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  1. Article ; Online: Rural-Urban Differences in HIV Sexual Risk Behaviors and HIV Service Utilization Among Adolescent Sexual Minority Males in the United States.

    Owens, Christopher / Hurtado, Manuel / Moskowitz, David A / Mustanski, Brian / Macapagal, Kathryn

    Archives of sexual behavior

    2024  

    Abstract: In the United States, HIV prevalence is increasing in rural areas, specifically among rural adolescent sexual minority males (ASMM). However, it is unclear what HIV sexual risk behaviors rural ASMM engage in and what HIV preventative services they ... ...

    Abstract In the United States, HIV prevalence is increasing in rural areas, specifically among rural adolescent sexual minority males (ASMM). However, it is unclear what HIV sexual risk behaviors rural ASMM engage in and what HIV preventative services they utilize. This study aimed to (1) document the lifetime HIV sexual risk behaviors and service utilization of rural ASMM and (2) compare rural-urban differences in the prevalence of HIV sexual risk behaviors and service utilization. We analyzed data collected from 1615 ASMM who participated in a baseline survey for an online HIV prevention program from April 2018 to June 2020. We compared the prevalence of lifetime HIV sexual risk behaviors and HIV healthcare utilization among rural and urban participants via descriptive statistics, chi-square tests, linear and logistic regressions, and zero-inflated Poisson regressions. These analyses indicated that rural ASMM were more likely than urban ASMM to engage in condomless sex when they had anal sex. Rural ASMM could benefit from offline and online evidence-based HIV prevention interventions, especially interventions that increase condom use.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184221-3
    ISSN 1573-2800 ; 0004-0002
    ISSN (online) 1573-2800
    ISSN 0004-0002
    DOI 10.1007/s10508-024-02840-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cigarette Use and Vaping Among Sexual and Gender Minority (SGM) Adolescents Assigned Male at Birth: Patterns of Use and Associations with Demographic and Psychosocial Factors.

    Kraus, Ashley / Moskowitz, David A / Ma, Junye / Macapagal, Kathryn

    International journal of behavioral medicine

    2022  Volume 29, Issue 5, Page(s) 685–690

    Abstract: Background: This study described cigarette and electronic nicotine delivery systems (ENDs) use and their demographic and psychosocial correlates in a sample of sexual and gender minority (SGM) adolescents assigned male at birth.: Methods: One-way ... ...

    Abstract Background: This study described cigarette and electronic nicotine delivery systems (ENDs) use and their demographic and psychosocial correlates in a sample of sexual and gender minority (SGM) adolescents assigned male at birth.
    Methods: One-way ANOVA, multivariate linear regression, and correlation analyses were conducted to examine correlates of cigarettes/ENDs use on 159 SGM adolescent users, ages 15-18.
    Results: Fifty-three percent of the sample used cigarettes/ENDs, with differences based on sexual orientation: bisexual, pansexual, and queer adolescents used ENDs more than gay adolescents. White adolescents smoked more cigarettes than adolescents of color, independent of ENDs use. Regarding psychosocial correlates, alcohol use and depression were associated with greater daily cigarette use, while sexual orientation identity was associated with greater daily ENDs use.
    Conclusions: This study characterized frequency and psychosocial correlates of cigarettes/ENDs use among SGM adolescents. Findings highlighted several risk factors for tobacco use and will inform future interventions for SGM adolescents.
    MeSH term(s) Adolescent ; Demography ; Female ; Humans ; Infant, Newborn ; Male ; Sexual Behavior/psychology ; Sexual and Gender Minorities ; Tobacco Products ; Vaping/epidemiology
    Language English
    Publishing date 2022-02-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1187972-5
    ISSN 1532-7558 ; 1070-5503
    ISSN (online) 1532-7558
    ISSN 1070-5503
    DOI 10.1007/s12529-021-10037-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Top, Bottom, and Versatile Anal Sex Roles in Same-Sex Male Relationships: Implications for Relationship and Sexual Satisfaction.

