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  1. Article: Editorial: Emerging and Re-emerging Vector-borne and Zoonotic Diseases.

    Rodriguez-Morales, Alfonso J / Cardona-Ospina, Jaime A / Collins, Matthew H

    Frontiers in medicine

    2021  Volume 8, Page(s) 714630

    Language English
    Publishing date 2021-08-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.714630
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  2. Article ; Online: PRESCRIBING PATTERNS AND THE USE OF ANTHELMINTIC DRUGS IN COLOMBIAN PATIENTS: A CROSS-SECTIONAL STUDY.

    Montes-Montoya, Maria Camila / Gaviria-Mendoza, Andrés / Murillo-Muñoz, Maria Mónica / Cardona-Ospina, Jaime Andrés / Machado-Alba, Jorge Enrique

    The Journal of parasitology

    2023  Volume 109, Issue 6, Page(s) 537–542

    Abstract: Intestinal parasites continue to be a public health problem in low- and middle-income countries. Broad use of anthelmintics during deworming programs is still necessary in many regions. However, description of the usage of these medications in general ... ...

    Abstract Intestinal parasites continue to be a public health problem in low- and middle-income countries. Broad use of anthelmintics during deworming programs is still necessary in many regions. However, description of the usage of these medications in general medical practice has been limited. The objective of this study was to determine the use of anthelmintic drugs and their indications in a group of Colombian patients. This was a descriptive study from a drug-dispensing database, identifying patients with prescriptions for anthelmintic drugs. A total of 381 cases were randomly selected, and their medical records were reviewed, analyzing sociodemographic, clinical, and pharmacological variables (indication of use). The lack of diagnosis registration or clinical manifestations of parasites was determined as a prescription without indication. In total, 50.9% (n = 194) of patients were female, and 67.4% of all patients were under 18 yr of age. The diagnosis of helminthiases was clearly stated in 114 (29.9%) patients, and only 4.2% (n = 16) of these had microbiological confirmation. The most commonly used anthelmintic drug was albendazole (70.4% of all prescriptions). The use of anthelmintics was not indicated in 266 cases (69.8%). Nutritional supplements or vitamin prescriptions were associated with using anthelmintics without indication (odds ratio: 2.25; 95% confidence interval: 1.26-4.03). A high proportion of patients lacked symptoms or diagnoses in their clinical records that supported the use of anthelmintic drugs.
    MeSH term(s) Adolescent ; Adult ; Child ; Female ; Humans ; Male ; Albendazole/therapeutic use ; Anthelmintics/therapeutic use ; Colombia/epidemiology ; Cross-Sectional Studies ; Helminthiasis/drug therapy ; Helminthiasis/epidemiology
    Chemical Substances Albendazole (F4216019LN) ; Anthelmintics
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 300870-8
    ISSN 1937-2345 ; 0022-3395
    ISSN (online) 1937-2345
    ISSN 0022-3395
    DOI 10.1645/22-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype.

    Bos, Sandra / Graber, Aaron L / Cardona-Ospina, Jaime A / Duarte, Elias M / Zambrana, Jose Victor / Ruíz Salinas, Jorge A / Mercado-Hernandez, Reinaldo / Singh, Tulika / Katzelnick, Leah C / de Silva, Aravinda / Kuan, Guillermina / Balmaseda, Angel / Harris, Eva

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 382

    Abstract: Dengue viruses (DENV1-4) are the most prevalent arboviruses in humans and a major public health concern. Understanding immune mechanisms that modulate DENV infection outcome is critical for vaccine development. Neutralizing antibodies (nAbs) are an ... ...

    Abstract Dengue viruses (DENV1-4) are the most prevalent arboviruses in humans and a major public health concern. Understanding immune mechanisms that modulate DENV infection outcome is critical for vaccine development. Neutralizing antibodies (nAbs) are an essential component of the protective immune response, yet their measurement often relies on a single cellular substrate and partially mature virions, which does not capture the full breadth of neutralizing activity and may lead to biased estimations of nAb potency. Here, we analyze 125 samples collected after one or more DENV infections but prior to subsequent symptomatic or inapparent DENV1, DENV2, or DENV3 infections from a long-standing pediatric cohort study in Nicaragua. By assessing nAb responses using Vero cells with or without DC-SIGN and with mature or partially mature virions, we find that nAb potency and the protective NT50 cutoff are greatly influenced by cell substrate and virion maturation state. Additionally, the correlation between nAb titer and protection from disease depends on prior infection history and infecting serotype. Finally, we uncover variations in nAb composition that contribute to protection from symptomatic infection differently after primary and secondary prior infection. These findings have important implications for identifying antibody correlates of protection for vaccines and natural infections.
    MeSH term(s) Chlorocebus aethiops ; Animals ; Humans ; Child ; Antibodies, Neutralizing ; Cohort Studies ; Serogroup ; Vero Cells ; Coinfection ; Dengue/prevention & control
    Chemical Substances Antibodies, Neutralizing
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44330-8
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  4. Article ; Online: Gastroenterologists, Hepatologists, COVID-19 and the Use of Acetaminophen.

