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  1. Article: Thoracic duct disruption without lymphangiographic thoracic duct visualization for refractory chylothorax: A case report.

    Hirano, Takaki / Yamamoto, Masayoshi / Kondo, Hiroshi / Oba, Hiroshi

    Radiology case reports

    2023  Volume 19, Issue 1, Page(s) 242–245

    Abstract: Percutaneous treatments, including thoracic duct embolization (TDE) and thoracic duct disruption (TDD), are reportedly effective and safe alternatives to surgical thoracic duct ligation for refractory chylothorax. When catheterization of the thoracic ... ...

    Abstract Percutaneous treatments, including thoracic duct embolization (TDE) and thoracic duct disruption (TDD), are reportedly effective and safe alternatives to surgical thoracic duct ligation for refractory chylothorax. When catheterization of the thoracic duct is impossible, TDD can be performed as long as the thoracic duct can be opacified by lymphangiography. However, no report has described percutaneous treatment when the thoracic duct cannot be visualized. In this case, TDE was not feasible because intranodal lymphangiography failed to opacify the thoracic duct: cannulation was not achieved. Therefore, we aimed to disrupt the thoracic duct by puncturing the retrocrural area where it was anatomically suspected to be located. Chylothorax improved thereafter. In cases without lymphangiographic thoracic duct visualization, TDD by puncturing the retrocrural space might improve refractory chylothorax.
    Language English
    Publishing date 2023-11-02
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2023.09.097
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  2. Article ; Online: REBOA Zone Estimation from the Body Surface Using Semantic Segmentation.

    Takata, Takeshi / Yamada, Kentaro / Yamamoto, Masayoshi / Kondo, Hiroshi

    Journal of medical systems

    2023  Volume 47, Issue 1, Page(s) 42

    Abstract: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an endovascular procedure for hemorrhage control. In REBOA, the balloon must be placed in the precise place, but it may be performed without X-ray fluoroscopy. This study aimed to ... ...

    Abstract Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an endovascular procedure for hemorrhage control. In REBOA, the balloon must be placed in the precise place, but it may be performed without X-ray fluoroscopy. This study aimed to estimate the REBOA zones from the body surface using deep learning for safe balloon placement. A total of 198 abdominal computed tomography (CT) datasets containing the regions of the REBOA zones were collected from open data libraries. Then, depth images of the body surface generated from the CT datasets and the images corresponding to the zones were labeled for deep learning training and validation. DeepLabV3+, a deep learning semantic segmentation model, was employed to estimate the zones. We used 176 depth images as training data and 22 images as validation data. A nine-fold cross-validation was performed to generalize the performance of the network. The median Dice coefficients for Zones 1-3 were 0.94 (inter-quarter range: 0.90-0.96), 0.77 (0.60-0.86), and 0.83 (0.74-0.89), respectively. The median displacements of the zone boundaries were 11.34 mm (5.90-19.45), 11.40 mm (4.88-20.23), and 14.17 mm (6.89-23.70) for the boundary between Zones 1 and 2, between Zones 2 and 3, and between Zone 3 and out of zone, respectively. This study examined the feasibility of REBOA zone estimation from the body surface only using deep learning-based segmentation without aortography.
    MeSH term(s) Humans ; Semantics ; Aorta ; Hemorrhage ; Abdomen ; Balloon Occlusion/methods
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423488-1
    ISSN 1573-689X ; 0148-5598
    ISSN (online) 1573-689X
    ISSN 0148-5598
    DOI 10.1007/s10916-023-01938-z
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  3. Article ; Online: Endotheliopathy of liver sinusoidal endothelial cells in liver disease.

    Kondo, Reiichiro / Iwakiri, Yasuko / Kage, Masayoshi / Yano, Hirohisa

    Pathology international

    2023  Volume 73, Issue 9, Page(s) 381–393

    Abstract: Liver is the largest solid organ in the abdominal cavity, with sinusoid occupying about half of its volume. Under liver disease, hemodynamics in the liver tissue dynamically change, resulting in injury to liver sinusoidal endothelial cells (LSECs). We ... ...