    Moskowitz, David A / Garcia, Christopher P

    Archives of sexual behavior

    2018  Volume 48, Issue 4, Page(s) 1217–1225

    Abstract: Across much of the gay and bisexual male research on sexual position self-label (i.e., calling oneself a top, bottom, or versatile), there exist two commonalities: (1) studies tend to focus almost entirely on individual, relationally single androphilic ... ...

    Abstract Across much of the gay and bisexual male research on sexual position self-label (i.e., calling oneself a top, bottom, or versatile), there exist two commonalities: (1) studies tend to focus almost entirely on individual, relationally single androphilic men; (2) studies rarely account for relationships and relationship dynamics. In response, we explored the role of self-label over sexual and relationship satisfaction among gay and bisexual partnered men. Specifically, we looked at whether adopted sexual position identities were consonant or dissonant (i.e., matching or mismatching) with enacted behavior in relationships and how that impacted men's attitudes toward different relational attributes. Through an online survey, we sampled 169 men in same-sex relationships, asking them questions about their ideal penetrative role identities and their reality penetrative roles with their partner. We then asked them to rate their relationship on 10 sexual and interpersonal attributes. Multiple regression modeling suggested ideal-reality penetrative role dissonance was predictive of sexual dissatisfaction among tops who bottomed in their relationships and, to a lesser extent, bottoms who topped. In contrast, penetrative role dissonance was predictive of relationship satisfaction among tops who bottomed in their relationship, but not bottoms who topped. We conclude that a potential reason for this paradox among tops who bottom may be sexual altruism. That is, men may be satisfied with other aspects within their relationships, understand their partner's anal sex preferences, and accommodate that position in response to their initial relationship satisfaction.
    MeSH term(s) Adult ; Homosexuality, Male/statistics & numerical data ; Humans ; Male ; Orgasm ; Sexual Behavior/psychology ; Sexual Partners/psychology
    Language English
    Publishing date 2018-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184221-3
    ISSN 1573-2800 ; 0004-0002
    ISSN (online) 1573-2800
    ISSN 0004-0002
    DOI 10.1007/s10508-018-1240-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Perspectives on Cigarette Use, Vaping, and Antitobacco Campaigns Among Adolescent Sexual Minority Males and Gender Diverse Youth.

    Ma, Junye / Kraus, Ashley J / Owens, Christopher / Moskowitz, David A / Birnholtz, Jeremy / Macapagal, Kathryn

    LGBT health

    2022  Volume 9, Issue 7, Page(s) 479–488

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Adolescent ; Ethnicity ; Humans ; Male ; Minority Groups ; Nicotine ; Sexual and Gender Minorities ; Tobacco Products ; Vaping
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2727303-9
    ISSN 2325-8306 ; 2325-8292
    ISSN (online) 2325-8306
    ISSN 2325-8292
    DOI 10.1089/lgbt.2021.0460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Migraine research comes of age in the 21st century.

    Moskowitz, Michael A / Dodick, David W / Scher, Ann I / van den Maagdenberg, Arn M J M

    The Lancet. Neurology

    2022  Volume 21, Issue 11, Page(s) 955–958

    MeSH term(s) Humans ; History, 21st Century ; History, 20th Century ; Migraine Disorders/therapy ; Migraine Disorders/history
    Language English
    Publishing date 2022-10-18
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(22)00398-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Immunochemotherapy plus lenalidomide for high-risk mantle cell lymphoma with measurable residual disease evaluation.

    Epstein-Peterson, Zachary D / Drill, Esther / Aypar, Umut / Batlevi, Connie Lee / Caron, Philip / Dogan, Ahmet / Drullinsky, Pamela / Gerecitano, John / Hamlin, Paul A / Ho, Caleb / Jacob, Allison / Joseph, Ashlee / Laraque, Leana / Matasar, Matthew J / Moskowitz, Alison J / Moskowitz, Craig H / Mullins, Chelsea / Owens, Colette / Salles, Gilles /
    Schöder, Heiko / Straus, David J / Younes, Anas / Zelenetz, Andrew D / Kumar, Anita

    Haematologica

    2024  Volume 109, Issue 4, Page(s) 1149–1162

    Abstract: Chemoimmunotherapy followed by consolidative high-dose therapy with autologous stem cell rescue was a standard upfront treatment for fit patients with mantle cell lymphoma (MCL) in first remission; however, treatment paradigms are evolving in the era of ... ...

