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  1. Article ; Online: Evolutionary analysis of JC polyomavirus in Misiones' population yields insight into the population dynamics of the early human dispersal in the Americas.

    Pereson, Matias J / Sanabria, Daiana J / Torres, Carolina / Liotta, Domingo J / Campos, Rodolfo H / Schurr, Theodore G / Di Lello, Federico A / Badano, Inés

    Virology

    2023  Volume 585, Page(s) 100–108

    Abstract: Background: JC polyomavirus (JCV) has an ethno-geographical distribution across human populations.: Objective: Study the origins of the population of Misiones (Argentina) by using JCV as genetic marker.: Methods: Viral detection and ... ...

    Abstract Background: JC polyomavirus (JCV) has an ethno-geographical distribution across human populations.
    Objective: Study the origins of the population of Misiones (Argentina) by using JCV as genetic marker.
    Methods: Viral detection and characterization was conducted by PCR amplification and evolutionary analysis of the intergenic region sequences.
    Results: 22 out of 121 samples were positive for JCV, including 5 viral lineages: MY (n = 8), Eu-a (n = 7), B1-c (n = 4), B1-b (n = 2) and Af2 (n = 1). MY sequences clustered within a branch of Native American origin that diverged from its Asian counterpart about 21,914 years ago (HPD 95% interval 15,383-30,177), followed by a sustained demographic expansion around 5000 years ago.
    Conclusions: JCV in Misiones reflects the multiethnic origin of the current population, with an important Amerindian contribution. Analysis of the MY viral lineage shows a pattern consistent with the arrival of early human migrations to the Americas and a population expansion by the pre-Columbian native societies.
    MeSH term(s) Humans ; JC Virus/genetics ; Biological Evolution ; Population Dynamics ; Human Migration ; Americas/epidemiology ; DNA, Viral/genetics
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2023.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evolutionary analysis of JC polyomavirus in misiones’ population yields insight into the population dynamics of the early human dispersal in the Americas

    Pereson, Matias J. / Sanabria, Daiana J. / Torres, Carolina / Liotta, Domingo J. / Campos, Rodolfo H. / Schurr, Theodore G. / Di Lello, Federico A. / Badano, Inés

    Virology. 2023 June 05,

    2023  

    Abstract: JC polyomavirus (JCV) has an ethno-geographical distribution across human populations. Study the origins of the population of Misiones (Argentina) by using JCV as genetic marker. Viral detection and characterization was conducted by PCR amplification and ...

    Abstract JC polyomavirus (JCV) has an ethno-geographical distribution across human populations. Study the origins of the population of Misiones (Argentina) by using JCV as genetic marker. Viral detection and characterization was conducted by PCR amplification and evolutionary analysis of the intergenic region sequences. 22 out of 121 samples were positive for JCV, including 5 viral lineages: MY (n = 8), Eu-a (n = 7), B1-c (n = 4), B1-b (n = 2) and Af2 (n = 1). MY sequences clustered within a branch of Native American origin that diverged from its Asian counterpart about 21,914 years ago (HPD 95% interval 15,383–30,177), followed by a sustained demographic expansion around 5000 years ago. JCV in Misiones reflects the multiethnic origin of the current population, with an important Amerindian contribution. Analysis of the MY viral lineage shows a pattern consistent with the arrival of early human migrations to the Americas and a population expansion by the pre-Columbian native societies.
    Keywords Polyomaviridae ; genetic markers ; humans ; intergenic DNA ; nationalities and ethnic groups ; population growth ; virology ; Argentina ; Virus ; Phylogeny ; Migration ; Amerindian ; Ancestry
    Language English
    Dates of publication 2023-0605
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2023.05.009
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: TNF-α Levels in Respiratory Samples Are Associated with SARS-CoV-2 Infection.