    Rodríguez-Morales, Alfonso J / Cardona-Ospina, Jaime A / Murillo-Muñoz, Maria Mónica

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2020  Volume 18, Issue 9, Page(s) 2142–2143

    MeSH term(s) Acetaminophen ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Gastroenterologists ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Acetaminophen (362O9ITL9D)
    Keywords covid19
    Language English
    Publishing date 2020-05-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2020.04.025
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  5. Article ; Online: Editorial

    Alfonso J. Rodriguez-Morales / Jaime A. Cardona-Ospina / Matthew H. Collins

    Frontiers in Medicine, Vol

    Emerging and Re-emerging Vector-borne and Zoonotic Diseases

    2021  Volume 8

    Keywords vector-borne diseases ; zoonotic diseases ; emerging ; tropical diseases ; emerging infectious diseases ; global health ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Autoimmunity or Lineage-Specific Virulence as Drivers of Chikungunya Chronic Arthritis: Comment on the Article by Chang et al.

    Gérardin, Patrick / Cardona-Ospina, Jaime A / Rodríguez-Morales, Alfonso J

    Arthritis & rheumatology (Hoboken, N.J.)

    2018  Volume 70, Issue 11, Page(s) 1892–1893

    MeSH term(s) Americas ; Arthritis ; Autoimmunity ; Chikungunya Fever ; Cross-Sectional Studies ; Humans ; Synovial Fluid ; Virulence
    Language English
    Publishing date 2018-08-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.40665
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  7. Article ; Online: Phylodynamic analysis in the understanding of the current COVID-19 pandemic and its utility in vaccine and antiviral design and assessment.

    Cardona-Ospina, Jaime A / Rojas-Gallardo, Diana M / Garzón-Castaño, Sandra C / Jiménez-Posada, Erika V / Rodríguez-Morales, Alfonso J

    Human vaccines & immunotherapeutics

    2021  Volume 17, Issue 8, Page(s) 2437–2444

    Abstract: Over the last decades, the use of phylogenetic methods in the study of emerging infectious diseases has gained considerable traction in public health. Particularly, the integration of phylogenetic analyses with the understanding of the pathogen dynamics ... ...

    Abstract Over the last decades, the use of phylogenetic methods in the study of emerging infectious diseases has gained considerable traction in public health. Particularly, the integration of phylogenetic analyses with the understanding of the pathogen dynamics at the population level has provided powerful tools for epidemiological surveillance systems. In the same way, the development of statistical methods and theory, as well as improvement of computational efficiency for evolutionary analysis, has expanded the use of these tools for vaccine and antiviral development. Today with the Coronavirus Disease 2019 (COVID-19), this seems to be critical. In this article, we discuss how the application of phylodynamic analysis can improve the understanding of current pandemic dynamics as well as the design, selection, and evaluation of vaccine candidates and antivirals.
    MeSH term(s) Antiviral Agents/therapeutic use ; COVID-19 ; Humans ; Pandemics ; Phylogeny ; SARS-CoV-2 ; Vaccines
    Chemical Substances Antiviral Agents ; Vaccines
    Language English
    Publishing date 2021-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2664176-8
    ISSN 2164-554X ; 2164-5515
    ISSN (online) 2164-554X
    ISSN 2164-5515
    DOI 10.1080/21645515.2021.1880254
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  8. Article ; Online: Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype

    Sandra Bos / Aaron L. Graber / Jaime A. Cardona-Ospina / Elias M. Duarte / Jose Victor Zambrana / Jorge A. Ruíz Salinas / Reinaldo Mercado-Hernandez / Tulika Singh / Leah C. Katzelnick / Aravinda de Silva / Guillermina Kuan / Angel Balmaseda / Eva Harris

    Nature Communications, Vol 15, Iss 1, Pp 1-

    2024  Volume 13

    Abstract: Abstract Dengue viruses (DENV1–4) are the most prevalent arboviruses in humans and a major public health concern. Understanding immune mechanisms that modulate DENV infection outcome is critical for vaccine development. Neutralizing antibodies (nAbs) are ...