    Abstract Chemoimmunotherapy followed by consolidative high-dose therapy with autologous stem cell rescue was a standard upfront treatment for fit patients with mantle cell lymphoma (MCL) in first remission; however, treatment paradigms are evolving in the era of novel therapies. Lenalidomide is an immunomodulatory agent with known efficacy in treating MCL. We conducted a single-center, investigator-initiated, phase II study of immunochemotherapy incorporating lenalidomide, without autologous stem cell transplant consolidation, enriching for patients with high-risk MCL (clinicaltrials gov. Identifier: NCT02633137). Patients received four cycles of lenalidomide-R-CHOP, two cycles of R-HiDAC, and six cycles of R-lenalidomide. The primary endpoint was rate of 3-year progression-free survival. We measured measurable residual disease (MRD) using a next-generation sequencing-based assay after each phase of treatment and at 6 months following end-oftreatment. We enrolled 49 patients of which 47 were response evaluable. By intent-to-treat, rates of overall and complete response were equivalent at 88% (43/49), one patient with stable disease, and two patients had disease progression during study; 3-year progression-free survival was 63% (primary endpoint not met) and differed by TP53 status (78% wild-type vs. 38% ALT; P=0.043). MRD status was prognostic and predicted long-term outcomes following R-HiDAC and at 6 months following end-of-treatment. In a high-dose therapy-sparing, intensive approach, we achieved favorable outcomes in TP53- wild-type MCL, including high-risk cases. We confirmed that sequential MRD assessment is a powerful prognostic tool in patients with MCL.
    MeSH term(s) Adult ; Humans ; Lenalidomide/therapeutic use ; Lymphoma, Mantle-Cell/diagnosis ; Lymphoma, Mantle-Cell/drug therapy ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Prognosis ; Immunotherapy
    Chemical Substances Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2024-04-01
    Publishing country Italy
    Document type Clinical Trial, Phase II ; Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.282898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Recognition and Construction of Top, Bottom, and Versatile Orientations in Gay/Bisexual Men.

    Moskowitz, David A / Roloff, Michael E

    Archives of sexual behavior

    2017  Volume 46, Issue 1, Page(s) 273–285

    Abstract: Research on gay and bisexual men's sexual position self-label (i.e., being a top, bottom, or versatile during anal sex) has revealed only independent snapshots of its development by focusing primarily on the influence of penis size. Moreover, the basic ... ...

    Abstract Research on gay and bisexual men's sexual position self-label (i.e., being a top, bottom, or versatile during anal sex) has revealed only independent snapshots of its development by focusing primarily on the influence of penis size. Moreover, the basic chronology of development of the sexual position self-label has barely been addressed. In response, we implemented a survey of 282 gay and bisexual men that measured demographics (including height and penis size), age of sexual recognitions, sexual position self-label, and attitudinal constructs suggested by previous literature as important (e.g., pleasure, control, anxieties, and gender typicality). Results suggested that men's sexual position self-label was learned over a 15-year timespan. Ages of first same-sex genital manipulation and first anal sex experiences were related to age at first self-labeling. With respect to predictors of labels, a multivariate path model was created. The model did not support the direct importance of penis size, but identified indirect paths that linked penis size to top/bottom identification (e.g., smaller penis sizes leading to topping-anxieties and thus, a bottom label). Finding bottoming to be pleasurable and the importance of sexual control dynamics were the only two direct predictors. The path model substantiated the reliance both bottoms and tops show towards seeking (or not seeking among tops) gender typical, sexually dominant partners. It also supported previous evidence regarding race; specifically, while race may activate differences in sexual behavioral dynamics, it is not a great predictor of the sexual position self-label. This study shows that sexual position self-labeling has enormous complexity and cannot be reduced down to penis size.
    MeSH term(s) Adult ; Bisexuality/statistics & numerical data ; Cross-Sectional Studies ; Homosexuality, Male/statistics & numerical data ; Humans ; Male ; Middle Aged ; Sexual Behavior/statistics & numerical data ; Surveys and Questionnaires
    Language English
    Publishing date 2017-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184221-3
    ISSN 1573-2800 ; 0004-0002
    ISSN (online) 1573-2800
    ISSN 0004-0002
    DOI 10.1007/s10508-016-0810-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Matched control analysis suggests R-CHOP followed by (R)-ICE may improve outcome in non-GCB DLBCL compared to R-CHOP.