    Pereson, Matias J / Badano, Maria Noel / Aloisi, Natalia / Chuit, Roberto / E de Bracco, M M / Bare, Patricia

    Microbiology spectrum

    2022  Volume 10, Issue 1, Page(s) e0141121

    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/immunology ; Child ; Female ; Genome, Viral ; Humans ; Interleukin-6/analysis ; Male ; Middle Aged ; Respiratory System/chemistry ; Respiratory System/virology ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Tumor Necrosis Factor-alpha/analysis ; Young Adult
    Chemical Substances Interleukin-6 ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01411-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies.

    Badano, María Noel / Pereson, Matias J / Sabbione, Florencia / Keitelman, Irene / Aloisi, Natalia / Chuit, Roberto / de Bracco, María M E / Fink, Susana / Baré, Patricia

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: SARS-CoV-2 breakthrough infections, associated with waning immunity, increase systemic antibody levels. In this study, we analyzed the impact of the infection timing on the magnitude of the systemic humoral response and whether breakthrough infections ... ...

    Abstract SARS-CoV-2 breakthrough infections, associated with waning immunity, increase systemic antibody levels. In this study, we analyzed the impact of the infection timing on the magnitude of the systemic humoral response and whether breakthrough infections also boost antibody levels in the salivary compartment. We observed that the combination of infection plus vaccination, regardless of infection timing, produced a sharp increase in systemic antibodies, which were higher in subjects infected after third doses. Moreover, despite high systemic antibody levels, breakthrough infections after dose three occurred and boosted antibody levels in the salivary compartment. These results suggest that current vaccination strategies against COVID-19 should be improved. Results also showed that determination of salivary antibodies against SARS-CoV-2 could be a valuable tool in disease prevalence studies, for the follow-up of vaccinated individuals, and to assist vaccination strategies against COVID-19, especially in settings where blood sampling cannot be fulfilled.
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evolutionary analysis of SARS-CoV-2 spike protein for its different clades.

    Pereson, Matías J / Flichman, Diego M / Martínez, Alfredo P / Baré, Patricia / Garcia, Gabriel H / Di Lello, Federico A

    Journal of medical virology

    2021  Volume 93, Issue 5, Page(s) 3000–3006

    Abstract: The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become the main target for antiviral and vaccine development. Despite its relevance, e information is scarse about its evolutionary traces. The aim of this study was to ...

    Abstract The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become the main target for antiviral and vaccine development. Despite its relevance, e information is scarse about its evolutionary traces. The aim of this study was to investigate the diversification patterns of the spike for each clade of SARS-CoV-2 through different approaches. Two thousand and one hundred sequences representing the seven clades of the SARS-CoV-2 were included. Patterns of genetic diversifications and nucleotide evolutionary rate were estimated for the spike genomic region. The haplotype networks showed a star shape, where multiple haplotypes with few nucleotide differences diverge from a common ancestor. Four hundred seventy-nine different haplotypes were defined in the seven analyzed clades. The main haplotype, named Hap-1, was the most frequent for clades G (54%), GH (54%), and GR (56%) and a different haplotype (named Hap-252) was the most important for clades L (63.3%), O (39.7%), S (51.7%), and V (70%). The evolutionary rate for the spike protein was estimated as 1.08 × 10
    MeSH term(s) COVID-19/virology ; Evolution, Molecular ; Genome, Viral ; Humans ; Pandemics ; Phylogeny ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/classification ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Heterologous Gam-COVID-Vac (Sputnik V)/mRNA-1273 (Moderna) vaccination: Author's response.

    Pereson, Matías J / Neukam, Karin / Amaya, Lucas / Bare, Patricia / Echegoyen, Natalia / Badano, María Noel / Lucero, Alicia / Martelli, Antonella / Garcia, Gabriel H / Videla, Cristina / Martínez, Alfredo P / Di Lello, Federico A

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2022  Volume 28, Issue 11, Page(s) 1514–1515

    MeSH term(s) Humans ; 2019-nCoV Vaccine mRNA-1273 ; COVID-19/prevention & control ; Vaccination
    Chemical Substances 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4)
    Language English
    Publishing date 2022-06-17
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2022.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Heterologous gam-COVID-vac (sputnik V)/mRNA-1273 (moderna) vaccination induces a stronger humoral response than homologous sputnik V in a real-world data analysis.