    Abstract Liver is the largest solid organ in the abdominal cavity, with sinusoid occupying about half of its volume. Under liver disease, hemodynamics in the liver tissue dynamically change, resulting in injury to liver sinusoidal endothelial cells (LSECs). We discuss the injury of LSECs in liver diseases in this article. Generally, in noninflamed tissues, vascular endothelial cells maintain quiescence of circulating leukocytes, and unnecessary blood clotting is inhibited by multiple antithrombotic factors produced by the endothelial cells. In the setting of inflammation, injured endothelial cells lose these functions, defined as inflammatory endotheliopathy. In chronic hepatitis C, inflammatory endotheliopathy in LSECs contributes to platelet accumulation in the liver tissue, and the improvement of thrombocytopenia by splenectomy is attenuated in cases with severe hepatic inflammation. In COVID-19, LSEC endotheliopathy induced by interleukin (IL)-6 trans-signaling promotes neutrophil accumulation and platelet microthrombosis in the liver sinusoids, resulting in liver injury. IL-6 trans-signaling promotes the expression of intercellular adhesion molecule-1, chemokine (C-X-C motif) ligand (CXCL1), and CXCL2, which are the neutrophil chemotactic mediators, and P-selectin, E-selectin, and von Willebrand factor, which are involved in platelet adhesion to endothelial cells, in LSECs. Restoring LSECs function is important for ameliorating liver injury. Prevention of endotheliopathy is a potential therapeutic strategy in liver disease.
    MeSH term(s) Humans ; Endothelial Cells ; COVID-19 ; Liver Diseases ; Hepatic Veins
    Language English
    Publishing date 2023-08-17
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1194850-4
    ISSN 1440-1827 ; 1320-5463
    ISSN (online) 1440-1827
    ISSN 1320-5463
    DOI 10.1111/pin.13361
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  4. Book ; Online: On the Audio Hallucinations in Large Audio-Video Language Models

    Nishimura, Taichi / Nakada, Shota / Kondo, Masayoshi

    2024  

    Abstract: Large audio-video language models can generate descriptions for both video and audio. However, they sometimes ignore audio content, producing audio descriptions solely reliant on visual information. This paper refers to this as audio hallucinations and ... ...

    Abstract Large audio-video language models can generate descriptions for both video and audio. However, they sometimes ignore audio content, producing audio descriptions solely reliant on visual information. This paper refers to this as audio hallucinations and analyzes them in large audio-video language models. We gather 1,000 sentences by inquiring about audio information and annotate them whether they contain hallucinations. If a sentence is hallucinated, we also categorize the type of hallucination. The results reveal that 332 sentences are hallucinated with distinct trends observed in nouns and verbs for each hallucination type. Based on this, we tackle a task of audio hallucination classification using pre-trained audio-text models in the zero-shot and fine-tuning settings. Our experimental results reveal that the zero-shot models achieve higher performance (52.2% in F1) than the random (40.3%) and the fine-tuning models achieve 87.9%, outperforming the zero-shot models.

    Comment: 6 pages
    Keywords Computer Science - Multimedia ; Computer Science - Computation and Language ; Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Sound ; Electrical Engineering and Systems Science - Audio and Speech Processing
    Subject code 420
    Publishing date 2024-01-18
    Publishing country us
    Document type Book ; Online
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  5. Article ; Online: Percutaneous Covered Stenting in Splenic Vein for Left-sided Portal Hypertension Caused by Chronic Splenic Vein Obstruction.

    Yamamoto, Masayoshi / Hitomi, Suguru / Hara, Takuya / Kondo, Hiroshi / Oba, Hiroshi

    Interventional radiology (Higashimatsuyama-shi (Japan)

    2023  Volume 9, Issue 1, Page(s) 31–35

    Abstract: Left-sided portal hypertension (LSPH), an uncommon manifestation of portal hypertension, is characterized by conditions such as isolated gastric varices and splenomegaly, which result from impeded splenic venous drainage in the presence of pancreatic ... ...