    Bantilan, Kurt S / Smith, Alexandra N / Maurer, Matthew John / Teruya-Feldstein, Julie / Matasar, Matthew J / Moskowitz, Alison J / Straus, David J / Noy, Ariela / Palomba, M Lia / Horwitz, Steven M / Hamlin, Paul A / Portlock, Carol S / Cerhan, James R / Habermann, Thomas M / Salles, Gilles A / Nowakowski, Grzegorz S / Moskowitz, Craig H / Zelenetz, Andrew D

    Blood advances

    2024  

    Abstract: Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is considered the standard-of-care for patients with advanced-stage diffuse large B-cell lymphoma (DLBCL), despite findings that non-germinal center B-cell-like (non-GCB) ... ...

    Abstract Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is considered the standard-of-care for patients with advanced-stage diffuse large B-cell lymphoma (DLBCL), despite findings that non-germinal center B-cell-like (non-GCB) patients have significantly worse outcome with this regimen. We evaluated the prognostic significance of baseline risk factors, including cell of origin (COO) classified by the Hans algorithm, within an alternative chemoimmunotherapy program. At Memorial Sloan Kettering Cancer Center (MSK), 151 patients with DLBCL received sequential R-CHOP induction and (R)-ICE (rituximab, ifosfamide, carboplatin, and etoposide) consolidation. Outcome analysis based on COO was validated with a propensity score matched cohort treated with R-CHOP from the Mayo Clinic component of the Molecular Epidemiology Resource (MER). Among the GCB (n=69) and non-GCB (n=69) patients at MSK, event-free survival (EFS) of non-GCB was superior to that of GCB (HR 0.53, 95% CI 0.29-0.98). Overall survival (OS) demonstrated an association in the same direction but was not statistically significant (HR 0.68, 95% CI 0.33-1.42). Propensity score matched patients from MSK (n=108) demonstrated a small attenuation in the HRs for EFS (HR 0.57, 95% CI 0.27-1.18) and OS (HR 0.76, 95% CI 0.33-1.79) and were no longer statistically significant. In contrast, the matched MER cohort (n=108) demonstrated an EFS association (HR 1.17, 95% CI 0.70-1.95) and OS association (HR 1.13, 95% CI 0.64-2.00) in the opposite direction, but were also not statistically significant. R-CHOP induction and (R)-ICE consolidation may overcome the negative prognostic impact of the non-GCB phenotype, per the Hans algorithm, and can be preferentially selected for this population.
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023011408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Exploring anal self-examination as a screening tool for women at risk for anal cancer: awareness, interest, and barriers to behavioral uptake.

    Moskowitz, David A / Rahman, Musarrat / Li, Dennis H

    Cancer causes & control : CCC

    2019  Volume 30, Issue 6, Page(s) 559–568

    Abstract: Purpose: Anal cancer is the second most common human-papillomavirus-related cancer in women, with women also at an elevated risk of incidence relative to men. Anal self-examination (ASE) is an efficient way for women to screen between provider visits ... ...