    Pereson, Matías J / Amaya, Lucas / Neukam, Karin / Baré, Patricia / Echegoyen, Natalia / Badano, María Noel / Lucero, Alicia / Martelli, Antonella / Garcia, Gabriel H / Videla, Cristina / Martínez, Alfredo P / Di Lello, Federico A

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2022  Volume 28, Issue 10, Page(s) 1382–1388

    Abstract: Objectives: To compare the homologous prime-boost vaccination scheme of Gam-COVID-Vac (Sputnik V (SpV)) to its heterologous combination with mRNA-1273 (Moderna (Mod)) vaccine.: Methods: SARS-CoV-2 anti-spike (S)-receptor binding domain (RBD) IgG ... ...

    Abstract Objectives: To compare the homologous prime-boost vaccination scheme of Gam-COVID-Vac (Sputnik V (SpV)) to its heterologous combination with mRNA-1273 (Moderna (Mod)) vaccine.
    Methods: SARS-CoV-2 anti-spike (S)-receptor binding domain (RBD) IgG concentration was assessed three to seven weeks after complete vaccination. Reactogenicity was evaluated by declared side events and medical assistance required until day 7 post boost.
    Results: Of 190 participants enrolled, 105 received homologous SpV/SpV and the remaining heterologous SpV/Mod vaccination scheme, respectively. Median (interquartile range (IQR)) age was 54 (37-63) years, 132 out of 190 (69.5%) were female, and 46 out of 190 (24.2%) individuals had a prior confirmed COVID-19. Anti-S-RBD IgG median (IQR) titers were significantly higher for SpV/Mod (2511 (1476-3992) binding antibody units (BAU)/mL) than for SpV/SpV (582 (209-1609) BAU/mL; p < 0.001] vaccination scheme. In a linear model adjusted for age, gender, time to the serological assay, and time between doses, SpV/Mod (4.154 (6.585-615.554); p < 0.001] and prior COVID (3.732 (8.641-202.010); p < 0.001) were independently associated with higher anti-S-RBD IgG values. A higher frequency of mild and moderate adverse effects was associated with the heterologous scheme (20 of 85 (23.5%) vs. 13 of 105 (12.4%); p = 0.043 and 27 of 85 (31.8%) vs. 14 of 105 (13.3%); p = 0.002), respectively, although it was well tolerated by all individuals and no medical assistance was required.
    Discussion: The heterologous SpV/Mod combination against SARS-CoV-2 is well tolerated and significantly increases humoral immune response as compared to the homologous SpV/SpV immunization.
    MeSH term(s) 2019-nCoV Vaccine mRNA-1273/adverse effects ; Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Data Analysis ; Female ; Humans ; Immunoglobulin G ; Male ; Middle Aged ; SARS-CoV-2/genetics
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Immunoglobulin G ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4)
    Language English
    Publishing date 2022-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2022.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies

    María Noel Badano / Matias J. Pereson / Florencia Sabbione / Irene Keitelman / Natalia Aloisi / Roberto Chuit / María M. E. de Bracco / Susana Fink / Patricia Baré

    Vaccines, Vol 11, Iss 534, p

    2023  Volume 534

    Abstract: SARS-CoV-2 breakthrough infections, associated with waning immunity, increase systemic antibody levels. In this study, we analyzed the impact of the infection timing on the magnitude of the systemic humoral response and whether breakthrough infections ... ...