    Abstract Left-sided portal hypertension (LSPH), an uncommon manifestation of portal hypertension, is characterized by conditions such as isolated gastric varices and splenomegaly, which result from impeded splenic venous drainage in the presence of pancreatic disease. We employed a percutaneous transhepatic technique to achieve regression of isolated gastric varices by implanting a covered stent within a blocked splenic vein and by embolizing the posterior gastric vein and varices using N-butyl-2-cyanoacrylate. We report the successful treatment of stenting for LSPH by the covered stent placement.
    Language English
    Publishing date 2023-12-14
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 3140862-X
    ISSN 2432-0935 ; 2432-0935
    ISSN (online) 2432-0935
    ISSN 2432-0935
    DOI 10.22575/interventionalradiology.2023-0011
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  6. Article ; Online: Turtle skull development unveils a molecular basis for amniote cranial diversity.

    Sato, Hiromu / Adachi, Noritaka / Kondo, Satomi / Kitayama, Chiyo / Tokita, Masayoshi

    Science advances

    2023  Volume 9, Issue 46, Page(s) eadi6765

    Abstract: Amniote skulls display diverse architectural patterns including remarkable variations in the number of temporal arches surrounding the upper and lower temporal fenestrae. However, the cellular and molecular basis underlying this diversification remains ... ...

    Abstract Amniote skulls display diverse architectural patterns including remarkable variations in the number of temporal arches surrounding the upper and lower temporal fenestrae. However, the cellular and molecular basis underlying this diversification remains elusive. Turtles are a useful model to understand skull diversity due to the presence of secondarily closed temporal fenestrae and different extents of temporal emarginations (marginal reduction of dermal bones). Here, we analyzed embryos of three turtle species with varying degrees of temporal emargination and identified shared widespread coexpression of upstream osteogenic genes
    MeSH term(s) Animals ; Turtles/genetics ; Turtles/anatomy & histology ; Core Binding Factor Alpha 1 Subunit/metabolism ; Skull/anatomy & histology ; Head ; Reptiles/anatomy & histology
    Chemical Substances Core Binding Factor Alpha 1 Subunit
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adi6765
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  7. Article ; Online: Proton Pump Inhibitors Ameliorate Oxaliplatin-induced Peripheral Neuropathy: Retrospective Analysis of Two Real-world Clinical Databases.

    Kobayashi, Akihide / Ikemura, Kenji / Wakai, Eri / Kondo, Masayoshi / Okuda, Masahiro

    Anticancer research

    2023  Volume 43, Issue 12, Page(s) 5613–5620

    Abstract: Background/aim: Chemotherapy-induced peripheral neuropathy (CIPN) due to oxaliplatin (L-OHP) is a major clinical problem. Effective and safe preventive strategies for CIPN are urgently needed. Although proton pump inhibitors (PPIs) have various off- ... ...

    Abstract Background/aim: Chemotherapy-induced peripheral neuropathy (CIPN) due to oxaliplatin (L-OHP) is a major clinical problem. Effective and safe preventive strategies for CIPN are urgently needed. Although proton pump inhibitors (PPIs) have various off-target effects, their clinical impact on L-OHP-induced CIPN remains unclear. In the present study, we investigated the effects of PPIs on L-OHP-induced CIPN in patients using two real-world clinical databases.
    Patients and methods: We retrospectively analyzed the electronic medical records of Osaka University Hospital to examine the effect of PPIs on CIPN development in 217 patients who received XELOX (L-OHP plus capecitabine) therapy for colorectal cancer. In addition, the Japanese Adverse Drug Event Report (JADER) database was used to validate the effects of PPIs on L-OHP-induced CIPN.
    Results: The incidences of CIPN (grade ≥2) and discontinuation of L-OHP were significantly lower in patients with PPIs than in those without PPIs. Multivariate analysis showed that concomitant PPIs use was an independent factor that significantly contributed to the prevention of grade ≥2 CIPN (odds ratio=0.054, p<0.001). Kaplan-Meier analysis showed that the time to onset of grade ≥2 CIPN was significantly prolonged in patients with PPIs without affecting the therapeutic efficacy of L-OHP (p=0.004). Moreover, JADER database analyses revealed that the reporting odds ratio of any PPI for L-OHP-induced CIPN was 0.485.
    Conclusion: Concomitant PPI use ameliorated L-OHP-induced CIPN in patients with colorectal cancer.
    MeSH term(s) Humans ; Oxaliplatin/adverse effects ; Proton Pump Inhibitors/therapeutic use ; Retrospective Studies ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/drug therapy ; Peripheral Nervous System Diseases/prevention & control ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/chemically induced ; Antineoplastic Agents/adverse effects
    Chemical Substances Oxaliplatin (04ZR38536J) ; Proton Pump Inhibitors ; Antineoplastic Agents
    Language English
    Publishing date 2023-11-29
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16764
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    Zs.A 1642: Show issues Location:
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  8. Article ; Online: Percutaneous Methods for Reinsertion of a Dislodged External Pancreatic Duct Stent.

