Objective: This study aimed to determine the behavioral changes of allergic rhinitis after Indonesian House Dust Mites (IHDM) allergenic extract administration as an immunotherapy. Methods: Eight male BALB/c mice aged 6-8 weeks in each group were treated for seven groups. The sensitization phase is given intraperitoneal, the desensitization phase is given by subcutaneous, and the challenge phase is given intranasal. The allergic parameters were observed, such as nose rubbing and sneezing. The parameters were observed for 15 minutes after the challenge administration. Results: The results showed that the administration of Indonesian House Dust Mites as immunotherapy decreased the frequency of nose rubbing and sneezing after the administration of immunotherapy compared to the allergic rhinitis model. Conclusions: The administration of the Indonesia House Dust Mites as immunotherapy decreased the allergic rhinitis immune response by altering the behavioral parameter.
    Keywords Desensitization ; IHDM ; neglected disease ; phenotype ; sneezing ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  4. Article: Allergic rhinitis behavioral changes after Indonesian house dust mites allergenic extract administration as immunotherapy.

    Pratama, Yusuf Alif / Marhaeny, Honey Dzikri / Rohmah, Lutfiatur / Kasatu, Salsabilla Madudari / Nurhan, Ahmad Dzulfikri / Rahmadi, Mahardian / Khotib, Junaidi

    Journal of public health in Africa

    2023  Volume 14, Issue Suppl 1, Page(s) 2510

    Abstract: Background: Allergy is a hypersensitivity reaction that is generally mediated by Immunoglobulin E (IgE). More than 25% of the world's population is suspected of having these various diseases, and the prevalence and progression of these diseases have ... ...

    Abstract Background: Allergy is a hypersensitivity reaction that is generally mediated by Immunoglobulin E (IgE). More than 25% of the world's population is suspected of having these various diseases, and the prevalence and progression of these diseases have continued to increase significantly in recent years. Among these allergyrelated diseases, allergic rhinitis and food allergy are the types of allergies with the highest prevalence. Clinical manifestations of allergic rhinitis include sneezing, rhinorrhea, nasal itching, and nasal congestion.
    Objective: This study aimed to determine the behavioral changes of allergic rhinitis after Indonesian House Dust Mites (IHDM) allergenic extract administration as an immunotherapy.
    Methods: Eight male BALB/c mice aged 6-8 weeks in each group were treated for seven groups. The sensitization phase is given intraperitoneal, the desensitization phase is given by subcutaneous, and the challenge phase is given intranasal. The allergic parameters were observed, such as nose rubbing and sneezing. The parameters were observed for 15 minutes after the challenge administration.
    Results: The results showed that the administration of Indonesian House Dust Mites as immunotherapy decreased the frequency of nose rubbing and sneezing after the administration of immunotherapy compared to the allergic rhinitis model.
    Conclusions: The administration of the Indonesian House Dust Mites as immunotherapy decreased the allergic rhinitis immune response by altering the behavioral parameter.
    Language English
    Publishing date 2023-03-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2574977-8
    ISSN 2038-9930 ; 2038-9922
    ISSN (online) 2038-9930
    ISSN 2038-9922
    DOI 10.4081/jphia.2023.2510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Phyllanthin and hypophyllanthin, the isolated compounds of

    Marhaeny, Honey Dzikri / Widyawaruyanti, Aty / Widiandani, Tri / Fuad Hafid, Achmad / Wahyuni, Tutik Sri

    Journal of basic and clinical physiology and pharmacology

    2021  Volume 32, Issue 4, Page(s) 809–815

    Abstract: Objectives: Phyllanthus niruri: Methods: Molegro Virtual Docker 6.0 used to determine the best binding energy through the rerank score which shows the total energy bonds calculation.: Results: Phyllanthin and hypophyllanthin demonstrated to ... ...

    Abstract Objectives: Phyllanthus niruri
    Methods: Molegro Virtual Docker 6.0 used to determine the best binding energy through the rerank score which shows the total energy bonds calculation.
    Results: Phyllanthin and hypophyllanthin demonstrated to possess greater binding affinity toward the COVID-19 inhibition sites than their native ligand. The rerank score of phyllanthin and hypophyllanthin are lower than the native ligands 6LZG and 5R7Y. This result indicated that phyllanthin and hypophyllanthin have a stronger interaction than the native ligands both in spike glycoprotein (entry inhibitor) and main protease (translation and replication inhibitor).
    Conclusions: In conclusion, phyllanthin and hypophyllanthin are predicted to have strong activity against COVID-19 through inhibiting spike glycoprotein and main protease under
    MeSH term(s) COVID-19/drug therapy ; Computer Simulation ; Humans ; Ligands ; Lignans/pharmacology ; Lignans/toxicity ; Molecular Docking Simulation ; Molecular Structure ; Phyllanthus/chemistry ; Plant Extracts/pharmacology ; SARS-CoV-2/drug effects
    Chemical Substances Ligands ; Lignans ; Plant Extracts ; hypophyllanthin (22ZZ21E33P) ; phyllanthin (75O1TFF47Z)
    Language English
    Publishing date 2021-06-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1071737-7
    ISSN 2191-0286 ; 0792-6855 ; 0334-1534
    ISSN (online) 2191-0286
    ISSN 0792-6855 ; 0334-1534
    DOI 10.1515/jbcpp-2020-0473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Differentiation of osteoblasts: the links between essential transcription factors.

    Khotib, Junaidi / Marhaeny, Honey Dzikri / Miatmoko, Andang / Budiatin, Aniek Setiya / Ardianto, Chrismawan / Rahmadi, Mahardian / Pratama, Yusuf Alif / Tahir, Muhammad

    Journal of biomolecular structure & dynamics

    2022  Volume 41, Issue 19, Page(s) 10257–10276

    Abstract: Osteoblasts, cells derived from mesenchymal stem cells (MSCs) in the bone marrow, are cells responsible for bone formation and remodeling. The differentiation of osteoblasts from MSCs is triggered by the expression of specific genes, which are ... ...

    Abstract Osteoblasts, cells derived from mesenchymal stem cells (MSCs) in the bone marrow, are cells responsible for bone formation and remodeling. The differentiation of osteoblasts from MSCs is triggered by the expression of specific genes, which are subsequently controlled by pro-osteogenic pathways. Mature osteoblasts then differentiate into osteocytes and are embedded in the bone matrix. Dysregulation of osteoblast function can cause inadequate bone formation, which leads to the development of bone disease. Various key molecules are involved in the regulation of osteoblastogenesis, which are transcription factors. Previous studies have heavily examined the role of factors that control gene expression during osteoblastogenesis, both in vitro and in vivo. However, the systematic relationship of these transcription factors remains unknown. The involvement of ncRNAs in this mechanism, particularly miRNAs, lncRNAs, and circRNAs, has been shown to influence transcriptional factor activity in the regulation of osteoblast differentiation. Here, we discuss nine essential transcription factors involved in osteoblast differentiation, including Runx2, Osx, Dlx5, β-catenin, ATF4, Ihh, Satb2, and Shn3. In addition, we summarize the role of ncRNAs and their relationship to these essential transcription factors in order to improve our understanding of the transcriptional regulation of osteoblast differentiation. Adequate exploration and understanding of the molecular mechanisms of osteoblastogenesis can be a critical strategy in the development of therapies for bone-related diseases.Communicated by Ramaswamy H. Sarma.
    MeSH term(s) Transcription Factors/genetics ; Transcription Factors/metabolism ; Cell Differentiation/genetics ; Osteoblasts/metabolism ; Gene Expression Regulation ; Osteogenesis/genetics
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2022.2148749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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