    Abstract Purpose: Anal cancer is the second most common human-papillomavirus-related cancer in women, with women also at an elevated risk of incidence relative to men. Anal self-examination (ASE) is an efficient way for women to screen between provider visits for potential anal masses. While studied in male populations, no research has explored women's awareness of the self-test.
    Methods: In response, 345 women recruited from online advertisements and listservs were surveyed to assess their experiences using health care, history of Pap smears, knowledge of anal cancer, awareness and attitudes surrounding ASEs, and potential educational modalities to promote ASE enactment.
    Results: Results indicated the sample failed two key anal cancer knowledge tests (receiving a 68%/100% for risk factors and 61%/100% for signs/symptoms), and only 2.3% of participants had ever heard of ASEs before the survey. Most thought ASEs would be somewhat helpful as a screening tool, but little interest was shown towards future performance. Analyses revealed this disinterest was due to lack of knowledge, perceived discomfort with performing ASEs, and perceived irrelevance of ASEs.
    Conclusions: Future interventions should push for a stronger role of providers (e.g., gynecologists) in anal health, education, and screening. Additionally, campaigns should be crafted to promote the ASE as an easy, at-home screening tool that could trigger an early warning for anal disease.
    MeSH term(s) Adolescent ; Adult ; Aged ; Anus Neoplasms/diagnosis ; Early Detection of Cancer/methods ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Mass Screening/methods ; Middle Aged ; Papanicolaou Test/methods ; Papillomaviridae/isolation & purification ; Self-Examination/methods ; Surveys and Questionnaires ; Vaginal Smears ; Young Adult
    Language English
    Publishing date 2019-04-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1064022-8
    ISSN 1573-7225 ; 0957-5243
    ISSN (online) 1573-7225
    ISSN 0957-5243
    DOI 10.1007/s10552-019-01175-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: CD38 is associated with communal behavior, partner perceptions, affect and relationship adjustment in romantic relationships.

    Sadikaj, Gentiana / Moskowitz, D S / Zuroff, David C / Bartz, Jennifer A

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 12926

    Abstract: Given the significance of close relationships for human survival, it is thought that biological mechanisms evolved to support their initiation and maintenance. The neuropeptide oxytocin is one such candidate identified in non-human animal research. We ... ...

    Abstract Given the significance of close relationships for human survival, it is thought that biological mechanisms evolved to support their initiation and maintenance. The neuropeptide oxytocin is one such candidate identified in non-human animal research. We investigated whether variation in CD38, a gene involved in oxytocin secretion and attachment behavior in rodents, predicts romantic relationship dynamics in daily life. Community couples participated in an event-contingent recording (ECR) study in which they reported their social behavior, perception of their partner's behavior, and affect during their interactions with one another over a 20-day period; couples also completed various measures of relationship adjustment. Out of the 111 couples (N = 222 individuals) who provided either ECR and/or relationship adjustment information, we had information on CD38 for 118 individuals. As hypothesized, variation in rs3796863, a single nucleotide polymorphism (SNP) identified in prior work, predicted communal behaviors (e.g., the expression of affection), as well as overall relationship adjustment, such that individuals with the CC (vs. AC/AA) allele reported higher levels of communal behavior across their daily interactions with their romantic partner, as well as higher levels of relationship adjustment. Individuals with the CC (vs. AC/AA) allele of rs3796863 also reported less negative affect and felt insecurity in their interactions with their romantic partner. Notably, we found that variation in the romantic partner's rs3796863 SNP was related to the person's outcomes, independent of the person's rs3796863 genotype. These findings support the role of oxytocin in the interpersonal processes implicated in the maintenance of close relationships.
    MeSH term(s) ADP-ribosyl Cyclase 1/genetics ; ADP-ribosyl Cyclase 1/metabolism ; Emotional Adjustment ; Female ; Genetic Association Studies ; Humans ; Interpersonal Relations ; Love ; Male ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Oxytocin/metabolism ; Polymorphism, Single Nucleotide ; Sexual Partners/psychology
    Chemical Substances Membrane Glycoproteins ; Oxytocin (50-56-6) ; CD38 protein, human (EC 3.2.2.5) ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6)
    Language English
    Publishing date 2020-08-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-69520-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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