    Abstract Abstract Dengue viruses (DENV1–4) are the most prevalent arboviruses in humans and a major public health concern. Understanding immune mechanisms that modulate DENV infection outcome is critical for vaccine development. Neutralizing antibodies (nAbs) are an essential component of the protective immune response, yet their measurement often relies on a single cellular substrate and partially mature virions, which does not capture the full breadth of neutralizing activity and may lead to biased estimations of nAb potency. Here, we analyze 125 samples collected after one or more DENV infections but prior to subsequent symptomatic or inapparent DENV1, DENV2, or DENV3 infections from a long-standing pediatric cohort study in Nicaragua. By assessing nAb responses using Vero cells with or without DC-SIGN and with mature or partially mature virions, we find that nAb potency and the protective NT50 cutoff are greatly influenced by cell substrate and virion maturation state. Additionally, the correlation between nAb titer and protection from disease depends on prior infection history and infecting serotype. Finally, we uncover variations in nAb composition that contribute to protection from symptomatic infection differently after primary and secondary prior infection. These findings have important implications for identifying antibody correlates of protection for vaccines and natural infections.
    Keywords Science ; Q
    Subject code 570
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: The association of neutralizing antibodies with protection against symptomatic dengue virus infection varies by serotype, prior infection history, and assay condition.

    Bos, Sandra / Graber, Aaron L / Cardona-Ospina, Jaime A / Duarte, Elias M / Zambrana, Jose Victor / Ruíz Salinas, Jorge A / Mercado-Hernandez, Reinaldo / Singh, Tulika / Katzelnick, Leah C / de Silva, Aravinda / Kuan, Guillermina / Balmaseda, Angel / Harris, Eva

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: The four dengue virus serotypes (DENV1-4) are the most prevalent arboviruses in humans and a major public health concern worldwide. Understanding immune mechanisms that modulate DENV infection outcome is critical for epidemic preparedness and development ...

    Abstract The four dengue virus serotypes (DENV1-4) are the most prevalent arboviruses in humans and a major public health concern worldwide. Understanding immune mechanisms that modulate DENV infection outcome is critical for epidemic preparedness and development of a safe and effective vaccine. Neutralizing antibodies (nAbs) are an essential component of the protective response, yet their measurement often relies on a single cellular substrate and partially mature virions, which do not capture the full breadth of neutralizing activity and may lead to biased estimations of nAb potency. Here, we investigated the characteristics of nAbs associated with protection against dengue cases using samples collected after one or more DENV infections but prior to subsequent symptomatic or inapparent DENV1, DENV2, or DENV3 infections from a long- standing pediatric cohort study in Nicaragua. By assessing nAb responses using Vero cells with or without the attachment factor DC-SIGN and with mature or partially mature virions, we found that nAb potency and the protective NT
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.20.23291522
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  10. Article ; Online: Sensitive and Stable Molecular Detection of Dengue, Chikungunya, and Zika Viruses from Dried Blood Spots.

    Cardona-Ospina, Jaime A / Stittleburg, Victoria / Millan-Benavidez, Natalia / Restrepo-Chica, Juliana / Key, Autum / Rojas-Gallardo, Diana Marcela / Piantadosi, Anne / Collins, Matthew H / Waggoner, Jesse J

    The American journal of tropical medicine and hygiene

    2022  Volume 107, Issue 2, Page(s) 296–299

    Abstract: Standard molecular detection of many pathogens, in particular RNA viruses, requires appropriate handling in the field for preserving the quality of the sample until processing. This could be challenging in remote tropical areas. Dengue virus (DENV), ... ...

    Abstract Standard molecular detection of many pathogens, in particular RNA viruses, requires appropriate handling in the field for preserving the quality of the sample until processing. This could be challenging in remote tropical areas. Dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV) are RNA viruses, prominent among the causes of fever in the tropics. We aimed to test the stability of arboviral RNA in contrived dried blood spots prepared on Whatman 903 Protein saver cards as a means of sample collection and storage. We were able to detect DENV, CHIKV, and ZIKV by real-time RT-PCR up to 180 days after card inoculation with stable Ct values across the study period. Our study supports dried blood spots (DBS) on protein saver cards as a platform for stable detection of arboviral RNA of sufficient quality to be used in diagnostic RT-PCR assays and next generation sequencing.
    MeSH term(s) Humans ; Zika Virus/genetics ; Chikungunya Fever/diagnosis ; Zika Virus Infection/diagnosis ; Dengue/diagnosis ; Dengue Virus/genetics ; Chikungunya virus/genetics ; RNA, Viral/genetics
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.21-1087
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