    Abstract SARS-CoV-2 breakthrough infections, associated with waning immunity, increase systemic antibody levels. In this study, we analyzed the impact of the infection timing on the magnitude of the systemic humoral response and whether breakthrough infections also boost antibody levels in the salivary compartment. We observed that the combination of infection plus vaccination, regardless of infection timing, produced a sharp increase in systemic antibodies, which were higher in subjects infected after third doses. Moreover, despite high systemic antibody levels, breakthrough infections after dose three occurred and boosted antibody levels in the salivary compartment. These results suggest that current vaccination strategies against COVID-19 should be improved. Results also showed that determination of salivary antibodies against SARS-CoV-2 could be a valuable tool in disease prevalence studies, for the follow-up of vaccinated individuals, and to assist vaccination strategies against COVID-19, especially in settings where blood sampling cannot be fulfilled.
    Keywords SARS-CoV-2 breakthrough infections ; vaccines ; anti-spike antibody levels ; humoral response ; IgG specific salivary antibodies ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Seroprevalence of hepatitis B, hepatitis C and HIV infection among patients undergoing haemodialysis in Buenos Aires, Argentina.

    Pereson, Matías J / Martínez, Alfredo P / Isaac, Katia / Laham, Gustavo / Ridruejo, Ezequiel / Garcia, Gabriel H / Flichman, Diego M / Di Lello, Federico A

    Journal of medical microbiology

    2020  Volume 70, Issue 1

    Abstract: Introduction. ...

    Abstract Introduction.
    MeSH term(s) Adult ; Aged ; Antibodies, Viral/blood ; Argentina/epidemiology ; Cross-Sectional Studies ; Epidemiological Monitoring ; Female ; HIV Infections/blood ; HIV Infections/epidemiology ; HIV Infections/virology ; HIV-1/classification ; HIV-1/genetics ; HIV-1/immunology ; HIV-1/isolation & purification ; Hepacivirus/classification ; Hepacivirus/genetics ; Hepacivirus/immunology ; Hepacivirus/isolation & purification ; Hepatitis B/blood ; Hepatitis B/epidemiology ; Hepatitis B/virology ; Hepatitis B virus/classification ; Hepatitis B virus/genetics ; Hepatitis B virus/immunology ; Hepatitis B virus/isolation & purification ; Hepatitis C/blood ; Hepatitis C/epidemiology ; Hepatitis C/virology ; Humans ; Male ; Middle Aged ; Phylogeny ; Renal Dialysis/adverse effects ; Retrospective Studies ; Seroepidemiologic Studies
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2020-11-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Phylogenetic analysis of SARS-CoV-2 in the first few months since its emergence.

    Pereson, Matías J / Mojsiejczuk, Laura / Martínez, Alfredo P / Flichman, Diego M / Garcia, Gabriel H / Di Lello, Federico A

    Journal of medical virology

    2020  Volume 93, Issue 3, Page(s) 1722–1731

    Abstract: During the first few months of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution in a new host, contrasting hypotheses have been proposed about the way the virus has evolved and diversified worldwide. The aim of this study was to ... ...

    Abstract During the first few months of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution in a new host, contrasting hypotheses have been proposed about the way the virus has evolved and diversified worldwide. The aim of this study was to perform a comprehensive evolutionary analysis to describe the human outbreak and the evolutionary rate of different genomic regions of SARS-CoV-2. The molecular evolution in nine genomic regions of SARS-CoV-2 was analyzed using three different approaches: phylogenetic signal assessment, emergence of amino acid substitutions, and Bayesian evolutionary rate estimation in eight successive fortnights since the virus emergence. All observed phylogenetic signals were very low and tree topologies were in agreement with those signals. However, after 4 months of evolution, it was possible to identify regions revealing an incipient viral lineage formation, despite the low phylogenetic signal since fortnight 3. Finally, the SARS-CoV-2 evolutionary rate for regions nsp3 and S, the ones presenting greater variability, was estimated as 1.37 × 10
    MeSH term(s) Amino Acid Substitution/genetics ; Animals ; Biological Evolution ; COVID-19/pathology ; Chiroptera/virology ; Coronavirus Papain-Like Proteases/genetics ; Evolution, Molecular ; Genome, Viral/genetics ; Humans ; Phylogeny ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Coronavirus Papain-Like Proteases (EC 3.4.22.2) ; papain-like protease, SARS-CoV-2 (EC 3.4.22.2)
    Keywords covid19
    Language English
    Publishing date 2020-10-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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