    Yamamoto, Masayoshi / Furui, Shigeru / Yamada, Kentaro / Kondo, Hiroshi / Oba, Hiroshi

    Cardiovascular and interventional radiology

    2021  Volume 44, Issue 7, Page(s) 1147–1150

    MeSH term(s) Humans ; Pancreatic Ducts/diagnostic imaging ; Pancreaticojejunostomy ; Stents
    Language English
    Publishing date 2021-03-21
    Publishing country United States
    Document type Letter
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-021-02818-0
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    Zs.A 1378: Show issues Location:
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  9. Book ; Online: Large-scale Vision-Language Models Learn Super Images for Efficient and High-Performance Partially Relevant Video Retrieval

    Nishimura, Taichi / Nakada, Shota / Kondo, Masayoshi

    2023  

    Abstract: In this paper, we propose an efficient and high-performance method for partially relevant video retrieval (PRVR), which aims to retrieve untrimmed long videos that contain at least one relevant moment to the input text query. In terms of both efficiency ... ...

    Abstract In this paper, we propose an efficient and high-performance method for partially relevant video retrieval (PRVR), which aims to retrieve untrimmed long videos that contain at least one relevant moment to the input text query. In terms of both efficiency and performance, the overlooked bottleneck of previous studies is the visual encoding of dense frames. This guides researchers to choose lightweight visual backbones, yielding sub-optimal retrieval performance due to their limited capabilities of learned visual representations. However, it is undesirable to simply replace them with high-performance large-scale vision-and-language models (VLMs) due to their low efficiency. To address these issues, instead of dense frames, we focus on super images, which are created by rearranging the video frames in a $N \times N$ grid layout. This reduces the number of visual encodings to $\frac{1}{N^2}$ and compensates for the low efficiency of large-scale VLMs, allowing us to adopt them as powerful encoders. Surprisingly, we discover that with a simple query-image attention trick, VLMs generalize well to super images effectively and demonstrate promising zero-shot performance against SOTA methods efficiently. In addition, we propose a fine-tuning approach by incorporating a few trainable modules into the VLM backbones. The experimental results demonstrate that our approaches efficiently achieve the best performance on ActivityNet Captions and TVR.

    Comment: 13 pages, 11 figures
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Multimedia
    Subject code 004
    Publishing date 2023-12-01
    Publishing country us
    Document type Book ; Online
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  10. Article: Apocynin-Tandospirone Derivatives Suppress Methamphetamine-Induced Hyperlocomotion in Rats with Neonatal Exposure to Dizocilpine.

    Uehara, Takashi / Kurachi, Masayoshi / Kondo, Takashi / Abe, Hitoshi / Itoh, Hiroko / Sumiyoshi, Tomiki / Suzuki, Michio

    Journal of personalized medicine

    2022  Volume 12, Issue 3

    Abstract: Accumulating evidence implicates oxidative stress as a potential pathophysiological mechanism of schizophrenia. Accordingly, we synthesized new chemicals using apocynin and tandospirone as lead compounds ( ...

    Abstract Accumulating evidence implicates oxidative stress as a potential pathophysiological mechanism of schizophrenia. Accordingly, we synthesized new chemicals using apocynin and tandospirone as lead compounds (
    Language English
    Publishing date 2022-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12030366
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